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A “repurposed” drug that could prevent breast cancer as well as treat it will be offered to almost 300,000 women, NHS officials have revealed.

Anastrozole has been used to treat hormone-sensitive breast cancer.

But trials have shown it can also stop the disease from occurring in the first place. It’s predicted cases could be cut by by 49% over 11 years.

The drug will be offered to 289,000 post-menopausal women who are considered to have at least a moderate risk of breast cancer in England.

“This is the first drug to be repurposed though a world-leading new programme to help us realise the full potential of existing medicines in new uses to save and improve more lives,” NHS chief executive Amanda Pritchard said.

Anastrozole was first recommended as a preventive option by the National Institute for Health and Care Excellence (Nice) in 2017, but, with the drug unlicensed in this use, uptake remained low.

Now scientists have found the protective effect lasts for years after a woman has stopped taking the drug – and has been licensed by the Medicines and Healthcare products Regulatory Agency .

Lesley-Ann Woodhams, who has a family history of the condition, completed the full five-year course of anastrozole in January 2023 and described it as a “gift”.

Lesley-Ann Woodhams has a history of breast cancer in her family
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Lesley-Ann Woodhams has a history of breast cancer in her family

“I’d watched my mum battle breast cancer and my risk was very high,” she said.

“I could live a life without constantly worrying or giving a thought to what could be if I’d developed breast cancer.

“It really was a gift, it gave my family and myself peace of mind and more importantly, a continued future to look forward to.”

breast cancer symptoms

You should see a GP if you notice any of the following:

• a new lump or area of thickened tissue in either breast that was not there before;

• a change in the size or shape of one or both breasts;

• a discharge of fluid from either nipple;

• a lump or swelling in either armpit;

• a change in the look or feel of skin, such as puckering or dimpling, a rash or redness;

• a rash (like eczema), crusting, scaly or itchy skin or redness on or around the nipple;

• a change in the appearance of a nipple, such as becoming sunken into the breast.

How does it work?

The treatment is taken as a 1mg tablet, once a day for five years and works by cutting down the amount of oestrogen the body makes by blocking an enzyme called aromatase.

The most common side effects of the medicine are hot flushes, feeling weak, pain or stiffness in the joints, arthritis, skin rash, nausea, headache, osteoporosis, and depression.

Breast cancer is the most common cancer in England, with around 47,000 women in England diagnosed each year.

Baroness Delyth Morgan, chief executive at the charity Breast Cancer Now, said the move is a “major step forward” that will enable more women to reduce their chance of developing the disease.

Read more from Sky News:
Most people can’t identify lesser-known symptoms of breast cancer
Surgeons carry out caesarean and ovaries removal at same time to cut cancer risk
Cervical cancer treatment breakthrough could cut deaths by 35%

Health Minister Will Quince said: “We’ve already seen the positive effect anastrozole can have in treating the disease when it has been detected in post-menopausal women and now we can use it to stop it developing at all in some women.”

The moves adds to the NHS’s armoury of preventative breast cancer medication, with tamoxifen and raloxifene already licensed to prevent breast cancer.

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Poem shows how to check for breast lumps

According to the NHS, the first symptom of breast cancer most women notice is a lump or an area of thickened tissue in their breast.

Most breast lumps are not cancerous, but it’s always best to have them checked by a doctor, officials say.

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Widow has ‘no regrets’ over assisted suicide of husband despite ‘ongoing’ police investigation

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Widow has 'no regrets' over assisted suicide of husband despite 'ongoing' police investigation

A woman who is under police investigation after assisting the suicide of her husband at Dignitas in Switzerland has told Sky News she has no regrets.

Louise Shackleton has spoken publicly for the first time since her husband’s death in December, as parliament prepares to vote again on legislation to introduce assisted dying in England and Wales.

Mrs Shackleton surrendered herself to police after returning from Switzerland having seen her husband Anthony die. He had been suffering with motor neurone disease for six years.

