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SpaceX’s Dragon cargo ship is scheduled to launch Tuesday (March 14) evening, carrying nearly 6,300 pounds (2,860 kilograms) of cargo to the International Space Station (ISS). But among the spacewalk equipment, vehicle hardware and fresh fruit for the crew, there will be several small devices that contain something a little more unusual: beating human heart tissue. 

The tissue will be used in two experiments — Cardinal Heart 2.0 and Engineered Heart Tissues-2 — which will test whether existing drugs can help prevent or reverse spaceflight’s negative effects on the heart.

Research indicates that spaceflight can shrink the heart, because in microgravity, the heart muscles don’t need to work as hard to pump blood through the upper parts of the body. In addition, the heart may change shape under the influence of microgravity, as blood shifts upward, out of the legs and abdomen and into the head and torso, causing the heart to swell, according to NASA (opens in new tab) . 

Studies suggest that the heart also undergoes cellular changes associated with aging during spaceflight. Therefore, this research is not only critical to future space exploration but could also lead to improved treatments for age-related heart dysfunction and disease on Earth, Devin Mair (opens in new tab) , a doctoral candidate at Johns Hopkins University who’s involved in Engineered Heart Tissues-2, said during a NASA news conference Tuesday.  

Related: Tiny ‘hearts’ self-assemble in lab dishes and even beat like the real thing 

The experiments are part of the Tissue Chips in Space initiative, a joint project of the National Institutes of Health and the International Space Station National Laboratory aimed at understanding the effects of spaceflight and microgravity on the human body, according to NASA (opens in new tab) . 

The Engineered Heart Tissues-2 (opens in new tab) experiment involves two devices that carry cardiomyocytes — the heart muscle cells that contract — in small, fluid-filled chambers. The muscle cells were grown from stem cells and coaxed into 3D shapes in the lab. They were then strung between two posts within each chamber, similar to how tennis nets are suspended between a pair of posts. One post contains a magnet that moves each time the muscle cells contract. A sensor tracks the magnet’s movement, allowing the researchers to monitor muscle contractions in real time. RELATED STORIES—Lab-grown miniplacentas resemble the real thing so much, they fooled a pregnancy test

—Scientists grew human tear ducts in a lab and taught them to cry

—What are ‘minibrains’? Everything to know about brain organoids 

Mair and his colleagues previously sent heart tissue to space in March 2020, and in that experiment, they observed signs that cells’ mitochondria were malfunctioning, he said at the NASA news conference. Mitochondria provide power to cells and thus fuel the pumping of the heart, and their dysfunction has been tied to a variety of heart problems, including irregular heartbeat and heart failure. In an experiment launched on this trip to the ISS, the team will continue to study mitochondrial dysfunction, as well as test several existing drugs to see if they prevent or reverse the problems, Mair said.  

“These drugs specifically target mitochondrial dysfunction and upstream mechanisms that lead to this dysfunction,” Mair told Live Science in an email.

Similarly, the Cardinal Heart 2.0 (opens in new tab) experiment will use tiny, 3D clumps of heart tissue, known as heart organoids, to test whether already-approved drugs can protect heart cells from the stress of microgravity. The organoids will be treated prior to Dragon’s launch, with the goal of preventing the negative effects of microgravity from setting in, Dilip Thomas (opens in new tab) , a postdoctoral researcher at the Stanford Cardiovascular Institute who’s involved in Cardinal Heart 2.0, said at the news conference. These drugs include a statin and an anti-hypertensive drug used for heart failure, Thomas told Live Science in an email.

The organoids, grown from stem cells, are tiny models of full-size hearts that mimic key features of the organ’s structure and function. They contain cardiomyocytes, as well as cells that provide physical scaffolding for heart muscles (cardiac fibroblasts), and ones that line blood vessels (endothelial cells). 

The Dragon spacecraft is set to launch at 8:30 p.m. EDT Tuesday (0030 GMT Wednesday) from NASA’s Kennedy Space Center in Florida. Here’s how to watch it live (opens in new tab) .

