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By Dr. Priyom Bose, Ph.D. Reviewed by Danielle Ellis, B.Sc.

What happens after HIV infection?
Evolution of HIV diagnostic assays
Conclusions
References
Further reading

Acquired immunodeficiency syndrome (AIDS) is caused by the human immunodeficiency virus (HIV) that attacks the body’s immune system, making it vulnerable to all infections. One of the major concerns of the early AIDS epidemic that began in 1981 was the lack of proper diagnostic measures to identify infected individuals.1 Since the development of the first HIV diagnostic assay in 1985, scientists have continued to improve diagnostic accuracy, detection speed, and cost.

Image Credit: Hanna Karpiak/Shutterstock.com What happens after HIV infection?

The immune system produces antibodies after encountering harmful foreign substances or antigens. HIV infects the vital cells associated with immunity, such as macrophages, helper T cells, and dendritic cells, and disrupts their function. The three important HIV antigens are p24, gp 41, and gp 120.2

HIV is a slow-replicating retrovirus that is transmitted through sexual intercourse, sharing an infected needle, or by blood transfer.3 After HIV infection, the viral load cannot be measured immediately due to low plasma load. Typically, the viral RNA can be measured within 10 to 12 days after infection.4

Antibodies to p24 and gp 41 are the first serological markers used to detect HIV infection. IgG antibodies appear approximately three weeks after infection. In the majority of HIV-infected individuals, HIV antibodies appear to circulate within 1 to 2 months of the infection. However, in a few cases, it may take up to six months to appear at a detectable level.5 Evolution of HIV diagnostic assays

Over the years, scientists have developed many immunoassays and nucleic acid amplification tests (NAATs) to accurately and high-throughput HIV diagnosis. These tests are broadly divided into two categories, namely, screening and confirmatory tests. Typically, HIV tests are performed on blood, oral fluids, or urine samples.6

HIV screening is performed by various immunoassays that focus on detecting IgG antibodies against HIV-1 antigens in the serum. Techniques such as Western blot, line immunoassay (LIA), and recombinant immunoblot are used as confirmatory tests.7 Some of the important HIV diagnostic assays are discussed below: Serological testing for HIV

In the mid-1980s, simple serological tests for HIV antibodies were developed based on culture-derived viral antigen preparation.7 These tests enabled HIV diagnosis and assessed blood and blood product supplies. Since the early assays, various serological assays have been developed that aided simple/rapid testing, high-throughput screening, confirmatory tests, incidence determination, and epidemiological surveillance. Since its first development, five generations of enzyme immunoassays (EIAs) have emerged based on varied antigen preparations and detection chemistries.8

First-generation assays: The first-generation EIAs detect IgG antibodies from antigens derived from whole viral lysates of HIV-positive cultures. Since crude antigen lysate contains impurities, this method exhibited reduced specificity and high false positivity. In contrast, immunofluorescence assays or Western blotting (WB) have shown higher specificity and lower false positivity.

Second-generation assays: Second-generation assays involve the use of recombinant proteins or synthetic peptides derived from the immunodominant regions (IDR) of HIV-1 proteins and gp36 of HIV-2, which increases sensitivity and decreases false positivity.

Third-generation assays: Third-generation assays, including the Genetic Systems HIV-1/HIV-2 Plus O EIA, use a variety of antigens to detect HIV-1 and -2 antibodies in the serum. A major advantage of third-generation sandwich format assays is their ability to detect HIV-1 IgM antibodies early, enabling quicker HIV diagnosis.

Fourth-generation assays: The fourth-generation EIAs, including the Abbott Architect HIV Ag/Ab Combo assay, utilize fully automated chemiluminescent microparticle technology that can instantaneously identify antibodies to HIV-1 and HIV-2 and HIV-1 p24 antigen. This technique has further allowed early HIV diagnosis. Other advantages of fourth-generation high-throughput assays are their capacity to perform more than 150 tests per hour and their ability to test specimens immediately upon arrival and generate results within 30 minutes.  These assays are suitable for facilities, such as blood banks, that handle high volumes of blood samples.

