Live worm found in woman’s brain in world-first discovery
A woman who was experiencing forgetfulness and depression has had an 8cm-long parasitic roundworm removed from her brain.
The 64-year-old English woman, who was living in New South Wales, Australia, was admitted to hospital in January 2021 after three weeks of abdominal pain and diarrhoea, followed by a dry cough and night sweats.
By 2022, her symptoms had evolved to include forgetfulness and depression, prompting medical professionals to refer her to Canberra hospital.
An MRI scan of her brain revealed that a motile helminth – a parasitic roundworm – was living in the right frontal lobe lesion of her brain.
Surgical intervention became the only option, and doctors successfully removed the roundworm, which measured 8cm (80mm) in length and 1mm in diameter.
The live roundworm after it has been removed from the patient’s right frontal lobe. Pics: Centers for Disease Control and Prevention
Identified as a third-stage larva of the Ophidascaris robertsi nematode species, the case is unprecedented in medical history, and has been documented in the journal of Emerging Infectious Diseases.
Typically, this parasitic worm lives in the digestive tracts of carpet pythons indigenous to the Australian state of New South Wales.
Medical professionals suspect the woman inadvertently ingested the worm’s eggs by eating edible grasses that were tainted with snake faeces, however, the actual cause cannot be confirmed.
After the eggs hatched within her body, medics believe the larvae embarked on a journey to her brain. This could have been influenced by the medication she was taking, which compromised her immune system.
“We hypothesised that she inadvertently consumed eggs either directly from the vegetation or indirectly by contamination of her hands or kitchen equipment,” the medics said.
An image of the woman’s brain showing the right frontal lobe lesion
Ordeal began in 2021 – with evolving symptoms
The woman’s ordeal began in January 2021 when she was admitted to a hospital in Canberra.
Despite comprehensive tests, the results of her numerous medical tests remained inconclusive. Eventually, she received a diagnosis of pneumonia originating from an undisclosed source and was prescribed steroids.
Although her condition initially showed signs of improvement, she found herself readmitted to the hospital a few weeks later, plagued by a fever and an unrelenting cough.
Doctors suspected the presence of T-cell driven hypereosinophilic syndrome, a condition that can be life-threatening, characterised by the immune system going into overdrive. To address this, she was administered immunosuppressing medication as part of her treatment.
The worm seen under a microscope
A CT scan also unveiled multiple troubling findings, including pulmonary opacities, hepatic and splenic lesions.
Three weeks later, her condition worsened, prompting her admission to a tertiary hospital. With persistent fever and cough, her medical team escalated the investigation.
By January 2022, she experienced further changes, including forgetfulness and worsening depression over a three-month period, prompting doctors to examine her brain.
Subsequent scans unveiled a brain lesion, leading to her undergoing surgery in June of the previous year.
‘String-like structure’ discovered in brain
During the surgical procedure, an unusual “string-like structure” was discovered within the lesion, and to doctors’ astonishment, it began to wriggle.
Examination of the worm indicated its affiliation with a family of parasites typically exclusive to snakes. This marked the first documented instance of such a parasite infecting a human.
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Subsequent medical procedures revealed the absence of any additional worms residing within her body.
Half a year after the surgery, while the woman’s forgetfulness and depression had shown signs of improvement, they persisted to some extent.
Medical experts emphasised the significance of ongoing monitoring, as studies on rats have demonstrated that the worm’s eggs can endure within the body for over four years.
But they added that while the species of worm had been known to infect animals’ digestive systems, it had not been discovered in the brain of any species before.
The medics said that while the particular worm in question is exclusive to Australia, there are similar species located in other parts of the world, suggesting the potential for further occurrences in the future.
They also emphasised that the case underscored the persisting danger of zoonotic diseases transmitted between humans and animals.
Zoonotic diseases, which transfer from animals to humans, are frequently mentioned as potential triggers for pandemics.
Ramesh lives in fear every day. A police siren is enough to alarm him.
He’s one of up to 400,000 visa overstayers in the UK, one lawyer we spoke to believes.
It’s only an estimate because the Home Office has stopped collecting figures – which were unreliable in the first place.
Britain is being laughed at, one man told us, “because they know it’s a soft country”.
‘Ramesh’ came to the UK from India
We meet Ramesh (not his real name) at a Gurdwara, a Sikh place of worship, where he goes for food and support.
He insists he can’t return to India where he claims he was involved in political activism.
Ramesh says he came to the UK on a student visa in 2023, but it was cancelled when he failed to continue his studies after being involved in a serious accident.
He tells us he is doing cash-in-hand work for people who he knows through the community where he is living and is currently working on a house extension where he gets paid as little as £50 for nine hours labouring.
“It’s very difficult for me to live in the UK without my Indian or Pakistani community – also because there are a lot of Pakistani people who give me work in their houses for cleaning and for household things,” he adds.
‘What will become of people like us?’
Anike has lived in limbo for 12 years.
Now living in Greater Manchester, she came to the UK from Nigeria when her sister Esther was diagnosed with a brain tumour – she had a multi-entry visa but was supposed to leave after three months.