“I have committed a crime, which I have admitted to, of assisting him by simply pushing him on to a plane and being with him, which I don’t regret for one moment. He was my husband and I loved him,” she said.

“We talked at length over two years about this. What he said to me on many occasions is ‘look at my options, look at what my options are. I can either go there and I can die peacefully, with grace, without pain, without suffering or I could be laid in a bed not being able to move, not even being able to look at anything unless you move my head’.

“He didn’t have options. What he wanted was nothing more than a good death.”

The law in the UK prohibits people from assisting in the suicide of others, but prosecutions have been rare.

For Greg Milam story. Copy and pictures submitted via email. A woman who is under police investigation after assisting the suicide of her husband at Dignitas in Switzerland has told Sky News she has no regrets. Louise Shackleton has spoken publicly for the first time since her husband’s death in December. Mrs Shackleton surrendered herself to police after returning from Switzerland having seen her husband Anthony die. He had been suffering with Motor Neurone Disease for six years.
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Louise Shackleton has spoken publicly for the first time since her husband Anthony’s death

In a statement, a North Yorkshire Police spokesman told Sky News: “The investigation is ongoing. There is nothing further to add at this stage.”

The next vote on the assisted dying bill for England and Wales has been delayed by three weeks to give MPs time to consider amendments.

The legislation would permit a person who is terminally ill with less than six months to live to legally end their life after approval by two doctors and an expert panel.

‘He was at total peace with his decision’

Mrs Shackleton says she saw her husband “physically and mentally” relax once on the flight to Switzerland.

She said: “We had the most wonderful four days.

“He was laughing. He was at total peace with his decision.

“It was in those four days that I realised that he wanted the peaceful death more than he wanted to suffer and stay with me, which was hard, but that’s how resolute he was in having this peace.

“I was his wife, we’d been together 25 years, we’d known each other since we were 18. I couldn’t do anything else but help him.”

For Greg Milam story. Copy and pictures submitted via email. A woman who is under police investigation after assisting the suicide of her husband at Dignitas in Switzerland has told Sky News she has no regrets. Louise Shackleton has spoken publicly for the first time since her husband’s death in December. Mrs Shackleton surrendered herself to police after returning from Switzerland having seen her husband Anthony die. He had been suffering with Motor Neurone Disease for six years.

‘We need to safeguard people’

She said the hardest part of the journey came after her husband’s death.

“There was this panic and this fear that I was leaving him,” she said. “That was a horrific experience.

“If the law had changed in this country, I would have been with family, family would have been with us, family would’ve been with him. But as it was, that couldn’t happen.”

Opponents to the assisted dying bill have raised concerns about the safety of vulnerable people and the risk of coercion and a change in attitudes toward the elderly, seriously ill and disabled.

They say improvements to palliative care should be a priority.

“I think that we need to safeguard people,” said Mrs Shackleton. “I think that sometimes we need to suffer other people’s choices, and when I mean suffer I mean we have to acknowledge that whilst we’re not comfortable with those, that we need to respect other people, other people wishes.”

For Greg Milam story. Copy and pictures submitted via email. A woman who is under police investigation after assisting the suicide of her husband at Dignitas in Switzerland has told Sky News she has no regrets. Louise Shackleton has spoken publicly for the first time since her husband’s death in December. Mrs Shackleton surrendered herself to police after returning from Switzerland having seen her husband Anthony die. He had been suffering with Motor Neurone Disease for six years.

Read more:
Assisted dying: What is in the legislation?
Debate over assisted dying delayed

Anthony, who died aged 59, was a furniture restorer who had earned worldwide recognition for making rocking horses.

“I think the measure of the man is that nobody has ever said a bad word about him in the whole of his life because he was just so caring and giving,” his widow said.

‘This is about a dying person’s choice’

She said she had chosen to speak publicly because of a promise she had made him.