Fifth-generation assays: Fifth-generation assays, such as the Bio-Rad BioPlex 2200 HIV Ag-Ab assay, use magnetic beads coated with p24 monoclonal antibodies and epitopes specific for HIV-1 and HIV-2. This type of assay has a major advantage in  that it can confirm HIV infection in a single test. Interested in Assay Kits? Explore Equipment Here

Despite the advancements in EIA assays, the challenges associated with the generation of false positive results persist. Therefore, EIA-reactive specimen is typically retested with supplemental tests, such as Western Blot. Rapid diagnostic tests Related StoriesSweden exceeds UNAIDS HIV goals but faces new challengesNutrition's pivotal role in combating tuberculosis: addressing N-AIDS for better outcomes

The first HIV rapid test was available in the early 1990s. It determined an individual's serostatus before surgery, maternal labor/delivery, and organ transplant. Rapid diagnostics is based on immunochromatographic technology that uses blood from finger pricks to assess HIV status. 9 This test can provide results in less than 30 minutes and can be used in point-of-care (POC) settings. Since this test presents both false positive and negative results, it is essential to confirm the findings with laboratory-based HIV assays.

The main advantage of this technique is that any non-laboratory staff can perform it in a primary health care center. Even though decentralization of HIV diagnostic services has increased HIV test service in remote areas, it has been challenged by the lack of national guidelines, waste disposal, inventory management, and quality assurance (QA) monitoring.10

HIV self-testing, based on rapid testing methods, has allowed individuals who would otherwise refrain from testing in fear of discrimination to perform the test privately and start proper intervention. The World Health Organization (WHO) has prequalified several HIV rapid tests for HIV self-testing, including the Insti HIV-1/HIV-2 antibody tests and the Oraquick rapid HIV-1/2 antibody test.10 Nucleic acid test (NAT)

The NAT identifies HIV nucleic acid, i.e., either RNA or proviral DNA, in the blood sample. This test is based on the principles of polymerase chain reaction (PCR), nucleic acid sequence-based amplification, or ligase chain reaction.11 This test has proved to be vital in situations when an antibody against HIV is absent in serum. NAT is also performed in newborns of HIV-infected mothers. Unlike other assays, this test can detect HIV even after recent or possible exposure to the virus. Furthermore, NAT can quantify viral load.

Revolutions in Infectious Disease Testing Conclusions

The advancements in HIV diagnostic assays have played a vital role in identifying, staging, and monitoring infected individuals, even when they are under antiretroviral therapy. These assays have played an important role in surveillance and identification of transmission hot spots. Extraordinary progress in HIV testing methodologies has not only reduced false positives but decreased assessment time as well. References Sharp PM, Hahn BH. Origins of HIV and the AIDS pandemic. Cold Spring Harb Perspect Med. 2011;1(1):a006841. doi: 10.1101/cshperspect.a006841. Foster JE., et al. Viruses as Pathogens: Animal Viruses, With Emphasis on Human Viruses. Viruses. 2018; 157-187. doi.org/10.1016/B978-0-12-811257-1.00007-3 Dasgupta A, Wahed. Human immunodeficiency virus (HIV) and hepatitis testing. Clinical Chemistry, Immunology and Laboratory Quality Control (Second Edition). 2021; 513-533. doi.org/10.1016/B978-0-12-815960-6.00015-7 Konrad BP, et al. On the duration of the period between exposure to HIV and detectable infection. Epidemics. 2017; 20, 73-83. doi.org/10.1016/j.epidem.2017.03.002 Davis LE. Acute viral meningitis and encephalitis. Infections of the Nervous System, 1987; 156-176. doi.org/10.1016/B978-0-407-02293-5.50014-3 Pant PN. Oral fluid-based rapid HIV testing: issues, challenges and research directions. Expert Review of Molecular Diagnostics. 2007; 7 (4), 325-328, DOI: 10.1586/14737159.7.4.325 Abdullah DM, et al. The contemporary immunoassays for HIV diagnosis: a concise overview. Asian Biomed (Res Rev News). 2023;17(1):3-12. doi: 10.2478/abm-2023-0038. Alexander TS. Human Immunodeficiency Virus Diagnostic Testing: 30 Years of Evolution. Clin Vaccine Immunol. 2016;23(4):249-53. doi: 10.1128/CVI.00053-16. Aidoo S, et al. Suitability of a rapid immunochromatographic test for detection of antibodies to human immunodeficiency virus in Ghana, West Africa. J Clin Microbiol. 2001;39(7):2572-5. doi: 10.1128/JCM.39.7.2572-2575.2001. Parekh BS, et al. Diagnosis of Human Immunodeficiency Virus Infection. Clin Microbiol Rev. 2018;32(1):e00064-18. doi: 10.1128/CMR.00064-18. Garrett, P. E. Quality control for nucleic acid tests: Common ground and special issues. Journal of Clinical Virology. 2001; 20(1-2), 15-21. doi.org/10.1016/S1386-6532(00)00150-5

