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So the new variant has a name, but we’ve no idea about its reputation.

On paper at least the Omicron variant looks terrifying. It has more mutations than any previously observed strain of COVID.

And the mutations aren’t just a random jumble of genetic changes. A worrying number of them are in parts of the virus we know are important for becoming more infectious as well as avoiding antibodies and other parts of the immune system.

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How worrying is the new COVID variant?

Take the receptor-binding domain, a key part of the virus’ spike protein that allows it to grab onto our cells. The Delta variant has two mutations in the RBD, the now rare Beta variant (formerly known as the South Africa variant) has three.

Omicron has 10. If there was a menu of possible mutations suited to the human host, Omicron ordered the full English.

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This is what made scientists sit up and take notice when their colleagues in South Africa first published the sequence of the new variant.

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But what caused today’s international response was evidence that a recent and steep spike in cases in south African cases may be due to Omicron. Its powers may not just be theoretical.

But we’re probably weeks away from knowing whether Omicron is a serious worry or another of COVID’s many evolutionary dead-ends.

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New COVID -19 variant named Omicron

First, its role in the recent spike in cases in South Africa isn’t confirmed. It certainly makes up the majority of cases in the COVID surge in Gauteng province (the area surrounding Johannesburg and Pretoria), and there’s evidence it’s on the rise elsewhere in South Africa.

But cases are very low in the country – around 70 times lower than the daily average in the UK. Even a small increase in numbers of a new variant can look alarming when numbers are low.

Then there’s the fact the short natural history of COVID-19 has taught us that appearances can be deceptive.

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New COVID variant: Q and A

The Beta variant is a case in point. It was effective at evading antibodies from vaccines, it caused a significant wave of infection in South Africa but it never gained a foothold against the more infectious Delta variant.

When Delta spread to South Africa it rapidly displaced Beta.

Having lots of mutations, so the theory goes, could incur costs to the virus in some other part of its biology, making it less fit in a slightly different environment to the one it evolved in.

What scientists in South Africa are doing now is growing the Omicron strain in the laboratory so they can start to test it against antibodies from vaccinated or previously infected people.

They’re also planning to share samples with their colleagues abroad including teams in the UK.

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These experiments should confirm whether Omicron truly is more contagious, or can avoid vaccines and hold its own against the delta strain.

But that will take weeks of work. Until then, eyes will be on South Africa’s outbreak to see whether it provides more answers: is this just a first, but short-lived, flush from a flashy but flawed viral mutant? Or are we witnessing COVID’s next big evolutionary step?

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Ukraine war: Zelenskyy warns partners not to let Putin ‘deceive’ them on ceasefire

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Ukraine war: Zelenskyy warns partners not to let Putin 'deceive' them on ceasefire

Volodymyr Zelenskyy has called on Ukraine’s partners to make sure Russia doesn’t “deceive” them over a ceasefire.

After breakthrough talks between Ukrainian and US officials in Saudi Arabia, Kyiv said it was ready to accept a proposed 30-day ceasefire with Russia.

But his nightly address on Wednesday evening, a day after the Jeddah summit, President Zelenskyy said, “we must move toward peace” – but issued a warning to allies.

“The key factor is our partners’ ability to ensure Russia’s readiness not to deceive but to genuinely end the war,” the Ukrainian leader said. “Because right now, Russian strikes have not stopped.”

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From Tuesday: Ukraine backs ceasefire plan

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The focus has now switched to Vladimir Putin’s response to the proposed ceasefire. President Trump said the US had received “some positive messages” adding: “We have people going to Russia right now”.

However, he warned Moscow: “In a financial sense, yeah we could do things very bad for Russia, would be devastating for Russia.”

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Will Russia go for ceasefire deal?

European defence ministers, meeting in Paris, said now was the time for Moscow to show it was serious about ending the war.

UK Defence Secretary John Healey was among those attending, and had a direct message for Russia’s president: “I say to president Putin, over to you, you want to talk, prove it.”

Mr Healey called on Russia to accept the ceasefire and end the war, adding, “the pressure is now on Putin”.

For his part, President Putin has been playing to his domestic audience with a visit to Kursk, where Russian troops finally seem to be gaining the upper hand against Ukrainian forces who seized territory in the Russian region last year.

The Russian line is approaching Sumy from Kursk Oblast
Image:
The Russian line is approaching Sumy from Kursk Oblast

Dressed in camouflage, the Russian president called for his forces to defeat the enemy and completely liberate Kursk, in remarks reported by the Interfax news agency.

