Prime Minister Boris Johnson and his wife Carrie are expecting their second baby, she has announced.
In an Instagram post Carrie Johnson also said she had a miscarriage earlier this year.
She wrote: “Hoping for our rainbow baby this Christmas.
“At the beginning of the year, I had a miscarriage which left me heartbroken. I feel incredibly blessed to be pregnant again but I’ve also felt like a bag of nerves.”
Mrs Johnson added: “Fertility issues can be really hard for many people, particularly when on platforms like Instagram it can look like everything is only ever going well.
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“I found it a real comfort to hear from people who had also experienced loss so I hope that in some very small way sharing this might help others too.”
A “rainbow baby” is a child born after a miscarriage, stillborn or neonatal death.
Mrs Johnson previously used Instagram to announce the name of her first son, Wilfred Lawrie Nicholas Johnson – with the name Nicholas chosen in a nod to the two doctors who saved the prime minister’s life when he had COVID-19.
The baby was named after the prime minister’s grandfather, Wilfred, and her grandfather, Lawrie, as well as the two doctors, Dr Nick Price and Professor Nick Hart, who treated him in intensive care.
He was only the fourth child born to a sitting prime minister in 170 years.
Tony Blair’s wife Cherie gave birth to son Leo in May 2000, three years after her husband’s first election victory, and David Cameron and wife Samantha welcomed daughter Florence in 2010.
Lord John Russell, who served as the prime minister twice between 1846 and 1952, and again between 1865 and 1866, was the last PM to father a child while on office.
The co-manager for Donald Trump’s presidential election campaign has called Lord Mandelson an “absolute moron” – as the peer was officially announced as the next UK ambassador to the US.
The Labour grandee, who served in Sir Tony Blair and Gordon Brown’s cabinets, will become the UK’s top diplomat in Washington as president-elect Donald Trump returns to the White House in January.
The peer also described Mr Trump as “little short of a white nationalist and racist” during an interview with an Italian journalist in 2019, according to the newspaper.
In the post on X, Mr LaCivita said: “This UK govt is special replace a professional universally respected Ambo with an absolute moron – he should stay home! SAD!”
He added: “Mandelson described Trump as a danger to the world and ‘little short of a white nationalist’.”
The 71-year-old said: “We face challenges in Britain but also big opportunities and it will be a privilege to work with the government to land those opportunities, both for our economy and our nation’s security, and to advance our historic alliance with the United States.”
The prime minister said: “The United States is one of our most important allies and as we move into a new chapter in our friendship, Peter will bring unrivalled experience to the role and take our partnership from strength to strength.”
Sir Keir also thanked outgoing US ambassador Dame Karen Pierce, who will leave the post at the beginning of next year.
“I would also like to thank Dame Karen Pierce for her invaluable service for the last four years, and in particular the wisdom and steadfast support she has given me personally since July,” he said.
“She made history as the first woman to serve as UK ambassador to the US and she has been an outstanding representative of our country abroad. I wish her all the very best in future.”
Lord Mandelson was one of the key architects of New Labour and helped the party return to power in the 1990s.
He served as Sir Tony’s trade secretary and Northern Ireland secretary before standing down as an MP in 2004 to become a European Commissioner.
After Mr Brown awarded him a peerage in 2008 Lord Mandelson returned to government as business secretary.