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After Super Saturday at London 2012, there was Magic Monday in Tokyo as British athletes won three gold medals in the space of a few hours.

Adam Peaty was Britain’s banker and did not disappoint, storming to victory in the 100 metres breaststroke to become the first British swimmer to retain an Olympic title.

The 26-year-old is unbeaten in seven years and now owns the 17 fastest times in history. He was as close to a sure thing as it is possible to get.

Adam Peaty comfortably took gold in the 100m breaststroke
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Adam Peaty comfortably took gold in the 100m breaststroke
Peaty will have a change to add to his medal haul, when he competes in the men's medley relay and potentially in the mixed relay
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Peaty will have a chance to add to his medal haul, when he competes in the men’s medley relay and potentially in the mixed relay

Peaty said: “It just means the world to me. I thought I had the best preparation but morning finals changed everything and threw that out of window.”

“I felt the pressure but I needed to put myself on edge. You can do whatever you want in your own pool but when it comes to being out here it’s not about a time.

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Adam Peaty’s parents ‘immensely proud’

“I was racing myself. It wasn’t about the time but the race.

“Thanks to the nation for being behind me for five years and my family and my beautiful boy.”

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Peaty’s success turned into a gold rush in the afternoon in the Japan when divers Tom Daley and Matty Lee claimed a stunning victory in the 10-metre synchronised platform event, before 21-year-old Tom Pidcock dominated the men’s mountain bike race.

Tom Daley and Matty Lee on their way to Olympic gold
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Tom Daley and Matty Lee on their way to Olympic gold
Thomas Daley and Matty Lee of Britain react after winning gold medals during the men's synchronized 10m platform diving final at the Tokyo Aquatics Centre at the 2020 Summer Olympics, Monday, July 26, 2021, in Tokyo, Japan. (AP Photo/Dmitri Lovetsky)
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The pair got emotional on the medals podium. Pic: AP

Daley made his Olympic debut back in 2008 aged only 14 and has been in the spotlight ever since, enduring the death of his father and biggest supporter Rob when still a teenager and then coming out in 2013.

He had two bronze medals to his name from London and Rio but, at the age of 27, has finally won the gold he coveted alongside debutant Lee, with the pair producing a stunning final dive to defeat the Chinese favourites.

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‘Proud’ parents of a gold medal diver

“It’s kind of unbelievable. I’ve dreamt, as has Matty, since I started diving 20 years ago for this moment of becoming an Olympic champion,” said Daley.

“To take it to my fourth Olympic Games when I think a lot of people would have not considered it to be my peak Olympic Games, I thought I was going to win an Olympic gold medal in Rio and that turned out the complete opposite by a long shot.

“It was my husband [Dustin Lance Black] who said to me my story wasn’t finished and that my son or child, we didn’t know at the time, needed to be there to watch me win an Olympic gold medal.”

Lee said: “In 2018 I moved my whole life to London from Leeds, I had nothing really in London.

“Our aim was to get an Olympic medal and for it to go the way we wanted it to is awesome.

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‘Proud to be a gay man and Olympic champion’

“I owe a lot to Tom because he has taught me a lot.”

Lee’s parents, Helen and Tim Lee, who could not travel to Tokyo due to COVID restrictions, invited friends and family over to watch him clinch gold with Daley.

They told Sky News that they had spoken to their son and that “he seemed like his normal self” and showed off his medal.

Pidcock is also an Olympic champion at the age of just 21 after a fearless display in Izu.

He started on the fourth row of the race but quickly got himself into the leading group and powered his way past the Swiss pair of Mathias Flueckiger and Nino Schurter to take control on the fourth of seven laps.

Tom Pidcock in action in Tokyo
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Tom Pidcock in action in Tokyo
Tom Pidcock celebrates gold in Tokyo
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His victory comes less than two months after he suffered a broken collarbone in a training crash

Flueckiger was the only man who could even remotely keep up, as Pidcock won by 20 seconds, even having time to snatch a Union Flag and hold it aloft as he crossed the line.

When asked how it felt to win gold, Pidcock told Eurosport: “Not real really. It’s pretty crazy that I became an Olympian and I was trying to tell myself at the start of the race it’s special just to be here.”

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His victory comes less than two months after he suffered a broken collarbone in a training crash on the road.

