Before he died alone in his jacuzzi, Matthew Perry had received three injections of ketamine in the space of just six hours. “Shoot me up with a big one,” he told his personal assistant, ahead of the final, fatal dose.

According to court documents, in the period leading up to 28 October 2023, Kenneth Iwamasa was illegally administering Perry with between six and eight shots of the drug, an anaesthetic that can have hallucinogenic effects, each day.

A live-in assistant, he admitted to finding the actor unconscious at his Pacific Palisades home on at least two occasions in the weeks prior.

The hit that ultimately killed the Friends star was supplied by Jasveen Sangha, also known as the “Ketamine Queen” – a dealer who apparently only dealt “with high-end and celebs”. She has agreed to plead guilty to five charges and will appear in court later today.

Her charges, along with others filed against Iwamasa and others over the supply of ketamine to Perry, exposed part of Hollywood’s underground drug network – and put the spotlight on the world of celebrity, money and power.

‘Yes men’ with terrible consequences

Perry’s death was met with both utter shock and a sad sense of the inevitable. The world knew him best as Chandler Bing, the comic heartbeat of Friends. But behind the jokes and the sarcasm, he was deeply troubled.

“It almost felt like we’d been mourning Matthew for a long time because his battle with that disease was a really hard one for him to fight,” is how his former co-star Jennifer Aniston described his addiction in a recent interview. “As hard as it was for all of us and for the fans, there’s a part of me that thinks this is better… I’m glad he’s out of that pain.”

The actor was an addict, and vulnerable – but also a huge star, worth millions.

Iwamasa was administering the injections, ultimately playing God – but to him, the power most likely lay with his famous boss. His actions may seem inexcusable, but did he feel he had a choice?

“I think it was a situation that increasingly got more and more out of control,” says Bonnie Low-Kramen, a former celebrity assistant turned trainer, and author of Be The Ultimate Assistant.

Those who do the job, especially in Los Angeles, can be put under an enormous amount of pressure, she says, “tasked with doing things many of us wouldn’t imagine carrying out for our employers. It is a job which comes with an inherent power imbalance”.

Which means it can be incredibly hard to say no.

“When people are rich and famous, they often have people around them who won’t say no,” she says. “And assistants are in the yes business anyway.

“We’re in the business of figuring out, ‘well, let’s solve the problem…’. When money is no object, there are new rules that apply in that situation and that can be really hard to handle.”

Iwamasa is not the first celebrity assistant asked to administer or pick up illegal drugs, she says, and Perry is not the first star to die after taking drugs.

Ms Low-Kramen highlights the deaths of Janis Joplin, Prince and John Belushi as just a few other examples.

“Unfortunately, there are so many examples of this tragic end, where the abuse of drugs gets to a point where they’ve handled it for a really long time, and then the day comes when it can’t be handled anymore.”

For those struggling with addiction, being surrounded by “yes men” can have terrible consequences, says Garrett Braukman, an addiction treatment executive in Hollywood.

“Treatment is difficult for people when they have yes men. They have a lot of people that are going to tell them you can get whatever you want, you can get drugs, you can get alcohol, you could do whatever, and no one is willing to really look at that from the perspective of how dangerous that is.”

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Mr Braukman says addiction can go hand in hand with fame and that a “high” percentage of his patients work in the entertainment industry.

“I don’t know how I would be able to stay clean and sober if I go to my grandma’s house and there’s 20 guys outside of my grandma’s house taking pictures of me walking in. You become an animal to a degree that people are watching.”

Rise in use of ketamine

The use of ketamine recreationally has been on the rise in recent years, in the UK as well as the US. In England, some 3,609 people started treatment for problems with the drug in the year 2023-2024 – more than eight times the number in 2014-2015, when 426 sought help, according to government statistics.

In January, drag queen The Vivienne was found dead in the bath at their home in Cheshire, aged 32. The star’s family later told how the performer had died “from the effects of ketamine use causing a cardiac arrest”.

Ketamine is usually taken recreationally as a crushed powder, but also sometimes injected or swallowed – making people feel detached and dreamlike. It can also cause severe bladder and kidney problems.

Perry’s struggles with alcohol and other drugs, before ketamine, were long running and well documented, starting with drinking as a teenager before moving on to painkilling prescription drugs Vicodin and OxyContin, and tranquilliser Xanax.

“I have spent upward of $7m (£5.8m) trying to get sober,” he wrote in his memoir, released when he was clean, just a year before his death.

While accepting the almost unsurpassable legacy of the hit show that made him a star, he said he hoped his support for fellow addicts would be the achievement he was best remembered for.

“When I die, I don’t want Friends to be the first thing that’s mentioned – I want helping others to be the first thing that’s mentioned and I’m going to live the rest of my life proving that.”

He only lived for another year.

Illegal use v therapy

Before he died, Perry had been undergoing legal ketamine infusion therapy to treat depression and anxiety. The drug can be used as a treatment in clinical settings in the US, and some specialist and private centres in the UK – although there are concerns from some medics here about its use even in those settings.

