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By Dr. Chinta Sidharthan Jan 26 2024 Reviewed by Lily Ramsey, LLM

In a recent study published in Communications Biology, a team of scientists investigated how type 2 diabetes and genetic susceptibility to the disease impacted the severity of and mortality risk associated with coronavirus disease 2019 (COVID-19) using data from the United Kingdom (U.K.) Biobank.

Study:  Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank . Image Credit: PeopleImages.com – Yuri A/Shutterstock.com Background

Despite widespread vaccination across the globe, the COVID-19 pandemic continues, albeit in a less virulent form, with new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

SARS-CoV-2 infections have been found to manifest in a wide range of symptoms, from asymptomatic to severe cases involving acute respiratory distress, pneumonia, and death.

A significant number of COVID-19 cases are also known to progress into post-acute COVID-19 syndrome, commonly known as long coronavirus disease (long COVID).

Extensive research also indicates that clinical factors such as age, smoking behavior, and the presence of comorbidities such as type 2 diabetes, obesity, cardiovascular disease, hypertension, and respiratory diseases are risk factors for severe COVID-19.

Genome-wide association studies have also shown that genetic variants linked to increased risk of cardiovascular disease, type 2 diabetes, lung disease, and those involved in immune mechanisms are associated with a higher risk of severe SARS-CoV-2 infections. About the study

In the present study, the scientists used U.K. Biobank data to investigate whether type 2 diabetes and polygenic risk scores for type 2 diabetes were associated with increased severity of SARS-CoV-2 infections and a higher COVID-19 mortality rate.

Additionally, they examined the effect of vaccinations on this association and evaluated the impact of numerous SARS-CoV-2 variants, including the recently emerged Omicron variants. Related StoriesLong COVID's impact on cardiovascular health: what we do and do not knowNew research finds semen microbiome's impact on male fertilityPaxlovid treatment in 20% of COVID-19 patients could avert 850,000 hospitalizations, save up to $170 billion

The polygenic risk scores for type 2 diabetes from the genome-wide association study summary statistics obtained from the U.K. Biobank were first used to determine the genetic predisposition for type 2 diabetes.

Here, to account for the confounding impact of body mass index (BMI) on type 2 diabetes, the researchers included BMI as a covariate while calculating the type 2 diabetes polygenic risk scores in the genome-wide association study.

Subsequently, they used the proportional odds models to determine whether type 2 diabetes and the genetic predisposition to type 2 diabetes were associated with increased severity of SARS-CoV-2 infections.

They also examined how type 2 diabetes or the genetic risk for type 2 diabetes impacted survival time when the individual was infected with SARS-CoV-2.

Furthermore, the impact on survival time was reexamined with respect to vaccination status and for a wide range of SARS-CoV-2 variants.

Lastly, the researchers also examined whether mortality rates were significantly different between three groups — COVID-19, type 2 diabetes, and genetic predisposition to type 2 diabetes — using a stratified survivor analysis. Results

The findings indicated that type 2 diabetes, as well as polygenic risk scores for type 2 diabetes, were associated with increased COVID-19 severity. The mortality rate was also found to be higher for individuals with type 2 diabetes or a genetic predisposition to it.

Based on the time of infection, the mortality rate for type 2 diabetes patients infected with SARS-CoV-2 was two to seven times higher than for those who did not have SARS-CoV-2 infections.

The rate of fatalities was also found to be higher for the early SARS-CoV-2 variants, with the fatality risk decreasing across Alpha, EU1, and Delta variants to the Omicron variants.

Furthermore, vaccinated type 2 diabetes patients had a significantly lower risk of severe SARS-CoV-2 infections than non-vaccinated ones.

The association between polygenic risk scores for type 2 diabetes and increased risk of severe COVID-19 also indicates an interplay between the genetic factors underlying type 2 diabetes and COVID-19, providing potential research avenues to explore to understand the novel genetic factors that are linked to severe SARS-CoV-2 infections. Conclusions

To summarize, the study examined the relationship between type 2 diabetes or the polygenic risk scores for type 2 diabetes and the odds of developing severe COVID-19.

The findings suggested that individuals who have either the genetic predisposition for or have type 2 diabetes are at an increased risk of severe SARS-CoV-2 infections and a higher risk of mortality due to COVID-19.

However, COVID-19 vaccinations were found to decrease the risk of severe COVID-19 and mortality in these groups. Journal reference:

Lee, A., Seo, J., Park, S., Cho, Y., Kim, G., Li, J., Liang, L., Park, T., & Chung, W. (2024). Type 2 diabetes and its genetic susceptibility are associated with increased severity and mortality of COVID-19 in UK Biobank. Communications Biology, 7(1), 122. doi: https://doi.org/10.1038/s42003024057991. https://www.nature.com/articles/s42003-024-05799-1

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Politics

Investigation demanded into Keir Starmer’s comms chief’s lobbying links

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Investigation demanded into Keir Starmer's comms chief's lobbying links

Sir Keir Starmer’s communications chief Tim Allan owns a minority stake in a lobbying firm and still discusses government activity with a senior consultant at the company, Sky News can reveal.

