Could the next public health crisis be caused by a fungus?

Such an emergency is the basis of the post-apocalypse TV drama series The Last Of Us, which has returned for its second season on Sky Atlantic.

Starring Pedro Pascal and Bella Ramsey, the show takes place in a world ravaged by a pandemic caused by a mass cordyceps outbreak, which transforms people into bloodthirsty abominations.

The prospect was outlined in its debut episode in 2023, when a prescient epidemiologist played by John Hannah warned how a warming climate could force some fungus to evolve into something more dangerous.

“Candida, ergot, cordyceps, aspergillus: any one of them could be capable of burrowing into our brains and taking control of not millions of us, but billions,” he said.

An extreme outcome with plenty of artistic licence taken – but is it entirely without scientific basis?

Do fungi really threaten humans?

“There are numerous fungi infecting the brains of human beings all over the planet, often with devastating outcomes,” says Professor Elaine Bignell, a world leader in the field of human fungal pathogen research.

“A number of fungal species are quite prominent pathogens and kill hundreds of thousands of people every year – it’s just the public is not well aware of this.”

A few of the dangers identified by The Last Of Us’s fictional epidemiologist previously featured on a list of health-threatening fungi by the World Health Organisation (WHO).

Among the fungi deemed most high-risk was Aspergillus fumigatus, a common mould widespread in the environment in homes and outdoors, which can cause “chronic and acute lung disease” and can be deadly.

Candida species, which are behind complaints like thrush and skin rashes, are also one of the leading causes of bloodstream infection in intensive care patients.

Cryptococcosis neoformans – which infects the lungs and brain, causing pneumonia and meningitis in immunosuppressed patients – also made the list. It kills more than 100,000 people a year in sub-Saharan Africa.

“One thing killer fungi do have in common is they are able to grow at human body temperature, and that’s unusual for a fungus,” Prof Bignell tells Sky News.

“Most fungi in the environment are suited to growing in more temperate conditions, and it places quite a strain on any microorganism to counteract an immune response in a human body and cope with the high temperature.”

What about cordyceps?

Cordyceps was not on the threat list – but it is absolutely real.

The parasitic fungus infects and takes over the mind of insects, as it does to humans in The Last Of Us.

“There are about 600 species,” says Dr Mark Ramsdale, a professor in molecular microbiology at the MRC Centre for Medical Mycology.

“They are predominantly insect pathogens. It’s their insect host that they manipulate and change their behaviour. And so from that perspective, there is some basis there.”

Found in tropical forests, the fungus penetrates an insect’s body via spores, which are released to allow a fungus to reproduce and defend itself.

The fungus then guides its host into more humid locations to help it grow, before feeding on the remains and launching new spores from its corpse.

When it comes to humans, cordyceps is used in treatments and therapeutics – notably Chinese herbal medicines.

“There’s a long history of relationships between humans and this particular group,” Dr Ramsdale tells Sky News.

“There’s no evidence they’re causing disease in humans. However, in terms of their insect relationships, they do manipulate their hosts – and several fungi have evolved this capacity over time.”

Could climate change the picture?

Another facet of The Last Of Us shared by the WHO’s landmark report was the potential influence of climate change on the nature of fungi and our relationship with it.

Prof Bignell says the impact of global heating will be “profound” for all microbes on our planet.

There are some 150,000 identified species of fungi in the world, well short of the millions estimated to exist, and few have what it takes to cope with the 37C temperature and other stresses imposed by the human body.

But some do, and more could – either those yet to be discovered or which adapt to survive on a warming planet.

Read more:
Fungus unknown to science discovered in Scotland

“It changes the selection pressures that are put on those huge, diverse life forms,” says Dr Ramsdale.

“Perhaps some could potentially make that transition from one lifestyle to another and become pathogenic in a context we haven’t thought of before.”

So the show’s pandemic may be far from factual, but it’s not completely without merit.

“What really is the most removed from the current status quo is the scale and the rate of the infections occurring in The Last Of Us,” says Prof Bignell.