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YouTuber Jake Paul strikes defeat against former boxing champ Mike Tyson in Texas

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YouTuber Jake Paul strikes defeat against former boxing champ Mike Tyson in Texas

YouTuber-turned-boxer Jake Paul has defeated one of the greatest-ever fighters, former heavyweight world champion Mike Tyson, who’s more than twice his age.

The bout was won on a unanimous points decision at the AT&T Stadium in Arlington, Texas – home of the Dallas Cowboys and the biggest NFL stadium in the US.

The fight was already controversial but then arguably failed to live up to the hype. Boos were heard from the crowd in the final two rounds, after a perceived lack of action.

Mike Tyson, left, fights Jake Paul during their heavyweight boxing match, Friday, Nov. 15, 2024, in Arlington, Texas. (AP Photo/Julio Cortez)
Image:
The heavyweight boxing match took place in Arlington, Texas. Pic: AP

Boxing careers compared

This was not Paul’s first professional fight. The 27-year-old American YouTube star made his debut in 2020 with his most high-profile clash against Tyson Fury’s brother Tommy Fury last year, which he lost by a split decision.

The so-called “Problem Child” has since defeated former UFC contender Nate Diaz, professional boxer Andre August, former Gold Gloves champion Ryan Bourland and most recently MMA fighter Mike Perry.

In contrast, “Iron Mike” Tyson, 58, was ranked among the best heavyweight boxers of all time.

More on Jake Paul

During his career, he knocked out 44 opponents – retiring from professional boxing in 2005 after defeat against Kevin McBride.

He returned to the ring in 2020 for a bout against fellow boxing icon Roy Jones, which ended in an unofficial draw.

Mike Tyson, left, fights Jake Paul during their heavyweight boxing match, Friday, Nov. 15, 2024, in Arlington, Texas. (AP Photo/Julio Cortez)
Image:
Mike Tyson struggled at times against Jake Paul, 31 years his junior. Pic: AP

‘Someone’s getting put to sleep’

Earlier this week, Paul said he believed the bout would not go the distance. “No, someone’s getting put to sleep,” he said. “It’s going to be a war, and we’re both heavy hitters. It’s not going the full 16 minutes.”

Tyson was more reflective: “I’ve been through so many ups and downs since my last fight with Kevin McBride,” he said.

“I’ve been in rehab. I’ve been in prison, been locked up. Never in a million years did I believe I’d be doing this.”

Several states would not allow the bout to go ahead, and the Texas Athletic Commission only agreed to the fight if there were changes, due to Tyson’s age.

It limited the contest to eight rounds lasting a maximum of two minutes instead of three. Both boxers were also required to wear heavier gloves, designed to lessen the force of punches.

The fight was initially scheduled for 20 July, but was postponed when Tyson suffered an ulcer flareup.

Taylor defends title

Katie Taylor, center, celebrates after defeating Amanda Serrano during their undisputed super lightweight title bout, Friday, Nov. 15, 2024, in Arlington, Texas. (AP Photo/Julio Cortez)
Image:
Katie Taylor celebrates after defeating Amanda Serrano in Texas. Pic: AP

Meanwhile, among the undercard fights, Irish boxer Katie Taylor successfully defended her super lightweight world title against Puerto Rico’s Amanda Serrano.

But it was tight. Taylor claimed the rematch 95-94 for all three judges in an epic battle.

The bout came two and a half years after the pair fought at Madison Square Garden, which Taylor won on a split decision.

Bout suffered from buffering

Earlier in the evening thousands of Netflix users in the US reported problems seeing the coverage, with some posting on social media about buffering.

At one point, more than 98,000 people had reported issues according to Downdetector, which tracks outages.

This breaking news story is being updated and more details will be published shortly.

Please refresh the page for the fullest version.

You can receive Breaking News alerts on a smartphone or tablet via the Sky News App. You can also follow @SkyNews on X or subscribe to our YouTube channel to keep up with the latest news.

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US

YouTuber Jake Paul strikes defeat against former boxing champ Mike Tyson in Texas

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YouTuber Jake Paul strikes defeat against former boxing champ Mike Tyson in Texas

YouTuber-turned-boxer Jake Paul has defeated one of the greatest-ever fighters, former heavyweight world champion Mike Tyson, who’s more than twice his age.