Further ReadingAll HIV ContentThe Economic Impacts of AIDSRecent Advancements in Treating HIV

Last Updated: Nov 29, 2024

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Politics

Reform deputy attacks govt for ‘protecting rights’ of illegal migrants – and fires back at Archbishop of York

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Reform deputy attacks govt for 'protecting rights' of illegal migrants - and fires back at Archbishop of York

Reform UK has hit back at both the Archbishop of York and the government following criticism of its immigration policies.

Leader Nigel Farage announced the party’s flagship immigration plan during a flashy news conference held at an aircraft hangar in Oxford on Tuesday.

The party pledged to deport anybody who comes to the UK illegally, regardless of whether they might come to harm, and said it would pay countries with questionable human rights records – such as Afghanistan – to take people back.

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It also said it would leave numerous international agreements, and revoke the Human Rights Act, in order to do this.

The policy was criticised by the Conservatives, who said Mr Farage was “copying our homework”, while parties such as the Liberal Democrats and the Greens condemned it.

More on Migrant Crossings

Archbishop Stephen Cottrell and Richard Tice MP. Pics: PA
Image:
Archbishop Stephen Cottrell and Richard Tice MP. Pics: PA

But the plan came under fire from an altogether different angle on Saturday, when the Archbishop of York accused it of being an “isolationist, short-term kneejerk” approach, with no “long-term solutions”.

Stephen Cottrell, who is the acting head of the Church of England, told Sunday Morning With Trevor Phillips that he had “every sympathy” with those who find the issue of immigration tricky. But he said Reform UK’s plan does “nothing to address the issue of what brings people to this country”, and would in fact, make “the problem worse”.

Please use Chrome browser for a more accessible video player

In full: Richard Tice on Sunday Morning With Trevor Phillips

Speaking on the same programme, Richard Tice, Reform’s deputy leader, responded to the archbishop’s criticisms, saying that “all of it is wrong”.

The MP for Boston and Skegness said he was a Christian who “enjoys” the church – but that the “role of the archbishop is not actually to interfere with international migration policies”.

Mr Tice then turned his fire on the government, accusing ministers of being “more interested in protecting the rights of people who’ve come here illegally… than looking after the rights of British citizens”.

He accused ministers of having “abandoned” their duty of “looking after the interests of British citizens”.

Mr Tice reaffirmed his party’s policy that the UK should leave the European Convention on Human Rights (ECHR), calling it a “70-year-old, out-of-date, unfit-for-purpose agreement”.

The Reform UK deputy leader also:

• Defended plans to pay the Taliban to take migrants back, comparing it to doing business deals with “people you don’t like”

• Said the Royal Navy should be deployed in the English Channel as a “deterrent”, but added: “We’re not saying sink the boats”

• Urged the government to call an early general election

Please use Chrome browser for a more accessible video player

Farage ‘wants to provoke anger’

Meanwhile, Bridget Phillipson, the education secretary, told Sky News that Reform “want to provoke anger, but they don’t actually want to solve the problems that we face in front of us”.