He also said enemy troops captured in the region will be treated as terrorists, as Russia’s chief of the general staff told Mr Putin that Ukrainian forces in the region are surrounded.

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Pakistan: Hostages killed after separatist militants hijack train carrying hundreds of passengers

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Pakistan: Hostages killed after separatist militants hijack train carrying hundreds of passengers

Hostages have been killed after separatist militants hijacked a train carrying hundreds of passengers in Pakistan, authorities have said.

The Pakistan military (ISPR) said 21 hostages were killed, as well as four security force soldiers, on the train that was carrying more than 400 people.

Earlier on Wednesday, the Baloch Liberation Army (BLA) claimed responsibility for the attack and said they had killed 50 people.

A Pakistani government spokesman described the attack as “an act of terrorism,” and passengers who had been freed described how gunfire was “coming from everywhere”.

ISPR director general Ahmed Sharif Chaudhry added in a statement: “Today we freed a large number of people, including women and children. The final operation was carried out with great care.”

A soldier stands guard next to a rescue train after the hijack by separatist militants. Pic: Reuters
Image:
A soldier stands guard next to a rescue train after the hijack by separatist militants. Pic: Reuters

The train was hijacked on Tuesday as it entered a tunnel in Bolan, a district in the southwestern province of Balochistan.

The Jaffar Express was packed with 440 people, including women and children, Mr Chaudhry told local broadcaster Dunya TV.

He added that “militants were in touch with their handlers and masterminds in Afghanistan via satellite phones” during the incident.

Passengers rescued by security forces from a passenger train attacked by insurgents arrive at a railway station in Quetta, Pakistan, Wednesday, March 12, 2025. (AP Photo/Arshad Butt)
Image:
Passengers rescued by security forces from the hijacked train. Pic: AP

The train was on a 1,000-mile journey from Quetta to the city of Peshawar.

Militants blew up the railway tracks before firing at the train, killing the driver and trapping it inside a tunnel at Mashkaf.

Security forces exchanged gunfire with the militants who were wearing vests loaded with explosives.

The train was hijacked as it entered a tunnel in Bolan, Pakistan
Image:
The train was hijacked as it entered a tunnel in Bolan, Pakistan

‘God saved us’

Noor Muhammad, who was travelling with his wife, said: “First, they hit the engine with an RPG (rocket-propelled grenade).

“After that, gunfire started and explosions were heard, RPGs were used. God saved us.

“They made us get off (the train) and told us to get down or they would shoot. We got down and then they said ‘leave’.”

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Passengers rescued by security forces from a passenger train attacked by insurgents comfort each other upon their arrival at a railway station in Quetta, Pakistan, Wednesday, March 12, 2025. (AP Photo/Arshad Butt)
Image:
Officials said a large number of the hostages had been rescued. Pic: AP

Bashir Yousaf, who was with his family, said: “Everyone was crying and passengers were shouting, everyone was lying on the floor trying to save their lives.

“The sound of gunfire was coming from everywhere, then they (insurgents) told us to get down.

“After getting off we were told not to look back. I just kept walking without looking back to save my family’s lives.”

A paramilitary soldier takes position at a railway station near the attack site of a passenger train by insurgents, in Mushkaf in Bolan district of Pakistan's southwestern Balochistan province, Wednesday, March 12, 2025. (AP Photo)
Image:
A soldier keeps watch near to the scene of the hijacked train. Pic: AP

Mr Chaudhry added to Dunya TV that security forces “first took out some of the militants and then began clearing compartment by compartment killing the militants”.

He said the total number of militants was 33, and added that no passenger was hurt or killed during rescue operations.

However, he added that before “the final clearance,” 21 people were killed by the militants. Four Frontier Corps soldiers were also killed.

“Perpetrators will be hunted down and will be brought to justice,” he said. “This incident of the Jaffar Express changes the rules of the game.”

Paramilitary soldiers and police officers deploy at a railway station near the attack site of a passenger train by insurgents, in Mushkaf in Bolan district of Pakistan's southwestern Balochistan province, Wednesday, March 12, 2025. (AP Photo)
Image:
Soldiers and police have been deployed at sites close to the hijacking. Pic AP

Earlier in the day, Pakistan’s Prime Minister Shehbaz Sharif condemned the attack and said security officials were “repelling” the militants, while interior minister Mohsin Naqvi called the attackers “enemies” of the country.

