Four amateur astronauts are due to spend about three days in orbit in a world first, after they blasted off from the Kennedy Space Centre in Florida on Wednesday evening.
The Inspiration4 mission, backed by SpaceX, was organised by entrepreneur Jared Isaacman, who is also one of the passengers.
They are the first all-civilian crew ever to circle the Earth from space.
During their trip, those on board will carry out a series of science experiments before returning home.
So who are the four crew members, how did they get there and what will happen in the next 72 hours or so.
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A giant leap in commercial space travel
Who are the amateur astronauts?
The four people aboard the Dragon capsule are Jared Isaacman, Hayley Arceneaux, Chris Sembroski, and Dr Sian Proctor.
Mr Isaacman is the man behind the mission, and paid an undisclosed sum to get the project off the ground.
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The 38-year-old made his money with a payment processing company – like SpaceX head Elon Musk – and now also operates a private air force.
Image: Jared Isaacman. Pic: Inspiration4/John Kraus
An experienced pilot, he wants the journey to raise awareness for St Jude’s Children’s Research Hospital in Memphis, Tennessee.
The other three members of the crew were selected according to Mr Isaacman’s conditions.
Hayley Arceneaux, 29, is an employee of St Jude’s, and had cancer during her childhood.
Taking someone from the hospital was a condition from Mr Isaacman.
Ms Arceneaux, a physician’s assistant, is the first person to travel to space with a prosthesis – part of her right femur was replaced by a metal rod during a bone cancer battle at the age of 10.
Dr Proctor, 51, is an entrepreneur and trained pilot herself.
She won her seat through a competition based on a set of business-related tasks.
Image: The four space tourists have defined roles. Pic: Inspiration4/John Kraus
The scientist previously applied for NASA‘s astronaut programme but was unsuccessful – but is now in space.
Last up is Chris Sembroski, 42, a US Air Force veteran who now works for Lockheed Martin.
He was selected from a lottery of people who donated to St Jude’s – a competition which received around 72,000 entries.
What are their roles?
The four space tourists have defined roles, according to their backgrounds.
They have been branded leadership, hope, prosperity and generosity.
Mr Isaacman is leadership, and he will be the mission commander in charge of the operation.
Hope is Ms Arceneaux, who will act as medical officer and will help with experiments being carried out – many of which are medically based.
Image: Dr Proctor unsuccesfully applied to be a NASA astronaut. Pic: Inspiration4/John Kraus
Dr Proctor is prosperity and the mission pilot. She will support Mr Isaacman.
Generosity is represented by Mr Sembroski, who is the mission specialist and will help “manage payload, science experiments, communications to mission control and more”.
What will they do?
Most of the experiments being carried out by the crew are “to increase humanity’s knowledge on the impact of spaceflight on the human body”.
SpaceX, the Translational Research Institute for Space Health (TRISH) at Baylor College of Medicine in Houston, Texas, and the Weill Cornell Medicine in New York City will analyse the data collected.
What experiments will they do
Collecting “research-grade ECG activity, movement, sleep, heart rate and rhythm, blood oxygen saturation, cabin noise and light intensity”
Test behavioural and cognitive function using computer software
Ultrasound scans for organs to see if non-experts can get good quality image and see how spaceflight affects the body
Draw and test blood to see how the immune system functions in space
Testing motor function before and after the flight
How is the ship controlled?
The crew are aboard a Dragon capsule, a reusable pod developed by SpaceX.
It can seat up to seven people, and has been to the International Space Station 25 times – 10 of which were repeat journeys.
Image: The Dragon capsule has room for seven people and solar panels to provide power
It is capable of carrying 365lbs (166kg) of cargo, which is being used for scientific equipment and crew essentials on this journey.
Solar panels on the outside of the craft are used to generate power for the capsule and crew.
Image: The touchscreen control panels in the capsule allow the crew to monitor telemetry
The vessel is largely automatically controlled, with a set of large touch screens instead of the traditional-looking dashboard of buttons, levers and toggles for the pilots to observe.
The pilots can also take control of the capsule with the touchscreens.
Sixteen Draco thrusters are used to direct the vehicle after it separates from the take-off rocket, and it has a set of parachutes for landing.
How are they getting back?
Image: A splashdown of a Dragon capsule. Pic: NASA
After the orbiting is complete, the capsule will head back to Earth.
According to the official plan, this will culminate in a “soft water landing” off the coast of Florida.
After re-entering our planet’s atmosphere, two “drogue” parachutes are deployed, before four main canopies are released.
The crew and vessel will then be retrieved from the water.
Elon Musk has stepped up his attacks on Donald Trump’s sweeping tax and spending bill – weeks after a spectacular fallout between the world’s richest man and the US president.
Following weeks of relative silence after clashing with Mr Trump over his “big beautiful bill”, the billionaire vowed to unseat politicians who support it.
In a post on X, Musk said those who had campaigned on cutting spending but then backed the bill “should hang their heads in shame”.
He added: “And they will lose their primary next year if it is the last thing I do on this Earth.”
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Musk also threatened to put their faces on a poster which said “liar” and “voted to increase America’s debt” by $5trn (£3.6trn).
The posts attracted a swift reply from Mr Trump, who claimed the billionaire “may get more subsidy than any human being in history” for his electric car business.
“Without subsidies, Elon would probably have to close up shop and head back home to South Africa,” he wrote on Truth Social.
“No more Rocket launches, Satellites, or Electric Car Production, and our Country would save a FORTUNE. Perhaps we should have DOGE take a good, hard, look at this? BIG MONEY TO BE SAVED!!!”
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Elon’s dad on the Musk-Trump bust-up
Musk spent at least $250m (£182m) supporting Mr Trump in his presidential campaign and then led the newly formed Department of Government Efficiency (DOGE), which sacked about 120,000 federal employees.
He has argued the legislation would greatly increase the US national debt and wipe out the savings he claimed he achieved through DOGE.
As the Senate discussed the package, Musk called it “utterly insane and destructive”.
The Tesla and SpaceX CEO said the bill’s massive spending indicated “we live in a one-party country – the PORKY PIG PARTY!!”
“Time for a new political party that actually cares about the people,” he wrote.
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Israeli Prime Minister Benjamin Netanyahu will be meeting Donald Trump next Monday, according to US officials.
The visit on 7 July comes after Mr Trump suggested it was possible a ceasefire in Gaza could be reached within a week.
On Sunday, he wrote on social media: “MAKE THE DEAL IN GAZA. GET THE HOSTAGES BACK!!!”
At least 60 people killed across Gaza on Monday, in what turned out to be some of the heaviest attacks in weeks.
Image: Benjamin Netanyahu, left, with Donald Trump during a previous meeting. Pic: Reuters
According to the Hamas-run health ministry, 56,500 people have been killed in the 20-month war.
The visit by Mr Netanyahu to Washington has not been formally announced and the officials who said it would be going ahead spoke on condition of anonymity.
An Israeli official in Washington also confirmed the meeting next Monday.
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White House Press Secretary Karoline Leavitt said the administration was in constant communication with the Israeli government.
She said Mr Trump viewed ending the war in Gaza and returning remaining hostages held by Hamas as a top priority.
The war in Gaza broke out in retaliation for Hamas’ 7 October 2023 attacks on southern Israel that killed 1,200 people and saw a further 250 taken hostage.
An eight-week ceasefire was reached in the final days of Joe Biden’s US presidency, but Israel resumed the war in March after trying to get Hamas to accept new terms on next steps.
Talks between Israel and Hamas have stalled over whether the war should end as part of any ceasefire.