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By Pooja Toshniwal Paharia Mar 17 2023 Reviewed by Danielle Ellis, B.Sc.

In a recent study published in JAMA Network Open, researchers assessed the relationship between coronavirus disease 2019 (COVID-19)-associated stress in the antenatal period and the mental well-being of mothers and their infants in the postpartum period. Study: Association of Antenatal COVID-19–Related Stress With Postpartum Maternal Mental Health and Negative Affectivity in Infants. Image Credit: GrooveZ/Shutterstock Background

Studies have reported that antenatal stressors significantly increase the risk of adverse postpartum outcomes regarding mental well-being, such as cognitive and behavioral problems among infants. Cases of anxiety and depression during pregnancy have significantly increased during the severe acute respiratory coronavirus 2 (SARS-CoV-2) pandemic, with lowered positive affectivity, worsened orienting behavior, and higher surgency among infants.

However, the association between COVID-19-associated stress and postpartum maternal and infant outcomes is not completely understood. Previous studies evaluating the effects of antenatal stressors on maternal and infantile health outcomes were largely cross-sectional, single-center, retrospective, with small sample populations, and often utilized unvalidated assessment measures with no documentation of psychometric properties. About the study

In the present longitudinal survey-based study, researchers evaluated the impact of antenatal SARS-CoV-2 infection-associated stress on postpartum maternal and infant mental health outcomes.

The study comprised 318 individuals aged ≥11.0 years who participated in the coronavirus disease 2019 risks across lifespan (CORAL) study conducted in the United Kingdom (UK), United States (US), and Australia. Females who were expecting at the initial evaluation between 5 May and 30 September 2020 and completed two follow-up evaluations between 28 October 2021 and 24 April 2022 at three-month intervals were considered for the analysis.

In addition, the participants were invited to fill out a fourth survey on maternal mental well-being and infant temperament in the follow-up period. COVID-19-associated stress levels were evaluated using the pandemic anxiety measurement scale. The team used the eight-component patient health questionnaire to assess depression among mothers and the seven-component general anxiety disorder (GAD) scale to assess generalized anxiety levels.

During follow-ups, postpartum distress levels were evaluated using the 10.0-component postpartum distress assessment measure, and health outcomes among infants were assessed using the Infant Behavior questionnaire. Individuals were recruited for the study through paid advertising, social media, mothers' group newsletters, mental well-being organizations, and web-based pregnancy forums. Related StoriesHyperinflammation triggers long COVID headachesWhat is the gastrointestinal impact of Long Covid?Early outpatient treatment of COVID-19 with metformin could reduce the risk of developing long COVID

Linear mixed-effects modeling was performed for the analysis. Sensitivity analyses were performed controlling for maternal mental health at initial evaluation and COVID-19 risks experienced during pregnancy and the age of the infants during follow-up assessments. The study participants were provided Amazon gift vouchers of A$100 for the initial survey and A$20 for follow-up surveys. Results

The mean age of the study participants was 32 years, and among the study participants, 28% (n=88), 30% (n=94), and 43% (n=136) resided in Australia, the United States, and the United Kingdom, respectively, among whom, 87% (n=276) were White, and 81% (n=256) had university degrees. A history of psychiatric disorders was reported by 36% (n=114) of the study participants.

Other races and ethnicities included in the sample population were Aboriginal or Torres Strait Islander, Asian, Hispanic, mixed, or other, among two, 12, eight, seven, and 10 participants, respectively. High school education was attained by 19 women and professional or vocational training by 41 women.

At the initial evaluation, the mean values for the number of children and the gestational age (in months) were 1.20 and 5.80, respectively. At the final evaluation, the mean infant age was 14 months. COVID-19-associated stress in the antenatal period showed significant associations with distress, anxiety, and depression among mothers and negative affectivity among infants in the postpartum period. Sensitivity analyses yielded similar findings.

At the initial evaluation, three women showed mild GAD and depression (mean scores on the GAD-7 scale and Patient Health questionnaire of 6.70 and 7.80, respectively), and symptoms remained elevated for 17.0 months postpartum. There were no interactive associations between the age of the infants and antenatal SARS-CoV-2 infection-associated stress with infant health outcomes. Conclusions

Overall, the study findings showed that antenatal pandemic-associated stressors must be targeted to improve mothers' and infants' postpartum outcomes. Expecting women must be considered vulnerable and prioritized during COVID-19 and other pandemics and provided appropriate care for physical and mental well-being.

