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Botnar Institute of Immune Engineering (BIIE) Jun 19 2024

“Swiss research institute established to focus on immune engineering and advancing global child and adolescent health.” The Botnar Institute of Immune Engineering (BIIE) is launching as an independent research institute in Basel/Switzerland with a mission to develop novel immune-based diagnostics and therapeutics and address gaps in advanced healthcare technologies, thus improving the health of children and young people around the globe. The BIIE is supported for the first 15 years by an endowment of over 1 billion USD from Fondation Botnar. Planned inaugural partnerships with the University of Oxford and ETH Zurich will further expand the BIIE’s capacity and global reach as it develops computational tools, diagnostics, therapeutics, and preventative medicines as well as train the next generation of immune engineers. As a priority, BIIE program outputs will be of benefit to the health of young people in low- and middle-income countries (LMICs). A new independent research institute, the Botnar Institute of Immune Engineering (BIIE) is launching in Basel, Switzerland.

The Botnar Institute of Immune Engineering (BIIE) is a newly founded non-profit research organization focused on developing computational tools and immune-based translational solutions for the diagnosis, treatment and prevention of disease. Outstanding investigators from around the globe will be recruited to its facility in Basel, Switzerland, to form a new hub of innovation in immune engineering.

The BIIE is made possible by the generous endowment of over 1 billion USD (to be provided over 15 years) from Fondation Botnar, a Swiss philanthropic foundation working to improve the health and well-being of young people around the world. Strategic partnerships

The Institute will establish strategic partnerships with internationally renowned public and private research institutions and work with philanthropic organizations that support its mission in the Global South. Inaugural strategic academic partners are planned with ETH Zurich, Switzerland, and the University of Oxford, UK, with additional global partners to be announced in the future.

The BIIE will move into a new purpose-built research facility in 2027. In the interim, the BIIE is planned to be hosted by the Department of Biosystems Science and Systems Engineering (D-BSSE) of the ETH Zurich, a newly opened state of the art facility in Basel. The D-BSSE operates at the intersection of systems biology, bioengineering and computational biology. Prof. Christian Wolfrum, ETH Zurich VP of Research noted, “Close collaborations with an immune engineering institute in Basel further accelerates the development of medical solutions, and compliments the program goals of ETH Zurich D-BSSE. Hosting the inaugural class of BIIE scientists is an ideal opportunity to develop a lasting partnership through joint professorships, student training programs, and shared infrastructure.”

In its first international partnership, the BIIE intends to work with the University of Oxford to create the Basel-Oxford Centre of Immune Engineering, plans include professorships and student training programs as well as access to the extensive global clinical research capabilities of Oxford University. Prof. Sir Andrew Pollard, Fellow of the Royal Society and Director of Oxford’s Vaccine Group stated, “Looking no further than recent events, one can see that immune engineering is a catalyst in the rapid development of globally accessible therapeutics, in particular, vaccines. Through this partnership with BIIE, Oxford researchers will benefit from vibrant collaborations that advance basic and clinical research specific to children and adolescents in low- and middle-income countries. BIIE’s strengths in biocomputation and immune engineering mean this partnership will further accelerate discovery as well as the creation of safe and effective medicines for children around the world.” Organization, leadership and team

Established to realize the vision of Fondation Botnar, the “Foundation for Immune Engineering for Global Child and Adolescent Health” (FIE) and its Board of Trustees will govern and oversee the BIIE as it grows into a vibrant Institute of up to 300 scientists and support staff.

The FIE’s Board of Trustees are notable for their accomplishments in academia, biotechnology and finance. Inaugural FIE Board Chair, Dr. Dominik Escher, a molecular biologist turned biotech entrepreneur and Managing Partner at Pureos Bioventures, summarized the opportunity, “Building a critical mass of immune engineers in Basel with a shared goal of improving the health of young people globally is both inspiring and complex.” Each FIE Trustee brings extensive expertise and leadership experience to the BIIE: Prof. Jennifer Cochran (Stanford University), Dr. Andrew P. May (DCVC Bio), Prof. Gunilla Karlsson Hedestam (Karolinska Institute), Prof. Folasade Tolulope Ogunsola (University of Lagos), Joe Stadler (UBS). In line with our mission to improve the wellbeing of young people, Fondation Botnar has made a bold investment to unlock scientific innovations specifically for the benefit of child and young people’s health in low- and middle-income countries. Understanding the immune system of children and young people in different parts of the world is key to developing solutions that can diagnose, prevent and treat infectious diseases and other health conditions. With this investment in an independent institute that provides cutting-edge research in immune engineering, not only we continue the Botnar family’s frequent support of biomedical research, but also firmly believe to make a difference in the translation of scientific innovation into healthcare practice.”

