The idea of scientists bringing pre-historic creatures back to life with some clever DNA trickery might sound familiar to fans of the 1993 Hollywood blockbuster Jurassic Park.
But for Colossal Biosciences – a company that hopes to reintroduce extinct species such as the dodo and the mammoth – it is more than just a film script.
It’s a reality – and one that could be just years away.
“We’ve got all the technology we need,” says Ben Lamm, chief executive of the firm, based in Dallas, Texas.
“It is just a focus of time and funding. But we are 100% confident [we can bring back] the Tasmanian tiger, the dodo, and the mammoth.”
The science behind the project is simple: Work out the genes that make an extinct animal what it is, and then replicate those genes using the DNA of a close existing relative.
“It’s almost reverse Jurassic Park,” says Mr Lamm, speaking to Sky News.
“In the film, they were filling in the holes in the dinosaur DNA with frog DNA.
“We are leveraging artificial intelligence and other tools to identify the core genes that make a mammoth a mammoth and then engineering them into elephant genomes.”
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That is the technical part.
But there are some other practical hurdles for Colossal to overcome, namely how, once you have mammoth cells, do you birth a real-life mammoth?
The answer, according to Colossal, is in the womb of an Asian elephant.
But it is a process that could take nearly two years, even after they have worked out how to do it.
“[Each of the] different projects [the mammoth, dodo, and Tasmanian tiger] have different challenges – the mammoth is really around gestation – which is around 22 months,” says Mr Lamm.
“The dodo gestation is pretty great – we are using surrogate chickens. The hardest part is cultivating the primordial germ cells.”
‘Feeling good about 2028’
So after around 4,000 years of extinction, when could we see the return of the mighty mammoth – a creature that fell victim to human hunting and the changing conditions brought about by the end of the last Ice Age.
“We are well into the editing phase,” says Mr Lamm.
“We don’t have mammoths yet, but we still feel very good about 2028.”
Away from the lab, led by Eriona Hysolli, Colossal’s head of biological sciences, there are other issues to overcome – including where the newly returned species will live once they are born.
Mr Lamm says the company is already working with local governments, conservation groups, indigenous people groups, private land lowers, and the public at large, to prepare for the animals to be returned to their natural habitat.
“Our ultimate goal is to put all the animals we make back into the wild,” he says.
‘New tools in the fight’ to protect nature
Colossal says the work is not just about rewilding animals previously lost to the world.
The company is currently working with Dr Paul Ling at Baylor College of Medicine in Houston, Texas, to create a vaccine to eradicate the deadly EEHV virus – which kills around 20% of baby elephants each year.
It is also working closely with the University of Alaska and the University of Stockholm on radiocarbon dating of American mammoths as well as sequencing their genome – the largest study of its type ever undertaken.
Mr Lamm also hopes that, through Colossal’s research, the company can tackle issues facing the world today, including a drop in biodiversity.
“I think we have a duty to this planet that we’ve been given – we are tending towards a loss of up to 50% biodiversity if we don’t do anything,” he says.
“Modern conservation is great, but we need new tools in the fight.
“Work on de-extinction goes hand-in-hand with species preservation, and if Colossal makes a couple of technologies, then maybe it will provide those tools.”
‘Jurassic Park helps people understand our work’
As for the Jurassic Park comparisons, well, there is one small issue, according to Mr Lamm.
In the Steven Spielberg-directed epic, the scientists use DNA embedded in fossilised mosquitoes in amber combined with frog DNA to bring dinosaurs back to life.
“Amber is not a good holder of DNA,” Mr Lamm says.
“But it’s a very entertaining movie and I think Jurassic Park made a lot of people interested in science. I saw it when I was younger and I was like: ‘Wow genetics is cool’.
“It did a lot to explain to the masses that genetic engineering is a thing and something that can be used in powerful ways, and I do think more people understand Colossal because of that.”
The company is also working on a film of its own, and, luckily for everyone, it’s not a dystopian thriller like Jurassic Park.
It has teamed up with award-winning director James Reed, a specialist in nature films, to document its “de-extinction” work.
“It’s really exciting. When you are doing anything bold, it is important to communicate and be transparent, and there’s nothing more transparent than having cameras around all the time,” says Mr Lamm.
Sam Moore, who sang Soul Man and other 1960s hits in the legendary Sam & Dave duo, has died aged 89.
Moore, who influenced musicians including Michael Jackson, Al Green and Bruce Springsteen, died on Friday in Coral Gables, Florida, due to complications while recovering from surgery, his publicist Jeremy Westby said.
No additional details were immediately available.
Moore was inducted with Dave Prater, who had died in a 1988 car crash, into the Rock and Roll Hall of Fame in 1992.
The duo, at the Memphis, Tennessee-based Stax Records, transformed the “call and response” of gospel music into a frenzied stage show and recorded some of soul music’s most enduring hits, including Hold On, I’m Comin’.
Many of their records were written and produced by the team of Isaac Hayes and David Porter and featured the record label’s house band Booker T & the MGs.
Sam & Dave faded after their 1960s heyday but Soul Man hit the charts again in the late 1970s when the Blues Brothers, John Belushi and Dan Aykroyd, recorded it with many of the same musicians.
