In-space manufacturing may sound like science fiction but it’s happening already, albeit on a very small scale. It’s a fledgling market that analysts and several startups are projecting will take off.
“If you look at pharma, semiconductors, beauty and health products and potentially food in the sense of like new crops, we estimated the market to be above $10 billion at some point in 2030, depending on the speed of maturation,” said Ilan Rozenkopf, a partner at McKinsey.
Space offers a unique environment for research and development because its higher levels of radiation, microgravity and near vacuumless state allows companies to come up with new manufacturing methods or materials that are not possible on Earth.
The practice is not entirely new. The International Space Station has hosted several experiments from academics, government agencies and commercial customers for things such as growing human tissue, making purer semiconductors and developing new or better drugs. In the 2024 fiscal-year budget, President Joe Biden even set aside $5 million for NASA to pursue cancer-related research on the ISS.
But access to the ISS has always been competitive and interest continues to grow. Now, several space startups see an opportunity to satisfy in-space manufacturing demand using compact space factories. One company is Varda Space Industries in Southern California. Varda’s mission is to help pharmaceutical companies improve their drugs or come up with new drug therapies by taking advantage of the unique properties of space, and then return those materials back to Earth.
Varda Space Industries’ first pharmaceutical manufacturing satellite and reentry vehicle attached to a Rocket Lab Photon bus.
Rocket Lab
Key to Varda’s business proposition is a phenomenon known as protein crystallization.
This occurs when super-saturated protein solutions are essentially evaporated to form a solid so scientists can study a protein’s structure. Understanding the crystal structure of a protein can help scientists get a better idea of disease mechanisms, identify drug targets and optimize drug design. Think drugs that have less side effects, are more effective or can withstand a greater array of conditions such as not needing to be refrigerated.
Years of research have shown that protein crystals grown in space are much higher quality than those grown on Earth. The plan is not to make the entire drug in outer space, just what is known as the primary active pharmaceutical ingredient, or the portion responsible for the therapeutic effects of a drug.
“You’re not going to see us making penicillin or ibuprofen or these types of very generic mass consumption targets, given the amount of crystalline you need to create is far beyond our current capabilities,” said Delian Asparouhov, co-founder and president of Varda Space Industries. “But there is a wide set of drugs that do billions and billions of dollars a year of revenue that actively fit within the manufacturing size that we can do even on our current manufacturing facility.”
Asparouhov said that in the U.S. in 2021 and 2022, of the hundreds and millions of doses of the Pfizer Covid vaccine administered, “the actual total amount of consumable primary pharmaceutical ingredient of the actual crystalline mRNA, it effectively was less than two milk gallon jugs.”
Across the Atlantic in Cardiff, Wales, Space Forge is working on designing its own in-space factory to manufacture next-generation semiconductors. Space Forge’s goal is to make semiconductor substrates using materials other than silicon to manufacture more efficient, higher performing chips.
“This next generation of materials is going to allow us to create an efficiency that we’ve never seen before,” said Andrew Parlock, managing director of Space Forge’s U.S. operations. “We’re talking about 10 to 100 X improvement in semiconductor performance.”
A rendering of Space Forge’s ForgeStar manufacturing satellite.
Space Forge
Just like with pharmaceuticals, the secret sauce to achieving this type of performance improvement in semiconductors lies in creating the perfect crystals in space. These types of advanced chips are important for industries such as 5G and electric vehicles. Similar to Varda, Space Forge plans to manufacture only part of the chips in space.
“Once we’ve created these crystals in space, we can bring them back down to the ground and we can effectively replicate that growth on Earth,” said Josh Western, CEO and co-founder of Space Forge. “So we don’t need to go to space countless times to build up pretty good scale operating with our FAB partners and customers on the ground.”
To learn more about in-space manufacturing as well as Varda and Space Forge’s plans to make the practice a viable business, watch the video.
Bay Area Rapid Transit (BART) passengers walk off a train at the Richmond station on March 15, 2023 in Richmond, California.
Justin Sullivan | Getty Images
Commuters in and around San Francisco rode into work for free on Tuesday morning due to an outage in the Clipper card system, which is used to handle payments for train, bus and ferry rides.
“ATTENTION: The Clipper system is experiencing an outage on all operators this morning,” the Bay Area Clipper account wrote in a post on X. “Please be prepared to pay your fare with another form of payment if required by your transit agency.”
Many buses were waving commuters on without asking for payment, and at Bay Area Rapid Transit (BART) train stations, the faregates were open, allowing travelers to walk through for free.
Clipper is owned by the Metropolitan Transportation Commission, which manages transportation for the nine-county Bay Area. The service is used by hundreds of thousands of tech workers in San Francisco and Silicon Valley.
The MTC website said there were 1.35 million unique Clipper cards — physical and digital — used in May, the highest monthly toll for the year and the most since December 2019, before the pandemic. A fact sheet from the MTC says Clipper is used by 800,000 transit riders a day across the region.
BART fare gates open on July 1, 2025, due to Clipper outage
Kif Leswing
BART, in particular, has undergone dramatic changes in recent years, most notably installing fare gates starting in late 2023, with full deployment expected to be completed by the end of this year.
In the first five months of the year, average BART station exits totaled between 170,000 and 182,000 a month, according to its website. Those numbers are way down from the pre-pandemic days of 2019, when averages were generally above 400,000 a month.
