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Cells that make up the cartilage at the end of children’s and teens’ bones determine their future length and shape, which, in turn, affect height.  (Image credit: Marko Geber via Getty Images)

Scientists have pinpointed 145 potential “height genes” in cells that make up the cartilage at the ends of children’s bones and affect how tall they grow.

These cartilage cells, known as chondrocytes, multiply and mature in areas of tissue called growth plates, which sit near the ends of long bones in children and teens and determine each bone’s future length and shape. When a person’s growth is complete, these cartilaginous growth plates “close” and are replaced by hard bone. Scientists already knew that chondrocytes play a role in bone growth and human height, but narrowing down which genes control the cells’ growth — and, thus, our statures — has proved difficult.

“Pinpointing specific genes associated with human height is a challenging task, as height is a complex trait that is influenced by both genetic and environmental factors,” Dr. Nora Renthal (opens in new tab) , a pediatric endocrinologist at Boston Children’s Hospital and Harvard Medical School and senior of the new study, told Live Science in an email. “Our study focused on cartilage cells specifically because they are the primary cell type involved in bone growth.”

In a study published Friday (April 14) in the journal Cell Genomics (opens in new tab) , Renthal and her colleagues screened 600 million mouse cartilage cells to find genes that influence how the cells proliferate and mature. They used CRISPR genome-editing technology to “knock out” candidate genes, which allowed the researchers to observe what happened when these genes were erased and no longer regulated cartilage cells.

Related: What determines a person’s height? 

The researchers found 145 genes that, when knocked out, triggered abnormal growth and development of mouse cartilage cells. These patterns of abnormal growth were similar to those seen in certain skeletal disorders, such as skeletal dysplasia — a group of genetic disorders that affect the development of bones, joints and cartilage in babies. Those with skeletal dysplasia are typically of short stature and have short limbs, among other symptoms.

Next, the researchers compared these 145 mouse genes with previous results from large-scale genetic studies of human height, called genome-wide association studies (GWAS). In those studies, researchers compared the DNA of thousands of people of different heights to look for gene variants associated with height, Renthal explained. To control for non-genetic factors that influence the trait under study, such as nutrition and disease in the case of human height, these factors are incorporated into GWAS, according to a 2021 review published in the journal Nature Reviews Methods Primers (opens in new tab) .

“These studies have contributed to our understanding of the genetic basis of complex traits like height by identifying specific genetic regions and genes that are associated with the trait,” Renthal said.

The comparison revealed a remarkable overlap between genetic “hotpots” linked to human height in the GWAS and the 145 genes that control cartilage cell growth in mice. This means that these genes, which the researchers have now precisely located in the human genome, could influence height more than other genetic factors do.RELATED STORIES—More than 150 ‘made-from-scratch’ genes are in the human genome. 2 are totally unique to us.

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“Our current study has helped to identify new genes potentially involved in bone growth and development,” Renthal said. “Specific genes and pathways involved in the maturation and proliferation of chondrocytes, the cells that make up cartilage in our bones, play a critical role in human height.”

Results from mouse cells may not mirror cellular processes in humans, Renthal noted in a statement (opens in new tab) , but the researchers think height genes could come in handy in clinical settings. 

“It is our hope that the identification of these 145 genes will help patients with skeletal dysplasia and other skeletal disorders,” Renthal told Live Science.

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Joe Biden allows Kyiv to begin firing US rockets deep into Russia – as politician warns it ‘risks World War Three’

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Joe Biden allows Kyiv to begin firing US rockets deep into Russia - as politician warns it 'risks World War Three'

Joe Biden has authorised Ukraine to begin firing US-supplied rockets deep into Russia – as Sir Keir Starmer prepares to push for “further support” for Kyiv at the G20 summit.

Mr Biden’s policy shift means Kyiv will now be able to use Army Tactical Missile Systems (ATACMS) for long-range attacks, two American officials have told Sky News’ US partner network NBC News.

Ukraine plans to conduct its first such attacks in the coming days, the sources said, without revealing details due to operational security concerns.

The US has eased restrictions on the use of ATACMS, which have a range of up to 190 miles, after Russia began deploying North Korean ground troops to supplement its own forces in the conflict.

