Lecanemab: New Alzheimer’s drug slows decline in memory – fuelling hope doctors will one day cure dementia
Doctors have hailed a “new era” of medicine after a study showed for the first time that a drug can slow the debilitating symptoms of Alzheimer’s.
Results from the clinical trial also revealed that the drug lecanemab cleared clumps of a protein called amyloid – thought to be a key cause of the most common form of dementia – from patients’ brains.
The data, published at a conference in San Francisco, led to an outpouring of optimism from scientists, many of whom had spent decades trying to understand what leads to the disease and find a treatment.
Rob Howard, professor of old age psychiatry at University College London, said the results were “wonderful and hope-filled” – adding: “At long last we have gained some traction on this most terrible and feared disease and the years of research and investment have finally paid off.
“It feels momentous and historic. This will encourage real optimism that dementia can be beaten and one day even cured.”
The manufacturers of the drug released top-line results in a news release earlier in the autumn, but many doctors held back from celebrating until full results were released at the Clinical Trials on Alzheimer’s Disease conference.
They showed that lecanemab slowed the decline in memory and mental agility by 27% in patients with mild Alzheimer’s.
‘Doctors are optimistic’
Critically, the drug removed so much of the amyloid protein that the patients wouldn’t have had enough evidence of Alzheimer’s disease on their brain scans to actually qualify for entry to the trial.
The study strongly suggests that the drug only starts to have a clinical effect once amyloid is reduced to low levels in the brain.
Results after 12 months of treatment suggested it was ineffective – but after 18 months, the effect was significant.
Doctors are optimistic that continued treatment will lead to even better results.
Professor Nick Fox, director of the Dementia Research Centre at University College London, said: “It confirms a new era of disease modification for Alzheimer’s disease, an era that comes after more than 20 years of hard work by many, many people, with many disappointments along the way.”
Lecanemab is not a cure. But even slowing the progression of Alzheimer’s disease would be game changing, delaying the need for specialist care and allowing people to spend more time with their families.
However, the drug has side effects.
One in eight patients given lecanemab suffered brain swelling and other changes, probably as a result of removing the amyloid protein. But most only had evidence of problems on brain scans. Fewer than one in 30 had actual symptoms such as headaches or confusion.
Some patients had bleeding in the brain, though deaths were no higher in those receiving treatment than those given a dummy drug.
Nevertheless, it underlines the need for careful monitoring of those on treatment.
Prof Fox said: “Any risk is clearly important, but I believe that many of my patients would be very willing to take such a risk.
‘Massive challenge for the NHS’
Doctors warned that lecanemab will be a massive challenge for the NHS, not just because the drug is given through an intravenous infusion every two weeks.
Most Alzheimer’s patients are currently diagnosed when they have moderate symptoms – too late for treatment with lecanemab. And just 1% have their diagnosis confirmed by a brain scan or lumbar puncture, a biopsy of their spinal fluid.
Susan Kohlhaas, director of research at Alzheimer’s Research UK said: “It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them.”
Until now there have only been drugs that treated symptoms rather than the underlying cause. But if lecanemab is licensed for use on the NHS then delays in treatment will result in brain cells dying and the disease progressing.
Prof John Hardy, from the UK Dementia Research Institute in London said the drug had been “a long time coming”.
He added: “I truly believe it represents the beginning of the end.
“The first step is the hardest, and we now know exactly what we need to do to develop effective drugs. It’s exciting to think that future work will build on this, and we will soon have life-changing treatments to tackle this disease.”
UK
Glastonbury organiser Emily Eavis says anti-IDF chants ‘crossed a line’ and no place at festival for ‘hate speech’
Glastonbury organiser Emily Eavis has said chants of “death to the IDF” on its West Holts stage on Saturday “very much crossed a line”.
Eavis, whose father Michael co-founded the festival, posted on Instagram on Sunday morning responding to rap duo Bob Vylan’s set the day before.
“Their chants very much crossed a line and we are urgently reminding everyone involved in the production of the Festival that there is no place at Glastonbury for antisemitism, hate speech or incitement to violence,” she wrote.
She said that while “as a festival, we stand against all forms of war and terrorism – we will always believe in – and actively campaign for – hope, unity, peace and love”, adding a performer’s comments “should never be seen as a tacit endorsement of their opinions and beliefs”.
Eavis added: “With almost 4,000 performances at Glastonbury 2025, there will inevitably be artists and speakers appearing on our stages whose views we do not share.”
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The rappers’ set was streamed live on the BBC on Saturday, showing one of them shouting the slogan into the mic, with some of the crowd joining in.
They also performed in front of a screen that claimed Israel’s actions in Gaza amount to “genocide”.
The Israeli embassy posted on X in the hours after the set saying it was “deeply disturbed by the inflammatory and hateful rhetoric”.
