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A 32-year-old woman is cancer-free after undergoing the UK’s first liver transplant for advanced bowel cancer.

Bianca Perea, a trainee lawyer from Manchester, was diagnosed with the most advanced kind of bowel cancer in November 2021, with doctors telling her they aimed to prolong her life rather than find a cure.

But, alongside other treatments including targeted drug therapy, chemotherapy and surgery, the transplant has been a huge success and Ms Perea now has no signs of cancer anywhere in her body.

Ms Perea first visited her GP in Wigan after feeling constipated and bloated. After tests, a colonoscopy and a biopsy, she was diagnosed with stage four bowel cancer, which had spread to all eight segments of her liver.

Ms Perea accepted the diagnosis, but said she refused to believe the outlook was so bleak.

“I don’t want to sound kind of ignorant or arrogant or anything like that but I just didn’t feel in my gut that that was going to be it,” she said.

Her mother asked about a possible transplant at that stage but was told it was not a feasible treatment.

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Ms Perea had 37 rounds of a targeted drug called panitumumab plus chemotherapy for two and a half years.

She had an excellent response to the treatment, which meant she was able to have an operation in May 2023 to remove the bowel tumour.

But scans showed she still had tumours in her liver, which could not be operated on.

EMBARGOED TO 0001 MONDAY JANUARY 6 Undated handout photo issued by The Christie NHS Foundation Trust of Bianca Perea who is cancer-free after undergoing the UK's first liver transplant for advanced bowel cancer. Bianca, a 32-year-old trainee lawyer from Manchester, was given the surgery in the hope it could offer a potential cure for her deadly disease. Issue date: Monday January 6, 2025.
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Bianca with her beloved dog. Pic: PA

Nevertheless, because her response to chemotherapy had been so good and her bowel cancer was seemingly gone, doctors began to look at liver transplants.

Ms Perea was added to the transplant list in February 2024 and was lucky enough to find a donor last summer.

File photo dated 30/11/17 of an NHS Blood and Transplant Small Human Organ in Transit box at St George's Hospital in Tooting, west London. Some 35 human organs were made available for transplant after being donated over Christmas Eve and Christmas Day, new figures have shown. The organs were provided by 11 donors across the UK after their death and included a heart, lungs, kidneys, livers, pancreas and bowel, NHS Blood and Transplant (NHSBT) said. Issue date: Friday December 27, 2024.
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An NHS Blood and Transplant Small Human Organ in Transit box at St George’s Hospital in Tooting, west London. File pic: PA

She said: “Within four weeks of going under the knife, I was able to drive and walk the family dogs, it was really quite incredible.

“To go from being told I’d only have a short time to live to now being cancer-free is the greatest gift.

“I’ve been given a second chance at life and I’m going to grab it with both hands. I am so grateful to the family who agreed to donate their loved one’s liver.

“I do believe this is a cure. They’re always hesitant to say that, obviously, but I am cancer-free right now.”

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Now, Ms Perea is looking forward to going on holiday this year and is working on improving her fitness.

“My liver is doing really well,” she said. “I get tests on that, and I’ve just had my second scan and that’s all clear, so it’s really good.”

Dr Kalena Marti, Ms Perea’s oncologist, said: “To see that Bianca has had such a positive outcome is wonderful.

“When we looked at the tumour cells in her liver after it had been removed, they weren’t active.

“This is excellent news, and we hope that this means that the cancer won’t come back.”

She added: “Advanced bowel cancer is complex and there are lots of different types of the disease, so what works for one person might not work for another. As a result, it’s important that we continue to develop new treatments.

“Thanks to the generosity of organ donors and their loved ones, we can now access liver transplants for some patients, which is fantastic.”

You can watch a full interview with Ms Perea at 8.30am this morning on Sky News Breakfast.

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UK weather: New snow warning as temperatures could drop to -16C this week

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UK weather: New snow warning as temperatures could drop to -16C this week

A fresh weather warning for snow has been issued for southern England, with cautions for snow and ice already in place across much of the country.

The Met Office’s yellow weather warning for snow covers the southern counties of England from 9am until midnight on Wednesday.

The warning stretches from Kent to Cornwall and up to south London and the Met Office said between two and five centimetres of snow could accumulate fairly widely, with as much as 10cm over higher ground.

Pic: Met Office
Image:
Pic: Met Office

This week is expected to see the coldest nights of the year, with temperatures potentially reaching -14C on Wednesday night and -16C on Thursday night, both in the North East of England and Scotland, the Met Office said.

Weather warnings issued on Tuesday for snow and ice covering the Midlands, parts of North Wales, the North West of England, west and northern parts of Scotland as well as Northern Ireland will remain in place until midday on Wednesday.

The forecaster said some roads and railways are likely to be affected and there could be icy patches on untreated roads.

