Personalised cancer treatment, matched to a patient via a simple blood test, is being hailed as “life-saving”, following an initial study.
The Target National trial, being conducted at The Christie hospital in Manchester, analyses a patient’s DNA to determine what type of therapy will work best for them.
If successful, researchers hope the procedure could become “routinely available on the NHS”.
Dr Matthew Krebs, the study’s chief investigator, tells Sky News its research was making “precision medicine” more accessible for a wider range of cancer patients.
“There are tiny bits of DNA which come off the cancer that circulate around in the bloodstream,” he explains, “so we can extract the DNA that specifically comes from the cancer.”
Image: Dr Matthew Krebs, the chief investigator of the Target National trial, says patients can get ‘more personalised’ treatment
That DNA is then analysed, allowing doctors to see its specific mutations and suggest bespoke treatment.
Dr Krebs says that means “rather than just treating generically with chemotherapy-type drugs” the patient gets a treatment “that’s more personalised to them”.
Although genetic and DNA testing for cancer patients is already being carried out in hospitals, typically the sample is collected using a biopsy.
That can involve surgery, be intrusive, painful and – in some cases – delayed.
Image: The trial analyses a patient’s DNA to determine what type of therapy will work best for them
‘It’s been life-saving’
The Target National study, funded by The Christie Charity and the Sir Bobby Robson Foundation, hopes to recruit 6,000 patients, to examine if the blood-test route, in effect a “liquid biopsy”, improves patient outcomes.
Dr Krebs says they know that the blood test route “won’t work for everyone”, but in some cases, it has already enabled patients with advanced cancers to be matched to drug trials.
Pamela Garner-Jones, 78, was told her stage four cervical cancer was “inoperable” and “no longer responding to treatment”.
“They were talking about palliative care,” she tells Sky News. “I thought they were making it up, I couldn’t believe it.”
At that point, Ms Garner-Jones was offered a place on the Target National study. Her blood test matched her to a new immunotherapy drug trial, that saw her tumour shrink by two-thirds.
Image: Pamela Garner-Jones was told her cervical cancer was ‘inoperable’ but a trial blood test helped her access a new drug, which shrunk her tumour
“Honestly, I couldn’t ask for anything more,” she says. “I’ve got more energy, my appetite’s back – it’s been life-saving.”
“It’s just a simple blood test and you’re not pumped full of no end of drugs,” she adds.
Ms Garner-Jones says she is now looking forward to a holiday with friends, meals out and being able to spend time in her garden.
“I’m made up,” she says. “Like a dog with two tails!”
No criminal charges will be brought over the death of an ice hockey player who died during a match in Sheffield, prosecutors have announced.
Nottingham Panthers’ Adam Johnson died in October 2023 after his neck was cut by an opposition player’s skate during a match at Sheffield’s Utilita Arena.
The Sheffield Steelers player, Matthew Petgrave, was arrested on suspicion of manslaughter and later bailed – but the Crown Prosecution Service (CPS) has now said it will not bring criminal charges against the Canadian.
Michael Quinn, deputy chief crown prosecutor, said: “This was a shocking and deeply upsetting incident. The CPS and South Yorkshire Police have worked closely together to determine whether any criminal charges should be brought against the other ice hockey player involved.
“Following a thorough police investigation and a comprehensive review of all the evidence by the CPS, we have concluded that there is not a realistic prospect of conviction for any criminal offence and so there will not be a prosecution.
“Our thoughts remain with the family and friends of Adam Johnson.”
Image: Tributes were left outside the Motorpoint Arena in Nottingham following the ice hockey player’s death. Pic PA
Before joining Nottingham Panthers, the Minnesota-born Johnson played in Pennsylvania for the Pittsburgh Penguins, and Sweden for the Malmo Redhawks.
He also played in California for Ontario Reign and in Germany for Augsburger Panther.
A post-mortem examination confirmed the 29-year-old died as a result of the fatal neck injury.
The crowd of 8,000 spectators watched in horror as desperate attempts were made to save his life as he lay on the ice, shielded by fellow players.
The game was abandoned and spectators were asked to leave in the aftermath.
Image: Pic PA
Kari Johnson, Johnson’s aunt, was watching the match via a livestream with his father and grandmother when he was fatally injured.
Speaking to Sky News at the time, Ms Johnson said: “It was a mess, it was a nightmare, it was like it wasn’t real. We were in shock, we couldn’t believe this was happening.”
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Kari Johnson said her nephew was ‘a kind soul’
Ms Johnson described her nephew as a “kind soul” and a “private kid” who “never would have wanted to be in the limelight like this”.