Meanwhile, Alex Yee also earned a silver medal in the triathlon.

The 22-year-old from Lewisham, south London, moved into the lead during the run but could not prevent Norway’s Kristian Blummenfelt from taking gold.

And there was heartbreak for Lauren Williams who narrowly missed out on gold in the 67kg taekwondo final.

Williams led by three points with 10 seconds to go but a late rally from Croatia’s Matea Jelic forced the Briton to settle for silver.

Disappointed, she said: “It’s not enough. I came here for a gold medal. I went out there to win and I tried my best. I’m very happy with how I performed and it’s just a shame about the end. I suppose an Olympic silver medal is not bad, is it?

“I want to say a massive thank you to the National Lottery for getting me out here and everyone at home.”

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UK boosts pandemic readiness with new vaccine factory

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UK boosts pandemic readiness with new vaccine factory

A US vaccine firm has opened the first mRNA manufacturing plant in the UK, against a backdrop of increasing anti-jab rhetoric back home.

The new facility outside Oxford is part of a £1bn investment in the UK by Moderna, which specialises in mRNA.

The novel vaccine technology delivered some of the most effective and fastest-to-develop jabs during the COVID pandemic.

Several pharma companies, including Germany’s leading mRNA pioneer BioNTech, are now racing to develop new therapies.

Moderna says the plant will produce up to 100 million doses of its existing vaccine products each year. It has also been designed to scale-up production to 250 million doses a year in the event of a new disease outbreak.

“God-forbid, if there is another pandemic, we can switch the facility any day,” said Moderna CEO Stephane Bancel.

The UK investment deal was agreed by the previous government, but the plant’s opening is welcome relief for the current one.

In recent weeks, four major pharmaceutical companies have halted planned investments in the UK following disputes over drug pricing and profitability in the UK.

‘A great statement’

It also promises to restore domestic vaccine manufacturing capability in the UK, the lack of which was exposed when dangerous supply interruptions threatened the early COVID response.

“It’s a really fast way of getting new vaccines discovered,” said Lord Patrick Vallance, former chief scientist and now science minister.

“It’s also a great statement of confidence in the UK that [Moderna has] chosen to base themselves here.”

Health Secretary Wes Streeting attended the opening
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Health Secretary Wes Streeting attended the opening

The Trump effect

The mRNA molecule is the same used by our cells to order the production of new proteins, and allows vaccines to be produced using just the genetic code of a virus or other biological target.

Moderna’s investment decision pre-dated Donald Trump’s return to the White House, but the Moderna CEO said its operation in the UK – a country that “still believes in vaccination” – may pay dividends if anti-vaccine rhetoric translates into a lack of demand for its products in the US.

“If there is less appetite by governments around the world, including in the US, to use vaccines, we might invest less in vaccines,” said Mr Bancel.

“We have to invest where there’s a demand for our products.”

Read more: All health claims made by Trump – and what experts say

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Is US politics fuelling a deadly measles outbreak?

The UK presents other attractions for the company which has suffered substantial losses as demand for its COVID vaccine has fallen.

It’s betting that leading UK universities and a large patient population will make for successful clinical trials.

The company has ongoing NHS trials of new jabs against seasonal flu, a combination COVID and flu vaccine, cancer vaccines and mRNA therapies for two inherited childhood diseases.

Moderna says it is now the largest private commercial sponsor of clinical trials in the UK.

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How one of the world’s rarest diseases left Sky’s Deborah Haynes critically ill

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How one of the world's rarest diseases left Sky's Deborah Haynes critically ill

Paddling in a bay on the tiny Channel Island of Sark, I suddenly felt very sick and cold.

Less than 48 hours later, I was being emergency evacuated to the intensive care unit of a London hospital via cart, tractor, lifeboat, private jet and ambulance.

Ultimately, an incredible team of doctors, nurses, and volunteers saved my life – for a second time, though falling ill with one of the rarest diseases in the world while in one of the remotest corners of the British Isles was an unfortunate first.

Deborah Haynes covers some of the biggest foreign stories around the world. She also hosts The Wargame podcast
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Deborah Haynes covers some of the biggest foreign stories around the world. She also hosts The Wargame podcast

I have something called atypical Haemolytic Uremic Syndrome (aHUS) that – when triggered – affects my immune system, destroying blood cells and harming other vital bodily functions.

