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Feb 28 2024 University of Exeter

Young people could be spared from going blind by a new genetic risk tool that could also help diagnose multiple sclerosis (MS) earlier, to start effective treatments.

Optic neuritis is a condition that affects people of all ages, but especially young adults, usually manifesting in blurred vision and sometimes pain when moving the eyes. Up to half of people affected in the UK eventually go on to develop MS – often many years later. Emerging evidence indicates that starting the very effective MS treatments earlier may improve long term health.

Optic neuritis occurs because of swelling in or around the optic nerve. For those with MS-related optic neuritis, the swelling subsides on its own, and vision usually recovers. For many people whose optic neuritis does not result from MS, the optic nerve can be permanently damaged unless high doses of steroids are given quickly, resulting in loss of sight. However, steroids can result in harmful side effects. When people first develop optic neuritis, it can be difficult for patients and their doctors to decide whether the possible benefits of steroid outweigh the possible harms, when the likely cause of the optic neuritis is unclear.

Identifying whether there is an underlying cause of optic neuritis can be challenging for clinicians, with many important test results taking weeks to return. Now, new research, published in Nature Communications and led by the University of Exeter and King's College London, has shown for the first time that combining genetic risk for MS with demographic factors significantly improves MS risk prediction in people presenting with optic neuritis.

Co-author Dr Tasanee Braithwaite, consultant ophthalmologist to the Medical Eye Unit at Guy's and St Thomas NHS Foundation Trust, and Adjunct Senior Lecturer at King's College London said: "As a doctor caring for many patients with optic neuritis, I'm excited by the possibility of translating this pilot research into front line clinical care in the near future. Whilst more research is needed, our study provides a strong signal that we could better identify patients at high risk of MS, perhaps enabling these people to have earlier MS treatment in the future. Whereas, if we could better identify people whose optic neuritis is very unlikely to result from MS, we could treat these people urgently to reduce irreversible vision loss and blindness."

The team analysed more than 300 common genetic variants linked to developing MS, combining them into a genetic risk score that helps clinicians understand an individual's chance of developing MS. They analysed data from 500,000 people in the UK Biobank, who have shared genetic samples, questionnaires and linked health information from their electronic medical records.

The researchers found 2,369 people who had MS in the UK Biobank, and 687 people with optic neuritis. Of those, 545 had no identifiable cause for their optic neuritis at the start of the study, and 124 went on to develop MS.

Applying the genetic risk score effectively helped separate those at lowest risk from those at high risk. Whilst the MS genetic risk score is not a diagnostic test, this study highlights that it could add one valuable additional piece of information to support doctors and patients to make better decisions. Since the first genome was sequenced three decades ago, we've been working towards the promise of being able to use genetics to improve outcomes for individual patients. This research is an excellent example of precision genetic diagnosis in practice."

Richard Oram, Co-Author, Professor of the University of Exeter Medical School Related StoriesCaffeine's protective effects against obesity and joint diseases supported by genetic studyMapping the genomic landscape of Type 2 diabetesIdentification of genetic determinants of micronucleus formation

Dr Clare Walton, Head of Research at MS Society, said: "Currently, 130,000 people live with MS in the UK and one in five will have experienced optic neuritis at the start of their MS journey. This research shows how using genetic scores could be a useful way to predict who will likely continue to an MS diagnosis. 

"Using immunotherapies in people at high risk of MS could significantly delay the onset of the condition, but these drugs come with side effects. This exciting study opens up the possibility of finding people in which the benefits will outweigh the risks." 

The research stemmed from a summer project led by University of Exeter Medicine student Pavel Loginovic. With funding from the University of Exeter, it expanded into a research collaboration involving academics in Finland and the US. The research was further funded through Fight for Sight and the Royal College of Ophthalmologists, who awarded Dr Braithwaite a Zakarian Award to support this work.

Pavel said: "I'm elated to see this paper published, and it's gratifying that it could have a real impact in moving research forward, ultimately aiming to get people with MS diagnosed and perhaps treated earlier. Leading this analysis while staying on top of my medical studies has been a challenge and an immense opportunity for growth, professional and personal. I've enjoyed the academic journey so far, and I'm excited for what's to come."

The study is entitled, 'Applying a genetic risk score model to enhance prediction of future Multiple Sclerosis diagnosis at first presentation with optic neuritis', and is published in Nature Communications. Source:

University of ExeterJournal reference:

Loginovic, P., et al. (2024). Applying a genetic risk score model to enhance prediction of future multiple sclerosis diagnosis at first presentation with optic neuritis. Nature Communications. doi.org/10.1038/s41467-024-44917-9.

