Lecanemab: New Alzheimer’s drug slows decline in memory – fuelling hope doctors will one day cure dementia
Doctors have hailed a “new era” of medicine after a study showed for the first time that a drug can slow the debilitating symptoms of Alzheimer’s.
Results from the clinical trial also revealed that the drug lecanemab cleared clumps of a protein called amyloid – thought to be a key cause of the most common form of dementia – from patients’ brains.
The data, published at a conference in San Francisco, led to an outpouring of optimism from scientists, many of whom had spent decades trying to understand what leads to the disease and find a treatment.
Rob Howard, professor of old age psychiatry at University College London, said the results were “wonderful and hope-filled” – adding: “At long last we have gained some traction on this most terrible and feared disease and the years of research and investment have finally paid off.
“It feels momentous and historic. This will encourage real optimism that dementia can be beaten and one day even cured.”
The manufacturers of the drug released top-line results in a news release earlier in the autumn, but many doctors held back from celebrating until full results were released at the Clinical Trials on Alzheimer’s Disease conference.
They showed that lecanemab slowed the decline in memory and mental agility by 27% in patients with mild Alzheimer’s.
‘Doctors are optimistic’
Critically, the drug removed so much of the amyloid protein that the patients wouldn’t have had enough evidence of Alzheimer’s disease on their brain scans to actually qualify for entry to the trial.
The study strongly suggests that the drug only starts to have a clinical effect once amyloid is reduced to low levels in the brain.
Results after 12 months of treatment suggested it was ineffective – but after 18 months, the effect was significant.
Doctors are optimistic that continued treatment will lead to even better results.
Professor Nick Fox, director of the Dementia Research Centre at University College London, said: “It confirms a new era of disease modification for Alzheimer’s disease, an era that comes after more than 20 years of hard work by many, many people, with many disappointments along the way.”
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Lecanemab is not a cure. But even slowing the progression of Alzheimer’s disease would be game changing, delaying the need for specialist care and allowing people to spend more time with their families.
However, the drug has side effects.
One in eight patients given lecanemab suffered brain swelling and other changes, probably as a result of removing the amyloid protein. But most only had evidence of problems on brain scans. Fewer than one in 30 had actual symptoms such as headaches or confusion.
Some patients had bleeding in the brain, though deaths were no higher in those receiving treatment than those given a dummy drug.
Nevertheless, it underlines the need for careful monitoring of those on treatment.
Prof Fox said: “Any risk is clearly important, but I believe that many of my patients would be very willing to take such a risk.
‘Massive challenge for the NHS’
Doctors warned that lecanemab will be a massive challenge for the NHS, not just because the drug is given through an intravenous infusion every two weeks.
Most Alzheimer’s patients are currently diagnosed when they have moderate symptoms – too late for treatment with lecanemab. And just 1% have their diagnosis confirmed by a brain scan or lumbar puncture, a biopsy of their spinal fluid.
Susan Kohlhaas, director of research at Alzheimer’s Research UK said: “It’s safe to say that the NHS is not ready for a new era of dementia treatment.
“We estimate that unless there are drastic changes in how people access specialist diagnostic tests for Alzheimer’s disease, only 2% of people eligible for drugs like lecanemab will be able to access them.”
Until now there have only been drugs that treated symptoms rather than the underlying cause. But if lecanemab is licensed for use on the NHS then delays in treatment will result in brain cells dying and the disease progressing.
Prof John Hardy, from the UK Dementia Research Institute in London said the drug had been “a long time coming”.
He added: “I truly believe it represents the beginning of the end.
“The first step is the hardest, and we now know exactly what we need to do to develop effective drugs. It’s exciting to think that future work will build on this, and we will soon have life-changing treatments to tackle this disease.”
As the two most powerful countries in the world, the relationship between the United States and China is the most consequential of all bilateral ties.
Any change in interactions and behaviour by either side does not just impact security, economic activity and trade in Washington and Beijing, but also affects the rest of the planet.
President Xi Jinping chose to make this point publicly as he said hello – and presumably goodbye – to Joe Biden when the two men met on the sidelines of an economic forum in Peru in what was likely their last face-to-face sit down before the US leader hands the keys to the White House over to Donald Trump.
Joe Biden and Xi Jinping shaking hands in Peru earlier this week. Pic: Reuters
“As two major countries, China and the United States should bear in mind the interest of the whole world and inject more certainty and positive energy into the turbulent world,” Mr Xi said, speaking through a translator.
“It is my consistent belief that as the world’s most important bilateral relationship, a stable China-US relationship is critical not only to the interests of the Chinese and American peoples but also to the future and destiny of the entire humanity.”
Mr Biden, whose relationship with his opposite number does not just span his four years as president but also when he previously served as vice president under Barack Obama, also focused on the importance of dialogue.
“We haven’t always agreed, but our conversations have always been candid and always been frank,” he said, sitting at a long table, surrounded by aides, with Mr Xi opposite him.
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“I think that’s vital. These conversations prevent miscalculations, and they ensure the competition between our two countries will not veer into conflict. Be competition, not conflict.”