The development was condemned by Biden officials as a possible expansion of the war.

President Joe Biden meets with Ukrainian President Volodymyr Zelenskyy in the Oval Office in September last year. Pic: AP
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Joe Biden meets with Volodymyr Zelenskyy in the Oval Office in September last year. Pic: AP

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A Russian politician and the son of president-elect Donald Trump have both likened the move to risking a third world war.

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Maria Butina told the Reuters news agency: “These guys, Biden’s administration, is trying to escalate the situation to the maximum while they still have power and are still in office.

“I have a great hope that Trump will overcome this decision if this has been made because they are seriously risking the start of World War Three which is not in anybody’s interest.”

Meanwhile, Donald Trump Jr wrote on X: “The Military Industrial Complex seems to want to make sure they get World War 3 going before my father has a chance to create peace and save lives… Imbeciles!”

The outgoing Biden administration’s move comes as there are concerns about the level of support the Trump White House may be willing to give Ukraine.

Mr Trump has previously vowed to limit US support for Ukraine and end its war with Russia.

In an evening address after Kyiv was given permission to fire deep into Russia, Ukrainian President Volodymyr Zelenskyy said: “Today, there’s a lot of talk in the media about us receiving permission for respective actions. But strikes are not carried out with words. Such things are not announced. Missiles will speak for themselves. They certainly will.”

Back in September, Russian President Vladimir Putin said if the US were to lift the ban on long-range missile use it would be seen as NATO’s “direct participation” in the war.

He added: “This, of course, will significantly change the very essence, the very nature of the conflict.”

The US military tests an early version of an Army Tactical Missile System in 2021. Pic: AP
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The US military tests an early version of an Army Tactical Missile System in 2021. Pic: AP

Meanwhile, the UK prime minister has said he has “no plans” to speak with the Russian president as world leaders gather for the G20 summit in Rio de Janeiro.

Mr Putin will not be attending the two-day summit which starts on Monday after saying in October that his presence would “disrupt the normal work of this forum”. Russia’s foreign minister Sergei Lavrov will be attending instead.

It will take place days after German Chancellor Olaf Scholz spoke to Mr Putin on what was the Russian leader’s first publicly announced conversation with the sitting head of a major Western power in nearly two years.

Asked if he had any plans to make a similar call, Sir Keir said: “It’s a matter for Chancellor Scholz who he speaks to. I have no plans to speak to Putin.”

Read more:
Why Biden’s move will trigger fury from Moscow
The city where schools go underground to flee Russian missiles
Xi tells Biden that China is ‘ready to work’ with Trump

Firefighters work at the site of a residential area hit by a Russian missile strike in the Lviv region of Ukraine. Pic: Reuters
Image:
Firefighters work at the site of a residential area hit by a Russian missile strike in the Lviv region of Ukraine. Pic: Reuters

Speaking to reporters while on his way to the summit, he added: “We are coming up to the 1,000th day of this conflict on Tuesday.

“That’s 1,000 days of Russian aggression, 1,000 days of huge impact and sacrifice in relation to the Ukrainian people and recently we’ve seen the addition of North Korean troops working with Russians which does have serious implications.

“I think on one hand it shows the desperation of Russia, but it’s got serious implications for European security […] and for Indo-Pacific security and that’s why I think we need to double down on shoring up our support for Ukraine and that’s top of my agenda for the G20.

“There’s got to be full support as long as it takes and that certainly is top of my agenda, shoring up that further support for Ukraine.”

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One of Russia’s ‘largest air attacks’

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The latest developments come after Russia launched a large-scale attack on Ukraine on Sunday, with Mr Zelenskyy claiming Moscow had launched a total of 120 missiles and 90 drones.

Two major strikes, which left a total of 18 people dead, hit a residential building in the northeastern city of Sumy as well as energy infrastructure across Ukraine, prompting emergency power cuts.

Hours later, Moscow mayor Sergei Sobyanin said Russia’s air defence units had destroyed a drone heading towards the city.

