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A new drug has been found to slow the progression of Alzheimer’s, with experts hailing it as a “turning point” in the fight against the disease.

Donanemab was found to slow “clinical decline” by up to 35%, allowing people with Alzheimer’s to continue performing day-to-day tasks such as shopping, housekeeping, managing their finances and taking medication.

Following the findings of a trial of the drug, Alzheimer’s Research UK said “we’re entering a new era” where the disease “could become treatable”.

The health spending watchdog in England, the National Institute for Health and Care Excellence (NICE), is already assessing whether the drug can be used in the NHS.

Meanwhile, Alzheimer’s Society said treatments such as donanemab could one day mean the disease is comparable to long-term conditions such as asthma or diabetes.

The charity believes this “could be the beginning of the end for Alzheimer’s disease”.

Donanemab works by removing plaques of a protein called amyloid that build up in the brain of people with Alzheimer’s.

Scientists have published the final results of a trial, known as TRAILBLAZER ALZ-2, examining the safety and efficacy of the drug, manufactured by US pharmaceutical giant Eli Lilly.

Researchers examined almost 1,800 people with early-stage Alzheimer’s, with half given a monthly infusion of donanemab into the bloodstream and the other half given a placebo over 18 months.

The study concluded, after 76 weeks of treatment, donanemab slowed clinical decline by 35.1% in people with early Alzheimer’s whose brain scans showed low or medium levels of a protein called tau.

When the results were combined for people who had different levels of this protein, there was a 22.3% slowing in disease progression.

Side effects

The researchers found among a small number of people there were some serious side effects such as brain swelling.

Meanwhile, three deaths in the donanemab group and one in the placebo group were considered “treatment related”.

The findings were published in the Journal of the American Medical Association and presented to the Alzheimer’s Association International Conference in Amsterdam.

Eli Lilly said some taking the drug would be able to finish the course of treatment in six months once their amyloid plaque cleared.

It said treatment with donanemab reduced amyloid plaque on average by 84% at 18 months, compared with a 1% decrease for participants given a placebo.

Some 47% taking the drug who had early-stage disease and low or medium levels of tau were found to stall the disease for a year.

It comes after trials showed another drug called lecanemab slowed progression of Alzheimer’s symptoms by 27% in patients in the early stages of the disease. The drug was approved for use in the US earlier this month.

Alzheimer’s drugs offer hope but remain out of reach in UK

The NHS is nowhere near ready to provide the first effective Alzheimer’s drugs to the huge numbers of people who need them.

Estimates by Alzheimer’s Research UK suggest 720,000 people in the UK would meet the treatment criteria used in the clinical trials of lecanemab and donanemab.

These drugs work best when given at the very first stages of Alzheimer’s, or earlier still when patients have what doctors call mild cognitive impairment.

But that needs a diagnosis the NHS just can’t deliver at the scale needed.

Read Thomas Moore’s analysis here.

‘It is possible to slow down the disease’

Dr Mark Mintun, group vice president of neuroscience research and development at Eli Lilly and president of Avid Radiopharmaceuticals, said: “People living with early, symptomatic Alzheimer’s disease are still working, enjoying trips, sharing quality time with family – they want to feel like themselves, for longer.

“The results of this study reinforce the importance of diagnosing and treating disease sooner than we do today.”

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November 2022: Inside a lab working on Alzheimer’s treatment

Dr Richard Oakley, associate director of research at Alzheimer’s Society, said: “This is truly a turning point in the fight against Alzheimer’s and science is proving that it is possible to slow down the disease.

“Treatments like donanemab are the first steps towards a future where Alzheimer’s disease could be considered a long-term condition alongside diabetes or asthma – people may have to live with it, but they could have treatments that allow them to effectively manage their symptoms and continue to live fulfilled lives.”

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He added: “Diagnosis will be key to the access of any new treatments.

“We can’t have a situation where treatments are approved for use in the UK but people aren’t diagnosed early or accurately enough to be eligible.

“We need early, and accurate, diagnoses available for everyone and the NHS ready to roll out treatments such as donanemab and lecanemab if and when they are approved in the UK.”

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Former deputy PM Oliver Dowden interviewed in election day betting probe

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Former deputy PM Oliver Dowden interviewed in election day betting probe

Former deputy prime minister Sir Oliver Dowden has become the most senior ally of Rishi Sunak to be interviewed in the official investigation into betting on the date of the general election, Sky News understands.

He follows Mr Sunak’s former parliamentary aide Craig Williams and former Downing Street chief of staff Liam Booth-Smith in being questioned by the Gambling Commission, the statutory body that regulates betting in the UK.

Mr Sunak has not yet been interviewed, Sky News understands, though “numerous people” including Conservative Party officials have been.

Tory conference latest: Maternity pay is ‘excessive’, Badenoch argues

A source close to Sir Oliver said the former senior cabinet minister is not and was never under investigation himself.

