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Profluent, a California-based artificial intelligence (AI)-first protein design company, announced its AI model that can generate CRISPR-like proteins that do not occur in nature on Tuesday. CRISPR or Clustered Regularly Interspaced Short Palindromic Repeats is a complex containing important proteins that scientists can use for precise gene editing in organisms. The company claims the usage of AI can create a vast number of such proteins that can help in creating bespoke cures for diseases which, at present, remain incurable.

Ali Madani, the founder and CEO of Profluent announced the AI model in a series of posts on X (formerly known as Twitter). The company has also made a blog post detailing the initiative and a pre-print version of its research paper has been published on bioRxiv. Besides announcing the DNA editor-generating AI model, the company also launched OpenCRISPR-1, one of the AI-created gene editors, as an initial open-source release licencing it for both ethical research and commercial uses.

Why OpenCRISPR AI Model matters

While CRISPR is a major focus of scientists, the research is limited due to the protein Cas9, which acts as a gene editor, and its equivalent being only available in nature. As a result, scientists spend a significant amount of time discovering different types of gene editors and their impact. Profluent claims its AI model, which is powered by an in-house large language model (LLM) trained on “massive scale sequence and biological context”, can now generate millions of diverse CRISPR-like proteins that do not occur in nature. In theory, these synthetic gene editors can play a pivotal role in finding cures for diseases previously thought to be incurable.

In its blog post, the company said, “OpenCRISPR-1 gene editor maintains the prototypical architecture of a Type II Cas9 nuclease but is more than 400 mutations away from SpCas9 and nearly 200 mutations away from any other known natural CRISPR-associated protein.”

What is CRISPR

CRISPR, put simply, is a complex or system found in bacteria and some other unicellular organisms. This complex contains the Cas9 (or similar proteins like Cas12 and Cas13) proteins that have a specific ability to make precise cuts in gene strands of DNA to enable editing. It was first discovered in 1987, and ever since scientists have been researching it extensively. The technology has vast applications and has already been used to artificially create crop variants that have a higher yield, are resistant to diseases, and are drought tolerant.

It is also used to change the DNA of mosquitoes so that they cannot spread diseases like malaria. Experiments are being conducted to cure patients suffering from diseases such as sickle-cell anaemia. It is also theorised that the technology can be used to edit the DNA of the embryo to create babies who are naturally resistant to diseases and possess genes that promote higher physical and mental abilities.

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Drone mapping reveals ancient settlement in the Caucasus Mountains

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January 9, 2025

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Drone mapping reveals ancient settlement in the Caucasus Mountains

A groundbreaking discovery has been made in the Caucasus Mountains where an ancient Bronze Age settlement, Dmanisis Gora, has been mapped using drone technology. This site, believed to be over 3,000 years old, reveals new insights into the evolution of large-scale settlements during the Late Bronze Age and Early Iron Age. Spanning an area far larger than initially expected, the research offers a fresh perspective on ancient urbanism and interactions between sedentary and mobile communities.

Drone Mapping Reveals Extensive Settlement

As reported by Science Daily, the project led by Dr. Nathaniel Erb-Satullo, Senior Lecturer in Architectural Science at Cranfield Forensic Institute and Dimitri Jachvliani, co-director at the Georgian National Museum, employed drone technology to create high-resolution models of the site. The drone, equipped with advanced imaging tools, captured nearly 11,000 photographs, which were later used to generate detailed maps of the settlement. This method allowed the identification of fortification walls, graves and other structural remnants spread across a vast area.

The site, originally thought to be much smaller, was found to include a 1-kilometre-long defensive wall protecting an outer settlement. This finding significantly alters the understanding of the region’s settlement patterns, which were influenced by interactions with pastoral communities and seasonal population dynamics.

Integrating Modern and Historical Data

To further analyse the settlement, drone-generated images were compared with declassified satellite imagery from the Cold War era. This comparison highlighted changes in the landscape over decades, distinguishing ancient features from those impacted by modern agricultural activities. Geographic Information System (GIS) software was employed to integrate and analyse the diverse datasets, revealing patterns in the site’s expansion and usage over time.

