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Elon Musk‘s brain implant startup Neuralink, which was valued at close to $2 billion (roughly Rs. 16,500 crore) in a private fundraising round two years ago, is now worth around $5 billion (roughly Rs. 41,300 crore) based on privately executed stock trades described to Reuters by five sources with knowledge of the matter.

Some purchases by bullish investors boosted the valuation in recent months, ahead of Neuralink’s May 25 announcement that U.S. regulators had approved a human trial on its brain chip, the sources said.

Experts have said it could take several years for Neuralink to secure commercial use clearance. Kip Ludwig, former program director for neural engineering at the U.S. National Institutes of Health (NIH), said he “optimistically” expected Neuralink to take at least 10 more years to commercialize its brain implant. The company also faces other challenges that include federal probes into its handling of animal research.

Following the trial’s approval, however, Neuralink shares were marketed privately to investors in recent days at a $7 billion (roughly Rs. 57,900 crore) valuation, equivalent to $55 (roughly Rs. 4,500) per share, according to an email seen by Reuters. Reuters could not establish whether the seller found buyers for that price. The email cited the U.S. Food and Drug Administration’s (FDA) approval of the clinical trial as grounds for the deal being “sweeter.”

Neuralink executives and Musk did not respond to requests for comment.

Musk has expressed grand ambitions for Neuralink, saying its chip would allow healthy and disabled people alike to pop into neighbourhood facilities for speedy surgical insertions of devices to treat obesity, autism, depression and schizophrenia. He even sees them being used for web-surfing and telepathy. A Neuralink executive recently gave more modest short-term objectives, such as helping paralyzed patients communicate through computerized text without typing.

The stock transactions at a valuation of around $5 billion (roughly Rs. 41,300 crore) have been carried out by shareholders such as employees and the company’s early backers, rather than Neuralink selling new shares to investors. Such so-called secondary trades are an imperfect gauge of a company’s value; their volume is thin and they lack the wider market consensus of a fundraising round or initial public offering (IPO).

Neuralink’s valuation jump in secondary trades is in sharp contrast to other startups. About 85percent of pre-IPO companies are currently valued in secondary trades at an average discount of 47 percent to their last funding round, according to data provider Caplight.

In Neuralink’s last known fundraising in 2021, it raised $205 million (roughly Rs. 1,700 crore) at an approximately $2 billion (roughly Rs. 16,500 crore) valuation, according to data provider Pitchbook.

Many of the recent stock sales have been to relatively small investors, who typically focus more on getting a slice of a company owned by Musk than scrutinizing its valuation. The maximum amount sought for the Neuralink shares marketed for sale at a $7 billion (roughly Rs. 57,900 crore) valuation was just $500,000, according to the email seen by Reuters.

Sim Desai, chief executive of Hiive, an online platform where the shares are traded, said demand for Neuralink stock has been “tremendous.” He pegged the valuation that buyers are willing to pay at around $4.5 billion (roughly Rs. 37,200 crore).

Some biomedical experts are skeptical. Arun Sridhar, a scientist and entrepreneur who specializes in neuromodulation, called Neuralink’s valuation “bonkers” based on how early the brain implant is in its clinical development.

“A study to assess safety and tolerability is in no shape or form valid to justify a $5 billion (roughly Rs. 41,300 crore) valuation,” said Sridhar, who helped launch Galvani Bioelectronics, a developer of implants backed by GSK Plc and Alphabet Inc’s Verily Life Sciences. Galvani is not a competitor of Neuralink because its implants under development will be installed in an artery to the spleen to help treat rheumatoid arthritis, rather than the brain.

Investigations

The FDA initially rejected Neuralink’s request for a human trial last year, citing safety reasons, Reuters has reported. Even after securing approval, the company faces several challenges.

Neuralink has come under scrutiny from U.S. lawmakers after Reuters reported in May that its animal-research board may have violated conflict-of-interest regulations. Neuralink employees who sat on that board, which oversees the welfare of the animals that were being tested, also stood to benefit from the implant’s quick development. Neuralink stock that some of the employees hold has jumped around 150 percent in value in just two years, based on the secondary trades.

The law enforcement arm of the U.S. Department of Agriculture has been investigating Neuralink for potential animal-welfare violations. Neuralink staff told Reuters last year that the company was rushing and botching surgeries on monkeys, pigs and sheep, resulting in far more animal deaths than necessary, as Musk pressured staff to receive FDA approval.

The Department of Transportation is separately probing whether Neuralink illegally transported dangerous pathogens on chips removed from monkey brains without proper containment measures.

Neither Musk nor Neuralink have responded to multiple requests for comment on the probes or the Reuters reports.

© Thomson Reuters 2023
 


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Dinosaurs were thriving before asteroid impact, study finds

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Dinosaurs were thriving before asteroid impact, study finds

Scientists say that dinosaurs weren’t doomed when an asteroid hit Earth. Fossil unearthings before the asteroid collision, at the end of the Cretaceous epoch, show that dinosaurs were losing variety and numbers. At first, some scientists thought this alteration showed dinosaurs were headed toward extinction even before the fatal asteroid incident. Nevertheless, this concept has long been argumentative, with other researchers insisting that dinosaur diversity was doing just fine at the time of their loss of life.

