The four of them had taken a boat and gone for a swim at Saint Nikolas Beach – however, Dr Mosley preferred to return on foot at around 1.30pm, Athens-based newspaper Kathimerini reported.
The CCTV images were captured by a restaurant at around 2pm local time, police believe.
The beachside eatery is located in the Pedi area of the island, a small town in a bay around 1.2km from Saint Nikolas Beach.
The images appear to show the 67-year-old wearing a dark t-shirt, shorts and a cap. He is carrying an umbrella.
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Dr Mosley, his wife and the other couple arrived in Symi for a week’s holiday on Tuesday, according to local media.
The doctor had been missing for just over 48 hours, as of Friday afternoon.
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Symi has been experiencing hot temperatures this week and its mayor Lefteris Papakalodoukas told a local news site the heat on Wednesday was “unbearable and one could easily faint in such conditions”.
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The rescue operation has been focusing on the Pedi area after a woman reported seeing him there on Wednesday.
The extensive search has so far seen five coastguard patrol boats deployed while private and commercial vessels in the area have also helped.
Police and firefighters have used drones to scan the island and a helicopter was deployed at around 7pm local time on Thursday. Sniffer dogs have also been used in the search.
Divers have been looking in the water, Symi deputy mayor Ilias Chaskas previously said.
Authorities have considered a number of possibilities, including Dr Mosley may have suffered a fall – or could have been bitten by a snake, Greek news website ekathimerini.com reported.
One woman in the Pedi area said the TV doctor’s disappearance was “strange” as the path he was thought to be on is “clear”.
“It’s a quiet place,” she said. “If you see the map of the area it’s a clear path, it’s nothing dangerous.
“Many people go every day, every few minutes, that’s the reason it’s very strange because it’s a clear path.”
Dr Mosley is a columnist and broadcaster who has made a number of films about diet and exercise.
He fronted the Channel 4 show Michael Mosley: Who Made Britain Fat? and was part of the BBC series Trust Me, I’m A Doctor. He has also appeared on numerous daytime television shows.
An international manhunt is under way for the husband of a murdered woman, whose body was found in the boot of a car.
The body of Harshita Brella was found in east London on Thursday, tens of miles away from her home in Corby.
On Sunday, Northamptonshire Police said they were looking for Pankaj Lamba – who they believe has left the country.
Sky News understands she had been under the protection of a court order designed for victims of domestic abuse.
“Our inquiries lead us to suspect that Harshita was murdered in Northamptonshire earlier this month by her husband Pankaj Lamba,” said chief inspector Paul Cash.
“We suspect Lamba transported Harshita’s body from Northamptonshire to Ilford by car.”
“Fast track” enquires were made after the force was contacted on Wednesday by someone concerned about Ms Brella’s welfare. After she failed to answer the door at her home in Skegness Walk, Corby, a missing person investigation was launched.
Her body was found inside the boot of a vehicle in Brisbane Road in the Ilford in the early hours of Thursday morning.
A post mortem – conducted at Leicester Royal Infirmary on Friday – established she had been murdered.
More than 60 detectives are working on the case, with lines of enquiry including going house to house and property searches, as well as looking at CCTV and ANPR.
“We are of course continuing to appeal for any information that will help us piece together exactly what happened as we work to get justice for Harshita,” said chief inspector Cash.
“I urge anyone listening to or reading this statement, that if you saw anything suspicious in the past week or have any information, no matter how small, please contact us. We would always rather receive well-meaning information that turns out to be nothing as opposed to not receiving it all.”
Force referred to police watchdog
On Saturday, Northamptonshire Police said it had made a mandatory referral to the Independent Office for Police Conduct due to previous contact between the force and the victim.
Northamptonshire Police previously said officers had been conducting investigations at three locations: Skegness Walk and Sturton Walk in Corby and Brisbane Road, Ilford, where Ms Brella’s body was found.
East Midlands Special Operations Major Crime Unit (EMSOU) and Northamptonshire Police said they were working “around the clock to establish the circumstances behind her death, including the exact location and timeframe in which it took place”.
Speaking about the recreation, she said: “We’ve got leading experts in their fields who have been working on this for 10 years and so everything has been meticulously researched, meticulously evidenced, so you are seeing the most accurate portrayal of Richard III”.
A team based at Face Lab at Liverpool John Moores University created the avatar based on the reconstruction of Richard III’s head with the help of a craniofacial expert.
His voice has been created by Professor David Crystal, a leading linguist in 15th-century pronunciation. He admitted that it’s impossible to know exactly how he spoke, but this is as close as they will get.
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The king was born in Northampton but spent a lot of his life in Yorkshire. His parents were also from the north of England.
Vocal coach Yvonne Morley-Chisholm spent a decade researching how the monarch would have sounded. She worked with the actor Thomas Dennis who was chosen as his body and face were such a a good physical match.
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Speaking to Sky News, she said people will be shocked at how different he sounded compared with traditional portrayals of the king on stage and screen.
The coach and actor also examined the king’s letters and diary so that “as you pronounced a word that’s how you would write it”.
History fans at the unveiling were delighted with the accent, with one telling Sky News: “Northerners are known to be happy, positive, all those lovely qualities.”
Born in Northampton but a northerner through and through, technology has brought the king’s speech back to life
A murder investigation has been launched after a woman’s body was found in the boot of a car in east London.
Detectives said a murder inquiry has been launched into the “suspicious” discovery in Ilford.
The woman, who has not been named but is from Corby in Northamptonshire, may have been the victim of a “targeted incident”, police say.
“Fast track” enquiries were made after the force was contacted by a member of the public with concerns about the welfare of the woman.
This led to the discovery of a body inside a car boot.
Northamptonshire Police said: “The investigation is ongoing and there will be continued police activity over the weekend in various locations, including Corby and Ilford.
“Although we believe that this was a targeted incident and there is no wider risk to members of the public, extra patrols will be taking place in Corby in the coming days for reassurance purposes.”
Detectives from the East Midlands Special Operations Unit major crime team and the Metropolitan Police are working on the case, to try and establish the circumstances that led to the woman’s death.