People are having to play “pharmacy bingo” – going from shop to shop to find stocks – as medicine shortages are worsening, experts have said.

Health leaders say some patients are even having to “ration” their drugs, with a new poll suggesting shortages are a “daily occurrence” for many of England’s pharmacies.

Treatments for ADHD, diabetes and epilepsy are among those affected this year, according to trade body Community Pharmacy England.

Its survey of more than 6,000 pharmacies and 2,000 staff found shortages are “wreaking havoc” on patients.

Nearly all (97%) of staff said patients were being inconvenienced, while 79% said health was being put at risk.

Some 98% said they were also giving out more “I owe yous” – where they can only fulfil part of the prescription.

Nearly all (99%) pharmacies reported supply problems at least weekly, and 72% said they were having “multiple issues a day”.

Another survey last month, by the Nuffield Trust thinktank, said drug shortages had more than doubled between 2020 and 2023 and that Brexit was likely to “significantly weaken” the UK’s ability to deal with the issues.

Shortages have also been a growing problem in Europe and the US in recent years.

However, the UK leaving EU supply chains is said to have added complications such as custom checks at borders and drug makers facing extra regulation.

The falling value of the pound after Brexit has also made it more expensive for the NHS to buy medicines.

Community Pharmacy England boss Janet Morrison said the supply problems were “beyond critical” and had become an “ongoing battle” for pharmacies.

“Patients with a wide range of clinical and therapeutic needs are being affected on a daily basis and this is going far beyond inconvenience, leading to frustration, anxiety and affecting their health,” she added.

“For some patients, not having access to the medicines they need could lead to very serious consequences, even leaving them needing to visit A&E.”

Ms Morrison said the survey was “yet another stark warning which must not be ignored”.

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William Pett from Healthwatch England called it an “ongoing issue that continues to wreak havoc on patients”.

“Healthwatch England hears about how shortages can lead to rationing and desperate instances of ‘pharmacy bingo’, where patients must travel from pharmacy to pharmacy looking for stock,” he said.

Paul Rees, head of the National Pharmacy Association, urged the government “to sort out the UK’s fragile medicines supply system, so that pharmacies can do their job and patients can get their lifesaving medicines in time”.

The Department of Health and Social Care is yet to comment.

A British girl has had her hearing restored after becoming the first person worldwide to take part in a pioneering new gene therapy trial.

Opal Sandy was born totally deaf due to auditory neuropathy, which disrupts nerve impulses from the inner ear to the brain.

But the 18-month-old’s hearing is now almost normal – and could improve further – after having the one-time treatment.

Opal was treated at Addenbrooke’s Hospital in Cambridge and the head of the trial, Professor Manohar Bance, said results were “better than I hoped or expected” and he hopes medics might be able to cure others with this type of deafness.

“We have results from (Opal) which are very spectacular – so close to normal hearing restoration. So we do hope it could be a potential cure,” he said.

Auditory neuropathy can be caused by a fault in the OTOF gene, which makes a protein called otoferlin and enables cells in the ear to communicate with the hearing nerve.

Opal, from Oxfordshire, had an infusion of the working gene into her right ear during surgery in September – the treatment developed by biotech firm Regeneron.

Her parents noticed changes in only four weeks and the improvements were especially noticeable 24 weeks later.

Jo and James Sandy, both 33, said they were “gobsmacked” when she responded to sound tests at home without her cochlear implant, the usual way to treat the condition.

“I thought it was a fluke or like a change in light or something that had caught her eye, but I repeated it a few times,” said Mrs Sandy.

They say she now enjoys the sound of slamming her cutlery on the table and playing with toy drums and wooden blocks.

“We were told she had near normal hearing last time,” she added. “I think they got responses at sort of 25 to 30 decibels.

“I think normal hearing is classed at 20 decibels, so she’s not far off. Before, she had no hearing whatsoever.”

Opal’s surgery was very similar to fitting a cochlear implant, according to Prof Bance.

He said the inner ear (cochlea) was opened and the treatment infused using a catheter over 16 minutes.

“We have to make a release hole in another part of the ear to let the treatment out because it has to go all the way through the ear,” he said.

“And then we just repair and close up, so it’s actually a very similar approach to a cochlear implant, except we don’t put the implant in.”

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He said the gene therapy potentially “marks a new era in the treatment for deafness”.

“It was just the fact that we’ve been hearing about this for so long, and there’s been so much work, decades of work… to finally see something that actually worked in humans… It was quite spectacular and a bit awe-inspiring really,” he said.

The treatment was developed especially for children with OTOF mutations, and a second child who has had the same surgery is also seeing positive results.

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The trial has three parts – with three deaf children, including Opal, getting a low dose in just one ear.

Another three children will get a high dose on one side. Then, if safe, a new set of children will get a dose in both ears at the same time.

Up to 18 people from the UK, US and Spain are being recruited and will be followed up for five years.

Results of the study were presented on Wednesday to the American Society of Gene and Cell Therapy conference in Baltimore.

Three men have been arrested on suspicion of terrorism offences.

The men have been taken into custody in northern England on suspicion of “commission, preparation and instigation of acts of terrorism”.

Greater Manchester Police said that at about 7.30pm, four warrants were executed in the Bolton, Great Lever, Abram and Hindley areas.

The men, aged 35, 36 and 51, were arrested at separate locations and have been taken into custody for questioning.

Scenes remain in place at the four addresses as inquiries are carried out, the force said, while warning the local community they may see an increased police presence in the coming days.

Assistant Chief Constable Rob Potts, who holds responsibility for counter terrorism policing in the north west, said: “This evening we have executed a number of planned warrants as part of an ongoing counter terrorism investigation.

“Three men have been taken into custody for questioning and scenes remain in place as we conduct further enquiries.

“Today’s activity has been the culmination of much detailed planning and we have put measures in place to minimise disruption to local residents as much as possible.”

He added: “I want to reassure members of the public that we do not currently believe there to be any wider threat linked to today’s activity.”