It said the slogan used “advocates for the dismantling of the State of Israel”.
The post on X added: “When such messages are delivered before tens of thousands of festivalgoers and met with applause, it raises serious concerns about the normalisation of extremist language and the glorification of violence.”
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What’s the Glastonbury controversy?
The Campaign Against Antisemitism (CAA) said it will be formally complaining to the BBC over its “outrageous decision” to broadcast the performance.
Avon and Somerset Police said they are looking at whether a criminal offence was committed.
“Video evidence will be assessed by officers to determine whether any offences may have been committed that would require a criminal investigation,” the force said in a post on social media.
Bob Vylan’s set may have pushed things too far
Bob Vylan, a punk-rap duo known for their politically charged lyrics taking on racism, fascism, police brutality, toxic masculinity, inequality and more, performed on the festival’s third biggest stage, West Holts, with a capacity of about 30,000.
They played to their own fans but no doubt thousands who had turned out to secure their place for the controversial Irish-language rappers Kneecap who followed.
After the Bob Vylan performance was aired live, clips quickly flooded social media – shared by those supporting the band and condemning them.
“The BBC didn’t cover Kneecap’s set at Glastonbury Festival over Free Palestine chants, so Bob Vylan, who BBC covered, stepped in,” posted the Celebrities4Palestine account alongside a clip on Instagram, also shared by Bob Vylan.
The IDF comments on stage may well have been made regardless. Or did Kneecap’s “cancelling” by the BBC, as some people saw it, encourage other acts to speak out even more?
Police are investigating both performances. Kneecap’s Naoise O Caireallain, who performs under the name Moglai Bap, at one point mentioned “a riot outside the courts” over his bandmate Liam Og O hAnnaidh’s (Mo Chara) upcoming second appearance on a terror charge, before clarifying: “No riots, just love and support, and support for Palestine.”
With its history of activism, Glastonbury has always championed free speech. But it seems Bob Vylan’s set may have pushed things too far.
It’s fair to say that here at Glastonbury, for most of the 200,000 people on site this weekend, it is still all about the music. The majority did not see these sets and many are not even aware of the criticism outside Worthy Farm.
Today is the final day of artist performances, with acts including Olivia Rodrigo, Rod Stewart and the Prodigy on the bill. But instead of the magic of the most famous festival in the world, both organisers and the broadcaster are now facing more questions about Bob Vylan and, to a lesser extent, Kneecap, as criticism mounts.
Bob Vylan went on stage just ahead of a performance by Kneecap, the Irish rap band that the prime minister and others called to be removed from the Glastonbury and other festival line-ups over alleged on-stage endorsements of terrorist groups Hamas and Hezbollah.
Ultimately, the BBC decided not to broadcast Kneecap’s set live, but have since made it available to watch on catch-up on iPlayer.
One of its members, Liam Og O hAnnaidh, was charged with a terror offence in May after being accused of displaying a flag in support of Hezbollah at a gig.
His bandmate Naoise O Caireallain told Glastonbury crowds on Saturday they should “start a riot outside the courts”, before clarifying: “No riots just love and support, and support for Palestine.”
O hAnnaidh – also known as Mo Chara – wore a Palestinian keffiyeh scarf for their set and told fans he was a “free man”.
Moglai Bap and Mo Chara of Kneecap on stage on Saturday. Pic: Reuters
Questions over why BBC broadcast chants
The government’s culture Secretary Lisa Nandy has spoken to BBC boss Tim Davie for an “urgent explanation” about what steps were taken around the Bob Vylan set.
Speaking to Sunday Morning With Trevor Phillips on behalf of the government, Health Secretary Wes Streeting described the chant as “appalling” and a “shameless publicity stunt”.
“The fact that we saw that chant at a music festival – when there were Israelis at a similar music festival who were kidnapped, murdered, raped, and in some cases still held captive,” he said in reference to the 7 October 2023 Hamas attack at the Nova music festival.
He added that while “there’s no justification for inciting violence against Israelis… the way in which Israel’s conducting this war has made it extremely difficult for Israel’s allies around the world to stand by and justify”.
“I’d also say to the Israeli embassy, get your own house in order, in terms of the conduct of your own citizens and the settlers in the West Bank,” he told Phillips.
Palestinian flags at Glastonbury. Pic: Reuters
Meanwhile, Conservative leader Kemi Badenoch reposted a clip of the Bob Vylan set describing it as “grotesque”.
“Violence against Jews isn’t edgy. The West is playing with fire if we allow this sort of behaviour to go unchecked,” she said on X.
Lucy McMullin, who was in the crowd for Bob Vylan, told Sky News: “When there’s children and civilians being murdered and starved, then I think it’s important that people are speaking out on these issues.
“However, inciting more death and violence is not the way to do it.”
A BBC spokesperson confirmed the Bob Vylan stream will not be made available to watch on its iPlayer.