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Ryanair raises fares after profits hit by lower ticket prices

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Ryanair raises fares after profits hit by lower ticket prices

Europe’s largest airline has seen annual earnings drop by 16% after cutting air fares – but revealed a price hike as it seeks to return to growth.

Ryanair reported profits after tax fell to €1.61bn (£1.35bn) for the year to 31 March, down from €1.92bn (£1.61bn) in 2024, still the second highest on record.

On average, plane tickets were 7% cheaper during this period than the 12 months before, it said.

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There had been a 21% rise in fares in the year up to March 2024, which bosses had signalled was due to end.

Higher-for-longer interest rates and inflation in the first half of the year meant ticket prices had to come down, the budget carrier said.

But fares are already back on the rise, Ryanair’s chief executive Michael O’Leary said.

The airline “cautiously” expects to recover “most, but not all” of the fare decline, which he said will boost profits.

Demand for summer flights is “strong”, Mr O’Leary said, with peak fares “modestly” ahead of last year.

In recent months, that rebound has already been under way. Fares since April are on track to be “a mid-high teen per cent ahead” by the end of next month, compared with the same period last year.

That trend is expected to continue to July, August and September, Mr O’Leary said.

“While we cautiously expect to recover most, but not all of last year’s 7% fare decline, which should lead to reasonable net profit growth in 2025-26, it is far too early to provide any meaningful guidance,” he said.

“The final 2025-26 outcome remains heavily exposed to adverse external developments, including the risk of tariff wars, macro-economic shocks, conflict escalation in Ukraine and the Middle East and European air traffic control mismanagement/short staffing.”

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Passenger numbers grew to a record 200 million on the back of cheaper fares, hitting a target that had been reduced due to delays in delivering new Boeing planes.

The US manufacturer has struggled with increased regulatory oversight after a door panel blew off an Alaska Airlines plane mid-flight in January last year. Strike action by staff had added to the delays.

The forecast for passenger numbers has been reduced again. Ryanair now aims to transport 206 million passengers in this financial year.

It hopes to reach 300 million passengers by 2034 and on Monday said it still expects to receive 300 new Boeing planes by 2033.

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Israel to allow ‘basic quantity of food’ into Gaza to avoid ‘starvation crisis’

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Israel to allow 'basic quantity of food' into Gaza to avoid 'starvation crisis'

Israel has said it will allow a “basic quantity of food” into the besieged enclave of Gaza to avoid a “starvation crisis” following a near three-month blockade.

Israeli Prime Minister Benjamin Netanyahu’s office said the decision was “based on the operational need to enable the expansion of the military operation to defeat Hamas“.

Gaza, where local authorities say more than 53,000 people have died in Israel’s 19-month campaign, has been under a complete blockade on humanitarian aid since 2 March.

It comes as global food security experts warn of famine across the territory and after a UN-backed report from last Monday which warned one in five people in Gaza were facing starvation.

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The statement from the prime minister’s office said it would “allow a basic quantity of food to be brought in for the population in order to make certain that no starvation crisis develops in the Gaza Strip”.

“Such a crisis would endanger the continuation of Operation ‘Gideon’s Chariots’ to defeat Hamas,” it added.

“Israel will act to deny Hamas’s ability to take control of the distribution of humanitarian assistance in order to ensure that the assistance does not reach the Hamas terrorists.”

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It comes after a British surgeon working in Gaza said in a video to Sky News the enclave is now “a slaughterhouse” amid Israeli bombardment.

Israel has just ramped up its offensive in Gaza where it’s been conducting a military campaign in retaliation for 1,200 people killed and 251 taken hostage by Hamas on 7 October 2023 – with Palestinian health officials reporting at least 130 people were killed overnight into Sunday.

Israel Defence Forces (IDF) confirmed troops had begun “extensive ground operations throughout the northern and southern Gaza Strip”.

The Hamas-run health ministry in Gaza said 464 people had died in Israeli military strikes in the week to Sunday.

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In a statement on Sunday, IDF said its air force struck “over 670 Hamas terror targets throughout the Gaza Strip to disrupt enemy preparations and support ground operations” over the past week.

Israel has launched an escalation to increase pressure on Hamas, seize territory, displace Palestinians to the south and take greater control over the distribution of aid.

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Easing trade and signing a defence pact would be manifesto promises delivered – and Starmer could use a win

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Easing trade and signing a defence pact would be manifesto promises delivered - and Starmer could use a win

This EU-UK summit has for months been openly billed by Sir Keir Starmer’s Downing Street as a hugely significant moment for this government.

