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A pharmaceutical firm that produced a leading Covid-19 jab said vaccines against cancer as well as cardiovascular and autoimmune diseases can be ready by 2030, which could potentially save millions of lives.

Modernas chief medical officer Paul Burton believes the company will be able to offer vaccines for all sorts of disease areas in as little as five years.

Studies into the vaccines have shown tremendous promise, Dr Burton told British newspaper The Guardian, adding that his company is developing cancer vaccines that target different tumour types.

We will have that vaccine, and it will be highly effective, and it will save many hundreds of thousands, if not millions, of lives. I think we will be able to offer personalised cancer vaccines against multiple different tumour types to people around the world, he said.

Cardiovascular diseases and cancer are a leading cause of death worldwide, according to the World Health Organisation (WHO).

An estimated 17.9 million people died of cardiovascular diseases in 2019, said WHO, while cancer accounted for nearly 10 million deaths in 2020, or nearly one in six deaths.

Dr Burton also told The Guardian that multiple respiratory infections could be covered by a single injection.

This would allow vulnerable people to be protected against Covid-19, flu and respiratory syncytial virus a virus that causes mild, cold-like symptoms.

Meanwhile, Dr Burton said messenger ribonucleic acid (mRNA) therapies could be available for rare diseases for which there are currently no drugs.

I think we will have mRNA-based therapies for rare diseases that were previously undruggable, and I think that 10 years from now, we will be approaching a world where you truly can identify the genetic cause of a disease and, with relative simplicity, go and edit that out and repair it using mRNA-based technology.

Vaccines based on mRNA teach cells to make a protein to prompt an immune response.

Moderna and drugmaker Pfizer-BioNTech were the first to use the technology to create the mRNA vaccines used to fight Covid-19.

Dr Burton attributed the progress of the vaccines to advancement in the field of mRNA, with some experts saying that 15 years of progress are now in the final stretches due to the quick roll-out of the Covid-19 jabs.

I think what we have learnt in recent months is that if you ever thought that mRNA was just for infectious diseases, or just for Covid-19, the evidence now is that thats absolutely not the case, The Guardian quoted him as saying.

It can be applied to all sorts of disease areas; we are in cancer, infectious disease, cardiovascular disease, autoimmune diseases, rare disease. We have studies in all of those areas, and they have all shown tremendous promise. More On This Topic MOH supporting development of mRNA cancer vaccines in Singapore Moderna, Merck see positive results from skin cancer vaccine In December 2022, Moderna and pharmaceutical company MSD announced that an mRNA cancer vaccine they are jointly developing reduced cancer recurrence or death in melanoma patients by 44 per cent in a phase two clinical trial.

Scientists said a high level of investment is needed to maintain the progress.

Professor Andrew Pollard, a director of the Oxford Vaccine Group and chair of Britains Joint Committee on Vaccination and Immunisation, said it was important not to lose sight of the threat of a new pandemic.

If you take a step back to think about what we are prepared to invest in during peacetime, like having a substantial military for most countries… Pandemics are as much a threat, if not more, than a military threat because we know they are going to happen as a certainty from where we are today. But were not investing even the amount that it would cost to build one nuclear submarine, he told The Guardian.

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Entertainment

Black Sabbath, Elton John and Rod Stewart among music giants paying tribute to Ozzy Osbourne

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Black Sabbath, Elton John and Rod Stewart among music giants paying tribute to Ozzy Osbourne

Black Sabbath have paid tribute to their former frontman Ozzy Osbourne after the megastar died at the age of 76.

Osbourne’s death on Tuesday morning was announced in a statement, which said he died surrounded by his family.

His death came just weeks after he reunited with his Black Sabbath bandmates – Tony Iommi, Terence “Geezer” Butler and Bill Ward – and performed a huge farewell concert for fans.

The band paid tribute to him on Instagram by sharing an image of Osbourne on stage at the farewell gig in Birmingham and writing “Ozzy Forever”.

Ozzy Osbourne’s life in pictures

Iommi, the band’s lead guitarist, said he was in disbelief at the news.

“It’s just such heartbreaking news that I can’t really find the words, there won’t ever be another like him. Geezer, Bill and myself have lost our brother.”

