World

Third person cured of HIV after stem cell transplant, researchers say

Published

2 years ago

February 21, 2023

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A stem cell transplant has cured a man of HIV, researchers have announced.

The patient, 53, is only the third person to be cured of the condition using the treatment.

He appears to be the fifth person in total to be cured overall.

He had not taken anti-retroviral medicine, or suppressants, for four years and has not relapsed.

Similar to the other two stem cell transplant patients – one in Berlin and another in London – the man, in Dusseldorf, had the transplant to treat a blood disorder, which in his case was leukaemia, that had developed alongside the HIV infection.

More than 10 years after the transplant and four years after ending his HIV therapy, he is in good health.

“I still remember very well the sentence of my family doctor: ‘Don’t take it so hard. We will experience together that HIV can be cured’,” he said.

“At the time, I dismissed the statement as an alibi. Today, I am all the more proud of my worldwide team of doctors who succeeded in curing me of HIV – and at the same time, of course, of leukaemia.

“On Valentine’s Day this year, I celebrated the 10th anniversary of my bone marrow transplant in a big way. My bone marrow donor was present as a guest of honour.”

Researchers say the virus not returning is the result of thorough scientific and therapeutic preparation and monitoring, adding that the study is the longest and most precise diagnostic monitoring of a patient following a stem cell transplantation.

A transplant destroys any unhealthy blood cells and replaces them with healthy ones removed from blood or bone marrow, and due to their high risk, are only carried out within the framework of treating other life-threatening conditions.

The team, led by medics at Dusseldorf University Hospital, hope the information they have gained will help more studies into cures for HIV.

Research should now be continued, experts suggest, to help HIV patients overcome infections without the need for this kind of strenuous intervention in the future.

The Dusseldorf patient was diagnosed with acute myeloid leukaemia (AML), a form of life-threatening blood cancer, six months after starting his HIV therapy, and underwent the stem cell transplant in 2013.

In 2018, after constant monitoring by doctors, the anti-viral HIV therapy – which had ensured any residual HIV was kept under control up to that point – was ended.

On behalf of the international team, Dr Bjorn-Erik Ole Jensen said: “Following our intensive research, we can now confirm that it is fundamentally possible to prevent the replication of HIV on a sustainable basis by combining two key methods.

“On the one hand, we have the extensive depletion of the virus reservoir in long-lived immune cells, and on the other hand, the transfer of HIV resistance from the donor immune system to the recipient, ensuring that the virus has no chance to spread again.

“Further research is now needed into how this can be made possible outside the narrow set of framework conditions we have described.”

The Nature Medicine journal has published the study.

In recent years, a man from California has been cured of HIV after his diagnosis in 1988, while Timothy Ray Brown, known as the Berlin Patient, was cured in 2007 – but later died from cancer.

World

At least 10 dead after fire rips through retirement home in Spain

Published

3 hours ago

November 15, 2024

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At least 10 dead after fire rips through retirement home in Spain

At least 10 people have been killed after a fire broke out at a retirement home in northern Spain in the early hours of this morning, officials have said.

A further two people were seriously injured in the blaze at the residence in the town of Villafranca de Ebro in Zaragoza, according to the Spanish news website Diario Sur.

They remain in a critical condition, while several others received treatment for smoke inhalation.

Firefighters were alerted to the blaze at the residence – the Jardines de Villafranca – at 5am (4am UK time) on Friday.

Those who were killed in the fire died from smoke inhalation, Spanish newspaper Heraldo reported.

The residence is home to 82 elderly residents.

The blaze started in one of the rooms, Fernando Beltran, the national government’s top official in the region, told reporters.

All of the victims were elderly residents, he added.

Fire crews, paramedics and police officers remain on site, said a spokesperson for the regional government of Aragon who confirmed the fatalities.

It took firefighters several hours to extinguish the blaze, they said.

The cause of the fire is unknown and is being investigated.

World

COP29: UN climate summits ‘no longer fit for purpose’, warn leading figures

Published

5 hours ago

November 15, 2024

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COP29: UN climate summits 'no longer fit for purpose', warn leading figures

UN climate talks are “no longer fit for purpose” and should only be hosted by countries who are trying to give up fossil fuels, veterans of the process have said.

An open letter to the United Nations, signed by former UN chief Ban Ki-moon, made a dramatic intervention in the 29th COP climate summit, under way in Baku, Azerbaijan.

Frustration over petrostate hosts – following last year’s summit in UAE – as well as the influence of fossil fuel lobbyists, prohibitive costs, and slow progress have been mounting in recent years.

The letter acknowledges the strides COPs have made on ramping up climate policies.

“But it is now clear that the COP is no longer fit for purpose,” the authors said.

“Its current structure simply cannot deliver the change at exponential speed and scale, which is essential to ensure a safe climate landing for humanity.”

The letter’s 22 signatories also include former Ireland President Mary Robinson and Christiana Figueres, former head of the UN climate body (UNFCCC) that runs the annual COP summits.

