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Reviewed by Lily Ramsey, LLM Aug 18 2023

A new study, 'Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study', published today (17 August 2023) in Nature Microbiology, proves that using DDNS to detect polio outbreaks can save public health authorities crucial time and money.

This research was jointly conducted by researchers at the Institut National de Recherche Biomédicale in Kinshasa who implemented DDNS in the Democratic Republic of the Congo (DRC) for the detection of polio outbreaks in collaboration with the MHRA, Imperial College London, the University of Edinburgh and various laboratories of the World Health Organization (WHO) Global Polio Laboratory Network (GPLN), with support from the Bill and Melinda Gates Foundation.

This is the first time that this type of scientific technique has been used to detect polio. Similar techniques have previously been used to detect COVID-19, Ebola, measles and monkeypox.

By enabling samples to be tested in the country where the outbreak originated rather than being sent to specialist laboratories abroad, the costs and delays of transport and testing can be reduced from an average of 42 days to an average of 19 days.

Currently, stool samples from countries with active polio outbreaks such as the DRC must be shipped around the world for lengthy, complex laboratory tests to confirm a polio case. Faster detection of polio in the regions where outbreaks still occur allows for a faster response by authorities through targeted, localised vaccination campaigns, minimising the opportunity for the virus to spread.

Javier Martin, Principal Scientist in Virology at the MHRA said: We are standing at a delicate and pivotal moment for the eradication of polio. While vaccination programmes have seen polio disappear in many countries, the delayed detection of outbreaks poses a major threat to those efforts.

By implementing detection methods such as DDNS, we can identify where outbreaks are and which polio strain is present much more quickly, allowing us to act at the earliest opportunity.

This is the result of years of work, collaborating with our partners. Together, we will continue to build on this research and support countries at risk of outbreaks to implement DDNS testing to help make polio a disease of the past."

This research showed that DDNS tests done locally in the DRC over a six-month period were an average of 23 days faster than the standard method, with over 99% accuracy.

Researchers also tested this technique in the UK and detected poliovirus in London in 2022, leading to the recent drive to ensure children under the age of 12 are vaccinated through the London polio catch-up campaign 2023.

Professor Placide Mbala-Kingebeni, Medical Doctor and Virologist at the Institut National de Recherche Biomédicale said: This is the perfect example of collaboration, where combining and sharing knowledge together with all our partners has supported the vital work of the INRB in the DRC where poliomyelitis remains a serious public health problem.

Collaboration and training with our partners has empowered the local team not only to master and confidently carry out this new technique but also to transfer the knowledge and skills to other African countries where poliovirus outbreaks are reported regularly.

The support and guidance of the Bill and Melinda Gates Foundation and the GPLN, who make these collaborations possible, enables the application and expansion of DDNS across Africa for the rapid detection of poliovirus and outbreak response, helping us move closer towards polio eradication."

Dr Alex Shaw, Research Fellow in the School of Public Health at Imperial College London said: This method allows the rapid confirmation of polio strains, facilitating swifter vaccine responses that can reduce the number of polio cases stemming from an outbreak. Development and validation of the method has been the result of fruitful collaboration between a consortium of many partners.

As a consortium we look forward to the training of additional national laboratories in this method, with prior trainees, including members of INRB, now taking on the role of trainers.

The sequencing technology used in this method is easily adapted for the detection and typing of other organisms. This rollout will therefore provide a foundation of skills and experience that can be redirected to the genomic surveillance of other pathogens as needed." Related StoriesCutting-edge research: machine learning identifies early predictors of type 1 diabetesBibliometric analysis reveals research trends connecting Alzheimer's disease and the gut microbiomeResearch uncovers new insights into post-COVID-19 syndrome (PCS) phenotypes and impact on quality of life

Polio is an infectious disease caused by the poliovirus, most commonly transmitted through contact with infected feces via contaminated food and water.

While many people may never show symptoms, in extreme cases, especially for babies and children under the age of five, polio can lead to permanent paralysis or death.

The WHO has identified delays in detection as one of the major challenges facing their Polio eradication strategy 2022-2026.

While faster detection methods such as DDNS cannot eradicate polio on their own, they play an essential part in managing outbreaks.

