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Share on Pinterest New research suggests that an inexpensive and common prescription drug used to treat migraine, nerve and back pain, and depression may also help improve irritable bowel syndrome (IBS) symptoms. Dima Berlin/Getty ImagesAn inexpensive and widely available drug called amitriptyline has been shown to improve IBS symptomsThe drug was found to be almost twice as effective as a placebo in a recent trial. Amitriptyline may improve IBS symptoms by regulating the nervous system and stopping the reuptake of serotonin by the brain. Experts say this is promising news for people with IBS, but Amitriptyline is not without risk.

New research has found that amitriptyline, a cheap and widely available prescription drug, can improve symptoms of Irritable Bowel Syndrome (IBS).

The research presented Monday at UEG Week 2023 found that doses of the drug (commonly used to treat a range of health concerns, including migraine, nerve and back pain, and depression) could also improve IBS.

Conducted by researchers at the Universities of Leeds, Southampton, and Bristol the study shows that patients taking amitriptyline were almost twice as likely to report an overall improvement in symptoms as those taking a placebo.

During the study, doctors prescribed amitriptyline and patients managed their own dose based on the severity of their symptoms, using an adjustment document designed for the trial.

As a result of the study, the trial team are now recommending that doctors support their patients with IBS to use amitriptyline to manage their symptoms.

Amitriptyline is an effective treatment for IBS and is safe and well tolerated, co-chief Investigator Dr. Alexander Ford, Professor of Gastroenterology at the University of Leedss School of Medicine, said in a press release. This new rigorously conducted research indicates that general practitioners should support patients in primary care to try low-dose amitriptyline if their IBS symptoms havent improved with recommended first-line treatments.

The trial team has made an adjustment document available to clinicians and patients. How amitriptyline may help treat IBS symptoms

Jaspreet Randhawa, holistic pharmacist and founder of Whole Body Pharmacist, says the results of this study are promising for patients who are living with IBS.

She isnt surprised that amitriptyline is beneficial for gut issues, as well as many other ailments.

The results make sense when looking at the method of action of amitriptyline on the nervous system; it works by stopping the reuptake of serotonin by the brain, she explains. With 90-95% of serotonin production occurring in the gut, it would seem viable that the gut can be affected by a regular dose of amitriptyline.

Dr. Semiya Aziz, a general practitioner and founder of Say GP, agrees with this synopsis. She notes that many of the conditions amitriptyline is used to treat are associated with nerve-based issues.

We know that IBS is a condition which affects the gastrointestinal tract and currently a large amount of research is being carried out on the effects of gut-brain axis and nervous system, she points out.

Therefore, its not difficult to understand how amitriptyline can help with IBS symptoms when we have used this drug to treat people with nerve-related problems in the past.

In particular, amitriptyline may play an important role in regulating the vagus nerve.

Irritation of this nerve can cause vagal nerve dysfunction and possibly IBS symptoms, Aziz explains.

Effecting both the nervous system and serotonin, Aziz reasons that amitriptyline alleviates IBS symptoms by having an overall calming effect on gut function, relieving pain and causing changes in bowel activity. Amitriptyline may improve future treatment of IBS symptoms

So, what does all this mean for how IBS may be treated in the future?

Aziz believes the findings of the study may be an important milestone in helping to relieve individuals who have exhausted all other options of treatment for IBS, especially where IBS has impacted their work, social and daily lives.

In reality, this is a drug that could easily be prescribed in primary care for patients suffering from IBS because it is cheap and widely available but it has its limitations, she warns.

In particular, she says it may be difficult for patients to adjust or self-dose themselves safely.

Realistically if the medication is given out for IBS, it will need to be regularly monitored and dosages adjusted by the patients [doctor] or the healthcare support system, Aziz notes.

Still, Randhawa thinks that amitriptyline can be of great benefit to a proportion of people living with IBS.

I believe some people will find significant relief of their IBS symptoms and I am confident that [doctors] will be able to assess the patients ability to manage their symptoms and hope they will review frequently to support them on their healthcare journey, she surmises. Concerns and risks of using amitriptyline to treat IBS

Common IBS symptoms include cramping, bloating, excessive gas, and diarrhea or constipation which can be debilitating and can range from mild to severe.