She told Sunday Morning With Trevor Phillips the UK had a “proud tradition [of] supporting those facing persecution”.

But she added: “We will make sure that people who have no right to be in this country are removed from this country. That’s right. It’s what people expect. It’s what this government will deliver.”

Ms Phillipson also insisted there “needs to be reform of the ECHR” and said the home secretary is “looking at the article eight provisions”, which cover the right to a private and family life, to see “whether they need updating and reforming for the modern age”.

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However, she refused to say what the government would do if it is found that the ECHR is unreformable. Instead, she defended Labour’s position of staying in the governance of the convention, saying that honouring the “rule of law” is important.

She added: “Our standing in the world matters if we want to strike trade deals with countries. We need to be a country that’s taken seriously. We need to be a country that honours our obligations and honours the rule of law.”

Please use Chrome browser for a more accessible video player

Sunday Morning With Trevor Phillips

Please use Chrome browser for a more accessible video player

Asylum seekers to remain at Bell Hotel

Ms Phillipson was also drawn on the recent court ruling in favour of the Home Office, which overturned an injunction banning The Bell Hotel in Epping from housing asylum seekers.

Challenged on whether the government is prioritising the rights of asylum seekers over British citizens, she said it “is about a balance of rights”.

The cabinet minister also repeated the government’s plans to end the use of hotels to house asylum seekers by 2029.

Please use Chrome browser for a more accessible video player

‘We should have overruled law’

Shadow Cabinet Office minister Alex Burghart said the Conservatives would be willing to leave the ECHR – if this route is recommended to them.

The Tories have asked a senior judge to look into the “legal intricacies” of leaving the convention, which he said is “not straightforward”. He said when the party receives that report, it will then make a decision.

Challenged on whether the Tories will leave if that is what the report recommends, he added: “If that’s what’s necessary, we will do it.”

Mr Burghart also said he believed the previous Conservative government’s biggest mistake was that “we did not go far enough on overruling human rights legislation”, which prevented it from “taking the tough action that was absolutely necessary”.

But he added the Conservatives have now “put forward very clear legislation that would solve this problem” – though he concluded Labour “isn’t going to do it” so the problem “is going to get worse”.

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World

‘The drones are always there… like a punishment’: A diary of daily life in Gaza

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'The drones are always there... like a punishment': A diary of daily life in Gaza

“We call drones our loyal friends, because they never leave us.”

Tasneem hears Israeli drones overhead, a constant fact of life in Gaza. It gets into your head, into your chest, she says.

“You can’t think, you can’t sleep. You can’t even be.”

“It’s always there, hanging above our heads, like some kind of punishment,” she says. In the background, the slow, constant buzz of a drone is audible.

“The people here in Gaza know that when the drone gets very low, at this level, something will happen. We all know what that something is… I don’t want to mention it.”

Tasneem al Iwini shared voicenotes with Sky News
Image:
Tasneem al Iwini shared voicenotes with Sky News

Tasneem al Iwini is 24. Like her peers across the world, she splits her time between work, studying for a master’s degree and spending time with her family of six.

Except she also has to deal with warplanes screaming overhead, rocketing food prices and the possibility that any day could be the last for her or her loved ones as Israel continues its war in Gaza.

To give a sense of what day-to-day life is like for her in Deir al Balah, Tasneem recorded a series of audio diary entries over the course of a week as part of her work with ActionAid and shared them exclusively with Sky News.

Smoke rises over Deir al Balah. Pic: Reuters
Image:
Smoke rises over Deir al Balah. Pic: Reuters

Day One: At least I’m still breathing

It’s incredibly hot today, Tasneem says. The kind of heat that makes your skin heavy and your thoughts slower.

I had so many things to do on my plate today, but honestly, I couldn’t move.

There’s no electricity and no fans, no air conditioner. So here I am just laying on my mattress and sweating.

My only relief is my plastic tray. I’m just using it as my personal fan…

I keep waving it back and forth, not to cool the room, but just to trick my brain into thinking I have control over this heat.