The MTC has plans to roll out an updated system called Clipper 2.0, which it says will be a “customer-focused, cost-effective fare collection system” with a “flexible platform for future fare structures.” Features include use across the various mobile operating systems, updated communication and “expanded retail, online and mobile sales.”
The update, however, has been routinely delayed, leading to tense confrontations at recent Clipper executive board meetings.
Corporate treasuries have surpassed ETFs in bitcoin buying for a third consecutive quarter as more companies try to benefit from the MicroStrategy playbook in a more crypto-friendly regulatory environment.
Public companies acquired about 131,000 coins in the second quarter, growing their bitcoin balance 18%, according to data provider Bitcoin Treasuries. ETFs showed an 8% increase or about 111,000 BTC in the same period.
“The institutional buyer who is getting exposure to bitcoin through the ETFs are not buying for the same reason as those public companies who are basically trying to accumulate bitcoin to increase shareholder value at the end of the day,” said Nick Marie, head of research at Ecoinometrics.
Public company bitcoin holdings increased 4% in April, a tumultuous month after the market was rocked by President Donald Trump’s initial tariffs announcement, versus 2% for ETFs, he pointed out.
“They don’t really care if the price is high or low, they care about growing their bitcoin treasury so they look more attractive to the proxy buyers,” Marie added. “It’s not so much driven by the macro trend or the sentiment, it’s for different reasons. So it becomes a different kind of mechanism that can push bitcoin forward.”
Bitcoin ETFs, whose collective U.S. launch in January 2024 was one of the most successful ETF debuts in history, still represent the largest holders of bitcoin by entity with more than 1.4 million coins held today, representing about 6.8% of the fixed supply cap of 21 million. Public companies hold about 855,000 coins, or about 4%.
Regulatory relief
The trend reflects the significant regulatory relief the crypto industry broadly is benefiting from under the Trump administration. In March, Trump signed an executive order for a U.S. bitcoin reserve, sending a strong message that the flagship cryptocurrency, which has long been a source of reputation risk among many investors, is here to stay. The last time ETFs outpaced public companies in bitcoin buying was in the third quarter of 2024, before Trump was re-elected.
In the second quarter, GameStop began buying bitcoin, after its board approved it as a treasury reserve asset in March; health-care company KindlyMD merged with Nakamoto, a bitcoin investment company founded by crypto entrepreneur David Bailey; and investor Anthony Pompliano’s ProCap, kicked off its own bitcoin purchasing program and is going public through a special purpose acquisition company, or SPAC.
Strategy, recently rebranded from MicroStrategy, is still the main behemoth in the bitcoin treasury game. The company pioneered the strategy that more than 140 public companies globally are now emulating. It holds about 597,000 BTC, and is followed by the bitcoin miner Mara Holdings, which has almost 50,000 coins.
“It’s going to be very hard to catch Strategy’s scale,” said Ben Werkman, chief investment officer at Swan Bitcoin. “They’re going to be the preferred landing spot for institutional capital because of the deep liquidity around their equity, while these smaller equities are going to be really good risk returns for retail investors and smaller institutions that want more of that upside – that initial growth that comes in kicking off the strategy – because a lot of people missed it with MicroStrategy.”
A long-term case?
Marie suggested that 10 years from now, there probably won’t be so many companies committed to the bitcoin treasury strategy. Firstly, he said, the more that enter the category, the more diluted the activity at each firm becomes. Plus, bitcoin may be so normalized by then that proxy buyers are no longer constrained by rules and mandates around direct exposure to bitcoin.
“You can think about this wave as a bunch of companies that are trying to benefit from this arbitrage,” Marie said.
Werkman pointed out that most investors that are attracted to bitcoin treasury companies today already have a thesis around bitcoin. For them, leveraged bitcoin equities are likely how they try to outperform bitcoin itself, the foundational component of their investments.
“What people really like about these companies, and why they like to get into these smaller companies, is because they can do something that the investors holding spot bitcoin can’t do: go and accumulate more bitcoin on your behalf because they have access to the capital markets and can issue securities,” Werkman said.
There’s also likely to be a fair number of companies that convert their existing treasury holdings to bitcoin without pursuing leverage the way Strategy does, Werkman noted.
“They’ve got that ability to generate more and more value behind their shares, backed by bitcoin, plus whatever the operations of the company are generating. It’s a unique value proposition,” he said.
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An image of a Quantix drone made by AeroVironment.
David Mcnew | Getty Images News | Getty Images
AeroVironment shares fell 7% Tuesday after the defense contractor said it plans to offer $750 million in common stock and $600 million in convertible senior notes due in 2030 to repay debt.
The drone maker said it would use leftover funding for general purposes such as boosting manufacturing capacity.
AeroVironment shares have soared 85% this year, ballooning its market value to about $13 billion.
Last week, shares of the Arlington, Virginia-based company rallied on strong fourth-quarter results, lifting higher as CNBC’s Jim Cramer called it the “next Palantir of hardware.”
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Last month, the company also closed its $4.1 billion acquisition of space-related defense tech company Blue Halo.
Earlier this month, President Donald Trump signed an executive order intended to boost drone production in the U.S. and crack down on unauthorized uses.
The company also has a high short interest level, which may have contributed to some of the recent gains, creating a short squeeze. This phenomenon occurs when a stock price surges, forcing those shorting the stock to purchase shares to cover their positions and prevent losses.