Connect with us

Published

4 years ago

on

A team of researchers at the Perelman School of Medicine at the University of Pennsylvania has discovered that obese mice, treated with the cytokine (a category of proteins) known as TSLP, reported significant fat and weight loss. Described as an “unforeseen finding,” researchers also said that the fat loss was in no way related to decreased food intake or faster metabolism. The treatment revealed, “TSLP prompted the immune system to release lipids through the skin’s oil-producing sebaceous glands.” 

The study is led by Taku Kambayashi, Associate Professor of Pathology and Laboratory Medicine at the University of Pennsylvania. He was joined by Ruth Choa, a fourth-year PhD medical student. Kambayashi said that despite being an unexpected discovery, the team has demonstrated that fat loss was possible by secreting calories from the skin in the form of energy-rich sebum. The professor added that the findings of the animal experiment also show that this could develop into a model for the treatment of obesity among people.  

Kambayashi said that they never thought the TSLP would have any impact on obesity itself. What they set out for was to find out if it impacted insulin resistance. “We thought that the cytokine could correct Type 2 diabetes, without actually causing the mice to lose any weight,” he said.

In order to see the effect of TSLP on Type 2 diabetes, the researchers administered on obese mice a viral vector to increase their bodies’ TSLP levels. Four weeks after the mice were administered injections, the team found that TSLP, besides affecting their diabetes risk, also reduced obesity in them. Compared to TSLP-treated mice, the control group continued to gain weight. The TSLP-treated mice lost 20 grams, going from 45 to just 25 grams in 28 days, the team said. 

Not just that, while the mice reported weight and fat loss, Kambayashi assumed that TSLP was perhaps sickening them. Upon further testing, the group realised that the mice receiving TSLP treatment were also eating 20 to 30 percent more. Besides, they also had similar energy expenditures, base metabolic rates, and activity levels compared to their non-treated counterparts.

Could this work on Humans?

The authors of the study said that in humans, shifting sebum release into “high gear” could feasibly lead to the “sweating of fat” and weight loss.

Kambayashi’s group next plans to test this hypothesis. He said that he doesn’t think humans naturally control their weight by regulating sebum production. “We may be able to hijack the process and increase sebum production to cause fat loss,” he said.

Related Topics:
Continue Reading

Science

MIT Just Proved Einstein Wrong in the Famous Double-Slit Quantum Experiment

Published

8 hours ago

on

July 31, 2025

By

MIT Just Proved Einstein Wrong in the Famous Double-Slit Quantum Experiment

Physicists at MIT conducted a precise version of the renowned double slit quantum experiment, which challenges Einstein’s objections to quantum mechanics. With the help of ultracold atoms and single photons, they have shown the reaction of the long-standing wave-particle duality discussion without traditional spring setups. The researchers ignored the classical apparatus components and allowed nature’s inherent uncertainty to unleash Bohr’s complementarity, as both wave and particle-like behaviour cannot be observed simultaneously. The finding matches the quantum theory and disagrees with Einstein’s local realistic expectations.

MIT’s Quantum Experiment Challenges Einstein’s Classical View

As per Sci Tech Daily, Einstein argued for the deterministic reality, and claimed that the particles must be definite properties irrespective of the observation and that nothing could travel faster than light. With the Copenhagen interpretation, Bohr held the views which posit that only measurement defines the physical reality, along with complementary properties such as wave and particle behaviour, which are exclusive. The result of MIT supports this interpretation by Bohr.

With the removal of spring elements and the intrinsic quantum uncertain reliability of the ultracold atoms, MIT has sidestepped classical interference artefacts. Through this design, the experiment cleanly isolates the quantum effects and makes the result more robust and vague. Their behaviour demonstrates the dual nature when the individual photons pass through this experiment.

Bohr’s Complementarity Confirmed: Nature Obeys Quantum Rules

The findings through this experiment not only give the mechanical predictions and however, but also reinforce the significance of the theorem by Bell. Experiments done by Delft and Aspect have questioned the inequabilities under restricted conditions, strongly discrediting the hidden variable arguments of Einstein.