Further research must be conducted to determine methods of reducing pandemic-associated stress to promote maternal and neonatal well-being in the postpartum period. The long-term relationships between SARS-CoV-2 infection-associated stress and maternal and neonatal health must be assessed.

Psychological and biological vulnerability markers among a more diverse group of pregnant women belonging to different ethnicities and residing in different geographical regions must be identified to personalize antenatal healthcare. Journal reference: Schweizer, S. et al. (2023) "Association of Antenatal COVID-19–Related Stress With Postpartum Maternal Mental Health and Negative Affectivity in Infants", JAMA Network Open, 6(3), p. e232969. doi: 10.1001/jamanetworkopen.2023.2969. https://jamanetwork.com/journals/jamanetworkopen/fullarticle/2802388

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O2 arena lease snapped up by pensions giant Rothesay

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O2 arena lease snapped up by pensions giant Rothesay

The long-term lease to the O2, London’s best-known live entertainment venue, has been sold to Britain’s biggest pensions insurance specialist.

Sky News understands a deal was signed last week for Rothesay, the title sponsor of England’s home Test cricket matches, to acquire the landmark’s 999-year lease for about £90m.

The agreement, which is likely to be announced within days, comes more than two months after Sky News reported that Rothesay was the frontrunner to clinch a deal.

Rothesay has become one of Britain’s most successful specialist insurers, having been established in 2007.

It now protects the pensions of more than one million people in Britain and makes more than £300m in pension payouts every month.

The auction of the O2 lease kicked off several months ago, when Cambridge University’s wealthiest college, Trinity, instructed advisers to launch a sale process.

Trinity College, which ranks among Britain’s biggest landowners, acquired the site in 2009 for a reported £24m.

The O2, which shrugged off its ‘white elephant’ status in the aftermath of its disastrous debut as the Millennium Dome in 2000, has since become one of the world’s leading entertainment venues.

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Operated by Anschutz Entertainment Group (AEG), it has played host to a wide array of music, theatrical, and sporting events over nearly a quarter of a century.

Trinity College, which was founded by Henry VIII in 1546, bought the O2 lease from Lend Lease and Quintain, the property companies that had taken control of the Millennium Dome site in 2002 for nothing.

In a joint statement issued in response to an enquiry from Sky News, Rothesay and Trinity College Cambridge said they were “pleased to confirm that Rothesay will be the long-term owner of The O2 arena, following a competitive auction process for the lease of this London landmark”.

A spokesperson for Rothesay said separately: “Prestigious and high-quality property assets like the O2 form an important part of Rothesay’s investment strategy, providing the predictable and dependable returns which create real security for the one million-plus pensions we protect.”

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Stakes high for Trump-Putin summit as Zelenskyy faces nightmare deal

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Stakes high for Trump-Putin summit as Zelenskyy faces nightmare deal

For Ukraine – its exhausted, brave soldiers, its thousands of bereaved families mourning their dead, and its beleaguered president – it is exactly what they feared it would be. 

They fear the compromise they will be forced to make will be messy, costly, unfair and ultimately beneficial to the invading tyrant who brought death and destruction to their sovereign land.

Six weeks ago, I spoke to President Zelenskyy in London.

War latest: Team Trump ‘risk being out of their depth’ at Putin meeting

I put it to him in our Sky News interview that Presidents Trump and Putin were heading towards making a deal between themselves, a grand bargain, in which Ukraine was but one piece on the chessboard.

Zelenskyy smiled as if to acknowledge the reality ahead.

He paused and then he said this: “We are not going to be a card in talks between great nations, and we will never accept that… I definitely do not want to see global deals between America and Russia.

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“We don’t need it. We are a separate story, a victim of Russian aggression and we will not reward it.”

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In full: Volodymyr Zelenskyy interview

It was a response that betrayed his greatest fear – that this will become essentially a Trump negotiation in which Zelenskyy and Ukraine will be told “take it or leave it”.

And, by the way, if you “leave it”, then it will be painful.

Harsh realities

It’s the prospect that now confronts Zelenskyy as Trump and Putin plough ahead on a course that has clear attractions for both of them.

Of course, Zelenskyy is right to say there can be no deal without Ukraine. But there are harsh realities at play here.

