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By Dr. Priyom Bose, Ph.D. Oct 5 2023 Reviewed by Lily Ramsey, LLM

In a recent study published in Scientific Reports, researchers investigated the potential of minimal exercise (MAE) to prevent dementia in cognitively normal older individuals with osteoarthritis (OA).

Study:  Minimal amount of exercise prevents incident dementia in cognitively normal older adults with osteoarthritis: a retrospective longitudinal follow-up study . Image Credit: Ground Picture/Shutterstock.com Background

Numerous studies have highlighted the benefits of regular aerobic exercise in preventing cardiovascular diseases (CVD) and degenerative brain disorders like senile dementia.

However, older adults with OA often face challenges in maintaining regular exercise due to joint pain and mobility limitations. Since about 10% of the elderly population worldwide develops dementia, finding preventive measures is crucial.

Physicians can play a vital role in influencing exercise behavior in older adults, but time constraints, limited training, and inadequate reimbursement hinder their ability to provide effective counseling.

MAE refers to the smallest amount of physical activity that can enhance health and reduce mortality, often involving brief, sporadic, or infrequent exercise sessions. About the study

This longitudinal, retrospective cohort study examined the impact of MAE on dementia prevention in older adults with OA. Participants from the History-Based Artificial Intelligence Activities of Daily Living (HAI-ADL) database were screened.

The study included participants aged 50 or older, diagnosed with OA, and possessing comprehensive medical records. The research compared dementia incidence among different MAE frequency groups. Study findings

The study included 242 participants without dementia but with OA, divided into MAE-no (121 participants), MAE-weekly (51 participants), and MAE-daily (70 participants) groups. The conversion rates to dementia were estimated at 47.9%, 33.3%, and 17.1% for the MAE-no, MAE-weekly, and MAE-daily groups, respectively. Related StoriesResearch could lead to the development of new weight-loss drug that mimics exerciseUnderstanding how exercise suppresses appetite could pave the way for new obesity drugsTraumatic life events may directly increase your risk for dementia

Adjusted for various factors, the Cox proportional hazards model indicated that both MAE-daily and MAE-weekly groups had a significant decrease in dementia incidence compared to the reference group.

The multivariate logistic regression model showed that MAE-daily significantly reduced dementia incidence and improved cardiac conditions. These findings align with previous research indicating that even minimal exercise can prevent cognitive decline in older individuals with OA. Conclusions

While the study has limitations, such as a small sample size and recruitment from specific centers in Taiwan, it underscores the importance of promoting MAE interventions, such as walking, in older populations with OA.

Even minimal exercise, when performed regularly, can enhance joint health and cognitive well-being, making it a valuable strategy for preventing dementia in this demographic. Journal reference:

Chung, Y. et al. (2023) Minimal amount of exercise prevents incident dementia in cognitively normal older adults with osteoarthritis: A retrospective longitudinal follow-up study. Scientific Reports, 13(1), pp.1-9. doi: https://doi.org/10.1038/s41598-023-42737-3. https://www.nature.com/articles/s41598-023-42737-3

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CNBC Daily Open: The weight of Nvidia’s crown

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CNBC Daily Open: The weight of Nvidia's crown

Jensen Huang is interviewed by media during a reception for the 2025 Queen Elizabeth Prize for Engineering, at St James’ Palace November 5, 2025 in London, England, U.K.

Yui Mok | Getty Images Entertainment | Getty Images

Uneasy lies the head that wears the crown.

Shares of artificial intelligence czar Nvidia fell 2.6% on Tuesday as signs of unrest continued rippling through its kingdom.

Over the month, Nvidia has been contending with concerns over lofty valuations and an argument from the “The Big Short” investor Michael Burry that companies may be overestimating the lifespan of Nvidia’s chips. That accounting choice inflates profits, he alleged.

The pressure intensified last week in the form of a potential challenger to the crown. Google on Nov. 18 announced the release of its new AI model Gemini 3 — so far so good, given that Nvidia isn’t in the business of designing large language models  — powered by its in-house AI chips — uhoh.

And on Monday stateside, Meta, a potential kingmaker, appeared to signal that it is considering not just leasing Google’s custom AI chips, but also using them for its own data centers. It seemed like Nvidia felt the need to address some of those rumblings.

The chipmaker said on the social media platform X that its technology is more powerful and versatile than other types of AI chips, including the so-called ASIC chips, such as Google’s TPUs. Separately, Nvidia issued a private memo to Wall Street that disputed Burry’s allegations.

Power, whether in politics or semiconductors, requires a delicate balance.

Remaining silent may shroud those in power in a cloak of untouchability, projecting confidence in their authority — but also aloofness. Deigning to address unrest can soothe uncertainty, but also, paradoxically, signal insecurity.

For now, the crown is Nvidia’s to wear — and the weight of it is, too.

What you need to know today

The UK Autumn Budget 2025 is here. Britain prepares for a “smorgasbord” of tax hikes to be unveiled Wednesday. Follow CNBC’s coverage of the Budget throughout the day on our live blog here

U.S. stocks advanced on Tuesday. Major indexes had their third straight winning session, erasing earlier intraday losses. Asia-Pacific markets rose Wednesday. Shares of Foxconn climbed more than 3% after the firm received approval for a contract amendment.

Meta is looking to use Google AI chips. That’s according to a Monday report by The Information. Nvidia on Tuesday wrote on X that its chips are “a generation ahead of the industry.” The chipmaker also sent analysts a memo on alleged bubble claims.