Sometimes I close my eyes and imagine I’m somewhere cold, as I actually prefer winter.

But then I hear the buzz of flies and mosquitoes in my ear and I remember this is Gaza, summer 2025. It’s exhausting, but at least I’m still breathing.

Day Two: Rocketing price of food

It’s Friday, which is a special day for us as it is the day we usually wait to cook something special. Today we are cooking maqluba (a traditional dish consisting of meat, rice and fried vegetables).

We haven’t tasted any kind of real protein like meat, chicken or fish for more than three months. I really miss chicken and fish badly.

But even this fake maqluba costs a lot, so many families can’t afford it… vegetables are very expensive.

Tasneem prepares meals with what she can get. Pic: Tasneem/ActionAid
Image:
Tasneem prepares meals with what she can get. Pic: Tasneem/ActionAid

Before the war we used to cook maqluba with at least four kilos of eggplants, because we are crazy about eggplants and its taste in maqluba . Now, if we manage to cook it with only two eggplants, that’s considered a luxury.

The price of one kilo of eggplant is more than 45 shekels. That’s approximately $12.50. Talking about tomatoes, the price is more than 90 shekels, which is approximately $27 per kilo.

Read more:
Number of dead in Gaza ‘reaches 63,000’ – as Israel declares city a combat zone
Israeli protesters attack ‘tyrant’ Netanyahu
Five journalists among 20 killed in Israeli strikes on hospital

Day Three: The drone reality

Here we go again. Our dear friend, the drone, Tasneem says as a buzzing noise hums in the background.

It just never leaves. It’s always there hanging above our heads like some kind of punishment.

The sound, I don’t even know how to describe it.

It’s not just noise. It gets into your head, into your chest. You can’t think, you can’t sleep, you can’t even be.

It drains something inside you slowly, and yet we live with it every day.

Later on:

Hi again. I’m just recording the gunfire. We are not sure what is happening outside, actually.

I can say that this is almost an every afternoon routine.

Tasneem al Iwini speaking about conditions in Gaza
Image:
Tasneem al Iwini speaking about conditions in Gaza

Day Four: A message to the world

Today I came across a small community kitchen, one of the very few still functioning.

Because of the current situation, especially the scarcity of food and the near-total blockade on the humanitarian aid, most of these kitchens have shut down…

Smoke rises following an Israeli strike in Deir al Balah. Pic: Reuters
Image:
Smoke rises following an Israeli strike in Deir al Balah. Pic: Reuters

Tasneem says that just after she left the office, the community kitchen was hit in an Israeli strike.

Three youths were killed, and many children were injured.

Those children were playing around and nearby the kitchen…

This time I went to send a message to the world, with a heavy heart burdened by the challenges and the impossible conditions we live under.

I still hold on to hope that this war will end… Because honestly, here in Gaza, we have lost trust in the world, governments and every actor.

Day Five: How many children must die?

Good evening, dear friends. I don’t really know what to say. I feel like my heart is just a drain.

Yesterday I promised to take you through the rest of my day, but honestly, I came home feeling exhausted…

I bought just two cucumbers, and that cost me $8. Yes, $8 for two cucumbers.

This is what it means to say that even the basics have become impossible to get in Gaza.

I came home, washed the cucumbers and cut them into small pieces so all of us could taste what it feels like to eat cucumber.

Tomatoes are even worse. They are completely unaffordable in the market.

Palestinians gather at an aid distribution centre. Pic: Reuters
Image:
Palestinians gather at an aid distribution centre. Pic: Reuters

And every time I think about the situation we are living through here in Gaza, I feel like I’m out of patience. I just can’t take more.

How many of us have to die before the world decides to intervene? And how many children must die, not from bombing or shelling, but from starvation and malnutrition?

Today, the telecommunications company in Gaza announced that in the next 24 hours it is expected that internet services will shut down again because of the fuel shortage and because of the occupation, who continue to block fuel from entering the Strip.