While clearly directed at him, it is doubtful that Mr Trump will heed the advice.
He has consistently criticised the Biden administration for being too soft on Beijing and has vowed to be much tougher – even saying he would impose 60% tariffs on Chinese imports.
The president-elect’s picks for top jobs in the White House, such as with China hawks Senator Marco Rubio as his desired secretary of state, and Representative Mike Walz as national security adviser, also point to a hardening in the US’ position on Beijing – which is on a trajectory to overtake Washington as the world’s number one superpower.
This moment of re-ordering in global dominance – something the UK was once forced to absorb when the sun set on the British Empire – is on course to happen regardless of who is in the White House.
But a more hostile and combative commander-in-chief in the White House makes it an increasingly perilous time for everyone.
It is perhaps why the current leaders in Beijing and Washington are so keen to stress that while their feelings towards one another go up and down, the ability to keep talking is critical.
Joe Biden has met with Xi Jinping for the last time as US president, where the Chinese leader said he is “ready to work” with Donald Trump.
Speaking at the Asia-Pacific Economic Cooperation forum in Lima, Peru, Mr Biden said the US and China’s relationship should be about “competition, not conflict”.
“We haven’t always agreed, but our conversations have always been candid and always been frank,” he said.
“We’ve never kidded one another. These conversations prevent miscalculations, and they ensure the competition between our two countries will not veer into conflict.
“We’ve been level with one another. I think that’s vital.”
Their last-ever meeting comes as president-elect Donald Trump vows to introduce blanket 60% tariffs on US imports of Chinese goods as part of a series of “America First” trade measures.
Pic: Reuters
But despite Mr Trump’s proposed measures, Mr Xi said his country’s goal “of a stable, healthy and sustainable China-US relationship remains unchanged”.
“Our commitment to mutual respect, peaceful coexistence and… cooperation as principles for handling China-US relations remains unchanged,” he added.
The Chinese president then said the country is “ready to work with the new US administration to maintain communication, expand cooperation and manage differences, so as to strive for a steady transition”.
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Neither Mr Xi nor Mr Biden responded to a question about whether there were concerns about Mr Trump’s proposed tariffs.
The president-elect has also named several China hawks to his transition team, such as Senator Marco Rubio as secretary of state and Representative Mike Waltz as national security adviser.
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Under Mr Biden, Washington has introduced restrictions on US investment in Chinese artificial intelligence, quantum computing and semiconductors.
Former house speaker Nancy Pelosi also visited the island of Taiwan – which China views as a breakaway province – in April 2022.
In their meeting at this time last year – which followed a surge in tensions when an alleged Chinese spy balloon was shot down over the US – both leaders said direct communication between American and Chinese military forces would be restored.
Former heavyweight champion Mike Tyson says the health scare in June, which forced the postponement of his boxing match with Jake Paul, almost cost him his life.
“I almost died in June,” Tyson wrote on X, adding that he “had 8 blood transfusions. Lost half my blood and 25lbs in hospital”.
The 58-year-old, who lost to the YouTuber-turned-boxer in a unanimous points decision in Texas, tweeted that the situation was far worse than people had realised.
Following Tyson’s recovery, after reportedly suffering an ulcer flareup, he reflected on the result of the fight.
“This is one of those situations when you lost but still won… no regrets to get in the ring one last time,” he said.
That contrasts with Tyson’s comments after the match in which he refused to confirm whether it would be his last fight.
“It depends on the situation,” Tyson said before suggesting a fight with Paul’s older brother, Logan Paul, who was standing near him in the ring.
Critics argued that the revised match – which involved fewer and shortened rounds, as well as heavier gloves – fell short of entertaining.
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Paul beats Tyson by unanimous decision
Some claimed it appeared more like a glorified sparring session.
It was Tyson’s first sanctioned pro bout since 2005, when he lost to Kevin McBride and then went into retirement – only briefly reappearing for an exhibition match in 2020 against Roy Jones Jr.
Jake Paul believes he can fight for a championship belt within two years. Pic: AP
Paul has plenty to prove
Paul, 27, still has plenty to prove. The social media influencer wants to be a championship fighter and compete for a championship belt within two years. “I think it could happen in the next 24 months,” Paul said.
“I truly, truly believe in my skills and my ability and my power. And the cruiserweight division is seemingly open for the taking on that timeline,” he added.
The only professional match he has lost so far has been to Tommy Fury, the less-accomplished brother of former heavyweight champion Tyson Fury.
But there are questions about when Paul will fight a contender in his prime, as opposed to former champions or mixed martial artists.
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Intriguingly, in the days before his fight with Tyson, Paul mentioned super middleweight champion Canelo Alvarez, considered one of the best boxers in the world.
According to reports, the Texas bout earned Paul $40m (£31.7m) versus $20m (£15.8m) for Tyson.
Netflix said 60 million households worldwide viewed the contest on its streaming platform, and nearly 50 million tuned in to watch the undercard which saw Ireland’s Katie Taylor beat Puerto Rico’s Amanda Serrano.
Even so there were some technical glitches. More than 90,000 users reported problems on Netflix at its peak, according to the website Downdetector, which tracks outages.
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