In primary care, it is difficult to identify the severity of IBS, so it is difficult to know who would benefit from the treatment the most, Aziz points out.

Add to that, there is still much uncertainty about the causative factor for IBS.

Aziz says its often the result of many factors, such as muscle contractions of the intestine or irritation of the nervous system due to stress or infections.

Most patients who present in primary care with IBS will present with multifactorial medical issues which may not easily be resolved by using just amitriptyline alone, she explains.

Therefore, it can be difficult to know just how effective amitriptyline will be for you.

Another point to consider is that the drug may have serious side effects at higher doses. These can include headaches, dizziness, and suicidal thoughts. Takeaway

While there is rarely a one-size-fits-all treatment to improve any health condition, its certainly promising that a cheap and widely available drug has been shown to positively impact IBS symptoms in a trial.

IBS is a debilitating condition that affects many people and amitriptyline appears to be an effective and accessible way to treat it.

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Hamas confirms direct peace talks with US – as it calls on Trump to ‘pressure’ Israel

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Hamas confirms direct peace talks with US - as it calls on Trump to 'pressure' Israel

A senior Hamas official has confirmed the militant group is in direct talks with the United States over peace in Gaza, adding that it believes Donald Trump can help broker a deal.

Speaking to Sky News’ lead world news presenter Yalda Hakim, Dr Basem Naim said Hamas has shared its proposed agreement both through mediators and “directly with some persons in the US administration”.

They are calling for “a prisoner exchange, total withdrawal of Israeli forces, allowing all the aid to get into Gaza and rebuilding of [the] Gaza Strip without forceful immigration,” he said.

Basem Naim being interviewed by Yalda Hakim
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Basem Naim

Dr Naim also addressed whether Hamas – which has been in power since it won the 2006 Palestinian election – could step down from government in order to secure peace.

“We have also told the Americans, we are ready to, again, to hand over the government immediately if we reach an end of this war,” he said.

Donald Trump at an air base in Qatar
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Trump, seen here at a US airbase in Qatar, is on the final day of a Middle East tour

Dr Naim added Hamas has “accepted” an Egyptian peace proposal which “is talking about forming a Palestinian, independent, politically unaffiliated body to run the Gaza Strip”.

“Before that, as long as we are still occupied people, we have all the right to continue defending our people and resisting the occupation with all means including under resistance,” he said.

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Turning his attention directly to the US president, the senior Hamas official said he thinks Mr Trump “has the capability and the will to reach this peaceful situation”.

He said: “Gaza and Gazans are deserving, like all other people everywhere, to live in peace and dignity.

“And I think President Trump can do it if he exercises enough pressure on the Israelis to end this war immediately. And we are ready to cooperate with him to achieve this goal of a more peaceful region.”

Responding to the interview with Hamas, White House National Security Council spokesman James Hewitt told Sky News that Hamas “has not demonstrated they are serious about peace” and that Mr Trump “has been clear Hamas must lay down their arms”.

“Hamas continues to wrongfully hold hostages, including American bodies, in the dungeons of Gaza who could easily be freed and have shown no changes in behaviour to indicate they will cease to attack civilians,” he added.

Hamas has set out ceasefire conditions – but Trump remains as stern as ever


 Yalda Hakim joined Sky News at the end of last year

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Lead world news presenter

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Donald Trump’s Middle East tour has been full of surprises.

But the revelation that officials in his administration are speaking directly to Hamas is one of the most significant.

As the US president addressed troops at the Al Udeid airbase in Qatar – the largest in the region – I sat down with a senior Hamas official who confirmed direct talks were ongoing.

In an exclusive interview, Dr Bassem Naim praised Trump and talked up chances of finding a peaceful resolution.

It’s a remarkable statement from a senior figure within the group, which is considered by the US and UK to be a terrorist organisation.

Much has been made of Trump’s ‘transactional’ approach here in the region.

