The Nobel Prize in medicine has been awarded to two scientists for their research which led to the development of effective mRNA vaccines against COVID-19.
The accolade, among the most prestigious in the scientific world, went to Katalin Kariko, from Hungary, and Drew Weissman, from the United States.
“Through their groundbreaking findings, which have fundamentally changed our understanding of how mRNA interacts with our immune system, the laureates contributed to the unprecedented rate of vaccine development during one of the greatest threats to human health in modern times,” the panel that awarded the prize said.
Both COVID-19 vaccines Pfizer/BioNTech and Moderna use something called messenger RNA (mRNA) to send genetic instructions to the body’s cells to recognise and destroy a particular part of the coronavirus called the spike protein.
When the body develops an immune response to this spike protein it is then able to fight off the coronavirus without having ever been exposed to the virus itself.
Ms Kariko is a professor at Sagan’s University in Hungary and an adjunct professor at the University of Pennsylvania.
She was senior vice president and head of RNA protein replacement at BioNTech until 2022 and has since acted as an adviser to the German firm.
Mr Weismann performed his prize-winning research with Ms Kariko at the University of Pennsylvania.
Thomas Perlmann, secretary of the Nobel Assembly, announced the prize and said both scientists were “overwhelmed” by the news when he contacted them.
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Image: The winners of the 2023 Nobel Prize in medicine were announced during a ceremony in Stockholm, Sweden
“This year’s Nobel Prize recognises their basic science discovery that fundamentally changed our understanding of how mRNA interacts with the immune system, and had a major impact on society during the recent pandemic,” said Rickard Sandberg, a member of the Nobel Assembly at Karolinska Institute.
“Together they have saved millions of lives, prevented severe COVID-19, reduced the overall disease burden and enabled societies to open up again.”
Dr Paul Hunter, a professor of medicine at the University of East Anglia, described the mRNA vaccines as a “game changer” in helping to shut down the coronavirus pandemic, crediting the jabs with saving millions of lives.
“If it hadn’t been for the mRNA technology, COVID would have been much worse,” he said.
“Vaccines generally were the turning point in slowing down COVID and the mRNA vaccines were just so much better than all the others.
“We would likely only now be coming out of the depths of COVID without the mRNA vaccines,” he added.
Monday’s announcement in Stockholm, Sweden, kicks off this year’s awards with the remaining five to be unveiled in the coming days.
The prizes, first handed out in 1901, were created by Swedish dynamite inventor and wealthy businessman Alfred Nobel, and are awarded for achievements in physics, chemistry, literature and peace, and in later years also for economics.
They carry a cash award of 11 million Swedish kronor (£820,000). The money comes from a bequest left by the prize’s creator, who died in 1896.
A large-scale Russian attack through the night into Sunday injured at least 11 in Kyiv and killed three people in towns surrounding the capital.
There were attacks elsewhere as well, including drone strikes in Mykolaiv, where a residential building was hit.
Image: An apartment building destroyed after a Russian attack in Mykolaiv. Pic: State Emergency Service of Ukraine
‘Massive’ attack
In Kyiv, the city’s administration warned “the night will be difficult”, as people were urged to remain in shelters.
The city’s mayor Vitaliy Klitschko described it as a “massive” attack.
He said: “Explosions in the city. Air defence forces are working. The capital is under attack by enemy UAVs. Do not neglect your safety! Stay in shelters!”
It came after at least 15 people were injured in attacks the night prior.
Russia claimed it also faced a Ukrainian drone attack on Sunday, and that it intercepted and destroyed around 100 of them near Moscow and across Russia’s central and southern regions.
Image: A municipality worker cleans up after a Russian drone strike on Kyiv. Pic: Reuters
Russia ‘dragging out the war’
Meanwhile, Russia and Ukraine continued a prisoner exchange, marking a rare moment of cooperation in the war.
Amid the most recent attacks, Ukrainian President Volodymyr Zelenskyy repeated his calls for sanctions on Russia.
Russia “fills each day with horror and murder” and is “simply dragging out the war”, he said.
Image: A resident looks at an apartment building that was damaged in a Russian drone strike. Pic: Reuters
“All of this demands a response – a strong response from the United States, from Europe, and from everyone in the world who wants this war to end,” Mr Zelenskyy added.
Every day “gives new grounds for sanctions against Russia”, he said, and each day without pressure proves the “war will continue”.
Ukraine, meanwhile, is ready for “any form of diplomacy that delivers real results”.
Nine of a doctor’s 10 children have been killed in an Israeli missile strike on their home in Gaza, which also left her surviving son badly injured and her husband in a critical condition.
Warning: This article contains details of child deaths
Alaa Al Najjar, a paediatrician at Al Tahrir Clinic in the Nasser Medical Complex, was at work during the attack on her home, south of the city of Khan Younis in southern Gaza, on Friday.
Graphic footage shared by the Hamas-run Palestinian Civil Defence shows the bodies of at least seven small children being pulled from the rubble.
Rescuers can be seen battling fires and searching through a collapsed building, shouting out when they locate a body, before bringing the children out one by one and wrapping their remains in body bags.