And this does not mean losing the internet only. It means patients in the ICUs will lose connection to life. It means ambulances, fridges for medications and blood, even water pumps for both drinking and domestic use will stop working.

I was planning today to come home and study for my final exams, but I just sat there for a moment thinking about our reality.

And I couldn’t, I couldn’t do anything. So instead, I decided to record this for you. This is what Gaza looks like right now.

Day Seven: The cemetery is full… and the horror of jets overhead

There are many types of weapons being used… and here in Gaza, we the people have learned to genuinely distinguish between them.

We know each sound by heart.

For example, we know the sound of the F-16 (fighter jet) very well. We can even guess when it has a target.

It has a special tone, like it’s rushing towards something. There is a tension in the air, and we feel it in our bodies.

Whenever I hear one of them, I swear I feel like this is the last moment of my life. I cover my ears with both hands and run to stay nearby my family, because in this moment my heart tells me, if something happens, let it happen to all of us together.

I know that’s not how it works, but that’s how I cope. That’s the only way I feel some false sense of control…

Sometimes it feels like the pilot is showing off, flying lower over the heads of women, children and civilians, as if to say: “Look at me. I can do this.”

Every time the jets go low, I start praying, I do everything I can as if it is the end of my life.

A Palestinian boy walks amid debris after strikes in Deir al Balah. Pic: AP
Image:
A Palestinian boy walks amid debris after strikes in Deir al Balah. Pic: AP

In another voicenote from the same day, Tasneem talked about her walk to work.

I pass by the cemetery every day. Today, I saw a situation that truly broke my heart.

There was a group of angry people gathered around the person who is responsible for digging graves.

They were shouting, saying the cemetery is completely full, and now they have started opening all the graves without knowing who is buried there and without getting any consent from the families of the dead.

They are placing new dead bodies on the top of the old ones, whether they are men, women or children.

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‘Many people here prefer death over displacement’

Most people were furious, and honestly, I was so disappointed and heartbroken when I saw this.

This is one of those things I wish I never had to witness, but I wanted to share it with you, because it says so much about how bad things have become.

‘Critical moment’ for Gaza

Tasneem works with the Palestinian NGOs Network in Gaza and has partnered with ActionAid in the UK.

A spokesperson for ActionAid UK said: “Humanitarian workers like Tasneem are risking their lives every day to support and advocate for their fellow Palestinians in Gaza, despite experiencing the same intolerable conditions that they are.

“Just imagine having to go to work when you haven’t had a proper meal in days, knowing that at any moment you could be killed by bombing: that is their daily reality. Yet still, people like Tasneem are bravely speaking out and telling their stories so that the world knows the truth about the horrors they are facing…

“This is a critical moment. It’s time for the world to take meaningful action and use every diplomatic lever available to bring about a permanent ceasefire and end the siege on Gaza immediately so that food and other aid can enter unhindered, rapidly and at scale.”

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UK

Reform deputy attacks govt for ‘protecting rights’ of illegal migrants – and fires back at Archbishop of York

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Reform deputy attacks govt for 'protecting rights' of illegal migrants - and fires back at Archbishop of York

Reform UK has hit back at both the Archbishop of York and the government following criticism of its immigration policies.

Leader Nigel Farage announced the party’s flagship immigration plan during a flashy news conference held at an aircraft hangar in Oxford on Tuesday.

The party pledged to deport anybody who comes to the UK illegally, regardless of whether they might come to harm, and said it would pay countries with questionable human rights records – such as Afghanistan – to take people back.

Politics latest – follow live updates

It also said it would leave numerous international agreements, and revoke the Human Rights Act, in order to do this.

The policy was criticised by the Conservatives, who said Mr Farage was “copying our homework”, while parties such as the Liberal Democrats and the Greens condemned it.

More on Migrant Crossings

Archbishop Stephen Cottrell and Richard Tice MP. Pics: PA
Image:
Archbishop Stephen Cottrell and Richard Tice MP. Pics: PA

But the plan came under fire from an altogether different angle on Saturday, when the Archbishop of York accused it of being an “isolationist, short-term kneejerk” approach, with no “long-term solutions”.