“Some fungi can get passed from one person to the next – and in the environment we are exposed to them all the time – but it would take a very significant variant to be able to cause the sorts of species extinction event they’re dramatising.”

So … no reason for alarm?

You can sleep easy knowing there won’t be a fungus that turns you into a zombie in your cereal tomorrow morning.

But COVID, researchers say, is proof we can’t rest on our laurels when it comes to public health threats and the potentially sudden nature of their arrival.

With fungal infection in humans being a relatively modern phenomenon, with few examples until the 1980s, and the absence of any antifungal vaccine research programmes, there’s certainly work to do.

“We have to be in a state of preparedness,” says Prof Bignell.

“We have to have a very good understanding of how different fungi can cause human diseases, how our immune systems cope with those microbes, and a good medicine cabinet with antifungal agents we know are effective.”

In the meantime, if you do happen to see anyone that looks like they’re covered in mushrooms and feasting on a member of their family – best steer clear.

The Last Of Us airs every Monday at 2am on Sky Atlantic.

DALLAS — Nathan MacKinnon had a part in both of Colorado’s strange goals in the second period before adding an empty-netter late as the Avalanche beat the Dallas Stars 5-1 in the opener of their first-round Western Conference playoff series Saturday night.

MacKinnon scored on a shot that deflected off Stars defenseman Ilya Lyubushkin, and knuckled past goalie Jake Oettinger late in the second period. That came during an extended power play, a double minor against the Stars after he took a high stick to the face.

That came after MacKinnon’s assist midway through the second period on a goal by Artturi Lehkonen, who was following his initial shot and falling down after a collision in front of the net when the puck ricocheted off his lower left leg into the top corner of the net. The play was reviewed and officials ruled that there was no kicking motion by Lehkonen while tumbling to the ice with Mavrik Bourque.

“He was really good tonight,” Avalanche coach Jared Bednar said. “You know, like, obviously they’re going to key on him — like we do on some of their players — but really strong defensive game from him. And obviously, his get-up-and-go on the offensive side of it, he’s making plays all night. I thought that line was dangerous.”

There wasn’t much Oettinger could do on either of those goals as the Stars lost Game 1 in their eighth consecutive series in the NHL playoffs since 2022. They are 0-7 in series openers under coach Pete DeBoer, six of those coming at home. DeBoer saw progress, however, calling the effort Saturday night “the best game we’ve played in 3-4 weeks.”

Devon Toews gave Colorado a 3-1 lead with 7:04 left. MacKinnon’s empty-net tally for his 50th career playoff goal came with 3:08 left, 11 seconds before Charlie Coyle scored.

This series-opening loss for the Stars came after they finished the regular season on an 0-5-2 stretch that included four losses at home after being 28-5-3 before that.

Game 2 is Monday night in Dallas, before the series shifts to Denver.

Mackenzie Blackwood stopped 23 shots in his first career playoff game.

It was pretty special,” Blackwood said. “I’ve been waiting to play in the playoffs for a long time and it was great to finally get my first one.”

Blackwood was one of 11 players who have seen action since being acquired through Colorado’s eight in-season trades. Those deals included the Avalanche trading Mikko Rantanen on Jan. 24 to Carolina in the East. He played only 13 games before a deadline deal March 7 sent him back to the Central Division with the Stars and included an eight-year, $96 million contract extension.

Rantanen, who had 101 points (34 goals, 67 assists) in 81 playoff games for the Avalanche, had three shots and one block over 18 minutes in his postseason debut with the Stars.

Oettinger had 19 saves, three when Colorado had a two-man advantage in the first period when Cale Makar drew two tripping penalties only 36 seconds apart from each other.

Roope Hintz, who had the penalty against MacKinnon, trimmed the Stars’ deficit to 2-1 on his goal with 13:15 left in the game, just before the end of a power play and about a minute after DeBoer called a timeout.

Bednar got his 50th playoff win with the Avs — in his 82nd postseason game, equal to a full regular season. That broke a tie with Bob Hartley for the most wins by a coach in franchise history. Both won Stanley Cups — Bednar in 2022 and Hartley in 2001.

The Associated Press contributed to this report.

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