Taiwan President pledges $40 billion more for defense. Lai Ching-te, Taiwan’s leader, on Wednesday said the self-governing island will improve its self-defense capabilities in the face of “unprecedented military buildup” by China.

[PRO] What to watch as UK budget is unveiled. Strategists told CNBC they will be monitoring the budget’s effects on interest rates, economic growth and the British pound — and one “rabbit out of the hat” from U.K. Finance Minister Rachel Reeves.

And finally…

Lights on in skyscrapers and commercial buildings on the skyline of the City of London, UK, on Tuesday, Nov. 18, 2025. U.K. business chiefs urged Chancellor of the Exchequer Rachel Reeves to ease energy costs and avoid raising the tax burden on corporate Britain as she prepares this year’s budget.

Bloomberg | Bloomberg | Getty Images

The UK’s Autumn Budget is coming: Here’s what it could mean for your money

The run-up to this year’s U.K. Autumn Budget has been different from the norm because so many different tax proposals have been floated, flagged, leaked and retracted in the weeks and months leading up to Wednesday’s statement.

It has also made it harder to gauge what we’re actually going to get when Finance Minister Rachel Reeves finally unveils her spending and taxation plans for the year ahead.

— Holly Ellyatt

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Uber rolls out driverless robotaxis in Abu Dhabi

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Uber rolls out driverless robotaxis in Abu Dhabi

Driverless WeRide robotaxis for Uber.

Courtesy: Uber

Uber on Wednesday rolled out fully driverless rides in its fourth market, launching the service in Abu Dhabi in partnership WeRide, a Chinese autonomous vehicle company.

The ride-hailing company said the launch in the United Arab Emirates capital represents the first driverless robotaxi service in the Middle East. In the U.S., Uber already offers robotaxi services in Austin, Phoenix and Atlanta through Alphabet’s Waymo.

Riders in Abu Dhabi can book a WeRide robotaxi when requesting an UberX or Uber Comfort ride, the ride-hailing company said.

WeRide, which is listed on the Nasdaq, formed its partnership with Uber in September 2024 and began offering autonomous rides with an operator on board in Abu Dhabi last December. Uber and WeRide also debuted robotaxi rides with a safety operator on board in Riyadh, Saudia Arabia, in October. In May, Uber said it plans to roll out the WeRide service to 15 more cities, including in Europe, over the next five years.

In recent years, Uber has bet big on autonomous vehicle technology through partnerships.

Uber started offering a robotaxi service in Austin and Atlanta earlier this year, and in Phoenix in late 2023. In July, the company landed a six-year robotaxi deal with electric vehicle maker Lucid and AV startup Nuro.

WeRide, meanwhile, has launched full driverless robotaxi services in China’s Beijing and Guangzhou, according to its website.

Uber has not said how it splits revenue from robotaxi rides with its partners.

Competitors have also readily adopted the technology, with Lyft announcing a deal with Waymo in September to launch robotaxis in Nashville next year.

Uber said the driverless vehicles in Abu Dhabi will operate in certain areas of Yas Island. Riders can boost their chance of a robotaxi drive by selecting the autonomous option. On-board support is available during the ride through the app and an in-vehicle tablet.

WATCH: WeRide CEO: We are using both Tesla and Waymo’s approach to scale robotaxi operations

WeRide CEO: We are using Tesla and Waymo's approach to scale robotaxi operations

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Uber launches true driverless robotaxi operations in the Middle East with WeRide [Video]

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Uber launches true driverless robotaxi operations in the Middle East with WeRide [Video]

Just over a year after Uber announced a strategic partnership in the Middle East with autonomous vehicle specialist WeRide, the companies have officially begun offering the public robotaxi rides without a driver or safety operator present on board.

Today’s latest milestone involving robotaxi operations in the Middle East dates back to September 2024, when Uber and WeRide initially announced a strategic partnership to bring autonomous rides to the UAE.

Three months later, the partner officially launched autonomous rides in Abu Dhabi, but with a safety operator present in the vehicle. At the time, Uber and WeRide said the supervised rides were “laying the groundwork” for a true driverless commercial operations planned for 2025.

That day has come.

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WeRide and Uber have confirmed that commercial robotaxi operations are officially underway in Abu Dhabi without any safety operators on board – a first for the Middle East.

Uber Middle East
Source: Uber

Uber rolls out Middle East robotaxi operations in Abu Dhabi

Uber shared details of its latest milestone late this evening or in the afternoon in the Middle East, depending on where you are.

Beginning today (Wednesday) customers in Abu Dhabi can select an UberX or Uber Comfort ride that enables them to be matched with a fully autonomous WeRide robotaxi without a driver inside. Riders in the Middle East can also increase their chances of hailing one of these driverless rides by select the “Autonomous” option in the Uber app.

In order to qualify, the prosepctive rider’s route must be part of WeRide’s operating territory in Abu Dhabi and a dedicated WeRide GXR Robotaxi vehicle (seen in the featured image above) must be available.

Similar to Uber’s partnership with Waymo in Austin and Atlanta, the global rideshare network will oversee fleet operations for WeRide vehicles, handling end-to end rider support. It has tapped Tawasul Transport to facilitate vehicle cleaning, maintenance, inspections, charging, and depot management. WeRide will remain responsible for vehicle testing.

As you may recall last spring, Uber and WeRide announced an expansion to their strategic partnership beyond the Middle East (although Dubai will be the city for its next robotaxi rollout). Over the next five years, Uber and WeRide intend to deploy true driverless public rides in 15 additional cities, some of which will be in Europe.

As promised, here’s some b-roll footage from Uber showing how riders in Abu Dhabi can order a WeRide robotaxi:

Source: Uber

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