“I felt that my husband’s journey shouldn’t be in vain. We discussed this on our last day and my husband made me promise to tell his story.

“He told me to fight and the simple thing that I’m fighting for is people to have the choice.

“This is about a dying person’s choice to either follow their journey through with disease or to die peacefully when they want to, on their terms, and have a good death. It’s that simple.”

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Feminists ‘feel braver about speaking out’ after gender ruling – but critics say it ‘stokes culture war’

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Feminists 'feel braver about speaking out' after gender ruling - but critics say it 'stokes culture war'

A former Labour MP who quit the party over Sir Keir Starmer’s leadership has welcomed the landmark Supreme Court ruling on the definition of a woman as a “victory for feminists”.

Rosie Duffield, now the independent MP for Canterbury, said the judgment helped resolve the “lack of clarity” that has existed in the politics around the issue “for years”.

She was speaking to Ali Fortescue on the Politics Hub on the same day the UK’s highest court delivered its verdict on one of the most contentious debates in politics.

Politics latest: MPs respond to Supreme Court ruling on gender

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How do you define a woman in law?

The judges were asked to rule on how “sex” is defined in the 2010 Equality Act – whether that means biological sex or “certificated” sex, as legally defined by the 2004 Gender Recognition Act.

Their unanimous decision was that the definition of a “woman” and “sex” in the Equality Act 2010 refers to “a biological woman and biological sex”.

Asked what she made about comments by fellow independent MP John McDonnell – who said the court “failed to hear the voice of a single trans person” and that the decision “lacked humanity and fairness” as a result, she said: “This ruling doesn’t affect trans people in the slightest.

“It’s about women’s rights – women’s rights to single sex spaces, women’s rights, not to be discriminated against.

“It literally doesn’t change a single thing for trans rights and that lack of understanding from a senior politician about the law is a bit worrying, actually.”

However, Maggie Chapman, a Scottish Green MSP, disagreed with Ms Duffield and said she was “concerned” about the impact the ruling would have on trans people “and for the services and facilities they have been using and have had access to for decades now”.

Susan Smith and Marion Calder give a statement, as the Supreme Court rules on an appeal by For Women Scotland about whether a person with a full gender recognition certificate which recognises that their gender is female is a woman under British equality laws, outside the Supreme Court in London, Britain, April 16, 2025. REUTERS/Maja Smiejkowska
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Susan Smith and Marion Calder, directors of For Women Scotland celebrate after the ruling. Pic: Reuters

“One of the grave concerns that we have with this ruling is that it will embolden people to challenge trans people who have every right to access services,” she said.

“We know that over the last few years… their [trans people’s] lives have become increasingly difficult, they have been blocked from accessing services they need.”

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‘Today’s ruling only stokes the culture war further’

Delivering the ruling at the London court on Wednesday, Lord Hodge said: “But we counsel against reading this judgment as a triumph of one or more groups in our society at the expense of another. It is not.

Campaigners for For Women Scotland (FWS) celebrate outside the Supreme Court in London after terms "woman" and "sex" in the Equality Act refer to a biological woman and biological sex, the Supreme Court has ruled. Picture date: Wednesday April 16, 2025.
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Campaigners celebrate outside the Supreme Court. Pic: PA

“The Equality Act 2010 gives transgender people protection, not only against discrimination through the protected characteristic of gender reassignment, but also against direct discrimination, indirect discrimination and harassment in substance in their acquired gender.

“This is the application of the principle of discrimination by association. Those statutory protections are available to transgender people, whether or not they possess a gender recognition certificate.”

Read more:
Supreme Court decision has immediate real-world consequences
Prisons across England and Wales now 98.9% full

Asked whether she believed the judgment could “draw a line” under the culture war, Ms Chapman told Fortescue: “Today’s judgment only stokes that culture war further.”

And she said that while Lord Hodge was correct to say there were protections in law for trans people in the 2020 Equality Act, the judgment “doesn’t prevent things happening”.