Classed as “ultra-rare”, there is only around one new incident of aHUS per two million people every year. And an attack can be fatal, so the speed of diagnosis is key.

In my case, I already knew about the condition as I first fell ill with it eight years ago.

When it happened a second time, the heroic efforts of Sark’s only doctor, a group of volunteer rescuers and the medics at University College Hospital (UCH) meant I was raced from the middle of the English Channel to an intensive care bed in just over 11 hours – enabling rapid and effective treatment.

Now back home and expected to make a full recovery, I thought I would share my experience to help raise awareness about this little-known disease as today is aHUS Awareness Day.

Deborah Haynes in ICU after falling ill with atypical Haemolytic Uremic Syndrome (aHUS)
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Deborah Haynes in ICU after falling ill with atypical Haemolytic Uremic Syndrome (aHUS)

‘I was feeling increasingly wretched’

My husband and I had planned to spend a few days in August on Sark – a beautiful island in between the UK and France that is a designated “dark sky” area because of an absence of light pollution.

There are no public streetlights on the territory.

More relevant to this story, cars and regular ambulances are also banned.

Instead of driving, Sark’s just over 500 residents and ferry-loads of tourists either walk, cycle or sit on the back of carts towed by horses – and on occasion tractors – to visit beaches, coves and other attractions.

A some 100-metre-high ridge connects the rock islands on Sark. File pic: AP
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A some 100-metre-high ridge connects the rock islands on Sark. File pic: AP

I started to feel queasy on the ferry that took us to Sark.

We initially thought it was seasickness.

But the nausea lingered as we walked from the port to our hotel to dump our bags.

Thinking a swim might make me feel better, we trekked down a steep path to the beach and ventured into the sea, which is when my body decided to break.

I came out of the water, shivering uncontrollably and thought I was going to faint. After getting myself dry, we tried to return to the hotel, but I started vomiting violently on the side of the path – much to the disgust of a family that was trying to overtake us.

Once back at the hotel, I collapsed into bed, only leaving it to be sick.

We speculated that it must be food poisoning and hoped it would pass within a day.

But 24 hours later, while I had stopped vomiting, I was feeling increasingly wretched and beginning to wonder whether it could be aHUS again.

The 'ultra-rare' condition is caused by part of the immune system becoming overactive
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The ‘ultra-rare’ condition is caused by part of the immune system becoming overactive

‘The onslaught is like an invisible storm’

The only other time I have been struck down by the disease was in January 2017, while working as the defence editor at The Times.

On that occasion, I took myself to my local hospital in Kent to be told that I had acute kidney failure and my bloods were “deranged”.

Fortunately, the haematologist on duty had been aware of aHUS – then a new acronym for me – and had me rushed to University College Hospital in London, which has a specialist team that can treat the condition led by Professor Marie Scully, a world-renowned expert.

I soon learnt that aHUS is caused by part of my immune system – called the complement system – becoming overactive and attacking my body rather than targeting bugs.

This “friendly fire” – likely linked to a genetic glitch that, in my case, had thankfully lain dormant for the first 40 years of my life – can be activated by infection, pregnancy or food poisoning, though sometimes the cause is unknown.

The subsequent onslaught is like an invisible storm that destroys a patient from the inside, shattering red blood cells, damaging small blood vessels and causing tiny clots.

The clots clog up kidneys and trigger acute renal failure.

If left untreated, other organs can also collapse, while the risk of a stroke or heart attack rises.

Without intervention, the prognosis is dire.

Between 10 to 15% of patients die during the initial illness, while up to 70% of patients develop end-stage renal failure, requiring a lifetime of dialysis.

Since 2013, however, patients in the UK have had access to a drug called eculizumab, which effectively turns off the malfunctioning part of the immune system. It is expensive – at many thousands of pounds a shot – but it saves lives, including mine.

An aHUS attack can be fatal, so the speed of diagnosis is key
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An aHUS attack can be fatal, so the speed of diagnosis is key

‘My protein levels were off the scale’

Lying in bed in Sark more than eight years on from the first episode, I did not want to believe my body had turned on itself again.

