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A drug that can slow the debilitating symptoms of Alzheimer’s has been approved by the medicines regulator.

In an unusual double-header assessment by authorities, the Medicines and Healthcare products Regulatory Agency (MHRA) has said the drug lecanemab is safe and effective enough for doctors to prescribe in Britain, but a separate NHS watchdog has ruled that it’s not cost-effective and won’t be available.

The decision by the National Institute for Health and Care Excellence (NICE) means that the first drug to show an effect in Alzheimer’s will only be available privately.

In the US the treatment costs £20,000 a year.

A key clinical trial has shown lecanemab can slow the decline in memory and mental agility by 27% in patients with mild Alzheimer’s.

But it can also cause swelling and bleeding in the brain of some patients.

NICE heard evidence it slows down progression of the disease by between four and six months but concluded that the costs of providing the treatment, including fortnightly infusions in hospital and intensive monitoring for side effects, combined with the relatively small benefits it provides to patients, means it cannot be considered good value for the taxpayer.

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Dr Samantha Roberts, chief executive of NICE, said: “This is a new and emerging field of medicine which will no doubt develop rapidly.

“However, the reality is that the benefits this first treatment provides are just too small to justify the significant cost to the NHS. It is an intensive treatment to give to patients involving a hospital visit every two weeks with skilled staff needed to monitor them for signs of serious side effects, plus the cost of purchasing the drug.

“Our independent committee has rigorously evaluated the available evidence, including the benefit for carers but NICE must only recommend treatments that offer good value to the taxpayer.”

The MHRA decision would not apply in Northern Ireland, which has a separate process.

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From November 2022: Inside a lab working on Alzheimer’s treatment

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New AI tool could be game-changer in battle against Alzheimer’s
Five patients developed Alzheimer’s from treatment, doctors find

While US authorities have approved the drug, the EU’s medical regulator rejected a licence because it considered the benefits too small to justify the risks.

According to results of the clinical trial published two years ago, the drug cleared clumps of a protein called amyloid – thought to be a key cause of the most common form of dementia – from patients’ brains.

It removed so much of the amyloid protein that the patients wouldn’t have had enough evidence of Alzheimer’s disease on their brain scans to actually qualify for entry to the trial.

The study strongly suggests the drug only starts to have a clinical effect once amyloid is reduced to low levels in the brain.

Results after 12 months of treatment suggested it was ineffective – but after 18 months, the effect was significant.

Doctors were optimistic at the time that continued treatment would lead to even better results.

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Christian B: Freed suspect in Madeleine McCann case attempts to confront prosecutor

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Christian B: Freed suspect in Madeleine McCann case attempts to confront prosecutor

The freed suspect in the Madeleine McCann case has come out of hiding to confront the prosecutor who has accused him of the British toddler’s murder.

Christian B, who cannot be fully identified under German privacy laws, travelled for hours to try to speak to lawyer Hans Christian Wolters.

Mr Wolters has stated publicly that he has evidence, which he has not revealed, to show that Christian B abducted and killed Madeleine, who vanished from her bed during a Portuguese holiday in 2007.

Christian B denies any involvement in her disappearance.

Christian B attempted to speak to lawyer Hans Christian Wolters
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Christian B attempted to speak to lawyer Hans Christian Wolters

The suspect, who was released from a rape sentence two weeks ago, told Sky News in an exclusive interview: “The prosecutor refused to meet me, but I told his representative I wanted his help to get my life back.

“I’m being hounded by the media, and it’s his fault. I want him to take responsibility.

“I was told there was nothing they could do to help. I had been convicted and released, and I wasn’t their responsibility.”

Madeleine McCann vanished from her bed during a Portuguese holiday in 2007. File pic: PA
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Madeleine McCann vanished from her bed during a Portuguese holiday in 2007. File pic: PA

Christian B, 49, was driven from jail by his lawyer Friedrich Fulscher on 17 September and, since then, has lived in local authority accommodation in the town of Neumunster, north of Hamburg.

Journalists quickly tracked him down and exposed his new address, prompting anger in the community from people worried about his convictions for child sex crimes.