His commitment to the ‘art of the deal’ can often achieve unexpected results but also anger his allies – which is almost certainly the case with Israel’s embattled Prime Minister Benjamin Netanyahu.

When I asked Dr Naim about the demands from Israel and the United States for Hamas to disarm and accept that it can no longer be the governing force in Gaza, he set out conditions that Hamas says would have to be met.

However, President Trump’s public stance on Hamas remains as stern as ever.

The group “needed to be dealt with” he said earlier, adding he has “concepts for Gaza,” and that the US should “take it” and turn it into a “freedom zone”.

Israel’s war in Gaza has now entered its 20th month with more than 53,000 people believed to be dead, according to Gaza’s Hamas-run health ministry.

Some 15,000 of them are children, according to UNICEF.

There are still more than 50 Israeli hostages held by Hamas in the Strip.

In a statement released on Thursday, Hamas highlighted the fact it recently released hostage Edan Alexander, an Israeli soldier with American citizenship.

It continued: “We expect, based on the understandings reached with the American side, and with the knowledge of the mediators, that humanitarian aid should have entered the Gaza Strip immediately, a call been made for a permanent ceasefire, and that comprehensive negotiations would have been held on all issues to achieve security and stability in the region, a goal we aspire to achieve.

“However, failure to achieve these steps, especially the entry of humanitarian aid to our people, will cast a negative effect over any efforts to complete negotiations on the prisoner exchange process.”

Read more:
Analysis of Gaza hospital attack contradicts Israel
Gaza aid ship bombed by drones

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Analysis: Israel’s escalation in Gaza

The US president has previously shared plans of his own for Gaza and in February, he posted a bizarre AI video showing the region transformed into a paradise complete with its own Trump tower and exotic beaches.

The States could “own that piece of land” and develop it, he said – but the idea was swiftly condemned as the effective “ethnic cleansing” of Palestinians from Gaza.

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Moment of Israeli strike on house

Mr Trump is currently on a visit to the Middle East, which has included stops in the United Arab Emirates, Qatar and Saudi Arabia – but not Israel.

There had been hopes his trip could lead to a ceasefire deal, but Israeli Prime Minister Benjamin Netanyahu has pushed ahead with an escalation of force on the Gaza Strip.

Israel has this week launched airstrikes on two consecutive nights while continuing to block aid for the region, worsening the humanitarian crisis.

Watch the full interview with Dr Basem Naim from 9pm this evening on The World With Yalda Hakim on Sky News

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Ben & Jerry’s co-founder arrested after US Capitol Gaza protest

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Ben & Jerry's co-founder arrested after US Capitol Gaza protest

The co-founder of Ben & Jerry’s has been arrested after disrupting a Senate hearing with a pro-Gaza protest.

Ben Cohen, Ben of the famous ice cream company Ben & Jerry’s, was one of seven people arrested at a Senate Health, Education, Labor and Pensions Committee hearing on Wednesday, Sky News’ US partner NBC News reported.

Robert F Kennedy Jr was speaking to the committee when the protests started with someone shouting: “RFK kills people with AIDs!”

“When Bobby lies, children die,” is also heard, as well as: “Anti-vax, anti-science, anti-America” in reference to Mr Kennedy’s vaccine views.

Police quickly flooded into the room and began dragging out protesters.

Moments after, Mr Cohen got to his feet and accused the US government of playing a role in the deaths of children in Gaza.

The ice cream boss can be seen in footage of the incident on his feet, gesturing as he shouted at the US health secretary.

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“You’re killing poor kids in Gaza and paying for it by cutting Medicaid for kids here,” shouted Mr Cohen.

He is one of the last protesters hauled out of the room.

But even as he’s removed, he can still be heard shouting.

“Congress and the senators need to ease the siege. They need to let food into Gaza. They need to let food to starving kids,” he said.

Mr Cohen was dragged out along with a number of other protesters.
Pic: Reuters
Image:
Mr Cohen was dragged out along with a number of other protesters.
Pic: Reuters

The other six protesters were charged with resisting arrest and assault on an officer, NBC News said.