The Labour leader promised in his 2024 election manifesto that the UK would sign a new security pact with the EU to strengthen cooperation and improve the UK’s trading relationship with the continent.

Since winning power in July, he has embarked on a charm offensive across European capitals in a bid to secure that better post-Brexit deal.

Monday is when the PM makes good on those promises at a historic summit at Lancaster House in London.

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There, the EU and UK are expected to sign a security and defence partnership, which has taken on a new sense of urgency since the arrival of President Trump in the White House.

It is an agreement that will symbolise the post-Brexit reset, with the PM, European Commission president Ursula von der Leyen and European Council president Antonio Costa also signing off on a communique pledging deeper economic cooperation.

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But, rather like the torturous Brexit negotiations I covered for years in London and Brussels under Conservative prime ministers, Sir Keir’s post-Brexit reset went down to the wire.

Discussions continued over night as the two sides snared up over details around fisheries, food trade and youth mobility.

It’s not that both sides did not want the reset: the war in Ukraine and the spectre of the US becoming an unreliable partner have pushed London and Brussels closer together in their common defence interest.

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Fishing and youth mobility – the two snags

But the pressure for this deal weighed more heavily on our prime minister than his European colleagues. He’s been talking for months about securing a reset and better trading relationship with the EU to bolster the UK economy.

His need to demonstrate wins is why, suggests one continental source, the Europeans let talks go to the wire, with London and Brussels in a tangle over fishing rights – key demands of France and the Netherlands – and a youth mobility scheme, which is a particular focus for Berlin.

In the end, the UK allowed EU fishing boats access to British waters 12 years.

“The British came with 50 asks, we came with two – on fishing and the youth mobility scheme,” says one European source.

EU sources say Brussels had offered a time-limited deal to lift checks on animal products – replicating London’s offer on fisheries – but the UK is reluctant to do this as it leaves too much uncertainty for farmers and supermarkets.

Donald Tusk, Friedrich Merz, Emmanuel Macron and Keir Starmer talk to the press after their meeting.
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Poland’s Prime Minister Donald Tusk, Germany’s Chancellor Friedrich Merz, France’s President Emmanuel Macron and Sir Keir Starmer talk to the press after their meeting on May 16, 2025 Pic: Reuters

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A deal on food products, known as sanitary and phytosanitary (SPS) goods, would be a boost for the economy, with potentially up to 80% of border checks disappearing, given the breadth of products – paint, fashion goods, leather as well as foods – with an animal component.

Any deal also means the UK would have to align with rules made in Brussels and make a financial contribution to the EU to fund work on food and animal standards.

Both elements will trigger accusations of Brexit “betrayal”, as the UK signs up as a “rule taker” and finds itself paying back into the EU for better access.

Government figures had been telling me how they are more than prepared to face down the criticisms thrown at them from the Conservatives.

But sensitivities around fishing, particularly in Scotland, where Labour is facing elections next year, weighed on talks.

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The other area of huge tension was over a youth mobility scheme, which would enable young adults from member states to study and work in the UK and vice versa.

Government sources familiar with the talks acknowledge some sort of scheme will be included, but want details to be vague – I’m told it might be “an agreement about a future agreement”, while the EU sees this a one of its two core demands.

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In talks late on Sunday night, the UK government appeared to be softening on re-opening the pre-Brexit Erasmus student exchange scheme as perhaps a way to get around the impasse, according to one EU source.

The UK rejoining this scheme had been rebuffed by Sir Keir last year, but was raised again last night in talks, according to a source.

Common ground on defence and security

Wherever the economic horsetrading lands, the two sides have found common ground in recent months is on defence and security, with the UK working in lockstep with European allies over Ukraine and relationships deepening in recent months as Sir Keir Starmer has worked with President Macron and others to try to smooth tensions between Kyiv and Washington and work on a European peace deal for Ukraine.

The expectation is that the two sides will sign a security partnership that will reiterate the UK’s commitment to build up the continent’s defence capability and stand united against Russian aggression with its partners.

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The deal should also mean British arms companies will be able to access the EU’s €150bn rearmament programme, which has been set up to create a massive surge in defence spending over the next five years as Europe prepares itself to better repel threats.

It is clearly in neither side’s interest for Monday to go wrong.

The EU and UK need to maintain a united front and, more importantly for Keir Starmer domestically, the PM needs to show an increasingly sceptical public he can deliver on his promises.

Easing trade barriers with Britain’s biggest trading partner and signing an EU defence pact would be two manifesto promises delivered.

And with his popularity sinking to a record low in recent days, he could really do with a win.

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