The BLA – designated a terrorist organisation by the UK – had demanded the release of Baloch political prisoners, activists, and missing persons within 48 hours.

It had threatened to start executing the hostages if the government did not fulfil its demands.

The group often targets infrastructure and security forces in Balochistan but has also struck in other areas, including the southern port city Karachi and the strategic port of Gwadar on the Arabian Sea.

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Pakistan: Hostages killed after separatist militants hijack train carrying hundreds of passengers

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Pakistan: Hostages killed after separatist militants hijack train carrying hundreds of passengers

Hostages have been killed after separatist militants hijacked a train carrying hundreds of passengers in Pakistan, authorities have said.

The Baloch Liberation Army (BLA) claimed responsibility for the attack and said they had killed 50 people on the train that was carrying more than 400.

Government officials have not confirmed how many hostages have been killed. Sarfraz Bugti, the chief minister in Balochistan province, said “we people have also been martyred, but we will share details later”.

More than 50 militants have been killed and the insurgent attack has now ended after a day-long stand-off, according to officials.

A soldier stands guard next to a rescue train after the hijack by separatist militants. Pic: Reuters
Image:
A soldier stands guard next to a rescue train after the hijack by separatist militants. Pic: Reuters

Security officials told the Associated Press news agency that more than 300 hostages had been rescued.

Pakistan’s junior interior minister Talal Chaudhry said 70 to 80 attackers had hijacked the train.

A Pakistani government spokesman described the attack as “an act of terrorism”.

Passengers who have been freed described how gunfire was “coming from everywhere”.

Passengers rescued by security forces from a passenger train attacked by insurgents arrive at a railway station in Quetta, Pakistan, Wednesday, March 12, 2025. (AP Photo/Arshad Butt)
Image:
Passengers rescued by security forces from the hijacked train. Pic: AP

The train was hijacked on Tuesday as it entered a tunnel in Bolan, a district in the southwestern province of Balochistan.

The Jaffar Express was packed with 425 people, including women and children.

The train was on a 1,000-mile journey from Quetta to the city of Peshawar.

Militants blew up the railway tracks before firing at the train, killing the driver and trapping it inside a tunnel at Mashkaf.

Security forces exchanged gunfire with the militants who were wearing vests loaded with explosives.

The train was hijacked as it entered a tunnel in Bolan, Pakistan
Image:
The train was hijacked as it entered a tunnel in Bolan, Pakistan

Passengers rescued by security forces from a passenger train attacked by insurgents comfort each other upon their arrival at a railway station in Quetta, Pakistan, Wednesday, March 12, 2025. (AP Photo/Arshad Butt)
Image:
Officials said a large number of the hostages had been rescued. Pic: AP

Noor Muhammad, who was travelling with his wife, said: “First, they hit the engine with an RPG (rocket-propelled grenade).

“After that, gunfire started and explosions were heard, RPGs were used. God saved us. They made us get off (the train) and told us to get down or they would shoot. We got down and then they said ‘leave’.”

Read more from Sky News:
Arrested captain of crashed ship is Russian national
Children under eight ‘should avoid drinking slushies’

Bashir Yousaf, who was with his family, said: “Everyone was crying and passengers were shouting, everyone was lying on the floor trying to save their lives.

“The sound of gunfire was coming from everywhere, then they (insurgents) told us to get down.

“After getting off we were told not to look back. I just kept walking without looking back to save my family’s lives.”

A paramilitary soldier takes position at a railway station near the attack site of a passenger train by insurgents, in Mushkaf in Bolan district of Pakistan's southwestern Balochistan province, Wednesday, March 12, 2025. (AP Photo)
Image:
A soldier keeps watch near to the scene of the hijacked train. Pic: AP

Paramilitary soldiers and police officers deploy at a railway station near the attack site of a passenger train by insurgents, in Mushkaf in Bolan district of Pakistan's southwestern Balochistan province, Wednesday, March 12, 2025. (AP Photo)
Image:
Soldiers and police have been deployed at sites close to the hijacking. Pic AP

Pakistan’s Prime Minister Shehbaz Sharif condemned the attack and said security officials were “repelling” the militants, while interior minister Mohsin Naqvi called the attackers “enemies” of Pakistan.

The BLA had demanded the release of Baloch political prisoners, activists, and missing persons within 48 hours.

It had threatened to start executing the hostages if the government did not fulfil its demands.

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