Local councillor Karin Mundt of the hard-right populist movement, Heimat Neumunster (Homeland Neumunster), took to Facebook to warn locals to be vigilant, not go out alone, and make sure that their children and elderly were safe.

She also called for a public protest under the slogan ‘Christian B. out of Neumunster – tougher measures against child abusers and rapists to protect all citizens!’

Germany operates draconian privacy laws, whereby even the media must get the consent of someone they photograph, or disguise their features.

Christian B pictured this month. Pic: Markus Hibbeler/Bild
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Christian B pictured this month. Pic: Markus Hibbeler/Bild

Pic: Markus Hibbeler/Bild
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Pic: Markus Hibbeler/Bild

Yet the group even decided to publish photos of Christian B, arguing that the danger he presents means he was a public person of interest, and that they had to make sure that elderly people were able to recognise him.

Two separate chat groups were set up, one dedicated to campaigning for Christian B to be booted out of Neumunster, the other to discuss alleged sightings of him.

Some claimed that Christian B had turned up near schools and that the police were called round, though other people said they worked at these schools, and that no police had been there.

Read more from Sky News:
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A woman at Domino’s pizza claimed that Christian B had turned up in a false beard, yet just days later, her colleague said she had seen the pictures and she was unsure that it was Christian B.

And throughout all this, a source close to Christian B’s defence claimed that he had not been out at all apart from to sort out his phone, and also once for a steak.

On Wednesday, one chat even discussed gathering at the town hall in the evening, and police vans then turned up to try to prevent this.

But the language of the chat became ever bolder – with people openly posting addresses they were convinced he was living at – and at one point, all people with English-sounding surnames were ejected from the group as people suspected they were journalists.

Explainer: What we know about Christian B

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Madeleine McCann suspect released from jail

Police quickly moved Christian B out of Neumunster, and reports he has since been spotted at a hotel in an unnamed town.

In a recent interview with Germany’s Stern magazine, Christian B’s main lawyer Dr Fulscher said: “The Braunschweig public prosecutor’s office has fuelled this media campaign of prejudgment.

“It has told the public that it is certain it has the right person. Without presenting sufficient evidence or even allowing my client to inspect the files.

“I find this highly questionable from a constitutional point of view. In my opinion, the Braunschweig public prosecutor’s office has made rehabilitation impossible.”

Prosecutor Mr Wolters told Sky News today that he’d been tipped off about the suspect’s visit to his office in Braunschweig near Hanover and refused to speak to him.

Christian B was released from Sehnde prison, near Hannover, earlier this month after a prosecutor failed to find enough evidence to charge him in the Madeleine case.

As part of his release conditions, he’s been fitted with an electronic ankle tag, has had to surrender his passport, and register his permanent address with probation officers.

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Penny Lancaster says she felt ‘belittled’ by ex-MasterChef host Gregg Wallace

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Penny Lancaster says she felt 'belittled' by ex-MasterChef host Gregg Wallace

Model Penny Lancaster has said she “felt ashamed and belittled” by how former MasterChef host Gregg Wallace treated her on the TV show.

Lancaster, who is also a TV personality, and is married to singer Rod Stewart, told Sky News’ The UK Tonight with Sarah-Jane Mee programme that she also felt let down by MasterChef’s production company Banijay UK.

“I didn’t feel like I was supported in that moment, I felt ashamed and belittled by the way Greg Wallace had treated me but equally I felt disappointed that the production company hadn’t come to my rescue,” Lancaster, 54 and a MasterChef contestant in 2021, said.

“There is a long way to go, but just by people coming forward and being honest about their experiences I think will help in the long term.”

At the end of July, Wallace, 60, apologised after a report commissioned by Banijay UK, and carried out by law firm Lewis Silkin, found 45 out of 83 allegations against him were substantiated.

Sir Rod Stewart criticised Wallace on Instagram in November 2024 and claimed he “humiliated” his wife when she was on the show.

He wrote: “Good riddance Wallace… You humiliated my wife when she was on the show, but you had that bit cut out didn’t you?

More on Gregg Wallace

“You’re a tubby, bald-headed, ill-mannered bully.”

Gregg Wallace. Pic: PA
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Gregg Wallace. Pic: PA

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Wallace ‘deeply sorry’ after more than half of allegations against him upheld

Sky News has approached Wallace for comment.