In the footage, Dr Al Najjar’s husband, Hamdi Al Najjar, who is also a doctor, is put on to a stretcher and then carried to an ambulance.
The oldest of their children was only 12 years old, according to Dr Muneer Alboursh, the director general of Gaza’s health ministry, which is run by Hamas.
Image: Nine children were killed in the strike. Pic: Palestinian Civil Defence
“This is the reality our medical staff in Gaza endure. Words fall short in describing the pain,” he wrote in a social media post.
“In Gaza, it is not only healthcare workers who are targeted – Israel’s aggression goes further, wiping out entire families.”
Image: Pic: Palestinian Civil Defence
British doctors describe ‘horrific’ and ‘unimaginable’ attack
Two British doctors working at Nasser Hospital described the attack as “horrific” and “unimaginable” for Dr Al Najjar.
Speaking in a video diary on Friday night, Dr Graeme Groom said his last patient of the day was Dr Al Najjar’s 11-year-old son, who was badly injured and “seemed much younger as we lifted him on to the operating table”.
Image: Hamdi Al Najjar, Dr Al Najjar’s husband who is also a doctor, was taken to hospital. Pic: Palestinian Civil Defence
The strike “may or may not have been aimed at his father”, Dr Groom said, adding that the man had been left “very badly injured”.
Dr Victoria Rose said the family “lived opposite a petrol station, so I don’t know whether the bomb set off some massive fire”.
Image: Pic: Palestinian Civil Defence
‘No political or military connections’
Dr Groom added: “It is unimaginable for that poor woman, both of them are doctors here.
“The father was a physician at Nasser Hospital. He had no political and no military connections. He doesn’t seem to be prominent on social media, and yet his poor wife is the only uninjured one, who has the prospect of losing her husband.”
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2:21
Nineteen of Gaza’s hospitals remain operational, all of them are overwhelmed with the number of patients and a lack of supplies
He said it was “a particularly sad day”, while Dr Rose added: “That is life in Gaza. That is the way it goes in Gaza.”
Sky News has approached the Israeli Defence Forces for comment.
Israel’s war against Hamas in Gaza began when the militant group stormed across the border into Israel on 7 October 2023, killing some 1,200 people, most of them civilians, and abducting 251 others.
Israel’s military response has flattened large areas of Gaza and killed more than 53,000 Palestinians, mostly women and children, according to Gaza’s Hamas-run health ministry, which does not differentiate between civilians and combatants in its count.
The head of the UN has said Israel has only authorised for Gaza what amounts to a “teaspoon” of aid after at least 60 people died in overnight airstrikes.
UN secretary general Antonio Guterres said on Friday the supplies approved so far “amounts to a teaspoon of aid when a flood of assistance is required,” adding “the needs are massive and the obstacles are staggering”.
He warned that more people will die unless there is “rapid, reliable, safe and sustained aid access”.
Image: A woman at the site of an Israeli strike in Jabalia, northern Gaza. Pic: Reuters
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Gaza: ‘Loads of children with huge burns’
Israel says around 300 aid trucks have been allowed through since it lifted an 11-week blockade on Monday, but according to Mr Guterres, only about a third have been transported to warehouses within Gaza due to insecurity.
The IDF said 107 vehicles carrying flour, food, medical equipment and drugs were allowed through on Thursday.
Many of Gaza’s two million residents are at high risk of famine, experts have warned.
Meanwhile, at least 60 people have been killed by Israeli airstrikes across Gaza overnight.
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Ten people died in the southern city of Khan Younis, and deaths were also reported in the central town of Deir al-Balah and the Jabaliya refugee camp in the north, according to the Nasser, Al-Aqsa and Al-Ahli hospitals where the bodies were brought.
Image: A body is carried out of rubble after an Israeli strike in Jabalia, northern Gaza. Pic: Reuters
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‘Almost everyone depends on aid’ in Gaza
The latest strikes came a day after two Israeli embassy workers were killed in Washington.
The suspect, named as 31-year-old Elias Rodriguez from Chicago, Illinois, told police he “did it for Gaza”.
Israeli Prime Minister Benjamin Netanyahu accused Sir Keir Starmer, Emmanuel Macron and Mark Carney of fuelling antisemitism following the shootings.
Mr Netanyahu also accused Sir Keir, Mr Macron and Mr Carney of siding with “mass murderers, rapists, baby killers and kidnappers”.
Image: Palestinians search for casualties in Jabalia, northern Gaza. Pic: Reuters
But UK government minister Luke Pollard told Sky News on Friday morning he “doesn’t recognise” Mr Netanyahu’s accusation.
Earlier this week, Mr Netanyahu said he was recalling negotiators from the Qatari capital, Doha, after a week of ceasefire talks failed to bring results. A working team will remain.
The war in Gaza began when Hamas-led militants attacked southern Israel on 7 October 2023, killing some 1,200 people, mostly civilians, and kidnapping 251 others.
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The militants are still holding 58 captives, around a third of whom are believed to be alive, after most of the rest were returned in ceasefire agreements or other deals.
Israel’s offensive, which has destroyed large swaths of Gaza, has killed more than 53,000 Palestinians, mostly women and children, according to Gaza’s Hamas-run health ministry.