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Blood groups are classified into systems based on specific antigens present on red blood cells. While the ABO and Rh systems are the most recognised, there are 47 blood group systems in total, encompassing over 360 antigens. Recent research led by NHS Blood and Transplant scientists has unveiled a new blood group system called MAL, which includes the AnWj antigen. Although this antigen was first identified in 1972, its genetic foundation has only recently been understood.

Significance of the Discovery

Dr. Louise Tilley from NHS Blood and Transplant spearheaded the research on the MAL system, marking a significant breakthrough. “The genetic background of AnWj has been a mystery for over 50 years,” noted Dr. Tilley. “Our team’s work to resolve this has been a major milestone, enabling us to offer improved care for patients with rare blood types.”

Impact on Blood Transfusion

The identification of the MAL system is crucial for patients who are AnWj-negative. These individuals can suffer severe reactions if given AnWj-positive blood. The new discovery allows for the creation of genotyping tests to identify these rare cases, thereby reducing transfusion-related risks.

Over 99.9% of people are AnWj-positive, with the Mal protein present on their red blood cells. Those who lack this protein may do so due to genetic reasons or specific health conditions.

Research Methodology and Findings

The research team, including Professor Ash Toye from the University of Bristol and Dr. Nicole Thornton from NHS Blood and Transplant, used whole exome sequencing to identify deletions in the MAL gene associated with the AnWj-negative phenotype. “It’s exciting to confirm AnWj’s genetic basis using advanced gene manipulation techniques,” said Professor Toye.

Challenges and Future Implications

Dr. Tim Satchwell from UWE Bristol highlighted the difficulty in identifying the MAL protein due to its small size and unique properties. This discovery is expected to improve blood transfusion safety and facilitate the identification of rare donors and patients, enhancing overall care.

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SpaceX Successfully Deploys 21 Starlink Satellites, Loses Falcon 9 Booster

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SpaceX Successfully Deploys 21 Starlink Satellites, Loses Falcon 9 Booster

A Falcon 9 rocket carrying 21 Starlink satellites was launched by SpaceX from Cape Canaveral Space Force Station on March 2. Liftoff took place at 9:24 p.m. ET on March 3, with the mission including 13 satellites equipped with direct-to-cell capabilities. The first stage of the rocket successfully landed on the droneship “Just Read the Instructions” stationed approximately 400 kilometres off Florida’s coast. However, the booster, designated B1086, was lost shortly after landing due to damage sustained by one of its landing legs.

Booster Loss After Landing

According to SpaceX, a fire at the aft end of the booster resulted in structural damage, leading to its collapse. The incident occurred after the rocket had completed its return to Earth and made contact with the landing platform. Data from this failure will be examined to improve the reliability of future Falcon 9 missions, as stated in SpaceX’s official mission description.

Mission Details and Starlink Expansion

The deployment of the 21 satellites took place approximately 65 minutes after launch, marking another step in the expansion of SpaceX’s Starlink constellation. More than 7,000 operational Starlink satellites are currently in orbit, contributing to global broadband coverage.

This launch marked the Falcon 9 booster’s fifth and final flight. The B1086 had previously been used for three Starlink missions, as well as the GOES-U and Maxar 3 missions. SpaceX has completed 26 Falcon 9 missions in 2025, with 19 dedicated to Starlink. The company continues to advance its satellite network despite the loss of the booster in this mission.

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Primordial Helium-3 May Be Locked in Earth’s Core, Study Finds

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Primordial Helium-3 May Be Locked in Earth’s Core, Study Finds

Helium-3, a rare isotope formed during the early solar system, may be locked within Earth’s solid core, as indicated by recent research. This discovery could provide insights into how quickly the planet was formed. Unlike helium-4, which is commonly produced through radioactive decay, helium-3 originates from the primordial gas cloud that shaped the solar system. While traces of this isotope have been detected in volcanic hotspots and mid-ocean ridges, the mechanism behind its retention for billions of years remains uncertain. Given helium’s volatile nature, most of it was expected to escape Earth’s mantle due to tectonic activity or the giant impact that led to the formation of the Moon.

Helium and Iron Interaction at Core Conditions

According to the study published in Physical Review Letters, researchers at the University of Tokyo led by Kei Hirose examined whether helium could mix with iron under conditions mimicking Earth’s core. Using a diamond-tipped anvil, the team subjected iron and helium to extreme pressures ranging from 50,000 to 550,000 times the atmospheric pressure at Earth’s surface. As per reports, the samples were heated to temperatures between 727 and 2,727 degrees Celsius before being depressurised and analysed at cryogenic temperatures to prevent helium escape. Findings indicated that solid iron could incorporate up to 3.3 percent helium, suggesting the isotope may remain trapped in the core over long periods.

Potential Impact on Earth’s Formation Timeline

Peter Olson, a geophysicist at the University of New Mexico, told that these results confirm helium’s compatibility with Earth’s solid core. However, he noted that only 4 percent of the core is solid, with the majority existing in a liquid state. Further research is needed to determine whether helium-3 could be similarly retained in the liquid portion. Olson also highlighted the significance of this discovery in dating Earth’s formation. If helium-3 was incorporated into the core, it suggests the planet formed rapidly within a few million years. A slower formation process spanning 100 million years would likely have resulted in minimal helium retention.

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SpaceX Delays Starship Flight 8 Launch After Technical Glitches

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SpaceX Delays Starship Flight 8 Launch After Technical Glitches

The scheduled test flight of SpaceX’s Starship Flight 8, which was expected to take off from the company’s Starbase facility in Texas on March 3, has been postponed due to last-minute technical issues. The launch was planned within a window starting at 6:30 p.m. ET with a mission to test various aspects of the rocket’s performance, including booster recovery and satellite deployment. SpaceX has not yet announced a new launch date, but updates are expected soon. The flight was set to be the eighth major test for Starship, which is designed to be the most powerful rocket ever built.

Starship’s Mission and Test Objectives

As per reports, the flight plan, Starship was expected to launch atop its Super Heavy booster, which was intended to return to the launch pad and be caught by the “chopstick” arms of the tower. The upper stage of the rocket was set to release four mock versions of SpaceX’s Starlink satellites on a suborbital trajectory before splashing down in the Indian Ocean approximately 66 minutes after liftoff. A similar test conducted on January 16 with Flight 7 saw the successful recovery of the booster, but the upper stage failed due to a propellant leak, leading to an explosion before it could complete its mission.

NASA’s Interest and Future Developments

NASA has selected Starship as the lunar lander for the Artemis program, which aims to return astronauts to the Moon in the coming years. The vehicle is also being developed for deep-space missions, including potential crewed journeys to Mars. Elon Musk, CEO of SpaceX, has indicated that future iterations of Starship may be even larger than the current model, which stands at 123 metres. The Federal Aviation Administration (FAA) is expected to grant approval for up to 25 Starship launches in 2025, marking a significant step toward the rocket’s operational use.

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