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A promising new Alzheimer’s drug could help spell “the beginning of the end” for the neurodegenerative disease.

US pharmaceutical giant Eli Lilly will announce the full clinical trial results for its Alzheimer’s drug donanemab at a conference in Amsterdam today.

The drug, which is taken as a monthly infusion into the bloodstream for 18 months, was found to slow mental decline by 36% in phase 3 trials, the company announced in May.

It works by targeting and removing clusters of the protein amyloid in the brain.

“After 20 years with no new Alzheimer’s disease drugs in the UK, we now have two potential new drugs in 12 just months,” Dr Richard Oakley, associate director at the Alzheimer’s Society, wrote in The Mirror.

“This could be the beginning of the end for Alzheimer’s disease.”

It comes after trials showed another drug called lecanemab slowed progression of Alzheimer’s symptoms by 27% in patients in the early stages of the disease. The drug was approved for use in the US earlier this month.

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After the results of the donanemab trial are released, experts around the world will study the findings to examine the benefits of the drug and whether they outweigh the risk of side effects.

Such risk factors could include brain swelling and bleeding.

Regulators in the UK would need to assess the drug to decide whether to licence it as safe – a process that could take between 12 and 18 months – then the NHS would decide which patients it can be prescribed to based on cost-effectiveness.

Estimates suggest the drugs could help 720,000 people, according to the Alzheimer’s Society and Alzheimer’s Research UK, including 286,000 with mild Alzheimer’s and 435,000 with mild cognitive impairment, which is a precursor to the disease.

** HOLD FOR RELEASE/PUBLICATION DATE TBD FOR MEDICAL WRITER MARILYNN MARCHIONE STORY ** Dr. William Burke goes over PET brain scan Tuesday, Aug. 14, 2018 at Banner Alzheimers Institute in Phoenix. It may be too late to stop Alzheimer's in people who already have some mental decline but Banner is conducting two studies that target the very earliest brain changes while memory and thinking skills are still intact in hope of preventing the disease. (AP Photo/Matt York).
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PET scanner. Pic: AP

Is UK ready for new Alzheimer’s drugs?

However, doctors previously warned thousands of patients in the UK may miss out on the benefits if such drugs become available due to a lack of brain scanners and specialist clinics.

Amyloid plaques can be detected by taking a sample of spinal fluid or by a PET scan, of which there are around 86 scanners in the UK.

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Around 850,000 people in Britain have Alzheimer’s disease, which is the most common form of dementia.

It causes mild memory loss and can seriously affect a person’s ability to carry out ordinary daily activities.

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UK will play its ‘full part’ in peacekeeping efforts in Ukraine, says Sir Keir Starmer

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UK will play its 'full part' in peacekeeping efforts in Ukraine, says Sir Keir Starmer

The UK will play its “full part” in peacekeeping in Ukraine, Sir Keir Starmer has said.

The prime minister told Sky News’ political editor Beth Rigby that the conflict with Russia was not just about “sovereignty in Ukraine” but about the impact it also had on the UK, including the cost of living crisis.

Sir Keir was speaking to Sky News while on a surprise visit to Ukraine on Thursday – his first since his party’s landslide election win six months ago.

The purpose of the trip was to discuss the next steps for Ukraine, with the situation now more uncertain following Donald Trump’s election victory in November.

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Mr Trump, whose inauguration takes place on 20 January, has said he wants a peace deal between Russia and Ukraine within 100 days.

But some European leaders fear pushing Kyiv into a deal could lead to Ukraine ceding some of its territory to Vladimir Putin.

European leaders now talking about peace rather than war

The war in Ukraine has ground on for nearly three years. From the start, Western allies have stood in solidarity with Kyiv.

The US has poured tens of billions in military aid into the war, while leaders across Europe have vowed to stand with Volodymyr Zelenskyy for as long as it takes to defeat Vladimir Putin on the battlefield.

But on Thursday, as Sir Keir Starmer stood shoulder-to-shoulder with President Zelenskyy at the remembrance wall for fallen soldiers and then side-by-side with the Ukrainian president at a joint press briefing, the changing reality of Donald Trump’s return to the White House in just five days was laid bare.

Even as a Russian drone hovered above the presidential palace – only to be blasted down by anti-aircraft guns – the significant development of this trip was that these leaders were not talking about war, but about peace.

Read Beth Rigby’s full analysis here

Sir Keir said he did not want “to get ahead of ourselves” but that the UK would play its “full part” in any peace negotiations – including by deploying British troops for peacekeeping.

Asked if he would be prepared to do that, the prime minister replied: “Well, I don’t want to get ahead of ourselves, but I do have indicated that we will play our full part – because this isn’t just about sovereignty in Ukraine.

“It’s about what the impact is back in the United Kingdom and our values, our freedom, our democracy. Because if Russia succeeds in this aggression, it will impact all of us for a very, very long time.”

On arriving in Ukraine to meet President Volodymyr Zelenskyy, a Russian drone was shot over the sky over the presidential palace.

Sir Keir said the drone threat was “a reminder of what Ukraine is facing every day” and that the war was brought about by “Russian aggression”.

Elsewhere in the interview, Sir Keir was asked about his views on Ukraine’s longstanding desire to join NATO – something President Putin strongly opposes.

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At a NATO summit in Washington last summer, the alliance’s members announced that Ukraine was on an “irreversible” path to NATO membership.

“We fully support Ukraine’s right to choose its own security arrangements and decide its own future, free from outside interference. Ukraine’s future is in NATO,” the declaration said.

