Connect with us

Published

on

Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.


Affiliate links may be automatically generated – see our ethics statement for details.

Continue Reading

Science

NASA Hubble Space Telescope Helps Confirm the First Solitary Black Hole

Published

on

By

NASA Hubble Space Telescope Helps Confirm the First Solitary Black Hole

For the first time, the existence of a lone black hole has been confirmed by scientists. This black hole has no star orbiting it. According to the statement by Kailash Sahu, astronomer at the Space Telescope Science Institute in Baltimore, “it’s the only one so far”. The discovery made headlines in the year 2022, when Sahu and his Team claimed a dark object was moving through the constellation Sagittarius. However, another team of researchers disputed the claims by identifying the object as a neutron star.

About the Discovery

This discovery came into the light three years ago. All the stellar-mass black holes are accompanied by stars that betray their presence and race around an invisible star, along with three times the sun’s mass. Such a procedure indicates the presence of black holes rather than a neutron star.

On the contrary, the solitary black holes are expected to be common, but are very hard to find. Likewise, the one in Sagittarius was identified while passing through the dim background star and additionally shifting its position due to the black hole’s gravity. Recently, Sahu’s efforts were reported in the Astrophysical Journal, about the new observations from NASA’s Hubble Space Telescope, confirming the presence of a lone black hole in Sagittarious.

Black Hole Key Findings

Although the passage occurred first in the year 2011, the original discovery relied on the Hubble measurements from the year 2011 to 2017. However, the new data has been gained from the Hubble observations from the year 2021 to 2022, accompanied by the data received from the Gaia Spacecraft.

How Big is a Black Hole?

The ideal size of this lone black home is seven times as huge as the sun. In recent observations, a different team of scientists revisited the project and identified the size as massive as six times that of the sun. The theories of the scientists match with that of Sahu’s observation.

The research continues for detecting the black holes in Sagittarius. Located at a distance of 5,000 light years away from Earth, this solitary black hole is yet to be observed from different aspects. The astronomer, Sahu, hopes to find more lone black holes with the effective use of the Nancy Grace Roman Space Telescope, which is set to launch in the year 2027.

Continue Reading

Science

Mars’ Carbonate Mystery and Ancient Atmosphere Deciphered

Published

on

By

Mars’ Carbonate Mystery and Ancient Atmosphere Deciphered

The evolution of Mars and its ancient atmosphere has been a prominent research topic for scientists. NASA’s Curiosity Mars rover could potentially be the ultimate solution for the temperature and other details about the planet. As per the assumptions made by the researchers, Mars’s atmosphere was crafted with a thick layer of carbon dioxide whereas the surface comprised liquid water. Likewise, the presence of carbonate minerals on the planet would be the result of a potential reaction between water, carbon dioxide, and Martian rocks, researchers say.

Presence of Siderite Detected

Recently reported in the April paper of Science, the presence of siderite has been discovered within the sulfate-rich rocky layers of Mount Sharp on Mars. The discovery was made at three of Curiosity’s drill sites.

According to the lead author and Associate Professor at the University of Calgary, Canada, Benjamin Tutolo, “The discovery of abundant siderite in Gale Crater represents both a surprising and important breakthrough in our understanding of the geologic and atmospheric evolution of Mars”.

About the Drilling Process

To achieve an understanding of the chemical and mineral makeup at the surface of Mars, Curiosity drills three to four centimeters down into the subsurface. Further, the powdered rock samples are then dropped into the CheMin instrument. This instrument analyses the rocks and soil via X-ray diffraction. The CheMin instrument is driven by NASA’s Ames Research Centre in California’s Silicon Valley.

The data analysis of the discovery was conducted by scientists at the Astromaterials Research and Exploration Science (ARES) Division at NASA Johnson Space Center in Houston.

Potential Findings and Atmosphere at Mars

The discovery of this carbonate mineral could potentially be hiding other minerals beneath the surface, in near-infrared satellite analysis. The possible presence of carbonates in sulfate-rich layers across Mars may result in the amount of carbon dioxide, which will be ideal to support the liquid water and create conditions warm enough to sustain water. Also, the scientists doubt the existence of other carbonates, or maybe they might have vanished from space.

To Conclude

The missions and analyses are still undergoing, and they will continue the research in the future. The findings can be confirmed post-research on the sulfate-rice area on the red planet. As the findings arrive, they will help us understand the transformation of the planet and will offer clarity on the ancient atmosphere.

Note: Curiosity is a part of NASA’s Mars Exploration Program (MEP) portfolio. It was built by NASA’s Jet Propulsion Laboratory, managed by Caltech in Pasadena, California. The mission is successfully led by JPL on behalf of NASA’s Science Mission Directorate in Washington.

Continue Reading

Science

JWST Might Have Revealed New Signs of Alien Life on Nearby Exoplanet

Published

on

By

JWST Might Have Revealed New Signs of Alien Life on Nearby Exoplanet

Scientists discovered suitable biosignature gases for alien life on planet K2-18b. On K2-18b, NASA’s James Webb Space Telescope (JWST) noticed dimethyl sulfide (DMS), a chemical primarily produced by living creatures on Earth. Notably, the exoplanet is nine times the size of our planet and exists in the habitable zone of its planetary system. As exoplanets pass in front of their home stars, the team probes planetary atmospheres using JWST’s Mid-Infrared Instrument (MIRI). Based on its size and other properties, astronomers think K2-18b is a “Hycean” world—that is, one with a large liquid-water ocean and a hydrogen-rich atmosphere.

Although the researchers estimate concentrations of more than 10 parts per million by volume on Earth, they are less than one part per billion. However, further research is required to confirm and expand on their findings.

NASA’s Webb Telescope Finds Possible Life Signs on Exoplanet K2-18b

According to a new study, which was published in The Astrophysical Journal Letters, chemical proof of life on the far-off exoplanet K2-18b has come from NASA’s James Webb Space Telescope. Rare on other planets or moons, these signals, which point to the presence of dimethyl sulfide and dimethyl disulfide, are found in marine plants and bacteria on Earth.

Because K2-18b boasts a hydrogen-rich atmosphere and a planet-wide ocean, researchers classify it as a “hycean world.” Methane and carbon dioxide, found in the planet’s atmosphere in 2023, were the first carbon-based compounds found in the habitable zone of an exoplanet. Though the levels had minimal statistical significance, the researchers also found likely DMS signals, therefore confounding DMS diagnosis. The results underline the possibilities of life on exoplanets.

JWST Data Hints at High Sulfur Levels on Exoplanet, Life or Not

MIRI observations from the JWST expose features in planetary atmospheres that point to DMS or DMDS helping to explain them. Scientists estimate that atmospheric DMS and DMDS levels could be substantially greater than on Earth, that is, above 10 parts per million. Differentiating DMS from DMDS requires more data. Scientists want to investigate undiscovered chemical processes involving no living entities able to generate DMS and DMDS from nothing.

Continue Reading

Trending