Scientists at the MHRA will continue to support the testing and validation of DDNS as a polio detection technique and training WHO laboratories around the world in how to use it. Source:

GOV.UKJournal reference:

Shaw, A. G., et al. (2023). Sensitive poliovirus detection using nested PCR and nanopore sequencing: a prospective validation study. Nature Microbiology. doi.org/10.1038/s41564-023-01453-4.

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Has altseason finished? XRP ETF applications flood in, and more: Hodler’s Digest, Feb. 2 – 8

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Has altseason finished? XRP ETF applications flood in, and more: Hodler’s Digest, Feb. 2 – 8

Is altcoin season potential still alive or running out of steam? XRP ETF filings flood in, and more: Hodler’s Digest

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Business

‘Ghost broking’: Reports of scammers selling fake car insurance rise by 30% over five years

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'Ghost broking': Reports of scammers selling fake car insurance rise by 30% over five years

Reports of “ghost broking”, scammers selling fake car insurance, have risen by 30% over the last five years, exclusive data obtained by Sky News reveals.

Ghost brokers sell false policies to drivers, manipulate information given to genuine insurance companies, or take out insurance and cancel it straight away. This leaves people without valid car insurance, which is illegal.

Wayne Simpson lost over £500 to a ghost broker.

He was looking for cheap car insurance and saw an advertisement on social media for a deal which was half the price of other companies.

He bought the policy, and it was only when he tried to make a claim after a crash that he discovered the truth: “We called up Aviva and they told me there wasn’t a policy taken out in my name and that the number we had given them was not a number they would use.

“That’s when the dust settles, and you realise it’s been a scam.”

Wayne Simpson
Image:
Wayne Simpson

Aviva was not at fault. Victims are lured in by genuine-looking websites and are sent professional-looking invoices.

Mr Simpson received insurance documents that looked so real, they even fooled the police officer at the accident.

“She said, ‘Your car’s not popping up as insured’. Straight away I went to my glove box, pulled the insurance documents, showed her the documents and she read through it and said, ‘That’s totally fine’,” he said.

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Police say young drivers are most likely to be targeted by ghost brokers, partly because they are often looking to reduce their insurance costs.

According to the RAC, almost half of young drivers said insurance costs were a top concern.

Exclusive data obtained by Sky News from Action Fraud reveals “ghost broking” reports have risen by 30% since 2019.

Detective Superintendent Tom Hill
Image:
Detective Superintendent Tom Hill

Detective Superintendent Tom Hill, head of the City of London Police’s Insurance Fraud Enforcement Department, said social media is behind this increase: “There are limited barriers to entry for social media accounts to be set up so people can take out car insurance and spread the word quite widely.

“Do your research and make sure you’re dealing with a genuine broker or genuine insurance company. If the conversation has been moved on to WhatsApp, for example, alarm bells should be ringing”.

In 2024, victims of ghost broking lost an average of £2,206.

Victims lose money to the scam and then have to pay additional costs to repair their cars after an accident. They could also face criminal charges, a fine or licence points if found to be driving without a valid licence.

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World

Hostage told Hamas crowd he hoped to see wife and daughters after release – suggesting he didn’t know they were killed on 7 October

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Hostage told Hamas crowd he hoped to see wife and daughters after release – suggesting he didn't know they were killed on 7 October

A released Israeli hostage told a Hamas crowd he hoped to see his wife and daughters after his release – suggesting he did not know they had been killed on 7 October.

Eli Sharabi, Ohad Ben Ami and Or Levy were the latest hostages freed this morning in front of a crowd of heavily armed fighters.

Both Mr Ami, 56, and Mr Sharabi, 52, were taken from Kibbutz Be’eri during the 7 October attack. Mr Levy, 34, was abducted from the Nova music festival.

It was not known if Mr Sharabi was aware his wife and children had been killed by Hamas over a year ago. His Bristol-born wife Lianne Sharabi, along with their children 16-year-old Noiya and 13-year-old Yahel, were killed while Mr Sharabi and his brother Yossi were taken hostage.

Yossi was later killed while in captivity.

Mr Sharabi was paraded on a podium by armed Hamas personnel and interviewed before his release earlier today.

In one of his answers, which was clearly given under duress, he said he was hoping to see his wife and daughters very soon, according to translations provided by our US partner NBC News.

Eli Sharabi appeared 'skinny' and 'gaunt', his relative said. Pic: Reuters
Image:
Eli Sharabi. Pic: Reuters

Mr Sharabi also told the crowd he was aware of his brother’s death and said he was “very angry” with the Israeli government.