“Some of the comments made during Bob Vylan’s set were deeply offensive,” their statement said.
“During this live stream on iPlayer, which reflected what was happening on stage, a warning was issued on screen about the very strong and discriminatory language. We have no plans to make the performance available on demand.”
The Israeli embassy has said it’s “deeply disturbed” by chants of “death to the IDF” at Glastonbury – as police also investigate the incident.
Video shows one of the members of Bob Vylan shouting the slogan into the mic and some of the crowd joining in.
The duo were performing ahead of a performance by Kneecap, the Irish act who the prime minister said should be ditched from the line-up.
“The Embassy of Israel in the United Kingdom is deeply disturbed by the inflammatory and hateful rhetoric expressed on stage at the Glastonbury Festival,” a statement said.
It said slogans like Saturday’s chant “advocate for the dismantling of the State of Israel”.
The BBC said some of the comments by Bob Vylan were ‘deeply offensive’. Pic: PA
The post on X added: “When such messages are delivered before tens of thousands of festivalgoers and met with applause, it raises serious concerns about the normalisation of extremist language and the glorification of violence.”
Avon and Somerset Police said they are looking at whether a criminal offence was committed.
“Video evidence will be assessed by officers to determine whether any offences may have been committed that would require a criminal investigation,” the force said in a post on social media.
Bob Vylan also performed in front of a screen quoting a claim that Israel’s actions in Gaza amount to genocide.
Culture Secretary Lisa Nandy has spoken to BBC boss Tim Davie for an “urgent explanation” about what due diligence it carried out into Bob Vylan.
Thousands watched the set on the West Holts stage. Pic: PA
A spokesman said the government strongly condemned the “threatening comments” by the group, whose X bio describes them as a “punk/rap/alt thing”.
A BBC statement said: “Some of the comments made during Bob Vylan’s set were deeply offensive.
“During this live stream on iPlayer, which reflected what was happening on stage, a warning was issued on screen about the very strong and discriminatory language.
“We have no plans to make the performance available on demand.”
Tory leader Kemi Badenoch re-posted a clip of the incident and called it “grotesque”.
“Violence against Jews isn’t edgy. The West is playing with fire if we allow this sort of behaviour to go unchecked,” she said on X.
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A statement from Glastonbury Festival said it “does not condone hate speech or incitement to violence of any kind from its performers”.
Kneecap also performed – with the BBC not showing them live. Pic: Reuters
Irish group Kneecap followed Bob Vylan – with the broadcaster not carrying their performance live amid concern over what they might do or say.
However, it’s understood their show will be made available on demand after a review.
One of its members, Liam Og O hAnnaidh, was charged with a terror offence in May after being accused of displaying a flag in support of proscribed terror group Hezbollah at a gig.
Pic: Reuters
There were Palestinian flags among the crowd for Kneecap’s show. Pic: Reuters
Bandmate Naoise O Caireallain told the packed Glastonbury crowd they should “start a riot outside the courts”, before clarifying: “No riots just love and support, and support for Palestine.”
O hAnnaidh – also known as Mo Chara – wore a Palestinian keffiyeh scarf for Saturday’s set and told fans he was a “free man”.
One girl has died and another is in a critical condition after a tree partially collapsed at a park in Essex.
The girls, aged seven and six, suffered serious injuries when they were among a number of children caught beneath the tree at Chalkwell Park in Southend.
Essex Police confirmed the seven-year-old girl died in hospital and her family is receiving support from specialist officers.
Three other children suffered minor injuries following the incident.
An East of England Ambulance Service spokesperson said: “We were called at 2.55pm to reports that a tree had fallen in Chalkwell Park in Chalkwell.
“Six ambulances, three ambulance officer vehicles, the London Air Ambulance and Kent Air Ambulance were sent to the scene.”
Police said an investigation is continuing into what caused the tree to collapse.
‘Unimaginable hardship’ for families
Chief Superintendent Leighton Hammett said: “Families are facing unimaginable hardship this evening and all of our thoughts are with them at this time.
“I cannot begin to put into words how difficult today’s events have been, and continue to be, for them.
“It’s also not lost on me how traumatic it must have been for the members of the public who witnessed this awful incident.
“Across a matter of moments, many of them went from enjoying the warm summer weather to rushing to the aid of strangers without a second thought.”
Chief Sup Hammett also paid tribute to police, ambulance and fire crews who “did all they could,” adding that “today’s loss is one they will all take personally”.
Death is ‘truly devastating’
Local MP David Burton-Sampson said: “The news of the sad death of one of the children involved in the incident at Chalkwell Park today is truly devastating.
“I am sure I reflect the thoughts of all our residents here in Southend in sending my deepest condolences to the child’s family and friends.
“My thoughts are also with the other children injured and I wish them a full and speedy recovery.
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