Challenging the Long-Held Narrative

According to a report by Live Science, the visible rarity of dinosaurs before their extinction may merely be due to a low fossil record. Emphasizsng four families—that is, the Ankylosauridae, Ceratopsidae, Hadrosauridae, and Tyrannosauridae—the studies of the scientists reveal records of approximately 8,000 fossils from North America dating to the Campanian age (83.6 million to 72.1 million years ago) and Maastrichtian age (72.1 million to 66 million years ago).

Th range of dinosaurs peaked 76 million years ago and started to shrink after the asteroid collision wiped off the nonavian dinosaurs. This drift was more pronounced than in the 6 million years before the mass annihilation, with the number of fossils from all four families reducing in the geological record.

Fossil Records and Statistical Models Paint a New Picture

Vegetation either covered or obscured geological outcrops from the Maastrichtian period in North America. Specifically, rock from this time that might contain dinosaur fossils was not easily accessible to the researchers who were searching for them. The study’s encapsulation might also have worldwide branching due to North America being home to half of the familiar fossils from this age.

A Catastrophic Exception, Not a Gradual End

There is no evidence of environmental conditions or other aspects that would specifically elaborate the reason of this decline, the researchers landed. All of the dinosaur broods were far-flung, as per models come into being developed by the researchers — and consequently at low risk for extinction, barring a catastrophic event such as the asteroid effect.

In the group of 8,000 fossil records evaluated, the team found that ceratopsians—a group that includes horned dinosaurs like Triceratops and its relatives — were the most common; most likely, they inhabited plain regions that were most conducive to preservation during the Maastrichtian era.

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Scientists Revive Dire Wolves Using Ancient DNA and Modern Gene Editing

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Scientists Revive Dire Wolves Using Ancient DNA and Modern Gene Editing

Three live dire wolf pups have been born using reconstructed DNA. The extinct species had last roamed North America around 12,500 years ago. The milestone was reached by a Dallas-based biotech firm that focuses on genetic conservation. Ancient DNA samples from fossilised remains were analysed. Modern gene-editing tools were used to mimic key characteristics of the extinct predator. These pups were brought to life by implanting modified embryos into domestic dog surrogates. The young wolves have been named Romulus, Remus and Khaleesi.

Ancient DNA edited in lab to recreate species

According to a study shared by Colossal Biosciences, DNA samples had been collected from two ancient dire wolf fossils. One was a 13,000-year-old tooth, while the other was a 72,000-year-old skull fragment. These fragments were compared to modern wolf relatives and grey wolves were chosen for DNA alteration because of their evolutionary proximity. Gene sequences that were found only in dire wolves were isolated. These were introduced into the DNA of grey wolves through targeted editing.

Cloning technique used to implant embryos

The altered genetic material was inserted into grey wolf egg cells after removing their original nuclei. These prepared cells were placed inside domestic dogs. Each surrogate received multiple embryos. Interestingly, only one embryo survived in each of the first two dogs. Both gave birth by caesarean section, while the third pup was born in a second round of implantation.

Physical traits match fossil record

The new pups have been observed to develop features consistent with known dire wolf fossils. Thick white coats, larger teeth and body structure have been reported. These results came from identifying changes in 14 genes. The gene edits were introduced using CRISPR technology.

The same company had previously cloned red wolves. The team had also created “woolly mice” as part of a mammoth revival effort. The successful dire wolf birth marks a new phase in gene-driven species restoration.

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Panama Tree Shocks Scientists With Lightning-Based Defense

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Panama Tree Shocks Scientists With Lightning-Based Defense

Lightning is commonly considered a sign of disaster in the forest, as lightning kills or damages trees. On the lowlands of Panama, the tonka bean tree (Dipteryx oleifera) might have evolved to capitalize on this natural occurrence. New research suggests that lightning strikes could help the tonka bean tree (Dipteryx oleifera). According to Live Science research, these trees not only survive these electrical interactions unharmed, but the lightning also harms their competitors and the parasitic vines that cling to the tonka bean plants.

The researchers published their findings on March 26 in the journal New Phytologist. Lightning is a major cause of tree mortality in tropical forests, particularly among the largest and oldest trees, which play important roles in carbon storage and biodiversity.

Lightning as a Canopy Weapon

On average, each lightning hit destroyed over 2.4 tons (2 metric tons) of adjacent tree biomass and approximately 80 percent of the lianas (parasitic vines) that plagued the tonka bean canopy. As per Gora’s assumption, the key to these trees’ lightning resistance comes from their physical structure.

A few studies describe the tree as having strong internal conductivity, letting lightning current flow through without building up damaging heat like a well-insulated wire. Because they tend to grow large — up to 130 feet (40 meters)—and live for centuries, a single tonka bean tree is estimated to be struck at least five times after reaching maturity. Each strike helps to clear out vines and competitors, opening up the canopy to help it thrive.

Ecological Impact and Evolutionary Marvel

Gregory Moore, a horticulturalist from the University of Melbourne who was not involved in the study, thinks the results will apply to other species. “The sort of work could also apply to other tree-dominated plant communities, such as woodlands or low woodlands where trees are widely separated, so it’s nothing like a tropical forest,” he said, adding that other tall trees are also possible targets of lightning strikes.

More Than Just a Tree

“We have long known that some trees can withstand multiple lightning strikes,” Moore said, noting that some tall trees survive Australian bushfires and grow up towering over their neighbors, making them prime targets for lightning strikes. “They are often referred to as stags because the top of the crown has been blown out, but they can survive for centuries after being hit by lightning,” he added.

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