Earlier on Wednesday, Mr Cohen had attended a pro-Palestine event with Democratic Representative Rashida Tlaib.

Afterwards, Mr Cohen tweeted out a video of the incident, saying: “I told Congress they’re killing poor kids in Gaza by buying bombs, and they’re paying for it by kicking poor kids off Medicaid in the US.

“This was the authorities’ response.”

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Mr Cohen is no stranger to protests or getting arrested.

In July 2023, he was arrested after protesting about the US prosecution of Julian Assange.

‘Poor kids in Gaza’

Israel has killed around 53,000 Palestinians during its war with Hamas, many of them women and children, according to the Hamas-run health ministry.

The Gaza health ministry does not distinguish between civilians and combatants in its count, but said that more than half of the fatalities are women and children.

It is said the real death toll in Gaza is higher because thousands of bodies remain buried under the rubble or in areas that medics cannot access.

Ben Cohen, of Ben & Jerry's.
File pic: AP
Image:
Ben Cohen, of Ben & Jerry’s.
File pic: AP

The fighting began after the militant group led an attack across the border in October 2023, killing 1,200 people and taking around 250 hostage.

Since Israel broke a ceasefire on 18 March, almost 3,000 people have been killed, the ministry said.

The Israeli military has claimed, without evidence, to have killed 17,000 militants.

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Three climbers dead after 200ft fall – while one ‘miraculously’ survives

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Three climbers dead after 200ft fall - while one 'miraculously' survives

Three climbers have died after they fell hundreds of feet on to jagged rock, while the survival of one man in the group is being called “miraculous”.

Vishnu Irigireddy, 48, Tim Nguyen, 63, Oleksander Martynenko, 36, died while climbing down a steep gully on the 7,800ft Early Winters Spire peaks in Washington state on Sunday.

Their fall was likely caused by a “weathered” piton, which is a metal spike serving as an anchor used to slow the descent down a steep mountainside, tearing from the rock, the Okanogan County Sheriff’s Office said.

The fourth climber, Anton Tselykh, 38, from Seattle, miraculously survived, despite also plummeting 200ft on to jagged rock and tumbling another 200ft before coming to rest in a tangle of ropes and climbing equipment.

The Okanogan County Search and Rescue team responds to a climbing accident in the North Cascades mountains in Washington on Sunday, May 11, 2025. (Okanogan County Sheriff's Office via AP)
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Rescuers near where the climbers were found. Pic: Okanogan County Sheriff’s Office/AP)

He suffered internal bleeding and severe head trauma, which caused him to pass out until around 10pm, hours after the estimated time of the fall, police said.

He managed to untangle himself before “crawling and feeling around in nearly pitch darkness” to find his way back to his car, Okanogan County Undersheriff David Yarnell told Sky News’ US partner NBC News.

Mr Tselykh drove west over the mountain range and collided with a guardrail on the way, falling unconscious, before finally reaching a pay phone to call for help.

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His survival “is miraculous to say the least,” Mr Yarnell said.

Mr Tselykh is being treated in a Seattle hospital and is in “satisfactory condition”, according to a hospital spokesperson.

The Okanogan County Search and Rescue team responds to a climbing accident in the North Cascades mountains in Washington on Sunday, May 11, 2025. (Okanogan County Sheriff's Office via AP)
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The bodies of the three climbers have been recovered. Pic: Okanogan County Sheriff’s Office/AP

The bodies of the three climbers have since been recovered, locating them via a GPS device in their kit.

Police said the three men had suffered massive leg and cranial traumas.

Authorities believe the group had been ascending the north Early Winters Spire peak when they decided to reverse course due to an approaching storm.

Read more from Sky News:
Ben & Jerry’s co-founder dragged out of Senate
Menendez brothers’ murder sentences reduced

The Early Winters Spires in the Northern Cascades consist of two 7,800ft peaks, which are popular with climbers.

The route the group was taking was of moderate difficulty and sees climbers moving between ice, snow and rock, according to a local guide, who cautioned that conditions can change rapidly depending on the weather.

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