Trump wants a deal on Ukraine – any deal – that he can chalk up as a win. He wants it badly and he wants it now.

It’s the impediment to a broader strategic deal with Putin and he wants it out of the way. It’s what he does, and it’s the way he does it. And President Putin knows it.

He knows Trump, he sees an opportunity in Trump, and he can’t get across Russia to Alaska fast enough. He will be back at global diplomacy’s top table.

Always a deal to be done

Make no mistake, when Trump says he just wants to stop the killing, he means it. Such wanton loss of young lives offends him. He keeps saying it.

He sees war, by and large, as an unnecessary waste of life and of money. Deals are there to be done. There’s always a deal.

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Is Trump out of his depth with Putin summit? – Professor Michael Clarke

Sadly for Ukraine, in this case, it is unlikely to be a fair deal.

How can any deal be “fair” when you are the victim of outrageous brutality and heinous crimes.

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But it may well be the deal they have to take unless they want to fight an increasingly one-sided war with much less help from Trump and America.

A senior UK diplomat told me if things turn out as feared, it should not be called a land-for-peace deal. It should be called annexation “because that’s what it is”.

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But here’s the rub.

Peace, calm, the end of the nightly terror of war has much to recommend it. In short, a bad peace can often seem better than no peace. But, ultimately, rewarded dictators always come back for more.

If Ukraine has to accept a bad peace, then it will want clear security guarantees to make sure it cannot happen again.

It is the very least they deserve.

There is much at stake in Alaska.

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Desperation only grows in Gaza, as crowds swell at protests in Israel

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Desperation only grows in Gaza, as crowds swell at protests in Israel

As if life in Gaza wasn’t hard enough, there is now a heatwave – compounding the problems of minimal water, food and the basics you need to keep a family alive.

To keep your children halfway clean, when you’ve been displaced over and over again, forced to live under tarpaulin rammed up against your neighbours.

“We suffer greatly, especially because we live in tents,” says Riham Akel, who was displaced from the north and now lives in Gaza City.

“They are made of cloth and plastic that do not protect us from the heat. In addition, there is no electricity, drinking water or water for washing, no fans or air conditioning.”

A girl waits for water in Gaza. Pic: Reuters
Image:
A girl waits for water in Gaza. Pic: Reuters

Given Israel’s planned takeover of Gaza City – and the evacuation of the 800,000 or so people now living there – it’s likely she’ll be forced to move again.

In Hostages Square in Tel Aviv, the crowds have swelled these past two Saturdays – almost doubling after Hamas published propaganda videos showing two of the remaining hostages starving in captivity – and now this week, Benjamin Netanyahu’s decision to push ahead with full security control of the Gaza Strip.

People here just want it to stop.

Protesters in Tel Aviv demand the immediate release of hostages held by Hamas. Pic: Reuters
Image:
Protesters in Tel Aviv demand the immediate release of hostages held by Hamas. Pic: Reuters

Yael said: “I feel like a hostage in my own country, as though no one listens to me – 80% of the citizens don’t want it anymore.”

“When you talk about the government it’s not only Gaza,” says David Solomon. “They are trying to undermine the democracy in Israel, they’re trying willingly to destroy the whole of Israel, they don’t care just for another year or two of their survival.”

Pic: Reuters
Image:
Pic: Reuters

There are also calls for IDF soldiers to refuse to carry out Netanyahu’s plan to take over Gaza City.

Another major point of contention is what many see as the failure of the International Red Cross to bring food to the hostages. Food for the Palestinians in Gaza is not much discussed, except for a small group on the fringes.

“We believe that the Israeli public is ignorant on purpose,” says Gilad Melzer – holding up a sign saying “Stop Genocide” with a photo of a starving child.

“Some of it wants to stay ignorant and some, the government wants to keep them ignorant of what is going on in Gaza and they’re ignorant as well of what is going on in the occupied territories.”

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Life and colour stripped from bustling port city

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Gaza: Aid drops ‘killing our children’

Benjamin Netanyahu seems to have made up his mind, though. He will ramp up the fight, despite international outcry, despite the opposition of his military leadership and despite the tens of thousands who rally each week in Hostages Square, hoping someone in government will bother to listen.

There is a sense of hopelessness here – that the solidarity of numbers still makes so little difference.

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