In a nutshell, MIT’s ultra double-slit experiment provides compelling evidence against the local realism of Einstein but in favour of the indeterminacy of quantum. Through the demonstration of the complementarity of the minimal classical interference, it is clear that the experiment underscores that nature follows the rules of quantum mechanics.

Continue Reading

Science

PSR J0922+0638 Pulsar Keeps Glitching Every 550 Days, Scientists Are Intrigued

Published

9 hours ago

on

July 31, 2025

By

PSR J0922+0638 Pulsar Keeps Glitching Every 550 Days, Scientists Are Intrigued

PSR J0922+0638 is one of the pulsars, which are typically ultradense remains of a massive star that exploded as a supernova. These are quite compact and lie a few miles away; however, they carry more weight than several other suns. Their density infers that the internal matter is packed tightly, and the borders diverge toward the black hole. However, the collapse of these stars is prevented due to the pressure from the quantum forces. Neutrons and protons smash together at the time of extreme densities, and then they create a single gigantic atomic nucleus. However, the core of the neutron stars is still a mystery.

Unraveling the Structure and Rotation of PSR J0922+0638

As per space report, these dense stars act as giant atomic nuclei together with the neutrons and protons pulled together under the gravity. One of the behaviours of pulsars is their rotation, which is stable. For example, PSR J0922+0638 rotates after every 0.43063, and this continues for thousands of years.

Astronomers studied the data from over 22 years to further understand the stability. The data was collected from South Africa’s MeerKAT array and China’s Nanshan Radio Telescope array. Although the changes were minuscule, even less than a billionth, the stars show an energy shift because of the intense physical forces. The scientists found a dozen glitches that we call a little change in the rate of rotation. The glitches followed a cycle in which rotation repeats after every 550 days.

Glitches, Magnetic Cycles, and the Mystery Within Pulsars

Furthermore, due to sudden glitches, a slow and cyclic speeding up and slowing down of the spin of the pulsar was seen during a 500-600-day period. This behaviour made the scientists question the glitches and the time variations of the pulsar, with the unawareness of the exact cause.

The theories put forward by the scientists comprise the magnetic cycle, which is similar to the movement of the superfluid in the star or the sun. Even after these theories, the internal mechanics of a pulsar are speculative. Further, long-term observations are important to know these secrets.

Continue Reading

Science

Starlink’s Unintended Signals Threaten Astronomical Research, Study Finds

Published

9 hours ago

on

July 31, 2025

By

Starlink’s Unintended Signals Threaten Astronomical Research, Study Finds

Astronomers have concerns over SpaceX’s Starlink connection, as the world is interlinked by the Starlink internet service, but there are big concerns about it. The satellite is interfering with the universe’s observation, and these fears have been confirmed by Curtin University. As per the analysis of 76 million images from the prototype station, it was found that the Starlink satellite emissions affect up to 30 percent images in some datasets. This kind of interference could change the outcome of the research that depends on that data.

Starlink’s Unintended Emissions Threaten Astronomical Research

As per NASA, it was found that from 1,806 Starlink satellites, there occurred 112,000 radio emissions. Further, it was observed that much of the interference is not deliberate. Some satellites detected emitting data in bands in which no signals are present at all. This includes 703 satellites that were identified at 150.8 MHz. This is meant to be protected for radio astronomy, as said by study lead Dylan Grigg.

Grigg observed that these unintended emissions might have come from onboard electronics. Astronomers can’t easily predict or filter these out as they are not part of the intentional signal. The International Telecommunication Union regulate the satellite emissions for protecting astronomical observations, current rules, and focuses on the intentional transmissions and does not address these unintended emissions, as said by Steven Tingay. Executive director of the Curtin Institute of Radio Astronomy.

Calls Grow for Policy Updates to Safeguard Radio Astronomy

The problem is not just the Starlink Satellite; the team found that it currently has the most expansive constellation, including around 7,000 satellites, which can be deployed during the survey. However, the satellite network can release non-deliberate transmissions too.

Tingay said that it is crucial to note that Starlink is not disturbing the current regulations, so there is nothing wrong with it. He further added that we hope this study adds support for the international efforts and updates the policies which control the impact of this technology on the radio astronomy that is currently going on.

Continue Reading

Trending