More on Ozzy Osbourne

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Watch: Ozzy’s last concert

Butler, Black Sabbath’s bassist and primary lyricist, thanked Osbourne for “all those years – we had some great fun”.

He said: “Four kids from Aston – who’d have thought, eh? So glad we got to do it one last time, back in Aston. Love you.”

Ozzy Osbourne salutes the crowd with his wife Sharon during the 46th Annual Grammy Awards. Pic: AP
Image:
Osbourne with his wife Sharon during the 46th Annual Grammy Awards. Pic: AP

Sir Elton John described Osbourne as his “dear friend” and a “huge trailblazer” who “secured his place in the pantheon of rock gods”.

“He was also one of the funniest people I’ve ever met,” the singer wrote on Instagram.

Ronnie Wood, of The Rolling Stones, wrote: “I am so very sad to hear of the death of Ozzy Osbourne. What a lovely goodbye concert he had at Back To The Beginning in Birmingham.”

Born John Michael Osbourne on 3 December 1948 in Aston, Birmingham, he became known as the godfather of heavy metal.

The self-styled Prince of Darkness pioneered the music genre with Black Sabbath before going on to have huge success in his own right.

He was famous for hits including Iron Man, Paranoid, War Pigs, Crazy Train and Changes, both with the band and as a solo star.

Legendary American heavy metal band Metallica shared an image of them with Osbourne from 1986 along with an emoji of a broken heart.

Posting on Instagram, Sir Rod Stewart said: “Sleep well, my friend. I’ll see you up there – later rather than sooner.”

Queen guitarist Sir Brian May said he was “grateful I was able to have a few quiet words” with Osbourne after his farewell show at Villa Park three weeks ago.

He said the world will miss the singer’s “unique presence and fearless talent”.

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Business

Goldman Sachs boss sounds warning to Reeves on tax and regulation

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Goldman Sachs boss sounds warning to Reeves on tax and regulation

London and the UK’s leading status in the global financial system is “fragile”, the boss of Goldman Sachs has warned, as the government grapples with a tough economy.

Speaking ahead of a meeting with the prime minister, David Solomon – chairman and chief executive of the huge US investment bank – told Sky News presenter Wilfred Frost’s The Master Investor Podcast of several concerns related to tax and regulation.

He urged the government not to push people and business away through poor policy that would damage its primary aim of securing improved economic growth, arguing that European rivals were currently proving more attractive.

Money latest: Mortgage shake-up to save ‘time and money’

He said: “The financial industry is still driven by talent and capital formation. And those things are much more mobile than they were 25 years ago.

“London continues to be an important financial centre. But because of Brexit, because of the way the world’s evolving, the talent that was more centred here is more mobile.

“We as a firm have many more people on the continent. Policy matters, incentives matter.

More on Uk Economy

“I’m encouraged by some of what the current government is talking about in terms of supporting business and trying to support a more growth oriented agenda.

“But if you don’t set a policy that keeps talent here, that encourages capital formation here, I think over time you risk that.”

He had a stark warning about the recent reversal of the “Non Dom” tax policy, which occurred across both the prior Conservative government and the current Labour government, which has played a part in some senior Goldman partners relocating away from London.

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Chancellor will not be drawn on wealth tax

Richard Gnodde, one of the bank’s vice-chairs, left for Milan earlier this year.

“Incentives matter if you create tax policy or incentives that push people away, you harm your economy,” Mr Solomon continued.

“If you go back, you know, ten years ago, I think we probably had 80 people in Paris. You know, we have 400 people in Paris now… And so in Goldman Sachs today, if you’re in Europe, you can live in London, you can live in Paris, you can live in Germany, in Frankfurt or Munich, you can live in Italy, you can live in Switzerland.

“And we’ve got, you know, real offices. You just have to recognise talent is more mobile.”

Goldman is understood to have about 6,000 employees in the UK.

Rachel Reeves is currently seeking ways to fill a black hole in the public finances and has refused to rule out wealth taxes at the next budget.

Mr Solomon expressed sympathy for her as her tears in parliament earlier this month led to speculation about the pressure of the job.

“I have sympathy, I have empathy not just for the chancellor, but for anyone who’s serving in one of these governments,” he said, referring to the turbulent political landscape globally.

