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Human ageing does not occur uniformly but instead accelerates significantly at around ages 44 and 60, claimed a new study. This research paper, published on August 14 in Nature Aging, highlights that physiological changes become more pronounced during these pivotal ages, which may be linked to increased risks of age-related diseases. The study focused on tracking the biological age of people, instead of chronological age which refers to the age people celebrate on their birthdays.

Key Findings from the Study

Researchers at Stanford University analyzed over 11,000 molecular markers in blood samples from 108 participants aged 25 to 75. They found that 81 percent of these markers showed notable changes at ages 44 and 60. These changes are particularly associated with heart health and metabolism. For instance, proteins related to atherosclerosis increased in the blood during these ages, and there was a decline in the ability to metabolize substances like caffeine and alcohol.

Potential Implications for Health

The study’s findings suggest that the acceleration of biological ageing around these ages could explain the heightened incidence of conditions such as coronary artery disease and type 2 diabetes in older adults. The research also pointed out that the body’s ability to process fatty acids, which help lower “bad” cholesterol, diminishes at these ages. While the study showed strong correlations, it has yet to determine the exact causes of these changes or how lifestyle factors like diet and exercise might influence them.

Unanswered Questions and Future Research

The reasons behind the accelerated ageing observed at ages 44 and 60 remain unclear. There is speculation that inflammation might play a role, especially in the over-60 age group, as suggested by increased levels of antioxidant enzymes in the blood. Additionally, the study noted that these age-related changes occur regardless of sex, indicating that factors beyond hormonal shifts may be at play.
The research was limited by its small sample size and geographic focus, which might not represent global ageing patterns. Future studies, possibly involving larger and more diverse populations, could provide further insights into the mechanisms driving these age-related changes and their broader implications for health.

Conclusion

This new study sheds light on the complex nature of ageing, showing that significant physiological changes occur at specific ages. Understanding these patterns could help in developing strategies to mitigate age-related health risks and improve quality of life as people age.

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Dinosaurs were thriving before asteroid impact, study finds

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April 9, 2025

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Dinosaurs were thriving before asteroid impact, study finds

Scientists say that dinosaurs weren’t doomed when an asteroid hit Earth. Fossil unearthings before the asteroid collision, at the end of the Cretaceous epoch, show that dinosaurs were losing variety and numbers. At first, some scientists thought this alteration showed dinosaurs were headed toward extinction even before the fatal asteroid incident. Nevertheless, this concept has long been argumentative, with other researchers insisting that dinosaur diversity was doing just fine at the time of their loss of life.

Challenging the Long-Held Narrative

According to a report by Live Science, the visible rarity of dinosaurs before their extinction may merely be due to a low fossil record. Emphasizsng four families—that is, the Ankylosauridae, Ceratopsidae, Hadrosauridae, and Tyrannosauridae—the studies of the scientists reveal records of approximately 8,000 fossils from North America dating to the Campanian age (83.6 million to 72.1 million years ago) and Maastrichtian age (72.1 million to 66 million years ago).

Th range of dinosaurs peaked 76 million years ago and started to shrink after the asteroid collision wiped off the nonavian dinosaurs. This drift was more pronounced than in the 6 million years before the mass annihilation, with the number of fossils from all four families reducing in the geological record.

Fossil Records and Statistical Models Paint a New Picture

Vegetation either covered or obscured geological outcrops from the Maastrichtian period in North America. Specifically, rock from this time that might contain dinosaur fossils was not easily accessible to the researchers who were searching for them. The study’s encapsulation might also have worldwide branching due to North America being home to half of the familiar fossils from this age.

A Catastrophic Exception, Not a Gradual End

There is no evidence of environmental conditions or other aspects that would specifically elaborate the reason of this decline, the researchers landed. All of the dinosaur broods were far-flung, as per models come into being developed by the researchers — and consequently at low risk for extinction, barring a catastrophic event such as the asteroid effect.

In the group of 8,000 fossil records evaluated, the team found that ceratopsians—a group that includes horned dinosaurs like Triceratops and its relatives — were the most common; most likely, they inhabited plain regions that were most conducive to preservation during the Maastrichtian era.