But after a little over 36 hours, with no improvement, my husband decided to get help.

His action likely saved me from even graver kidney damage or worse.

He set out to find Sark’s only GP, Dr Bruce Jenkins.

Blood tests are the best way to diagnose aHUS, but they were not an option on the island.

Instead, Dr Jenkins did a urine test, which is a good alternative.

Any trace of blood or protein in the urine is a sign that a person’s kidneys are in trouble.

My protein levels were off the scale of the test.

Upon seeing the result, Dr Jenkins instructed my husband to go back to our hotel and pack our bags – I was still floundering in bed – while he coordinated an emergency evacuation.

On Sark, given the lack of vehicles, this meant mobilising an ambulance cart towed by a tractor, which is operated by a team of Community First Responders – all volunteers.

The Sark medical team who helped save Deborah's life
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The Sark medical team who helped save Deborah’s life

The GP also contacted the main hospital on Guernsey, a larger Channel Island, which provides a marine ambulance service to rescue anyone with a medical emergency on Sark.

While all this was happening, I called an emergency number for the aHUS medics at University College Hospital to warn them I was likely suffering a relapse.

By chance, Professor Scully was on duty that day – a Friday – and over the weekend. She and her team sprang into action, contacting Sark and Guernsey to help.

Speed was key as my condition was worsening.

‘I asked a doctor if I was going to die’

Within minutes of the alert going out from Dr Jenkins, a tractor, pulling a white ambulance cart, arrived at our hotel, and the first responders guided me and my husband onboard.

They took us to the port to wait for the “Flying Christine”, an ambulance boat carrying two paramedics and operated by St John’s Ambulance and Rescue Service.

That team transported us via sea to Guernsey hospital before we were transferred to a specialist medical plane to be flown to Luton airport.

The last leg was a more conventional ambulance drive to UCH, where critical care doctors, as well as Professor Scully and her colleagues, were poised to start the treatment.

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This quick response by the NHS and a network of volunteers meant I was taken from my sickbed in Sark to life-saving treatment in London in barely 11 hours.

By this point, the aHUS attack had caused my haemoglobin and platelet levels to drop, and my kidneys were failing.

The main treatment was the eculizumab drug – administered intravenously – but I also needed blood transfusions and to be put on a machine that acts as a form of dialysis.

The relief of being in the best possible place for my condition was immense, but the next few days were still frightening as my body took time to respond.

At one point, I asked a doctor if I was going to die – she assured me I was not.

Deborah has now been discharged and says she is 'on the mend'
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Deborah has now been discharged and says she is ‘on the mend’

On another occasion, pumped full of medication, hooked up to various machines and drifting in and out of sleep, I dreamt I was under missile fire – an occupational hazard of being a journalist who covers war – and tried to leap out of bed to an imaginary shelter, prompting the nurse who was looking after me to spring into action and make sure I stayed put.

Gradually, though, the treatment started to work.

After nearly a fortnight in hospital, including one week in intensive care, I was well enough to be discharged.

Today, I am on the mend and incredibly grateful to everyone who helped to save me from myself.

Deborah Haynes and Professor Marie Scully will be on Sky News from 8.30am to speak about aHUS Awareness Day.

What is aHUS?

Atypical haemolytic uraemic syndrome is an ultra-rare disease that affects between 2.7 and 5.5 people per million population worldwide. It has an incidence rate of about 0.4 cases per million people a year and can occur at any age.

The disease affects part of the immune system called the complement system. It starts to destroy the body’s own cells, especially those that line blood vessels. This leads to clots forming within small vessels. The kidney is most commonly impacted, but all organs can be harmed.

AHUS is typically linked to a genetic fault in the complement system or a group of proteins meant to regulate it.

The trigger for an attack can be infection, pregnancy or food poisoning.

Symptoms can include feeling unwell or tired, becoming confused, blurred vision, shortness of breath, high blood pressure, nausea and vomiting, diarrhoea and abdominal pain.

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‘Living with a death sentence’: NHS cadaver implant leaves woman with one of world’s rarest diseases

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'Living with a death sentence': NHS cadaver implant leaves woman with one of world's rarest diseases

A woman infected with an incurable brain disease due to an NHS operation when she was three years old has told Sky News she is “living with a death sentence”.