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Watch the full interview here

However, Mr Zelenskyy has somewhat tempered his language around NATO membership, telling Sky News in an exclusive interview in November that a ceasefire deal could be struck if Ukrainian territory he controlled falls “under the NATO umbrella” – allowing him to negotiate the return of the rest later “in a diplomatic way”.

However, Mr Trump has acknowledged Moscow’s opposition to Ukraine joining NATO, saying: “Russia has somebody right on their doorstep, and I can understand their feeling about that.”

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Man arrested after death of woman and two-year-old girl found with serious injuries in Ashford, Surrey

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Man arrested after death of woman and two-year-old girl found with serious injuries in Ashford, Surrey

A man has been arrested after the death of a woman in her 20s and a two-year-old girl was found with serious injuries at an address in Ashford, Surrey.

The man, in his 30s, has been detained on suspicion of murder and attempted murder, Surrey Police said.

Officers went to a property in Woodthorpe Road, Ashford, at 1.15pm on Thursday following a report of concern for safety.

The woman and child were found at the address with serious injuries and despite treatment from paramedics, the woman died at the scene.

The child was taken to hospital.

An investigation, led by the Surrey and Sussex Police Major Crime Team, is under way and enquiries remain ongoing, police said.

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Madeleine McCann suspect won’t face charges for foreseeable future, prosecutor tells Sky News

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Madeleine McCann suspect won't face charges for foreseeable future, prosecutor tells Sky News

The man suspected of abducting Madeleine McCann won’t face any charges in the foreseeable future, a prosecutor has told Sky News.

German drifter Christian B, who cannot be fully identified under his country’s privacy law, is expected to be freed from an unrelated jail sentence this year while police in three countries continue to search for evidence against him.

Prosecutor Hans Christian Wolters said: “There is currently no prospect of an indictment in the Maddie case.

“As things stand, the accused Christian B’s imprisonment will end in early September.”

Madeleine, aged three, was asleep with her younger twin siblings in the family’s Portuguese rented holiday apartment before mother Kate discovered her missing at around 10pm on 3 May, 2007.

Her parents were dining nearby on the complex with friends and taking turns to check on all their sleeping children every half an hour.

Madeleine’s disappearance has become the world’s most mysterious missing child case.

Undated handout file photo of Madeleine McCann who disappeared from a holiday flat in Portugal seventeen years ago. Her parents, Kate and Gerry McCann, released a statement on the 17th anniversary of her disappearance, saying "the absence still aches". Earlier this week, it was confirmed that up to a further £192,000 has been granted by the Home Office for the Scotland Yard investigation into Madeleine's disappearance. Issue date: Friday May 3, 2024.
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Madeleine McCann, who disappeared from a holiday flat in Portugal. Pic: PA

Philipp Marquort, one of Christian B’s defence lawyers, welcomed the prosecutor’s pessimism about bringing charges.

He said: “This confirms the suspicions that we have repeatedly expressed, namely that there is no reliable evidence against our client.

“We regret that we have not yet been granted access to the investigation files. We have not yet been able to effectively counter the public prejudice arising from statements made by the prosecutor’s office.”

Christian B, 47, is in jail and coming to the end of his sentence for the rape of an elderly American woman in Praia da Luz, the Portuguese resort where Madeleine disappeared.

In October, he was acquitted on a series of rape and indecent assault charges after a non-jury trial in Germany, in which several references were made to his status as the main suspect in the Madeleine case.

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File photo dated 30/04/17 of Kate and Gerry McCann, whose daughter Madeleine disappeared from a holiday flat in Portugal seventeen years ago. They have released a statement on the 17th anniversary of her disappearance, saying "the absence still aches". Earlier this week, it was confirmed that up to a further ..192,000 has been granted by the Home Office for the Scotland Yard investigation into Madeleine's disappearance. Issue date: Friday May 3, 2024. PA Photo. See PA story POLICE Portugal. Photo credit should read: Joe Giddens/PA Wire....
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Kate and Gerry McCann. Pic: PA

The prosecutor said he was awaiting the court’s written judgment before launching an appeal against the acquittal. He believes the trial judges were biased against the prosecution.

If successful, he could apply for a new arrest warrant for Christian B to keep him in custody until a retrial with new judges.

He said: “We hope that the Federal Court of Justice will decide before the end of the accused’s imprisonment. If the Federal Court follows our legal opinion, we could apply for a new arrest warrant for the accused’s offences, so that the accused would then remain in custody beyond September 2025.

Mr Marquort said the defence team would oppose the prosecution’s appeal against the acquittal.

Prosecutor Mr Wolters has said in the past that he believes Madeleine is dead and that Christian B was responsible for her death. The suspect denies any involvement.

The case against Christian B is purely circumstantial; he’s alleged to have confessed to a friend that he abducted Madeleine, he has convictions for sex crimes against children, he was living in the area at the time, his mobile phone was close by when the young girl vanished and he re-registered one of his vehicles the next day.

The prosecutor won’t say what evidence he has to convince him Madeleine is dead, but he admitted he is still trying to find forensic evidence to link Christian B to the girl.

Christian B is acquitted of sex attacks not related to the Madeleine McCann case
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Christian B coming to the end of his sentence for the rape of an elderly woman

Jim Gamble, former head of the UK Child Exploitation and Online Protection centre, said he had expected the prosecutor to charge Christian B soon.

“He’s implied the whole way through that he has something more than the public are aware of,” he said.

“He’s made fairly definitive statements about whether Madeleine is alive or dead so you would expect their strategy to have been to charge him sooner rather than later.

“From what he’s said today I wonder if we’re witnessing the re-positioning of something to manage the disappointment that’ll come.”

Mr Wolters, who is based in Braunschweig, Lower Saxony, is investigating the case with the help of Portuguese police and detectives from Scotland Yard.

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