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Octopuses May Become Earth’s Next Dominant Species If Humans Go Extinct

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Octopuses May Become Earth's Next Dominant Species If Humans Go Extinct

In the event of human extinction due to war or climate change, octopuses have been identified as potential rulers of Earth, according to leading scientists. Their intelligence, dexterity, and adaptability are believed to position them as candidates for developing an advanced civilisation. Professor Tim Coulson, a zoologist at the University of Oxford, suggests that octopuses could evolve tools and technologies to build underwater cities akin to human societies should the right environmental conditions emerge.

Key Traits Supporting Octopus Dominance

As per a report by DailyMail UK, there are several attributes of octopuses that make them unique. Their problem-solving capabilities, decentralised nervous system, and ability to manipulate objects enable them to adapt to challenging environments. The report further highlights that while they are unlikely to fully transition to land due to their lack of a skeleton, it is believed they could find innovative ways to extend their time out of water, such as developing breathing apparatuses.

These marine creatures, already adept at using tools and hunting, could exploit niches left vacant in a post-human world, the report adds. Octopuses are known to thrive in diverse environments, from deep seas to coastal waters, and possess the capacity for both solitary survival and complex behaviours.

Primates Unlikely to Succeed Humans

Contrary to previous theories suggesting primates might replace humans, the report reveal that researchers argue that primates face many of the same extinction threats as humans. Slow reproductive rates, vulnerability to predators, and dependence on specific ecosystems reduce their chances of survival in a changed world. The report further mentions that while intelligent birds and insects demonstrate advanced behaviour, they lack the dexterity needed to create tools or transform their surroundings on a human scale.

Speculative but Plausible Future

Professor Coulson told the publication that the rise of octopuses as dominant species is speculative. Evolution is unpredictable, shaped by countless variables, random mutations, and extinction events. However, given the intelligence and adaptability of octopuses, they remain a strong contender for evolving into an advanced civilisation in the absence of human influence, he told the publication.

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AI Technology Detects Cancerous Brain Tumours in 10 Seconds During Surgery

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AI Technology Detects Cancerous Brain Tumours in 10 Seconds During Surgery

A groundbreaking artificial intelligence tool called FastGlioma has been developed, enabling surgeons to detect residual cancerous brain tumours within 10 seconds during surgery. The innovation, detailed in a recent study in Nature, is seen as a significant advancement in neurosurgery, outperforming traditional tumour detection methods. Researchers from the University of Michigan and the University of California, San Francisco, led the study, highlighting its potential to improve surgical outcomes for patients with diffuse gliomas.

Todd Hollon, M.D., a neurosurgeon at the University of Michigan Health, described FastGlioma as a transformative diagnostic tool that provides a faster and more accurate method for identifying tumour remnants. He noted its ability to reduce reliance on current methods, such as intraoperative MRI or fluorescent imaging agents, which are often inaccessible or unsuitable for all tumour types.

Addressing Residual Tumours During Surgery

As per the study from Michigan Medicine – University of Michigan, residual tumours, which often resemble healthy brain tissue, are a common challenge in neurosurgery. Surgeons have traditionally struggled to differentiate between healthy brain and remaining cancerous tissue, leading to incomplete tumour removal. FastGlioma addresses this by combining high-resolution optical imaging with artificial intelligence to identify tumour infiltration rapidly and accurately.

In an international study, the model was tested on specimens from 220 patients with low- or high-grade diffuse gliomas. FastGlioma achieved an average accuracy of 92%, significantly outperforming conventional methods, which had a higher miss rate for high-risk tumour remnants. Co-senior author Shawn Hervey-Jumper, M.D., professor of neurosurgery at UCSF, emphasised its ability to enhance surgical precision while minimising the dependence on imaging agents or time-consuming procedures.

Future Applications in Cancer Surgery

FastGlioma is based on foundation models, a type of AI trained on vast datasets, allowing adaptation across various tasks. The model has shown potential for application in other cancers, including lung, prostate, and breast tumours, without requiring extensive retraining.

Aditya S. Pandey, M.D., chair of neurosurgery at the University of Michigan, affirmed its role in improving surgical outcomes globally, aligning with recommendations to integrate AI into cancer surgery. Researchers aim to expand its use to additional tumour types, potentially reshaping cancer treatment approaches worldwide.

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