Stephen Cottrell, who is the acting head of the Church of England, told Sunday Morning With Trevor Phillips that he had “every sympathy” with those who find the issue of immigration tricky. But he said Reform UK’s plan does “nothing to address the issue of what brings people to this country”, and would in fact, make “the problem worse”.

Please use Chrome browser for a more accessible video player

In full: Richard Tice on Sunday Morning With Trevor Phillips

Speaking on the same programme, Richard Tice, Reform’s deputy leader, responded to the archbishop’s criticisms, saying that “all of it is wrong”.

The MP for Boston and Skegness said he was a Christian who “enjoys” the church – but that the “role of the archbishop is not actually to interfere with international migration policies”.

Mr Tice then turned his fire on the government, accusing ministers of being “more interested in protecting the rights of people who’ve come here illegally… than looking after the rights of British citizens”.

He accused ministers of having “abandoned” their duty of “looking after the interests of British citizens”.

Mr Tice reaffirmed his party’s policy that the UK should leave the European Convention on Human Rights (ECHR), calling it a “70-year-old, out-of-date, unfit-for-purpose agreement”.

The Reform UK deputy leader also:

• Defended plans to pay the Taliban to take migrants back, comparing it to doing business deals with “people you don’t like”

• Said the Royal Navy should be deployed in the English Channel as a “deterrent”, but added: “We’re not saying sink the boats”

• Urged the government to call an early general election

Please use Chrome browser for a more accessible video player

Farage ‘wants to provoke anger’

Meanwhile, Bridget Phillipson, the education secretary, told Sky News that Reform “want to provoke anger, but they don’t actually want to solve the problems that we face in front of us”.

She told Sunday Morning With Trevor Phillips the UK had a “proud tradition [of] supporting those facing persecution”.

But she added: “We will make sure that people who have no right to be in this country are removed from this country. That’s right. It’s what people expect. It’s what this government will deliver.”

Ms Phillipson also insisted there “needs to be reform of the ECHR” and said the home secretary is “looking at the article eight provisions”, which cover the right to a private and family life, to see “whether they need updating and reforming for the modern age”.

👉 Listen to Sky News Daily on your podcast app 👈

However, she refused to say what the government would do if it is found that the ECHR is unreformable. Instead, she defended Labour’s position of staying in the governance of the convention, saying that honouring the “rule of law” is important.

She added: “Our standing in the world matters if we want to strike trade deals with countries. We need to be a country that’s taken seriously. We need to be a country that honours our obligations and honours the rule of law.”

Please use Chrome browser for a more accessible video player

Sunday Morning With Trevor Phillips

Please use Chrome browser for a more accessible video player

Asylum seekers to remain at Bell Hotel

Ms Phillipson was also drawn on the recent court ruling in favour of the Home Office, which overturned an injunction banning The Bell Hotel in Epping from housing asylum seekers.

Challenged on whether the government is prioritising the rights of asylum seekers over British citizens, she said it “is about a balance of rights”.

The cabinet minister also repeated the government’s plans to end the use of hotels to house asylum seekers by 2029.

Please use Chrome browser for a more accessible video player

‘We should have overruled law’

Shadow Cabinet Office minister Alex Burghart said the Conservatives would be willing to leave the ECHR – if this route is recommended to them.

The Tories have asked a senior judge to look into the “legal intricacies” of leaving the convention, which he said is “not straightforward”. He said when the party receives that report, it will then make a decision.

Challenged on whether the Tories will leave if that is what the report recommends, he added: “If that’s what’s necessary, we will do it.”

Mr Burghart also said he believed the previous Conservative government’s biggest mistake was that “we did not go far enough on overruling human rights legislation”, which prevented it from “taking the tough action that was absolutely necessary”.

But he added the Conservatives have now “put forward very clear legislation that would solve this problem” – though he concluded Labour “isn’t going to do it” so the problem “is going to get worse”.

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