It called for the process to be streamlined and for countries to be held accountable for their promises.

Sky News analysis has found only “marginal” progress has been made since the “historic” pledge from COP28 last year to transition away from fossil fuels.

COP29 Analysis:
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The letter also called for “strict eligibility criteria” for host countries to exclude those “who do not support the phase out/transition away from fossil energy”.

This year’s host country, petrostate Azerbaijan, has been engulfed in controversy.

Its authoritarian president Ilham Aliyev used his opening address to criticise western hypocrisy and praise oil and gas as a “gift” from God. His criticism of France, with whom relations have long been tense, drove the French minister to cancel a trip to the summit.

While the government and its COP team run separate operations, host countries are supposed to smooth over disagreements and find consensus between the almost 200 countries gathered.

COP presidencies are also nominating themselves to be climate leaders and throwing their own countries under the spotlight.

Azerbaijan is a small developing country that relies significantly on oil and gas revenues. But it has made slow progress on building out clean power – getting just 1.5% of its energy from clean sources – and led a harsh crackdown on critics in the run up to the COP.

In an interview with Sky News on Sunday, its lead negotiator Yalchin Rafiyev was unable to say whether Azerbaijan preferred to extract all its oil and gas or seek another, cleaner economic pathway – hard though that would be.

In a news conference yesterday, Mr Rafiyev said the president had been “quite clear” and he would not comment further.

“We have opened our doors to everybody,” he added.

Some diplomats here have hinted that Azerbaijan’s presidency team mean well but might be a little out of their depth. They have never been out in front at previous COPs, but they also only had a year to prepare for their turn hosting the mighty summit.

“My sense of this is that they’re a little underprepared, a little overwhelmed and a little bit short,” said one, speaking anonymously, as is customary for diplomats trying to maintain good relations.

“But I’m not sure that that’s politics. It might just be bandwidth and preparation and things like that.”

Different regions in the world take turns to host a COP. This year it was up to Eastern Europe, but the selection process took longer than usual due to tensions over Russia’s war in Ukraine and between Azerbaijan and rival Armenia.

Achim Steiner of the UN Development Programme, called it “troubling” that some countries face questions over their host roles.

“Are there countries that are by definition good hosts and others are bad hosts?” he asked.

“In the United Nations, we maintain the principle of every nation, first of all, should have a right to be heard.

“Labels are not always the fairest way of describing a nation. Some of the largest oil producers have hosted this COP in the past, and seemingly this seemed to be a perfectly acceptable phenomenon.”

COP stands for “conference of the parties” and refers to countries (“parties”) who have signed the underlying climate treaty.

Azerbaijan’s COP29 team and the UN’s climate body have been contacted with a request to comment.

World

Body pulled from mine after police cut off supplies to ‘smoke out’ thousands of illegal miners

Published

21 hours ago

November 14, 2024

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Body pulled from mine after police cut off supplies to 'smoke out' thousands of illegal miners

A body has been recovered from a South African mine after police cut off basic supplies in an effort to force around 4,000 illegal miners to resurface.

The body has emerged from the closed gold mine in the northwest town of Stilfontein a day after South Africa’s government said it would not help the illegal miners.

Around 20 people have surfaced from the mineshaft this week as police wait nearby to arrest all those appearing from underground.

It comes a day after a cabinet minister said the government was trying to “smoke them [the miners] out”.

The move is part of the police’s “Close the Hole” operation, whereby officers cut off supplies of food, water and other basic necessities to get those who have entered illegally to come out.

Local reports suggest the supply routes were cut off at the mine around two months ago, with relatives of the miners seen in the area as the stand-off continues.

A decomposed body was brought up on Thursday, with pathologists on the scene, police spokesperson Athlenda Mathe said.

It comes after South African cabinet minister Khumbudzo Ntshavheni told reporters on Wednesday that the government would not send any help to the illegal miners, known in the country as zama zamas, because they are involved in a criminal act.

“We are not sending help to criminals. We are going to smoke them out. They will come out. Criminals are not to be helped; criminals are to be prosecuted. We didn’t send them there,” Ms Ntshavheni said.

Senior police and defence officials are expected to visit the area on Friday to “reinforce the government’s commitment to bringing this operation to a safe and lawful conclusion”, according to a media advisory from the police.

In the last few weeks, over 1,000 miners have surfaced at various mines in South Africa’s North West province, where police have cut off supplies.

Many of the miners were reported to be weak, hungry and sickly after going for weeks without basic supplies.

Illegal mining remains common in South Africa’s old gold-mining areas, with miners going into closed shafts to dig for any possible remaining deposits.

The illegal miners are often from neighbouring countries, and police say the illegal operations involve larger syndicates that employ the miners.

Their presence in closed mines has also created problems with nearby communities, which complain that the illegal miners commit crimes ranging from robberies to rape.

Illegal mining groups are known to be heavily armed and disputes between rival groups sometimes result in fatal confrontations.