The relationship between Tim Allan, Tom Baldwin and Strand Partners has led to accusations of a perception that one of Downing Street’s most senior figures has a conflict of interest – a potential breach of the special adviser code.

Tom Baldwin is a consultant for Strand Partners, a lobbying firm partly owned by Mr Allan, the government’s executive director of communications.

Multiple sources have told Sky News that Mr Allan and Mr Baldwin have discussed government affairs and politics since Mr Allan joined Number 10 in September. This is not challenged by Downing Street, who say the pair speak in Mr Baldwin’s capacity as a journalist.

Tim Allan at a Strand Partners event in July 2024, before he took a job in government. Pic: Strand Partners
Image:
Tim Allan at a Strand Partners event in July 2024, before he took a job in government. Pic: Strand Partners

Mr Baldwin is also Sir Keir’s biographer, a commentator and has appeared on Sky News.

As part of his role for Strand Partners, he has spoken at private briefings for Strand’s corporate clients about the inner workings of government.

There is no suggestion that Mr Baldwin – who is not a lobbyist – or Strand Partners have done anything wrong.

The revelations about Mr Allan have led to cross-party calls for an investigation and a member of Labour’s ruling National Executive Committee to demand he gives up his 10% shareholding in Strand Partners.

Zack Polanski, the Green Party leader, told Sky News: “I think it’s extraordinary that someone still has shares who’s at the heart of Downing Street… I think there’s lots of questions still to be asked, I think it’s important to know what these supposed appropriate mitigations are, what exactly are those and do they pass the public sniff test?”

Mr Allen is bound by the code of special advisers that says: “Special advisers must ensure that no conflict arises, or could reasonably be perceived to arise, between their official duties and their private interests, financial or otherwise.”

The code also says: “Special advisers must not misuse their official position or information acquired in the course of their official duties to further their private interests or those of others.”

Tom Baldwin, Journalist and Strategic Adviser at Strand Partners, speaking at a company dinner at Labour Party Conference in September 2025. Pic: Strand Partners.
Image:
Tom Baldwin, Journalist and Strategic Adviser at Strand Partners, speaking at a company dinner at Labour Party Conference in September 2025. Pic: Strand Partners.

Mr Baldwin and Mr Allan are understood not to discuss Strand Partners business. Mr Allan has undertaken to not take dividends or get involved in the running of the company while he is in government, and resigned as chairman on his appointment to Number 10 at the start of September.

But other lobbyists told me they are jealous of this level of access, giving rise to the perception of a conflict of interest.

Opposition parties are seeking an investigation. Lisa Smart, a Liberal Democrat frontbencher, said: “I’ve written to the cabinet secretary today because this appears to be a clear conflict of interest right at the heart of government.

“It cannot be the case that the executive director of communications for the government has shareholdings in a lobbying firm and is continuing to have conversations with senior consultants at that firm.”

Tim Allan (left, behind the flag) sitting in on a Cabinet meeting, in September. Pic: Number 10/Flickr
Image:
Tim Allan (left, behind the flag) sitting in on a Cabinet meeting, in September. Pic: Number 10/Flickr

Kevin Hollinrake, Conservative Party chairman, said: “[There] should be a full Cabinet Office investigation. I think the public need to see there are no conflicts of interest and no perceived conflicts of interests, and that’s not where we are right now.”

The member of Labour’s National Executive Committee said: “This is a massive conflict of interest when we promised integrity to the British public. The first thing he has to do is give up his shareholding.”

Since Mr Allan took up his role in September, Mr Baldwin has been allowed by Treasury officials in Downing Street to attend at least one restricted event with Chancellor Rachel Reeves, her news conference on the budget last week.

Mr Allan denies knowing about this in advance and said this is part of a multi-interview feature for a newspaper, but it is a sign of how close Mr Baldwin is with members of the government.

A Labour spokesperson said: “The allegation that Tim Allan has done anything to benefit Strand whilst in Number 10 is categorically false.

“Tom Baldwin is an established journalist, author and commentator, who regularly appears on Sky News. Any interactions with him are in his capacity as a journalist and have not related to Strand, its business or its clients.”

A Cabinet Office spokesperson said: “There is a rigorous process to capture any potential conflicts of interest, and ensure appropriate mitigations are in place to reflect specific circumstances. Ahead of his appointment, Tim Allan fully complied with this process.

“This is set out in the Special Adviser Code of Conduct and lists of special adviser interests are published annually.”

A Strand Partners spokesman said: “Tom Baldwin is a journalist and the biographer of the prime minister. He does not engage in government relations for Strand and this is not part of his terms of engagement with us.

“Tim Allan sought advice on his interests from the Cabinet Office and followed every element of the advice received. He receives no financial benefit from Strand and is not involved in our operations.”