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The BIIE management team is composed of scientific leaders. Prof. Sai Reddy (ETH Zurich) shall assume responsibilities as Scientific Director, Prof. Georg Holländer (University of Oxford, University of Basel, ETH Zurich) will be the Director of Global Engagement. Dr. Stephen Wilson, the Chief Executive Officer of the BIIE (fmr. Chief Operating Officer, La Jolla Institute for Immunology, USA), said, “The BIIE will bring together a critical mass of investigators, all of whom are experts in various aspects of immune engineering; combining their strengths and perspective should result in a sum greater than its parts. Every element of our operation will be designed to maximize collaboration, including the physical layout of the facility, which interweaves computational and experimental groups, along with frictionless access to cutting-edge instrumentation. Because we are focused on translating discoveries in the lab into real-world solutions, our researchers will enjoy tremendous latitude as well as the institutional support necessary to advance promising discoveries into clinical development.” Immune engineering with a global vision

The emerging field of immune engineering leverages advanced technologies to understand and develop immune-based solutions for the diagnosis, prevention and treatment of diseases. Integrating expertise in immunology, molecular and cellular engineering, genomics, artificial intelligence and other computational methods enables scientists to study immune responses at an unprecedented level of detail—from how individual cells react to pathogens to how genetic diversity within populations influence such responses. The immune system has been harnessed to treat a wide array of disorders, from infectious diseases to autoimmune disease and cancers. The BIIE will focus its research efforts on developing new approaches to improve health outcomes for children and adolescents, especially those in low- and middle-income countries (LMICs), who are often the most neglected and in need.

“Global impact is only possible with genuine global engagement.”, Prof. Folasade Tolulope Ogunsola, Vice Chancellor of University of Lagos and FIE Trustee said, “There are significant opportunities to elevate clinical research in the Global South if immune engineering tools are developed with specific intent; and with the establishment of the BIIE, we intend to remove barriers for research that improves the lives of children.” Source:

Botnar Institute of Immune Engineering (BIIE)

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Sports

Canes’ Andersen, 35, secures deal before Round 2

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Canes' Andersen, 35, secures deal before Round 2

RALEIGH, N.C. — The Carolina Hurricanes have signed goaltender Frederik Andersen to a one-year contract for next season, worth $2.75 million for the 35-year-old veteran.

General manager Eric Tulsky announced the deal Saturday, a little over 48 hours before his team starts the second round of the playoffs against the Washington Capitals.

Andersen could earn up to $750,000 in incentives for games played and his participation in a potential run to the Eastern Conference finals next season. He would get $250,000 for playing 35 or more games, another $250,000 for getting to 40 and $250,000 if the Hurricanes reach the East finals and he plays in at least half of the playoff games.

“Frederik has played extremely well for us and ranks in the top 10 all-time for winning percentage by an NHL goalie,” Tulsky said. “We’re excited that he will be staying with the team for next season.”

Andersen and the Hurricanes, the No. 2 seed in the Metropolitan Division, advanced past the New Jersey Devils in Round 1 last week. They will meet the Capitals, who won the division crown, for the right to make the NHL’s final four.

Extending Andersen could give the team a goaltending tandem with Pyotr Kochetkov for less than $6 million combined.

Anderson, a Denmark native who previously played for the Anaheim Ducks and Toronto Maple Leafs, has become coach Rod Brind’Amour’s most trusted option in net. He is expected to return to the starting role for Game 1 of the Capitals series after getting injured in the first round against New Jersey.

The Associated Press contributed to this report.

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UK

Child sexual abuse victims ‘denied justice’ after compensation scheme scrapped over cost

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Child sexual abuse victims 'denied justice' after compensation scheme scrapped over cost

Sky News can reveal that the government has rowed back on a national compensation scheme for victims of child sexual abuse, despite it being promised under the previous Conservative administration.

Warning – this story contains references to sexual and physical abuse

A National Redress Scheme was one of 20 key recommendations made by the Independent Inquiry into Child Sexual Abuse (IICSA), but a Home Office report reveals the government has scrapped it because of the cost.

Marie, who is 71, suffered alleged sexual, physical, and emotional abuse at Greenfield House Convent in St Helens, Merseyside, between 1959 and 1962, and is still fighting for compensation.

Greenfield House Convent, where Marie says she was abused
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Greenfield House Convent, where Marie says she was abused

As soon as she arrived as a six-year-old, Marie says her hair was cut off, her name changed, and she experienced regular beatings from the nuns and students.

She claims a nun instigated the violence, including when Marie was held down so that her legs were “spread-eagled” as she was sexually abused with a coat hanger.

Merseyside Police investigated claims of abuse at the convent, but in 2016, a suspect died before charges could be brought.

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Marie has received an apology from the Catholic body that ran the home; she tried to sue them, but her claim was rejected because it was filed too long after the alleged abuse.

Marie is still fighting for compensation for the abuse she suffered
Image:
Marie, 71, is still fighting for compensation for the abuse she says she suffered as a child

In February, ministers said the law would change for victims of sexual abuse trying to sue institutions for damages, which was a recommendation from the IICSA.