Dr. Erb-Satullo noted to Science Daily, that these findings offer invaluable data on population density, agricultural practices and the broader socio-economic landscape of ancient societies. Continued excavations have uncovered artefacts such as pottery shards and animal remains, shedding more light on the lives of the people who inhabited Dmanisis Gora. This research underscores the potential of drone technology in unearthing and documenting historical sites on an unprecedented scale

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Ancient Geological Hotspot Linked to Great Lakes’ Depth and Formation

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January 9, 2025

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Ancient Geological Hotspot Linked to Great Lakes' Depth and Formation

Evidence has emerged pointing to a significant role played by an ancient geographic hotspot in shaping the Great Lakes. Researchers have linked the formation of these massive water bodies to a hotspot that interacted with the Earth’s lithosphere millions of years ago. While the lakes are commonly attributed to glacial activity during the Ice Age, recent findings suggest that deeper geological processes may have contributed to their formation, providing insight into their extraordinary depth and size.

Study Highlights Geological Interactions

According to research published in Geophysical Research Letters, a team of scientists from the University of Houston and the University of Arizona investigated the Cape Verde hotspot’s historical activity. Hotspots, known for generating heat and material flow from the Earth’s mantle, are believed to have influenced the Great Lakes region approximately 225 to 300 million years ago. As Pangea, the ancient supercontinent, moved over this hotspot, thinning of the lithosphere occurred, making the ground beneath more susceptible to external forces.

Seismic Clues Support Hotspot Theory

As reported by phys.org, data from seismic wave analyses supported these claims. Unusual horizontal wave movement beneath the lakes indicated lithospheric deformation. This anomaly aligned with the passage of North America over the hotspot during its drift over geological time. These conditions, as reported, would have created a weakened crust, later amplified by glacial activity during the Ice Age.

Hotspot’s Legacy in the Great Lakes Formation

The research outlines how the Cape Verde hotspot likely underlay Lake Superior, Lake Huron, and Lake Erie at different points in history, contributing to the geological features that enabled the Great Lakes to form. The fragile crust allowed ice to carve deeper and larger depressions than would have been possible otherwise, creating the unique landscape seen today.

These findings reshape understanding of the Great Lakes’ origins, suggesting that both deep-Earth processes and surface phenomena played critical roles in their formation.

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LA wildfires rage as Santa Ana winds spread flames across 13,000 acres

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January 9, 2025

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LA wildfires rage as Santa Ana winds spread flames across 13,000 acres

Raging wildfires in Los Angeles County have scorched over 13,000 acres, forcing tens of thousands of residents to evacuate as powerful Santa Ana winds continue to fuel the blazes. Four fires—the Eaton Fire in Pasadena, the Palisades Fire in Pacific Palisades, a blaze in Sylmar and another in the Sepulveda Basin—have collectively caused widespread destruction. Over 1,000 structures have been damaged and two fatalities have been confirmed as firefighting efforts are challenged by dry weather and hurricane-force winds reaching speeds of 99 mph.

Santa Ana Winds Amplifying Fire Threats

According to the National Weather Service (NWS), the wildfires have been intensified by the Santa Ana winds, which are characterised by dry and warm air moving from the Great Basin towards the California coast. These winds descend over mountain ranges, increasing in speed and losing moisture, creating conditions that rapidly spread flames. Reports indicate that some areas have recorded wind speeds of up to 100 mph in mountain passes, complicating containment efforts and grounding firefighting aircraft overnight.

Hydrant Issues and Evacuations Reported

The Los Angeles Times has reported water supply problems, with several fire hydrants in Pacific Palisades running dry. This issue has further hindered firefighting operations as crews battle to control the Eaton Fire, which has consumed 10,600 acres near Altadena and Pasadena. Meanwhile, the Palisades Fire has burned through 2,900 acres. Evacuations remain in place as residents are warned to avoid affected areas.

Winds Expected to Subside

Forecasts from the NWS predict a decrease in wind activity by Wednesday afternoon as an ocean breeze is expected to bring relief. Efforts to contain the flames are anticipated to accelerate once conditions improve. Officials continue to monitor additional fires, including one in Riverside that has been partially contained and another reported in Ventura.

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