He has previously apologised to people he has hurt, saying in July that he knows he has said things that have offended people. He has denied a specific allegation of unwanted touching.

The BBC referred Sky News to their statement from July, in which the corporation said: “Although the full extent of these issues were not known at the relevant time, opportunities were missed to address this behaviour – both by the production companies running MasterChef and the BBC. We accept more could and should have been done sooner.

“We want to thank all those who took part in the investigation, including those who first raised concerns directly with the BBC in November last year. We apologise to everyone who has been impacted by Mr Wallace’s behaviour.”

Penny Lancaster speaks to Sarah-Jane Mee
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Penny Lancaster speaks to Sarah-Jane Mee

Banijay UK, the producers of MasterChef, told Sky News: “We are extremely sorry to anyone who has been impacted by any inappropriate behaviour by Gregg Wallace whilst working on our shows and felt unable to speak up at the time or that their complaint was not adequately addressed.

“Ways of reporting concerns whilst working on our productions, protocols around behaviour and training for both cast and crew, have improved exponentially in recent years and we constantly review welfare procedures across our productions to ensure that they are as robust as they can be.”

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London mayor Sadiq Khan hits out at ‘misinformation’ as new figures show fall in crimes

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London mayor Sadiq Khan hits out at 'misinformation' as new figures show fall in crimes

Sadiq Khan has hit back at politicians “spreading misinformation” about safety in London as new data shows the number of violent crimes leading to injury has fallen in every borough over the past year.

Figures from the mayor’s office for policing and crime compare the 12 months ending in August 2025 with the previous 12 months – and show there were 8,749 fewer crimes which resulted in someone being hurt, a drop of nearly 12%.

The borough of Havering in east London recorded the largest drop (16.3%) followed by Enfield in north London (16.1%).

The smallest decreases were in Greenwich (4.3%) and Kensington and Chelsea (4.6%).

Sir Sadiq said: “We’ve seen a number of politicians here and across the globe talking down London and spreading misinformation about crime and safety in the capital.

“The evidence is clear, our approach to tackling crime and its complex causes works. It’s driving down violence right across the capital.”

His comments come after Donald Trump reignited his feud with Sir Sadiq earlier this month by accusing him of doing a “terrible job” and claiming “crime in London is through the roof”.

More on London

The US president also hit out at the mayor in a speech at the UN General Assembly on Tuesday, where he also made the outlandish claim that London “wants Sharia law” – something there is no evidence for.

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Trump attacks UN and London mayor

Asked about the attacks, Sir Sadiq said: “I think President Trump has shown he is racist, he is sexist, he is misogynistic, and he is Islamophobic.”

He added that the public would be “wondering what it is about this Muslim mayor who leads a liberal, multicultural, progressive, successful city that means I appear to be living rent-free inside Donald Trump’s head”.

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According to the mayor’s office, overall homicides in London are at a 10-year low, and the city’s rate is lower than in Berlin, Brussels, Madrid, Paris and all major US cities.

The rate of homicide was down by 17% in the 12-month period to June this year compared with the 12-month period to May 2016, it previously said.

Sir Sadiq speaks with a police officer during a walkabout in the West End earlier this year. File pic: PA
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Sir Sadiq speaks with a police officer during a walkabout in the West End earlier this year. File pic: PA

Metropolitan Police Assistant Commissioner Rachel Williams said: “We’re targeting the most dangerous individuals, disrupting criminal networks, and investing in prevention to protect those most at risk.

“That’s why fewer people are being hurt, fewer lives are being lost, and London is becoming a safer city.”

The Conservatives rejected the suggestion that London is safer.

Shadow home secretary Chris Philp claims 'London isn't safer'
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Shadow home secretary Chris Philp claims ‘London isn’t safer’

Shadow home secretary Chris Philp said: “Under this Labour mayor, criminals know the odds are stacked in their favour.

“Only one in 20 robberies is solved, fewer offenders are being jailed, and more than a thousand police officers have been cut from the Metropolitan Police, with Sir Mark Rowley warning of further losses this year.

“Londoners don’t feel safer because London isn’t safer.”

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