Natalie Bralee-Brett was born with spina bifida, a birth defect caused by a gap between the brain and spinal cord.

In 1975, her mother Maureen was told by doctors at Great Ormond Street Hospital that Natalie would have an improved and prolonged life if they operated on her using a new procedure. 

But this, unknown to Maureen at the time, involved taking membrane taken from dead bodies and inserting it into Natalie’s spinal cord. Now nearly 40 years later this treatment is the very thing that could kill her.

Natalie Bralee-Brett was born with spina bifida
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Natalie Bralee-Brett was born with spina bifida

It has caused microbleeding on her brain, leading to memory loss. Natalie, 53, is also falling over constantly and suffers debilitating headaches. 

It also means Natalie is at high risk of dementia and could suffer a catastrophic stroke at any time. 

“Living with a death sentence, this is the only way I could describe it,” Natalie told Sky News. 

“Because every day, if you get a headache, you’re thinking ‘is this a sign of an episode that is linked to this problem? Is it a stroke?'” 

“I want to know why I’ve got this problem. And that probably makes me more angry than actually having to deal with this condition.”

Search for answers

Sky News has been following Natalie’s case for more than a year, and we have spoken to experts around the world to try to help Natalie get answers.

Natalie was given a dura mater graft in 1975. This is a piece of membrane collected from dead bodies. Its use is intended to protect the spinal cord and prevent fluid from leaking.

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Cadaver surgery leaves patient with incurable disease

Natalie as a child
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Natalie as a child

But over years, proteins already in the membrane can build up and cause plaques, leaving patients at high risk of diseases like Alzheimer’s. It can also make them vulnerable to strokes and brain haemorrhages. 

The procedure was common in the 1970s in the UK, across Europe and the US.

It’s thought tens of thousands of patients around the world might have undergone the procedure, but it is not known how many might be suffering the same life-limiting and potentially fatal consequences today. 

Natalie was diagnosed with a brain tumour in 2009, aged 37. A year later it was confirmed she had epilepsy. But it wasn’t until 2022 that Natalie was diagnosed with iatrogenic cerebral amyloid angiopathy (ICAA). 

Her family have now suffered another devastating blow.

Natalie’s brother Neil, who also had surgery for spina bifida in 1980, was diagnosed with ICAA in July. He’s no longer able to work and is suffering from Alzheimer’s.

Natalie and Neil with their mother Maureen
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Natalie and Neil with their mother Maureen

Natalie and Neil as children
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Natalie and Neil as children

The siblings were born with the same condition, underwent the same procedure, and are now infected with the same incurable brain disease. 

Natalie and Neil, 45, are the only siblings identified on the international ICAA register, which has just 52 confirmed cases.   

Natalie says her mother Maureen is “heartbroken”. 

ICAA cases ‘a heartbreaking tragedy’

Cases of ICAA have been identified in the Netherlands, Australia, Japan, Croatia, Austria, Italy, Spain, Slovenia, and the US.

Explained: Why cadaver implants are causing brain disease

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How cadaver graft caused incurable brain disease

Harvard Professor Steven Greenberg is one of the world’s leading ICAA experts. 

“We hope and believe the numbers will be limited,” he said. “The hope is that we’re talking hundreds.”

But for those who are impacted, “it is a heartbreaking tragedy, and we feel it very much as the healthcare providers taking care of them”.

ICAA is caused by a medical examination or treatment, relates to the brain, involves amyloid proteins that can stick together and cause a range of problems for major organs – and that is a disease of the blood vessels. 

Doctors believe there are three possible causes of the illness: cadaveric material introduced into a body during surgery, the use of human growth hormones containing cadaveric material and surgical tools not sufficiently sterilised. 

Professor Greenberg explained: ”When I was in medical school, one of my professors said ‘the I stands for I, the doctor caused the problem’.

“And in the case of iatrogenic CAA, this is kind of a heartbreaking echo of an era when it appeared that a good neurosurgical procedure was to use tissue from human cadavers to close defects in the nervous system.

“And I am not a surgeon and I certainly wasn’t practising at the time. But my understanding is that it appeared to be good natural biological material for closing up areas and then had this unexpected and tragic effect of introducing some kind of protein that would later cause disease in the brain.”

