The trial of a dentist accused of murdering his wife by poisoning her protein shakes has begun in the US state of Colorado.

James Craig denies using cyanide and tetrahydrozoline, an ingredient in over-the-counter eye drops, to kill Angela Craig in a suburb of Denver.

During the trial’s opening statements on Tuesday, prosecutors claimed the 47-year-old was having an affair with another dentist, had financial difficulties and may have been motivated by the payout from his wife’s life insurance.

Assistant District Attorney Ryan Brackley told the jury at Arapahoe District Court that the 43-year-old victim – who had six children with her husband – had been suffering worsening symptoms including dizziness, vomiting and fainting.

She died in March 2023 during her third trip to the hospital that month.

Mr Brackley accused Craig of poisoning her protein shakes – then giving his wife a final dose of poison while she was in hospital, and said: “He went in that [hospital] room to murder her, to deliberately and intentionally end her life with a fatal dose of cyanide … She spends the next three days dying.”

Craig, who shook his head at times during the prosecution’s opening statement, has pleaded not guilty to several charges, including first-degree murder, solicitation to commit murder and solicitation to commit perjury.

Prosecutors said Craig had tried to make it appear his wife of 23 years had killed herself. His internet history showed he had searched for “how to make a murder look like a heart attack” and “is arsenic detectable in an autopsy”.

In an argument, captured on home surveillance video, his wife also accused him of suggesting to hospital staff that she was suicidal.

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After Craig’s arrest in 2023, prosecutors alleged that he had offered a fellow prison inmate $20,000 (£14,993) to kill the case’s lead investigator and offered someone else $20,000 to find people to falsely testify that Angela Craig planned to die by suicide.

Craig’s attorney, Ashley Whitham, told the jury to consider the credibility of those witnesses, calling some “jailhouse snitches”.

Ms Whitham argued that the evidence didn’t show that he poisoned her, instead seeming to suggest she may have taken her own life.

She described Angela Craig as “broken”, partly by Craig’s infidelity and her desire to stay married, since they were part of The Church of Jesus Christ and Latter-day Saints.

Hospital staff had said Craig had been caring and “doting” while Angela Craig was in the hospital, said Whitham.

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The defence argued prosecutors had overdramatised Craig’s financial problems and dismissed the prosecution’s suggestion that Craig was motivated to kill because of an affair he was having with a fellow dentist from Texas.

“That’s simply not the case,” Whitham said, adding that Craig had many affairs over the years that his wife knew about. “He was candid with Angela that he had been cheating.”

The trial continues.

Donald Trump has said he will “refine the trade deal” with the UK during his private trip to Scotland later this month.

The US president told reporters outside the White House on Tuesday that he will meet with Sir Keir Starmer “probably in Aberdeen”.

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Mr Trump is expected to travel to Scotland in the coming weeks to visit his golf courses ahead of an official state visit in September.

“We’re going to be meeting with the British prime minister, very respectful, and we are going to have a meeting with him, probably in Aberdeen, and we’re going to do a lot of different things.

“We’re going to also refine the trade deal that we’ve made.

“So we’ll be meeting mostly […] at probably one of my properties, or maybe not, depending on what happens, but we’ll be in Aberdeen, in Scotland, meeting with the prime minister.”

The UK and US signed a trade deal earlier this year that reduced car and aerospace tariffs, but questions have remained about a promise from Washington to slash steel tariffs.

In May, the White House said it would exempt the UK from plans for a 25% tariff on global steel imports but that is yet to be ratified and the levy has since been doubled on all other countries.

Mr Trump had insisted that unless Britain could finalise the details of a metals trade deal with the US by 9 July, when wider “Liberation Day” tariff pauses were expected to expire, he would slap the UK with a 50% rate as well.

However that pause was extended until 1 August, with the US president saying nations would instead get letters informing them of his plans.

As Sky News’ economics and data editor Ed Conway has reported, the metals deal has floundered on two key issues, including that while the government has taken control of British Steel, the company itself still legally has Chinese owners.

Downing Street is still hoping it can secure 0% tariffs on steel.

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On Tuesday, a Downing Street spokesperson played down the significance of the meeting in Scotland, stressing it was a private trip so it “will not be a formal bilateral”.

Since taking office in January, Mr Trump has imposed tariffs on countries across the world in a bid to boost domestic production and address trade deficits.

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As well as sector specific tariffs, there is a baseline tariff of 10% for most other imports, though some countries face higher rates.

The UK was the first to hash out a deal on exemptions after a successful charm offensive by Sir Keir.

Mr Trump has praised the PM, telling the BBC earlier on Tuesday: “I really like the prime minister a lot, even though he’s a liberal.”

There are also plans for Scottish First Minister John Swinney to meet Mr Trump during his trip.

It will be followed by the official state visit between 17-19 September, when Mr Trump will be hosted by the King and Queen at Windsor Castle and accompanied by his wife Melania.

It will be Mr Trump’s second state visit to the UK, having previously been hosted during his first term in 2019.

Donald Trump has agreed to send “top of the line weapons” to NATO to support Ukraine – and threatened Russia with “severe” tariffs if it doesn’t agree to end the war.

Speaking with NATO secretary-general Mark Rutte during a meeting at the White House, the US president said: “We’ve made a deal today where we are going to be sending them weapons, and they’re going to be paying for them.

“This is billions of dollars worth of military equipment which is going to be purchased from the United States, going to NATO, and that’s going to be quickly distributed to the battlefield.”

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Weapons being sent include surface-to-air Patriot missile systems and batteries, which Ukraine has asked for to defend itself from Russian air strikes.

Mr Trump also said he was “very unhappy” with Russia, and threatened “severe tariffs” of “about 100%” if there isn’t a deal to end the war in Ukraine within 50 days.

The White House added that the US would put “secondary sanctions” on countries that buy oil from Russia if an agreement was not reached.

Later on Monday, Ukrainian leader Volodymyr Zelenskyy thanked Mr Trump and said he was “grateful” for the US president’s “readiness to help protect our people’s lives”.

After criticising Vladimir Putin’s “desire to drag it out”, he said he appreciated “preparing a new decision on Patriots for Ukraine” – and added Kyiv is “working on major defence agreements with America”.

It comes after weeks of frustration from Mr Trump over Mr Putin’s refusal to agree to an end to the conflict, with the Russian leader telling the US president he would “not back down” from Moscow’s goals in Ukraine at the start of the month.

During the briefing on Monday, Mr Trump said he had held calls with Mr Putin where he would think “that was a nice phone call”, but then “missiles are launched into Kyiv or some other city, and that happens three or four times”.

“I don’t want to say he’s an assassin, but he’s a tough guy,” he added.

Earlier this year, Mr Trump told Mr Zelenskyy “you’re gambling with World War Three” in a fiery White House meeting, and suggested Ukraine started the war against Russia as he sought to negotiate an end to the conflict.

After Mr Trump’s briefing, Russian senator Konstantin Kosachev said on Telegram: “If this is all that Trump had in mind to say about Ukraine today, then all the steam has gone out.”

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Meanwhile, Mr Zelenskyy met with US special envoy Keith Kellogg in Kyiv, where they “discussed the path to peace” by “strengthening Ukraine’s air defence, joint production, and procurement of defence weapons in collaboration with Europe”.

He thanked both the envoy for the visit and Mr Trump “for the important signals of support and the positive decisions for both our countries”.