Previously, people had to make a civil claim before they were 21, unless the victim could prove a fair trial could proceed despite the time lapse.

Campaigners argued for the time limit to be removed as, on average, victims wait 26 years to come forward. Changes to the 1980 Limitation Act could lead to more people making claims.

Peter Garsden, President of The Association of Child Abuse Lawyers
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Peter Garsden, President of The Association of Child Abuse Lawyers

Civil cases ‘can take three to five years’

But Peter Garsden, president of the Association of Child Abuse Lawyers, worries that when it comes to historical abuse where the defendant is dead, institutions will still argue that it is impossible to have a fair trial and will fight to have the case thrown out of court.

Mr Garsden said it takes “between three and five years” for a civil case to get to trial.

He warned that claimants “can end up losing if you go through that process. Whereas the Redress Scheme would be quicker, much more straightforward, and much more likely to give justice to the victims”.

Victim awarded £10 compensation

Jimbo, who was a victim of abuse at St Aidan’s children’s home in Cheshire, took his case to the High Court twice and the Court of Appeal three times, but, after 13 years, all he ended up with was £10 for his bus fare to court.

Despite the Lord Justice of Appeal saying he believed that the abuse had occurred, Jimbo lost his claim because of the time limit for child sexual abuse claims to be made.

Read more from Sky News:
Call for Labour minister to resign over grooming gang remarks
PM says govt will fund further local grooming gangs inquiries if ‘needed’

Neither Marie nor Jimbo is likely to benefit from the removal of the time limit for personal injury claims, which is why Mr Garsden is calling on the government to implement a National Redress Scheme for victims of sexual abuse, as recommended by the IICSA.

Hundreds of millions paid to victims

The governments in Scotland and Northern Ireland have set up compensation schemes and paid hundreds of millions of pounds to victims.

In 2023, the then Conservative government said a similar scheme would be organised for England and Wales.

But the Home Office admitted in its Tackling Child Sexual Abuse: Progress Update that it “is not currently taking forward any further steps on the IICSA proposal for a separate, national financial redress scheme for all survivors of child sexual abuse”.

“In the current fiscal environment, this recommendation is very difficult to take forward,” it added.

For victims, the scheme was the last chance of compensation for a lifetime blighted by abuse.

“The money is about justice and about all the other people who have had to suffer this abuse,” Marie said.

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Politics

OKX fires back at Tron’s Justin Sun over mysterious ‘freeze notice’

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<div>OKX fires back at Tron's Justin Sun over mysterious 'freeze notice'</div>

<div>OKX fires back at Tron's Justin Sun over mysterious 'freeze notice'</div>

OKX founder and CEO Star Xu has publicly defended the crypto exchange after Tron founder Justin Sun accused it of failing to act on a law enforcement request to freeze stolen funds following a recent hack of Tron’s official X account.

“OKX also has consumers protection policy according to law, we can’t freeze a customer’s funds according to your personal X post or an oral communication. I think you should understand it as the CEO of HTX,” Xu said in an X post.

OKX says there is no communication in the spam box, either

Xu said that the crypto exchange had not received any related correspondence through OKX’s official channels. “Our LE cooperation team just checked the email, including the spam box; we haven’t received any request related with this case,” Xu said.

Cryptocurrencies, Tron, OKX
Source: Star Xu

In what is now an unavailable X post, but was screenshotted by Xu, Sun had earlier claimed that OKX has not responded to a “freeze notice” sent to its official email address from a “relevant law enforcement agency.” Sun said that he had no other way to contact OKX’s compliance department.

“These stolen funds do not belong to me; I’m acting to protect the community,” Sun said. On May 3, Tron DAO told its 1.7 million X followers that its account had been compromised. Tron explained that during the breach, an unauthorized party posted a malicious contract address, sent direct messages, and followed unfamiliar accounts.

“If you received a DM from our account on May 2, please delete it and consider it the work of the attacker.”

In response to Sun’s claims of inaction, Xu publicly called on him to provide a screenshot showing when and where the law enforcement request was made.

The Tron incident is one of several recent security breaches involving high-profile crypto accounts on X.

Related: Over 14,500 Tron addresses at risk of silent hijacking

Kaito AI, an artificial intelligence-powered platform that aggregates crypto data to provide market analysis for users, and its founder, Yu Hu, were the victims of an X social media hack on March 15. The hackers opened up a short position on KAITO tokens before posting that the Kaito wallets were compromised and advised users that their funds were not safe.

The Pump.fun X account was compromised on Feb. 26 to promote a fake governance token called “PUMP” and other fraudulent coins.

Meanwhile, the X account of UK member of Parliament and Leader of the House of Commons, Lucy Powell, was hacked to promote a scam crypto token.

Magazine: Crypto wanted to overthrow banks, now it’s becoming them in stablecoin fight

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