Prof Greenberg hopes cases of ICAA are restricted to hundreds
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Prof Greenberg hopes cases of ICAA are restricted to hundreds

‘I deserve answers’

Natalie’s health is steadily deteriorating. The bleeding on her brain is causing memory loss, and she dreads what the next few months will bring. 

“The pattern seems to be every time I go for a scan, I’m being shown to have more bleeding,” she said.

“And the last scan showed that I also had inflammation. It’s always hanging over you because you get a headache, and you think ‘is this going to turn into something worse?’

“And because of being at risk of a stroke it’s constantly there, and it’s a condition that is going to get worse.”

Natalie’s agony is further compounded by the lack of information.

She wants to know more about the donor of the diseased membrane implanted into her brain. But there is no record of where the dura mater came from.

And most of the time these grafts were made up from more than one body.

Natalie said: “I think I deserve answers. And if you’ve got something wrong with you, you want to know it’s human nature. You want to know why you’ve got this problem.”

Diagnosing ICAA has only become possible due to advancements made in MRI scanning.

Specialists including Professor Greenberg have set up the international register so any neurologist suspecting ICAA can flag cases to their peers.

This isn’t the first time cadaveric dura mater grafts have infected patients.

The World Health Organisation advised against their use in 1997 after it was discovered they had been giving patients Creutzfeldt-Jakob disease (CJD) which at the time was also being spread by eating cattle infected with BSE or ‘mad cow disease’.

There were 228 of these confirmed cases worldwide.

Dura mater grafts were used in more than 20 surgical procedures over 25 years, with the last known use in the UK in 1992.

Natalie Bralee-Brett says she is 'living with a death sentence'
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Natalie Bralee-Brett says she is ‘living with a death sentence’

‘Something is seriously wrong’

Simon Stratford was only 34 and a father of four young children when he died in April 2003.

That was nearly 16 years after having surgery to remove a brain tumour. During the operation a Lyodura graft was inserted into Simon’s brain. The membrane was infected with CJD and a coroner’s inquest found that it was this procedure that caused Simon’s death.

Simon Stratford with three of his children
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Simon Stratford with three of his children

Speaking exclusively to Sky News, his widow Colleen said she warned doctors treating her husband that she knew he was dying.

“I kept saying to the doctors he’s getting worse and something seriously is wrong, and you know, Simon did say to me at that point he thought he was dying.

“He had a brain tumour removed which saved his life and then was given a life sentence. They said it was the Lyodura dura mater that took his life.”

Colleen Stratford said she warned doctors treating her husband that she knew he was dying
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Colleen Stratford said she warned doctors treating her husband that she knew he was dying

Sky News asked B. Braun, a major German manufacturer which made Lyodura, to help with our investigation. They declined to comment on the link between dura mater grafts and ICAA.

For more than a year we have been speaking to experts around the world. Scientists in Europe declined to be interviewed. Natalie’s own medical team in the UK also refused to be interviewed.

The risks posed by the grafts are being better understood but the scale of the damage they have caused is not.

Some specialists who spoke to Sky News but did not want to be named are keen to stress that surgeons who carried out operations using these grafts were acting on the best available medical evidence to improve the length and quality of patients’ lives.

Natalie had her operation at Great Ormond Street Hospital. It’s likely, at least hundreds of patients would have undergone the same procedure.

Sky News has been speaking to experts around the world about cadaver implants for more than a year
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Sky News has been speaking to experts around the world about cadaver implants for more than a year

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Following our investigation, its medical director Dr Sophie Varadkar told Sky News: “We understand that this situation may be deeply worrying for former patients who believe they could have been affected.

“At the time, this type of product was commonly used in surgical procedures worldwide, and sadly, the risks associated with it were not yet understood.”

“For any of our former patients who think they may be affected, we will support you with getting access to your medical records to allow you to discuss your concerns with your current doctors.”

The Department of Health told us concerns around ICAA – including new forms of transmission – were being investigated.

“The Advisory Committee on the Safety of Blood, Tissues and Organs is currently considering this issue with a view to providing further advice to the Government,” a spokesperson said.

“We encourage anyone with concerns about historical treatment to speak with their GP or specialist healthcare team for appropriate support and guidance.”

Do you have a story to share with us? Contact NHSstories@sky.uk

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