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Moore had mixed feelings about the hit becoming associated with the Saturday Night Live stars, remembering how young people believed it originated with the Blues Brothers.
Sam & Dave broke up in 1970 and neither had another major hit.
Moore later said his drug habit played a part in the band’s troubles and made record executives wary of giving him a fresh start.
He married his wife Joyce in 1982, and she helped him get treatment for his addiction that he credited with saving his life.
Moore spent years suing Prater after his former partner hired a substitute and toured as the New Sam & Dave.
He also lost a lawsuit claiming the pair of aging, estranged singers in the 2008 movie Soul Men was too close to the duo.
In another legal case, he and other artists sued multiple record companies and the American Federation of Television and Radio Artists in 1993, claiming he had been cheated out of retirement benefits.
Despite his million-selling records, he said in 1994 his pension amounted to just 2,285 US dollars (£1,872), which he could take as a lump sum or in monthly payments of 73 US dollars (£60).
“Two thousand dollars for my lifetime?” Moore said at the time. “If you’re making a profit off of me, give me some too. Don’t give me cornbread and tell me it’s biscuits.”
Moore wrote Dole Man, based on Soul Man, for Republican Bob Dole’s 1996 presidential campaign and was one of the few entertainers who performed at President Donald Trump’s inaugural festivities in 2017.
Eight years earlier, he objected to Democratic presidential candidate Barack Obama’s use of the song Hold On, I’m Comin’ during his campaign.
The fires that have been raging in Los Angeles County this week may be the “most destructive” in modern US history.
In just three days, the blazes have covered tens of thousands of acres of land and could potentially have an economic impact of up to $150bn (£123bn), according to private forecaster Accuweather.
Sky News has used a combination of open-source techniques, data analysis, satellite imagery and social media footage to analyse how and why the fires started, and work out the estimated economic and environmental cost.
More than 1,000 structures have been damaged so far, local officials have estimated. The real figure is likely to be much higher.
“In fact, it’s likely that perhaps 15,000 or even more structures have been destroyed,” said Jonathan Porter, chief meteorologist at Accuweather.
These include some of the country’s most expensive real estate, as well as critical infrastructure.
Accuweather has estimated the fires could have a total damage and economic loss of between $135bn and $150bn.
“It’s clear this is going to be the most destructive wildfire in California history, and likely the most destructive wildfire in modern US history,” said Mr Porter.
“That is our estimate based upon what has occurred thus far, plus some considerations for the near-term impacts of the fires,” he added.
The calculations were made using a wide variety of data inputs, from property damage and evacuation efforts, to the longer-term negative impacts from job and wage losses as well as a decline in tourism to the area.
The Palisades fire, which has burned at least 20,000 acres of land, has been the biggest so far.
Satellite imagery and social media videos indicate the fire was first visible in the area around Skull Rock, part of a 4.5 mile hiking trail, northeast of the upscale Pacific Palisades neighbourhood.
These videos were taken by hikers on the route at around 10.30am on Tuesday 7 January, when the fire began spreading.
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At about the same time, this footage of a plane landing at Los Angeles International Airport was captured. A growing cloud of smoke is visible in the hills in the background – the same area where the hikers filmed their videos.
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The area’s high winds and dry weather accelerated the speed that the fire has spread. By Tuesday night, Eaton fire sparked in a forested area north of downtown LA, and Hurst fire broke out in Sylmar, a suburban neighbourhood north of San Fernando, after a brush fire.
These images from NASA’s Black Marble tool that detects light sources on the ground show how much the Palisades and Eaton fires grew in less than 24 hours.
On Tuesday, the Palisades fire had covered 772 acres. At the time of publication of Friday, the fire had grown to cover nearly 20,500 acres, some 26.5 times its initial size.
The Palisades fire was the first to spark, but others erupted over the following days.
At around 1pm on Wednesday afternoon, the Lidia fire was first reported in Acton, next to the Angeles National Forest north of LA. Smaller than the others, firefighters managed to contain the blaze by 75% on Friday.
On Thursday, the Kenneth fire was reported at 2.40pm local time, according to Ventura County Fire Department, near a place called Victory Trailhead at the border of Ventura and Los Angeles counties.
This footage from a fire-monitoring camera in Simi Valley shows plumes of smoke billowing from the Kenneth fire.
Sky News analysed infrared satellite imagery to show how these fires grew all across LA.
The largest fires are still far from being contained, and have prompted thousands of residents to flee their homes as officials continued to keep large areas under evacuation orders. It’s unclear when they’ll be able to return.
“This is a tremendous loss that is going to result in many people and businesses needing a lot of help, as they begin the very slow process of putting their lives back together and rebuilding,” said Mr Porter.
“This is going to be an event that is going to likely take some people and businesses, perhaps a decade to recover from this fully.”
The Data and Forensics team is a multi-skilled unit dedicated to providing transparent journalism from Sky News. We gather, analyse and visualise data to tell data-driven stories. We combine traditional reporting skills with advanced analysis of satellite images, social media and other open source information. Through multimedia storytelling we aim to better explain the world while also showing how our journalism is done.