“It may offer protections once bad things have happened, once harassment, once discrimination, once bigotry, once assaults have happened,” she said.

She also warned some groups “aren’t going to be satisfied with today’s ruling”.

“We know that there are individuals and there are groups who actually want to roll back even further – they want to get rid of the Gender Recognition Act from 2004,” she said.

“I think today’s ruling just emboldens those views.”

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Arsenal reach Champions League semi-final with dramatic win over Real Madrid

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Arsenal reach Champions League semi-final with dramatic win over Real Madrid

Arsenal have reached the semi-finals of the Champions League after a dramatic victory over holders Real Madrid in Spain.

The north London side, who became the first English team to win twice at the Bernabeu following their triumph there 19 years ago, will face Paris Saint-Germain in the last four after the French side beat Aston Villa on Tuesday.

It is the third time the Gunners have made it through to the semis of the top club football tournament in Europe, and the first since 2009.

Arsenal went into the second leg of their quarter-final clash on Wednesday with a 3-0 lead.

Backed by a raucous home crowd, Madrid tried to get off to a strong start and Kylian Mbappe scored after two minutes. However, the goal was disallowed for a clear offside.

Arsenal had the chance to go ahead in the 13th minute but winger Bukayo Saka missed a penalty.

The Spanish hosts were awarded a penalty of their own about 10 minutes later when Mbappe stumbled under pressure from Declan Rice in the box – but the decision was overturned by VAR.

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Saka atoned for his tepid penalty as he chipped the ball past Madrid’s keeper Thibaut Courtois when put through on goal by auxiliary striker Mikel Merino in the 65th minute.

But Arsenal were pegged back just two minutes later as Vinicius Junior caught William Saliba dawdling on the ball and fired Real Madrid level.

Arsenal’s resolute defending kept the home side at bay until Gabriel Martinelli made a late break through the home side’s defence to put his side 2-1 ahead three minutes into injury time, as the Gunners made it 5-1 on aggregate.

(L-R) Arsenal's Declan Rice and Mikel Merino celebrate after the defeat against Real Madrid. Pic: AP
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(L-R) Arsenal’s Declan Rice and Mikel Merino celebrate after the defeat against Real Madrid. Pic: AP

‘We knew we were going to win’, says Rice

Arsenal midfielder Declan Rice has insisted his team are intent on winning the Champions League after their victory in Madrid.

Speaking to TNT Sport, Rice, who was named player of the match, said: “It’s such a special night, a historic one for the club. We have the objective of playing the best and winning the competition.

“We had so much belief and confidence from that first leg and came here to win the game. We knew we were going to suffer but we knew we were going to win. We had it in our minds, then we did it [in] real life. What a night.

“I knew when I signed, this club was on an upward trajectory. It’s been tough in the Premier League but in this competition we’ve done amazingly well.

“It’s PSG next, who are an amazing team.”

‘We have to be very proud of ourselves’, says Arteta

Arsenal boss Mikel Arteta told TNT Sport: “One of the best nights in my football career.

“We played against a team with the biggest history.

“To be able to win the tie in the manner we have done, I think we have to be very proud of ourselves.”

He added: “The history we have in this competition is so short. The third time in our history of what we have just done and we have to build on that. All this experience is going to help us, for sure.”

Real Madrid were seeking their third Champions League title in four seasons.

Mbappe twisted ankle

Their forward Mbappe twisted his right ankle during the game and was jeered by part of the crowd when his substitution was announced after a lacklustre performance.

The French star, who is still looking for his first Champions League title, was replaced by Brahim Diaz in the 75th minute following his injury. He was able to walk off the pitch by himself, but was limping slightly.

The other semi-final will be between Barcelona and Inter Milan.

The first legs are set to be played on 29 and 30 April, with the second legs on 6 and 7 May.

The final will be on 31 May.

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