Commenting on the chancellor’s Mansion House speech last week, he added: “The chancellor spoke here about regulation, she’s talking about regulation not just for safety and soundness, but also for growth.

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Takeaways from chancellor’s Mansion House speech

“And now we have to see the action steps that actually follow through and encourage that.”

One area he was particularly keen to see follow through from her Mansion House speech was ringfencing – the post financial crisis regulation that requires banks to separate their retail activities from their investment banking activities.

“It’s a place where the UK is an outlier, and by being an outlier, it prevents capital formation and growth.

“What’s the justification for being an outlier? Why is this so difficult to change? It’s hard to make a substantive policy argument that this is like a great policy for the UK. So why is it so hard to change?”

The Master Investor Podcast with Wilfred Frost is available across multiple podcast platforms

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Politics

Goldman Sachs boss sounds warning to Reeves on tax and regulation

Published

on

By

Goldman Sachs boss sounds warning to Reeves on tax and regulation

London and the UK’s leading status in the global financial system is “fragile”, the boss of Goldman Sachs has warned, as the government grapples with a tough economy.

Speaking ahead of a meeting with the prime minister, David Solomon – chairman and chief executive of the huge US investment bank – told Sky News presenter Wilfred Frost’s The Master Investor Podcast of several concerns related to tax and regulation.

He urged the government not to push people and business away through poor policy that would damage its primary aim of securing improved economic growth, arguing that European rivals were currently proving more attractive.

Money latest: Mortgage shake-up to save ‘time and money’

He said: “The financial industry is still driven by talent and capital formation. And those things are much more mobile than they were 25 years ago.

“London continues to be an important financial centre. But because of Brexit, because of the way the world’s evolving, the talent that was more centred here is more mobile.

“We as a firm have many more people on the continent. Policy matters, incentives matter.

More on Uk Economy

“I’m encouraged by some of what the current government is talking about in terms of supporting business and trying to support a more growth oriented agenda.

“But if you don’t set a policy that keeps talent here, that encourages capital formation here, I think over time you risk that.”

He had a stark warning about the recent reversal of the “Non Dom” tax policy, which occurred across both the prior Conservative government and the current Labour government, which has played a part in some senior Goldman partners relocating away from London.

Please use Chrome browser for a more accessible video player

Chancellor will not be drawn on wealth tax

Richard Gnodde, one of the bank’s vice-chairs, left for Milan earlier this year.

“Incentives matter if you create tax policy or incentives that push people away, you harm your economy,” Mr Solomon continued.

“If you go back, you know, ten years ago, I think we probably had 80 people in Paris. You know, we have 400 people in Paris now… And so in Goldman Sachs today, if you’re in Europe, you can live in London, you can live in Paris, you can live in Germany, in Frankfurt or Munich, you can live in Italy, you can live in Switzerland.

“And we’ve got, you know, real offices. You just have to recognise talent is more mobile.”

Goldman is understood to have about 6,000 employees in the UK.

Rachel Reeves is currently seeking ways to fill a black hole in the public finances and has refused to rule out wealth taxes at the next budget.

Mr Solomon expressed sympathy for her as her tears in parliament earlier this month led to speculation about the pressure of the job.

“I have sympathy, I have empathy not just for the chancellor, but for anyone who’s serving in one of these governments,” he said, referring to the turbulent political landscape globally.

Commenting on the chancellor’s Mansion House speech last week, he added: “The chancellor spoke here about regulation, she’s talking about regulation not just for safety and soundness, but also for growth.

Please use Chrome browser for a more accessible video player

Takeaways from chancellor’s Mansion House speech

“And now we have to see the action steps that actually follow through and encourage that.”

One area he was particularly keen to see follow through from her Mansion House speech was ringfencing – the post financial crisis regulation that requires banks to separate their retail activities from their investment banking activities.

“It’s a place where the UK is an outlier, and by being an outlier, it prevents capital formation and growth.

“What’s the justification for being an outlier? Why is this so difficult to change? It’s hard to make a substantive policy argument that this is like a great policy for the UK. So why is it so hard to change?”

The Master Investor Podcast with Wilfred Frost is available across multiple podcast platforms

Continue Reading

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