All three hostages made similar critical comments about Israel while on stage with the armed men.

The comments came as Stephen Brisley, Mr Sharabi’s brother-in-law, told Sky News presenter Anna Jones this morning that he wasn’t sure if he had found out about his family’s fate.

Israeli hostages are released by Hamas. Pic: Reuters
Image:
Israeli hostages were paraded on stage before being released by Hamas. Pic: Reuters

“All the way through this, we’ve wondered whether what’s kept him going is the prospect of being reunited with Lianne and the girls,” he said.

He described his brother-in-law as looking “skinny” and “gaunt”.

“You could see how skinny he is, how pale he is. You wonder how much daylight he’s seen – very gaunt face,” he said.

“I think what struck me the most is that Eli has a very happy face, he smiles with his whole face and smiles with his eyes and it was the lack of light in his eyes that I think is one of the most distressing parts of it.”

The hostages were reunited with family. Pic: IDF
Image:
The hostages were reunited with family. Pic: IDF

Israeli captive, Ohad Ben Ami waves as he is escorted by Hamas fighters. Pic: AP
Image:
Israeli captive, Ohad Ben Ami waves as he is escorted by Hamas fighters. Pic: AP

Photos after his release showed Mr Sharabi reuniting with his wider family.

Gaza ceasefire latest: Live updates as Hamas releases three Israeli hostages

Israeli captive Or Levy after his release. Pic: AP
Image:
Israeli captive Or Levy after his release. Pic: AP

Mr Brisley added: “You don’t know what the last 491 days have done to him, but it’s clearly had an incredible impact on him, and it was written all over his face.”

Armed and masked Hamas fighters. Pic: AP
Image:
Masked and armed Hamas fighters during the handover. Pic: AP

Israel’s Prime Minister Benjamin Netanyahu said: “We will not accept the shocking scenes that we saw today.”

(L-R) Eli Sharabi, Ohad Ben Ami, and Or Levy. Pics: Bring Them Home Now
Image:
Eli Sharabi, Ohad Ben Ami, and Or Levy (L-R). Pics: Bring Them Home Now

Read more:
What’s in the ceasefire deal?
The Israel-Hamas war in numbers

In return for the captives’ release, 183 Palestinian prisoners were released – some of which were convicted of being involved in attacks that killed dozens of people.

A bus carrying several dozen Palestinian prisoners from Israel’s Ofer prison arrived in the occupied West Bank, where their families and friends were waiting.

A Palestinian prisoner is checked by medical personnel after being released from Israeli prison as a result of a ceasefire agreement between Israel and Hamas. Pic: AP
Image:
A Palestinian prisoner is checked by medical personnel after being released from an Israeli prison as a result of a ceasefire agreement between Israel and Hamas. Pic: AP

Sky News Middle East correspondent Alistair Bunkall said some of the prisoners also looked to be in a “very bad condition”.

And in a statement later on Saturday, Prime Minister Sir Keir Starmer said he was “dismayed to see his (Mr Sharabi’s) frail condition and the circumstances of his release”.

He added: “Having met his relatives I appreciate the deep pain they have endured and my thoughts are with them.

“We must continue to see all the hostages freed – these people were ripped away from their lives in the most brutal circumstances and held in appalling conditions.

The ceasefire must hold and all efforts need to focus on full implementation of the remaining phases. This includes the return of further hostages, the continued increase of aid into Gaza and securing lasting peace in the Middle East.”

Some 18 Israeli hostages and more than 550 Palestinian prisoners have been freed since the ceasefire began on 19 January.

Under the deal, 33 Israeli hostages are to be released in an initial stage in exchange for almost 2,000 Palestinian prisoners and detainees.

Negotiations on a second phase of the deal began this week. It is aimed at returning the remaining hostages and agreeing to a full withdrawal of Israeli troops from Gaza in preparation to end the war.

It is feared US President Donald Trump’s proposal to move the Palestinian population out of Gaza so the US could take over could complicate the second and more difficult phase of the ceasefire.

Hamas’s cross-border attack into Israel saw around 1,200 Israelis killed and around 250 people taken hostage.

Since then Israel’s war in Gaza has killed more than 47,000, according to the Hamas-run health ministry, which does not differentiate between civilians and combatants.

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