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Politics

Resident doctor strikes: I don’t want people to suffer but we have to walk out again, says BMA chief

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Resident doctor strikes: I don't want people to suffer but we have to walk out again, says BMA chief

The British Medical Association (BMA) has defended a new round of resident doctor walkouts starting on Friday, insisting medics’ pay is still “way down” compared with 2008 and that the government has failed to finish “a journey” towards restoring it.

BMA chair Dr Tom Dolphin told Sky News the dispute remains rooted in years of pay erosion that have left resident doctors far behind other public sector workers.

“When we started the dispute, […] the lowest level of the resident doctors were being paid £14 an hour,” he said.

“There were some pay rises over the last couple of years that brought that partly back to the value it should be at, but not all the way.

“The secretary of state (Wes Streeting) himself called it a journey, implying there were further steps to come, but we haven’t seen that.”

Resident doctors outside Newcastle's Royal Victoria Infirmary during a five-day strike in July. File pic: PA
Image:
Resident doctors outside Newcastle’s Royal Victoria Infirmary during a five-day strike in July. File pic: PA

When asked if the row ultimately “comes down to money”, he replied: “In the sense that the secretary of state doesn’t want to or isn’t able to fund the pay increases to match the value that we had in 2008.”

Dr Dolphin argued that while “the general worker in the economy as a whole” has seen pay catch up since the 2008 financial crash, “doctors are still way down”.

The government points out that its 29% settlement last year was one of the largest in the public sector and was intended to draw a line under two years of walkouts.

How much do resident doctors earn?

After the most recent pay awards, in 2025/26 a medic just out of university receives a basic salary of £38,831 and has estimated average earnings of £45,900 after factors like extra pay for unsociable hours are taken into account, according to medical think tank the Nuffield Trust.

That average figure rises to £54,400 by the second year and a more senior speciality registrar earns an average of £80,500.

The BMA says that when the dispute started, the most junior doctors were making around £14 per hour. That works out at £29,120 per year for a 40-hour week.

That’s very close to the earnings of a doctor fresh out of medical school in 2022/23 – £29,384, according to Full Fact.

But that’s over a 52-week year without taking into account paid holiday or unsociable hours.

But Dr Dolphin said the deal still fell short: “The gap was biggest for doctors and needed the biggest amount of restoration, and that’s what we got.”

He defended the BMA’s use of the Retail Price Index (RPI), a metric rejected by the Office for National Statistics, saying it “better reflects the costs people face”.

Should resident doctors get a pay rise? Have your say in the poll at the bottom of this story.

Dr Tom Dolphin says resident doctors are still underpaid
Image:
Dr Tom Dolphin says resident doctors are still underpaid

‘Who do you think is treating the patients?’

With Chancellor Rachel Reeves preparing her budget amid warnings of deep cuts, Dr Dolphin said the BMA is not demanding an immediate cash injection.

“We’re quite happy for that money to be deferred with some kind of multi-year pay deal so that we can end the dispute and avoid having further industrial action about pay for several years to come,” he said.

“Money spent in the NHS is returned to the economy. For every pound you spend, you get several pounds back.”

When pressed on whether the £1.7bn cost of previous strike action could have been better spent on treatment and technology for NHS cancer patients, he hit back: “Who do you think is treating the cancer patients? It’s the doctors.”

Read more on Sky News:
Thousands of NHS redundancies
Sentence and fine over patient death

Health Secretary Wes Streeting has criticised the BMA for striking again. File pic: PA
Image:
Health Secretary Wes Streeting has criticised the BMA for striking again. File pic: PA

Strikes will cause disruption, union boss admits

Dr Dolphin rejected suggestions that the dispute could destabilise the government, calling the idea “implausible”.

He admitted prolonged strikes have tested public patience, but said the government had left doctors with no choice.

“A prolonged industrial dispute makes people annoyed with both sides,” he said. “It is vexing to us that we are still in this dispute.”

“I don’t want patients to suffer,” he added. “I accept that the strikes cause disruption… of course that’s upsetting for them. I completely get that. And I’m sorry that it’s happening.”

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Technology

Chinese tech giant Tencent’s quarterly revenue rises 15%, fueled by AI

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Chinese tech giant Tencent's quarterly revenue rises 15%, fueled by AI

Tencent on Thursday posted 15% year-on-year revenue growth, with AI boosting the Chinese tech giant’s performance in advertising targeting and gaming.

Here’s how Tencent performed in the third quarter of 2025, per earnings released on Thursday: 

  • Revenue: 192.9 billion Chinese yuan ($27.12 billion), surpassing the 189.2 billion Chinese yuan expected analysts, according to data compiled by LSEG. 
  • Operating profit: 63.6 billion yuan, versus 58.01 billion yuan expected by the street.  

Tencent boosted its capital expenditure earlier this year as it ramped up AI and eyed European expansion for its cloud computing services, which would compete against market leaders Amazon Web Services, Google Cloud and Microsoft Azure. It has its own AI foundational model in China called Hunyuan, however it also uses DeepSeek in some products.  

Tencent shares are up 56.7% year-to-date. 

This is a breaking news story. Please refresh for updates.

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