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Cells that make up the cartilage at the end of children’s and teens’ bones determine their future length and shape, which, in turn, affect height.  (Image credit: Marko Geber via Getty Images)

Scientists have pinpointed 145 potential “height genes” in cells that make up the cartilage at the ends of children’s bones and affect how tall they grow.

These cartilage cells, known as chondrocytes, multiply and mature in areas of tissue called growth plates, which sit near the ends of long bones in children and teens and determine each bone’s future length and shape. When a person’s growth is complete, these cartilaginous growth plates “close” and are replaced by hard bone. Scientists already knew that chondrocytes play a role in bone growth and human height, but narrowing down which genes control the cells’ growth — and, thus, our statures — has proved difficult.

“Pinpointing specific genes associated with human height is a challenging task, as height is a complex trait that is influenced by both genetic and environmental factors,” Dr. Nora Renthal (opens in new tab) , a pediatric endocrinologist at Boston Children’s Hospital and Harvard Medical School and senior of the new study, told Live Science in an email. “Our study focused on cartilage cells specifically because they are the primary cell type involved in bone growth.”

In a study published Friday (April 14) in the journal Cell Genomics (opens in new tab) , Renthal and her colleagues screened 600 million mouse cartilage cells to find genes that influence how the cells proliferate and mature. They used CRISPR genome-editing technology to “knock out” candidate genes, which allowed the researchers to observe what happened when these genes were erased and no longer regulated cartilage cells.

Related: What determines a person’s height? 

The researchers found 145 genes that, when knocked out, triggered abnormal growth and development of mouse cartilage cells. These patterns of abnormal growth were similar to those seen in certain skeletal disorders, such as skeletal dysplasia — a group of genetic disorders that affect the development of bones, joints and cartilage in babies. Those with skeletal dysplasia are typically of short stature and have short limbs, among other symptoms.

Next, the researchers compared these 145 mouse genes with previous results from large-scale genetic studies of human height, called genome-wide association studies (GWAS). In those studies, researchers compared the DNA of thousands of people of different heights to look for gene variants associated with height, Renthal explained. To control for non-genetic factors that influence the trait under study, such as nutrition and disease in the case of human height, these factors are incorporated into GWAS, according to a 2021 review published in the journal Nature Reviews Methods Primers (opens in new tab) .

“These studies have contributed to our understanding of the genetic basis of complex traits like height by identifying specific genetic regions and genes that are associated with the trait,” Renthal said.

The comparison revealed a remarkable overlap between genetic “hotpots” linked to human height in the GWAS and the 145 genes that control cartilage cell growth in mice. This means that these genes, which the researchers have now precisely located in the human genome, could influence height more than other genetic factors do.RELATED STORIES—More than 150 ‘made-from-scratch’ genes are in the human genome. 2 are totally unique to us.

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“Our current study has helped to identify new genes potentially involved in bone growth and development,” Renthal said. “Specific genes and pathways involved in the maturation and proliferation of chondrocytes, the cells that make up cartilage in our bones, play a critical role in human height.”

Results from mouse cells may not mirror cellular processes in humans, Renthal noted in a statement (opens in new tab) , but the researchers think height genes could come in handy in clinical settings. 

“It is our hope that the identification of these 145 genes will help patients with skeletal dysplasia and other skeletal disorders,” Renthal told Live Science.

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UK restores diplomatic ties with Syria

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UK restores diplomatic ties with Syria

The UK has re-established diplomatic ties with Syria, David Lammy has said, as he made the first visit to the country by a British minister for 14 years.

The foreign secretary visited Damascus and met with interim president Ahmed al Sharaa, also the leader of the rebel group Hayat Tahrir al-Sham (HTS), and foreign minister Asaad al Shaibani.

It marks the latest diplomatic move since Bashar al Assad’s regime was toppled by rebel groups led by HTS in December.

In a statement, Mr Lammy said a “stable Syria is in the UK’s interests” and added: “I’ve seen first-hand the remarkable progress Syrians have made in rebuilding their lives and their country.

“After over a decade of conflict, there is renewed hope for the Syrian people.

“The UK is re-establishing diplomatic relations because it is in our interests to support the new government to deliver their commitment to build a stable, more secure and prosperous future for all Syrians.”