Esther had serious complications from brain surgery and says she is reliant on her sister for care.
Immigration officials are in touch with her because she has to digitally sign in every month.
Anike has had seven failed applications for leave to remain on compassionate grounds refused but is now desperate to have her status settled – afraid of the shifting public mood over migration.
“Everybody is thinking ‘what will become of people like us?'” she adds.
‘It’s a shambles’
The government can’t say with any degree of accuracy how many visa overstayers there are in Britain – no data has been collated for five-and-a-half years.
But piecing together multiple accounts from community leaders and lawyers the picture we’ve built is stark.
Immigration lawyer Harjap Singh Bhangal told us he believed there could be several hundred thousand visa overstayers currently in Britain.
He says: “At this time, there’s definitely in excess of about 200,000 people overstaying in the UK. It might even be closer to 300,000, it could even be 400,000.”
Asked what evidence he has for this he replies: “Every day I see at least one overstayer, any immigration lawyers like me see overstayers and that is the bulk of the work for immigration lawyers.
“The Home Office doesn’t have any accurate data because we don’t have exit controls. It’s a shambles. It’s an institution where every wall in the building is cracked.”
The number of those who are overstaying visas and working cash in hand is also virtually impossible to measure.
‘They know Britain is a soft country’
“They’re laughing at us because they know Britain is a soft country, where you won’t be picked up easily,” says the local man we’ve arranged to meet as part of our investigation.
We’re in Kingsbury in northwest London – an area which people say has been transformed over the past five years as post-Brexit visa opportunities opened up for people coming from South Asia.
‘Mini-Mumbai’
The man we’re talking to lives in the community and helps with events here. He doesn’t want to be identified but raises serious questions about visa abuse.
“Since the last five years, a huge amount of people have come in this country on this visiting visa, and they come with one thing in mind – to overstay and work in cash,” he says.
“This area is easy to live in because they know they can survive. It looks like as if you are walking through mini-Mumbai.”
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‘The system is more than broken’
‘It’s taxpayers who are paying’
And he claims economic migrants are regularly arriving – who’ve paid strangers to pretend they’re a friend or relative in order to obtain a visitor visa to get to Britain.
He says: “I’ve come across so many people who have come this way into this country. It’s widespread. When I talk to these people, they literally tell me, ‘Oh, someone is coming tomorrow, day after tomorrow, someone is coming’.
“Because they’re hidden they may not be claiming benefits, but they can access emergency healthcare and their children can go to school.
“And who is paying for it? It’s the taxpayers who are paying for all this,” says the man we’ve met in north London.
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A Home Office spokesperson said: “We will not tolerate any abuse of our immigration system and anyone found to be breaking the rules will be liable to have enforcement action taken against them.
“In the first year of this government, we have returned 35,000 people with no right to be here – a 13% rise compared to the previous year.
“Arrests and raids for illegal working have soared to their highest levels since records began, up 63% and 51%.”
The government can’t say with accuracy how many visa overstayers there are in Britain – no data has been collated for five-and-a-half years.
Sky News has spoken to immigration lawyers about the numbers, and one believes there could be as many as 400,000 living across the country.
Harjap Singh Bhangal described the situation as a “shambles”.
“The Home Office doesn’t have any accurate data because we don’t have exit controls. It’s a shambles. It’s an institution where every wall in the building is cracked,” he told Sky’s Lisa Holland.
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The visa overstayers in ‘soft’ Britain
Why doesn’t the government know?
The Home Office used to gather data on visa overstayers by effectively checking a list of passport numbers associated with visas against a list of passport numbers of people leaving the UK, taken from airlines and other international travel providers.
If there was a passport number match in the arrivals and departures part of their database, that person was recorded to have left when they should have. If there wasn’t, they were a potential overstayer.
They stopped producing the figures because a combination of Brexit and COVID added complications that made the Home Office conclude they wouldn’t be able to get to a reliable number using the same method.
It’s now four and a half years since EU citizens had freedom of movement to the UK revoked, and more than three and a half years since pandemic-era travel restrictions ended.
And yet we are still waiting to see what a new method might look like.
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The old method wasn’t perfect. If someone changed their passport while in the UK, for example, or if the airline or individual entered the number wrong when they were leaving, there wouldn’t be a match.
The Home Office regarded the statistics as likely overestimating the true number of overstayers, and the Office for National Statistics designated the figures as “experimental” rather than “official” statistics, meaning the conclusions should be treated with caution. But they were a reasonable best guess.
With all that in mind, between April 2016 and March 2020 upwards of 250,000 people were flagged as potential overstayers, equivalent to 63,000 per year.
That’s more than the 190,000 people who are recorded to have arrived in the UK on small boats since 2018.
It represents 3.5% of the seven million visas that expired over that period, so at least 96.5% of people left when they should.
Other Home Office data reveals that more than 13 million visas were issued between 2020 and the end of June 2025, including a record 3.4 million in 2023.
But what we don’t know is how many have expired, which means it’s difficult for us to even guess how many people might have overstayed.
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