It is understood Sir Oliver spoke to the police to assist with their inquiries as part of their investigation into others. This is said to have taken place in early summertime and the officers involved were part of the Gambling Commission.

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The inquiry – launched in June – is set to continue for another three to six months.

News of Sir Oliver’s interview, along with the seizing of “hundreds of documents” from Tory HQ by the commission, has emerged on the day the Conservative Party Conference opened in Birmingham.

Ironically, the Gambling Commission’s head office, on the fourth floor of Victoria Square House, Victoria Square, Birmingham, is just a half-mile, 10-minute walk from the ICC, where the Tory conference is taking place.

Sir Oliver was knighted and Mr Booth-Smith was awarded a peerage in the former prime minister’s dissolution honours, announced less than an hour before the polls closed on 4 July.

The commission is investigating whether bets were placed on a July election by people with inside knowledge – in breach of gambling rules – in the days leading up to Mr Sunak’s shock announcement of the election date on 22 May.

A source told Sky News: “The general election betting investigation is still ongoing. Hundreds of documents have been seized by the Gambling Commission from CCHQ.

“The Gambling Commission has also employed more ex-police as investigators to take the case forward. It’s expected the case will continue for three to six months.”

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Gambling scandal: Another bruise for the Tories?

Asked if Mr Sunak has been interviewed, the source said: “I don’t believe so. Numerous people have been interviewed, in and out of CCHQ.

“Gambling Commission investigators have made numerous visits to CCHQ. Oliver Dowden was interviewed.”

What is the election betting scandal?

The election date betting scandal began in June when Craig Williams, formerly MP for Montgomeryshire and Mr Sunak’s parliamentary private secretary, admitted he was being investigated by the Gambling Commission.

Mr Williams had placed a £100 bet on a July election at Ladbrokes in his constituency just days before Mr Sunak announced on 22 May that the election would be held on 4 July. Based on odds at the time, he would have won £500.

“I put a flutter on the General Election some weeks ago,” he said in a post on X on 13 June. “This has resulted in some routine inquiries and I confirm I will fully co-operate with these.

“I don’t want it to be a distraction from the campaign. I should have thought through how it looks.”

Rishi Sunak delivers a speech calling for a general election, outside Number 10 Downing Street
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The commission is investigating whether bets were placed on a July election. Pic: Reuters

Mr Williams, who admitted he had made a “huge error”, was dropped by the Tories as their candidate in the new seat of Montgomeryshire and Glyndwr but remained on the ballot paper, but was defeated, coming third behind Labour and Reform UK.

As the Gambling Commission proceeded, Tony Lee, the party’s director of campaigns, and his wife Laura Saunders, who was Tory candidate for Bristol North West, were placed under investigation.

In a statement on the day news of the investigation was first reported, Saunders said she would be “cooperating with the Gambling Commission”, while Lee took a leave of absence from his role.

Then Nick Mason, the party’s chief data officer, became the fourth Conservative candidate or official to be investigated. He took a leave of absence and denied any wrongdoing.

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In a bizarre twist, a Labour candidate in the election, Kevin Craig, was then suspended by his party after betting against himself and the Gambling Commission launched an investigation into him.

Mr Craig, candidate in Central Suffolk and North Ipswich, posted on X that he had “enjoyed the odd bet for fun” throughout his life.

“A few weeks ago when I thought I would never win this seat I put a bet on the Tories to win here with the intention of giving any winnings to local charities,” he said.

“While I did not place this bet with any prior knowledge of the outcome, this was a huge mistake, for which I apologise unreservedly.”

Craig Williams admitted to betting on the election date. Pic: PA
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Craig Williams admitted to betting on the election date. Pic: PA

Then on 27 June Sky News revealed that Mr Booth-Smith, then Mr Sunak’s most senior adviser in Downing Street, had been interviewed by senior Gambling Commission officials and questioned about who knew about the timing of the election.

Sources emphasised, however, that Mr Booth-Smith was not a suspect and was interviewed as a witness and was “asked for help”.

Sky News has approached Mr Dowden and the Conservative Party for comment.

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UK weather: Met Office issues fresh heavy rain warnings

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UK weather: Met Office issues fresh heavy rain warnings

Fresh weather warnings have been issued for heavy rain, with some areas already saturated by earlier downpours to be hit.

Parts of the country saw more than the monthly average rainfall on Monday, while some counties in southern and central England have already had more than 250% of their September average, according to the Met Office.

Yellow weather warnings for wind and rain came into force on Sunday, while two fresh yellow warnings have been issued for heavy rain next week.

Sunday’s warning, meaning further heavy rain is likely to cause some travel delays and flooding, covers much of southern England and South Wales between 4pm on Sunday and 9am on Monday.