The bout was won on a unanimous points decision at the AT&T Stadium in Arlington, Texas – home of the Dallas Cowboys and the biggest NFL stadium in the US.

The fight was already controversial but then arguably failed to live up to the hype. Boos were heard from the crowd in the final two rounds, after a perceived lack of action.

Mike Tyson, left, fights Jake Paul during their heavyweight boxing match, Friday, Nov. 15, 2024, in Arlington, Texas. (AP Photo/Julio Cortez)
Image:
The heavyweight boxing match took place in Arlington, Texas. Pic: AP

Boxing careers compared

This was not Paul’s first professional fight. The 27-year-old American YouTube star made his debut in 2020 with his most high-profile clash against Tyson Fury’s brother Tommy Fury last year, which he lost by a split decision.

The so-called “Problem Child” has since defeated former UFC contender Nate Diaz, professional boxer Andre August, former Gold Gloves champion Ryan Bourland and most recently MMA fighter Mike Perry.

In contrast, “Iron Mike” Tyson, 58, was ranked among the best heavyweight boxers of all time.

More on Jake Paul

During his career, he knocked out 44 opponents – retiring from professional boxing in 2005 after defeat against Kevin McBride.

He returned to the ring in 2020 for a bout against fellow boxing icon Roy Jones, which ended in an unofficial draw.

Mike Tyson, left, fights Jake Paul during their heavyweight boxing match, Friday, Nov. 15, 2024, in Arlington, Texas. (AP Photo/Julio Cortez)
Image:
Mike Tyson struggled at times against Jake Paul, 31 years his junior. Pic: AP

‘Someone’s getting put to sleep’

Earlier this week, Paul said he believed the bout would not go the distance. “No, someone’s getting put to sleep,” he said. “It’s going to be a war, and we’re both heavy hitters. It’s not going the full 16 minutes.”

Tyson was more reflective: “I’ve been through so many ups and downs since my last fight with Kevin McBride,” he said.

“I’ve been in rehab. I’ve been in prison, been locked up. Never in a million years did I believe I’d be doing this.”

Several states would not allow the bout to go ahead, and the Texas Athletic Commission only agreed to the fight if there were changes, due to Tyson’s age.

It limited the contest to eight rounds lasting a maximum of two minutes instead of three. Both boxers were also required to wear heavier gloves, designed to lessen the force of punches.

The fight was initially scheduled for 20 July, but was postponed when Tyson suffered an ulcer flareup.

Taylor defends title

Katie Taylor, center, celebrates after defeating Amanda Serrano during their undisputed super lightweight title bout, Friday, Nov. 15, 2024, in Arlington, Texas. (AP Photo/Julio Cortez)
Image:
Katie Taylor celebrates after defeating Amanda Serrano in Texas. Pic: AP

Meanwhile, among the undercard fights, Irish boxer Katie Taylor successfully defended her super lightweight world title against Puerto Rico’s Amanda Serrano.

But it was tight. Taylor claimed the rematch 95-94 for all three judges in an epic battle.

The bout came two and a half years after the pair fought at Madison Square Garden, which Taylor won on a split decision.

Bout suffered from buffering

Earlier in the evening thousands of Netflix users in the US reported problems seeing the coverage, with some posting on social media about buffering.

At one point, more than 98,000 people had reported issues according to Downdetector, which tracks outages.

This breaking news story is being updated and more details will be published shortly.

Please refresh the page for the fullest version.

You can receive Breaking News alerts on a smartphone or tablet via the Sky News App. You can also follow @SkyNews on X or subscribe to our YouTube channel to keep up with the latest news.

Continue Reading

Politics

Elon Musk ‘shot down’ OpenAI’s ICO plan in 2018 over credibility concerns

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<div>Elon Musk 'shot down' OpenAI's ICO plan in 2018 over credibility concerns</div>

According to a court filing, Elon Musk said that the proposed initial coin offering (ICO) “would simply result in a massive loss of credibility for OpenAI.”

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