Foreign Secretary David Lammy shakes hands with Syrian interim president Ahmed al-Sharaa in Damascus. Pic: X / @DavidLammy
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Foreign Secretary David Lammy with Syria’s interim president Ahmed al Sharaa in Damascus. Pic: X / @DavidLammy

The Foreign, Commonwealth and Development Office has also announced a £94.5m support package for urgent humanitarian aid and to support the country’s long-term recovery, after a number of British sanctions against the country were lifted in April.

While HTS is still classified as a proscribed terror group, Sir Keir Starmer said last year that it could be removed from the list.

The Syrian president’s office also said on Saturday that the president and Mr Lammy discussed co-operation, as well as the latest developments in the Middle East.

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Since Assad fled Syria in December, a transitional government headed by Mr al Sharaa was announced in March and a number of western countries have restored ties.

In May, US President Donald Trump said the United States would lift long-standing sanctions on Syria and normalise relations during a speech at the US-Saudi investment conference.

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From May: Trump says US will end sanctions for Syria

He said he wanted to give the country “a chance at peace” and added: “There is a new government that will hopefully succeed.

“I say good luck, Syria. Show us something special.”

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Defiance in Tehran as Khamenei makes appearance

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Defiance in Tehran as Khamenei makes appearance

They rose to their feet in ecstatic surprise, shouting “heydar, heydar” – a Shia victory chant.

This was the first public appearance of their supreme leader since Israel began attacking their country.

He emerged during evening prayers in his private compound. He said nothing but looked stern and resolute as he waved to the crowd.

He has spent the last weeks sequestered in a bunker, it is assumed, for his safety following numerous death threats from Israel and the US.

His re-emergence suggests a return to normality and a sense of defiance that we have witnessed here on the streets of Tehran too.

Earlier, we had filmed as men in black marched through the streets of the capital to the sound of mournful chants and the slow beat of drums, whipping their backs with metal flails.

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Defiance on streets of Tehran

This weekend they mark the Shia festival of Ashura as they have for 14 centuries. But this year has poignant significance for Iranians far more than most.

The devout remember the betrayal and death of Imam Hussein as if it happened yesterday. We filmed men and women weeping as they worshipped at the Imamzadeh Saleh Shrine in northern Tehran.

The armies of the Caliph Yazid killed the grandson of the Prophet Muhammad in the seventh-century Battle of Karbala.

Shiite Muslims mark the anniversary every year and reflect on the virtue it celebrates, of resistance against oppression and injustice.

But more so than ever in the wake of Israel and America’s attacks on their country.

The story is one of prevailing over adversity and deception. A sense of betrayal is keenly felt here among people and officials.

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Many Iranians believe they were lured into pursuing diplomacy as part of a ruse by the US.

Iran believed it was making diplomatic progress in talks with America it hoped could lead to a deal. Then Israel launched its attacks and, instead of condemning them, the US joined in.

Death to Israel chants resounded outside the mosque in skies which were filled for 12 days with the sounds of Israeli jets. There is a renewed sense of defiance here.

One man told us: “The lesson to be learned from Hussein is not to give in to oppression even if it is the most powerful force in the world.”

A woman was dismissive about the US president. “I don’t think about Trump, nobody likes him. He always wants to attack too many countries.”

Pictures on billboards nearby draw a line between Imam Hussein’s story and current events. The seventh-century imam on horseback alongside images of modern missiles and drones from the present day.

Other huge signs remember the dead. Iran says almost 1,000 people were killed in the strikes, many of them women and children.

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Officially Iran is projecting defiance but not closing the door to diplomacy.

Government spokeswoman Dr Fatemeh Mohajerani told Sky News that Israel should not even think about attacking again.

“We are very strong in defence and as state officials have announced, this time Israel will receive an even stronger response compared to previous times,” she said.

“We hope that Israel will not make such a mistake.”

But there is also a hint of conciliation: Senior Iranian officials have told Sky News that back-channel efforts are under way to explore new talks with the US.

Israel had hoped its attacks could topple the Iranian leadership. That proved unfounded, the government is in control here.

For many Iranians, it seems quite the opposite happened – the 12-day war has brought them closer together.

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Secret Service seizes $400M in crypto, cold wallet among world’s largest

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Secret Service seizes 0M in crypto, cold wallet among world’s largest

Secret Service seizes 0M in crypto, cold wallet among world’s largest

Secret Service quietly amasses one of the world’s largest crypto cold wallets with $400 million seized, exposing scams through blockchain sleuthing and VPN missteps.

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