Between 20mm to 30mm of rainfall could be seen over nine to 12 hours, with up to 80mm in some localised places on higher ground.

The Environment Agency has issued 33 flood warnings, indicating flooding is expected, and 67 flood alerts, where flooding is possible, in place across England on Sunday afternoon.

Weather warnings issued for next week. Pic: Met Office
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Weather warnings issued for Monday. Pic: Met Office

Mark Garratt, flood risk manager at the Environment Agency, said rain expected on Sunday and Monday will bring a risk of surface water flooding in large parts of the southwest and southern England, spreading up into the Midlands, and on Monday, flooding in parts of Leicestershire is also possible.

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He said: “It is especially important that people do not drive through flood water – it is often deeper than it looks and just 30cm of flowing water is enough to float your car.

“Across the country, Environment Agency teams have been out checking flood defences and clearing any debris from storm drains and are also supporting local authorities in responding to surface water flooding.

“The advice to the public to keep checking their flood risk, and search ‘check for flooding’ and to sign up for free flood warnings on the latest situation or follow @EnvAgency on X for the latest flood updates.”

Check latest weather forecast where you are

A yellow warning for wind is in place across southwest England and Wales between 9am on Sunday until the end of the day.

Gusts of between 50mph and 60mph could be seen, with large waves, trees brought down, travel disruption and some power cuts.

Fresh rain warnings issued

Rain warnings cover eastern England between 8am on Monday and 3am on Tuesday, and North Wales and northwest England between 12.30am and 8pm on Monday.

Both forecast between 20mm and 40mm of rainfall widely, with 60mm possible in a few places across North Wales and northwest England and between 60mm to 80mm in some areas in eastern England.

Met Office meteorologist Liam Eslick said they are expecting some “pretty heavy persistent rain” across North Wales and northwest England.

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The higher ground in eastern England will see the most rainfall. Areas including Northamptonshire and Bedfordshire will see less rainfall, but are already saturated by recent heavy rain.

It comes after areas across England suffered heavy rain and localised flooding in recent days, with commuters facing widespread disruption on road and rail services.

About 650 properties were flooded in Bedfordshire, Northamptonshire and the home counties, according to the Environment Agency, which estimated around 8,200 properties had been protected.

By Tuesday night, higher pressure will move in, meaning a drier, sunnier spell, Mr Eslick said.

“Come Tuesday night into Wednesday we’re starting to see higher pressure, so turning a lot drier and plenty of sunny spells,” he said.

“But the following weekend, it does look like there’s a further low pressure coming in, but we’re still keeping an eye on that.”

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Lewis Hamilton opens up about mental health struggles

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Lewis Hamilton opens up about mental health struggles

Lewis Hamilton has said he has struggled with his mental health “for much of his life”, and blames the pressure of motor racing and bullying that he suffered at school.

Hamilton, 39, is one of the most successful Formula One (F1) drivers in history, having won a joint-record seven world titles.

The racer, who was born in Stevenage, has won more F1 races (105) than anyone else and also holds the records for most pole positions (104), and podium (top three) finishes (201).

Mercedes driver Lewis Hamilton during the British Grand Prix at Silverstone Circuit, Northamptonshire. Picture date: Sunday July 7, 2024.
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Mercedes driver Lewis Hamilton during the British Grand Prix at Silverstone. File pic: PA

But despite his career successes, he told The Sunday Times he had “some really difficult phases” during his 20s, admitting he has “struggled with mental health through my life”.

“[I’ve had] depression. From a very early age, when I was, like, 13. I think it was the pressure of the racing and struggling at school. The bullying. I had no one to talk to,” he said.

His life changed, he revealed, during the coronavirus pandemic in 2020, when, following a period of soul-searching, he began waking up at 5am to meditate before going for a run.

Despite initially struggling to find peace, he said the new routine was “a really great way of getting in touch with myself, my inner feelings, understanding what I can do”.

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Asked if he has ever seen a therapist, Hamilton replied: “I spoke to one woman, years ago, but that wasn’t really helpful. I would like to find someone today.”

Mercedes' Lewis Hamilton celebrates with the trophy at Silverstone Circuit, Northamptonshire. Picture date: Sunday July 7, 2024. PA Photo. See PA Story AUTO British. Photo credit should read: David Davies/PA Wire...RESTRICTIONS: Use subject to restrictions. Editorial use only, no commercial use without prior consent from rights holder.
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Lewis Hamilton celebrates winning the British Grand Prix. Pic: PA

Hamilton, who earlier this season became the oldest driver to win a Formula One race in the 21st century, will not add to his tally of championship titles this year.

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With six races remaining, the Mercedes driver is sixth in the standings but trails the championship leader, Max Verstappen, by 157 points with only 150 left to win.

He will move to Ferrari at the end of this season after 12 years with Mercedes.

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