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Scientists Revive Dire Wolves Using Ancient DNA and Modern Gene Editing

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April 8, 2025

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Scientists Revive Dire Wolves Using Ancient DNA and Modern Gene Editing

Three live dire wolf pups have been born using reconstructed DNA. The extinct species had last roamed North America around 12,500 years ago. The milestone was reached by a Dallas-based biotech firm that focuses on genetic conservation. Ancient DNA samples from fossilised remains were analysed. Modern gene-editing tools were used to mimic key characteristics of the extinct predator. These pups were brought to life by implanting modified embryos into domestic dog surrogates. The young wolves have been named Romulus, Remus and Khaleesi.

Ancient DNA edited in lab to recreate species

According to a study shared by Colossal Biosciences, DNA samples had been collected from two ancient dire wolf fossils. One was a 13,000-year-old tooth, while the other was a 72,000-year-old skull fragment. These fragments were compared to modern wolf relatives and grey wolves were chosen for DNA alteration because of their evolutionary proximity. Gene sequences that were found only in dire wolves were isolated. These were introduced into the DNA of grey wolves through targeted editing.

Cloning technique used to implant embryos

The altered genetic material was inserted into grey wolf egg cells after removing their original nuclei. These prepared cells were placed inside domestic dogs. Each surrogate received multiple embryos. Interestingly, only one embryo survived in each of the first two dogs. Both gave birth by caesarean section, while the third pup was born in a second round of implantation.

Physical traits match fossil record

The new pups have been observed to develop features consistent with known dire wolf fossils. Thick white coats, larger teeth and body structure have been reported. These results came from identifying changes in 14 genes. The gene edits were introduced using CRISPR technology.

The same company had previously cloned red wolves. The team had also created “woolly mice” as part of a mammoth revival effort. The successful dire wolf birth marks a new phase in gene-driven species restoration.

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Panama Tree Shocks Scientists With Lightning-Based Defense

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1 day ago

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April 8, 2025

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Panama Tree Shocks Scientists With Lightning-Based Defense

Lightning is commonly considered a sign of disaster in the forest, as lightning kills or damages trees. On the lowlands of Panama, the tonka bean tree (Dipteryx oleifera) might have evolved to capitalize on this natural occurrence. New research suggests that lightning strikes could help the tonka bean tree (Dipteryx oleifera). According to Live Science research, these trees not only survive these electrical interactions unharmed, but the lightning also harms their competitors and the parasitic vines that cling to the tonka bean plants.

The researchers published their findings on March 26 in the journal New Phytologist. Lightning is a major cause of tree mortality in tropical forests, particularly among the largest and oldest trees, which play important roles in carbon storage and biodiversity.

Lightning as a Canopy Weapon

On average, each lightning hit destroyed over 2.4 tons (2 metric tons) of adjacent tree biomass and approximately 80 percent of the lianas (parasitic vines) that plagued the tonka bean canopy. As per Gora’s assumption, the key to these trees’ lightning resistance comes from their physical structure.

A few studies describe the tree as having strong internal conductivity, letting lightning current flow through without building up damaging heat like a well-insulated wire. Because they tend to grow large — up to 130 feet (40 meters)—and live for centuries, a single tonka bean tree is estimated to be struck at least five times after reaching maturity. Each strike helps to clear out vines and competitors, opening up the canopy to help it thrive.

Ecological Impact and Evolutionary Marvel

Gregory Moore, a horticulturalist from the University of Melbourne who was not involved in the study, thinks the results will apply to other species. “The sort of work could also apply to other tree-dominated plant communities, such as woodlands or low woodlands where trees are widely separated, so it’s nothing like a tropical forest,” he said, adding that other tall trees are also possible targets of lightning strikes.

More Than Just a Tree

“We have long known that some trees can withstand multiple lightning strikes,” Moore said, noting that some tall trees survive Australian bushfires and grow up towering over their neighbors, making them prime targets for lightning strikes. “They are often referred to as stags because the top of the crown has been blown out, but they can survive for centuries after being hit by lightning,” he added.

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