He simply wanted to be “good at hockey and have fun”, she said, adding he was “having the time of his life in the UK” and was planning to get engaged to his girlfriend.
In January 2024, Sheffield’s senior coroner, Tanyka Rawden, suspended her investigation while the police inquiry took its course.
It later emerged that Ms Rawden had issued a Prevention of Future Deaths Report to Ice Hockey UK and the English Ice Hockey Association (EIHA) about the use of neck guards in the sport.
In the report, Ms Rawden said she was “sufficiently concerned that deaths may occur in the future if neck guards or protectors are not worn”, with the bodies given 56 days to say what action had been taken – or why action had not been taken.
Neck guards have been mandatory in the Elite League (EIHL), in which the Nottingham Panthers and Sheffield Steelers compete, since January 2024.
This followed the International Ice Hockey Federation’s decision in December to mandate the use of neck laceration protectors for its competitions.
Court decisions where people were granted asylum after arguing they had a “right to family life” will be reviewed as the government plans to ban migrants convicted of sex offences, the home secretary has said.
Foreign nationals who are added to the sex offenders register will forfeit their rights to protection under the Refugee Convention, the Home Office announced.
As part of the 1951 UN treaty, countries are allowed to refuse asylum to terrorists, war criminals and individuals convicted of a “particularly serious crime” – which is currently defined in UK law as an offence carrying a sentence of 12 months or more.
The government now plans to extend that definition to include all individuals added to the Sex Offenders’ Register, regardless of the length of sentence, in an amendment to the Border Security, Asylum and Immigration Bill, which is currently going through parliament.
Home Secretary Yvette Cooper told Sky News the new definition would also “take into account” sexual offence convictions in another country.
However, she was less clear if those affected will still be able to appeal against their removal from the UK under the European Convention on Human Rights (ECHR).
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Image: More than 10,000 people have now been detected crossing the Channel. Pic: PA
She said: “We continue to comply with international law, but the whole point is that our laws and our frameworks are about how we interpret international law… and how we make sure that the courts are then making their decisions based on the UK law that parliament has passed.”
She added the government is “reviewing” a “series of decisions” made in the courts where criminals have been allowed to stay in the UK under Article 8 of the Human Rights Act, which protects the right to respect “your private life, your family life, your home and your correspondence”.
“We are reviewing that because we do believe that the way in which it’s being interpreted in the courts is an issue and actually, there is greater clarification we can provide through our law to address that,” she said.
It is unclear how many asylum seekers will be affected by the change in law, as the government has been unable to provide any projections or past data on the number of asylum seekers added to the Sex Offenders’ Register.
Ms Cooper earlier said: “Sex offenders who pose a risk to the community should not be allowed to benefit from refugee protections in the UK. We are strengthening the law to ensure these appalling crimes are taken seriously.”
Safeguarding and Violence Against Women and Girls Minister Jess Philips said: “We are determined to achieve our mission of halving violence against women and girls in a decade.
“That’s exactly why we are taking action to ensure there are robust safeguards across the system, including by clamping down on foreign criminals who commit heinous crimes like sex offences.”
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Has Labour tackled migration?
The Home Office would like voters to see this as a substantial change. But that’s hard to demonstrate without providing any indication of the scale of the problem it seeks to solve.
Clearly, the government does not want to fan the flames of resentment towards asylum seekers by implying large numbers have been committing sex crimes.
But amid rising voter frustration about the government’s grip on the issue, and under pressure from Reform – this measure is about signalling it is prepared to take tough action.
Conservatives: ‘Too little, too late’
The Conservatives claim Labour are engaged in “pre-election posturing”.
Chris Philp, the shadow home secretary, said: “This is too little, too late from a Labour government that has scrapped our deterrent and overseen the worst year ever for small boat crossings – with a record 10,000 people crossing this year already.
“Foreign criminals pose a danger to British citizens and must be removed, but so often this is frustrated by spurious legal claims based on human rights claims, not asylum claims.”
The Home Office has also announced plans to introduce a 24-week target for appeal hearings (known as “first-tier tribunals”) to be held for rejected asylum seekers living in taxpayer-supported accommodation, or for foreign national offenders.
The current average wait is 50 weeks.
The idea is to cut the asylum backlog and save taxpayers money – Labour have committed to end the use of asylum hotels by the end of this parliament.
It’s unclear how exactly this will be achieved, although a number of additional court days have already been announced.
The government also plans to crack down on fake immigration lawyers who advise migrants on how to lodge fraudulent asylum claims, with the Immigration Advice Authority given new powers to issue fines of up to £15,000.