Members of the public walk through heavy snowfall on the high street of Saddleworth.
Pic: AP
A woman walks through heavy snowfall on the high street of Saddleworth.
Pic: AP
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Pics: AP

Meanwhile the Environment Agency has said at least 300 properties have flooded across England since New Year’s Eve. It estimates more than 41,000 properties have been protected.

Heavy rainfall over the New Year caused significant river and surface water flooding across the North West of England and Yorkshire and snowmelt has brought further disruption to parts of England, particularly the Midlands, the agency said.

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Floods minister Emma Hardy said: “My sympathies go out to the people, businesses and communities impacted by the recent flooding across the country.

“I want to express my heartfelt thanks for the vital work that the Environment Agency and emergency services are doing to keep people safe. People must continue to follow their advice and sign up for flood warnings.”

Flood warnings

Some 100 flood warnings were in force across England on Wednesday, with people urged to remain vigilant over the coming days.

A danger-to-life warning was issued on Tuesday morning for the River Soar near Barrow upon Soar, Leicestershire, but was later removed.

People living in caravan parks in the area were urged by the Environment Agency to act, with a large-scale evacuation needed to save lives.

Firefighters have rescued dozens of people across Leicestershire since Monday, Leicestershire Fire and Rescue Service said.

Hundreds of schools were closed across the UK, with road and rail links blocked, as Manchester, Bristol and Liverpool John Lennon airports suspended flights because of the conditions.

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Family of baby killed in car park crash on family holiday fundraise for funeral

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Family of baby killed in car park crash on family holiday fundraise for funeral

A six-month-old baby who died after a collision in a multi-storey car park was on a family holiday to Wales. 

Sophia Kelemen from Leigh, Manchester, died after the crash in a car park in the coastal town of Tenby, Pembrokeshire, on 2 January.

Sophia’s aunt, Adriana Kelemen, has now launched a fundraiser to help cover funeral costs.

Writing on the page, Ms Kelemen said “never in a million years” did she think she would have to write such a post.

Ms Kelemen said she hoped to “ease a very small part of [her] brother and sister-in-law’s hurt” by raising money to cover part of the funeral costs.

Sophia was taken to hospital after the crash and treated for her injuries but died the following day, police confirmed.

Dyfed-Powys Police said the crash happened on the ground floor of the car park and that a man had been charged in connection with the incident.

Sophia Kelemen. Pic: Adriana Kelemen/GoFundMe
Image:
Sophia Kelemen. Pic: Adriana Kelemen/GoFundMe

Speaking to the Manchester Evening News, Ms Kelemen described her niece as “smiley and bubbly” and “so advanced for her age”.

Sophia was “playful and energetic” and “the cutest and most adorable girl”, her aunt added.

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A spokesperson for Dyfed-Powys Police said Sophia’s family were being supported by specialist officers.

The force said it was a “tragic incident” and asked the public not to speculate on the circumstances.

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Jess Phillips does not rule out new national inquiry into grooming gangs

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Jess Phillips does not rule out new national inquiry into grooming gangs

Jess Phillips has said “nothing is off the table” when dealing with the grooming gangs scandal – including a new national inquiry if victims want one.

The safeguarding minister told Sky’s political editor Beth Rigby on the Electoral Dysfunction podcast that she would listen to victims on a new panel that was announced by the government this week.

“Nothing is off the table,” she said.

“And if the victims come forward to me in this victims panel and they say, ‘actually, we think there needs to be a national inquiry into this’, I’ll listen to them.”

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Beth Rigby and Jess Phillips

Her comments come days after it emerged she had rejected calls from Oldham Council to hold a government inquiry into grooming gangs in the town, and said the council should commission one instead.

That has led to tech billionaire Elon Musk attacking her and Sir Keir Starmer for not holding a national inquiry and accusing the prime minister of being “complicit” in the abuse.

Professor Alexis Jay finished an eight-year national inquiry into child sexual abuse in 2022 and set out recommendations for the government.

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The Conservatives tabled an amendment to the Children’s Safeguarding and Schools Bill on Wednesday to require a statutory inquiry into grooming gangs.

However, Education Secretary Bridget Phillipson told Sky News the Tories “don’t care about children” as the amendment could prevent the entire bill from going forward.

She said: “The measures that I’m setting out today and the legislation in many ways go further because it puts a requirement on all councils to have teams working to keep children safe.

“And the bandwagon jumpers that have come along in recent days, they don’t care about children, they don’t care about making sure that we stop this and we take action.

“They had years to do it and they didn’t do it.”

The Conservatives also rejected a call from Oldham Council for a government inquiry in 2022.

You can listen to Beth’s full interview with Jess Phillips in a special episode of Electoral Dysfunction released on Thursday.

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