According to a postmortem report, the actor had reportedly been clean for 19 months before he started obtaining the drug illegally as well.

It was not the supervised doses that killed him, but the idea of an addict taking the drug to help their problems might still sound shocking.

In California, ketamine drips are legally used as pain relief, to treat mood disorders and to help with addiction. Other celebrities and notable figures – including Chrissy Teigen, Elon Musk and Sharon Osbourne – have all shared details of ketamine therapy and how it helped them.

Dr Austin Harris, owner and medical director at NeuroRelief Ketamine Infusion Therapy, says historically the drug is “extremely safe” when used in the right conditions, and swears by its effectiveness.

At the clinic in California, he explained to Sky News how it can help people with mood disorders and chronic pain, as well as those in recovery from drug or alcohol abuse.

“Which a lot of people who don’t really understand this at a scientific level might think is an oxymoron,” he says. “But actually, it’s profoundly beneficial – done properly – in resetting both neurologic and psychological patterns for substance abuse.”

Ketamine infusion “restarts in our brain what should already be there”, he says, in terms of “the neurologic road workers, to be able to then direct, to build new patterns and actual new nerve pathways”.

One patient having therapy at the clinic also spoke to us, saying he had abused alcohol and marijuana, and occasionally opiate painkillers, for many years.

“I’ve had enough experience and decades of being addicted to drugs and alcohol and traumas and trying different things,” he said. “When I came out of that infusion I was like, wait a minute. I didn’t have the shakes. I didn’t have the cravings.”

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Dr Harris emphasises the need for administration by a professional in a clinical setting. “Matthew Perry was being illegally sold ketamine on the black market. The fact that a doctor happened to be one of several people that was illegally selling it to him should not be confused with the appropriate legal utilisation of ketamine.”

The actor was vulnerable, Dr Harris continues. “It’s absolutely abominable… You have someone with serious addiction problems, lifelong. And sadly, I think that he was really taken advantage of.”

The drugs stash

As well as Sangha and Iwamasa, the others charged over Perry’s death are Erik Fleming, an associate of Perry’s who was in contact with Sangha, Dr Mark Chavez, a physician, and Dr Salvador Plasencia, who also supplied ketamine illegally to Perry.

“I wonder how much this moron will pay,” Dr Plasencia said in a text exchange between him and Chavez.

After Perry died, Sangha desperately sought to cover her involvement. “Delete all our messages,” she instructed Fleming in a message on Signal.

In March 2024, law enforcement searched Sangha’s home and found 1.7kg of pressed pills containing methamphetamine, 79 vials of liquid ketamine, MDMA (ecstasy) tablets, counterfeit Xanax pills, baggies containing powdered ketamine and cocaine, and other drug-trafficking items such as a gold money counting machine, a scale, a wireless signal and hidden camera detector, drug packaging materials, and $5,723 in cash, according to her plea agreement.

Sangha was happy to supply to Hollywood’s rich and famous – and not an anomaly.

Several books have been written by Tinseltown dealers, and only a few months ago, the Sean “Diddy” Combs trial heard from a former personal assistant to the hip-hop mogul who testified about meeting sellers for his boss.

Now, as she becomes the last defendant to admit her role in Perry’s death, the Ketamine Queen’s guilty plea brings to a close the criminal investigation into the circumstances surrounding the tragedy.

But in a world where money talks, where fame and addiction or mental health issues often go hand-in-hand, it is unlikely to be the last.

Liz Truss has defended her record as prime minister and called for “institutional change” in Britain in the same way she claims Donald Trump delivered “revolution in the US”.

The former Conservative leader has spoken to Sky’s Wilfred Frost on his The Master Investor Podcast nearly three years after she resigned as prime minister – 44 days after taking over from Boris Johnson.

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Her downfall began when she and her then chancellor Kwasi Kwarteng unleashed £45bn of unfunded tax cuts on the markets in a mini-budget which sparked weeks of economic turmoil in 2022.

However, Ms Truss has now told Frost the fault for what happened during her premiership lay with the Bank of England (BoE) as she “wasn’t captain of the ship”.

She said: “The last time I looked, it’s the prime minister who is the democratically accountable person that runs the country, not the Bank of England… The Bank of England’s role is to work with the government to ensure financial stability, and they weren’t doing that. They were pursuing their own agenda.”

Ms Truss, the UK’s shortest-serving prime minister in history, added: “The fact is I wasn’t captain of the ship because I wasn’t running monetary policy. The Bank of England were running monetary policy. I’m very happy to take responsibility for things, provided I have the full ability to actually control them. I didn’t have the ability to control them.”

The former prime minister also accused the BoE and Office for Budget Responsibility (OBR) of briefing against her after the mini-budget.

She added: “My mistake, if you want to put it like that was underestimating the sheer malevolence of the economic blob in Britain.”

‘We’ve lost our way’

Ms Truss also said there is “economic stagnation” and poor public services in the UK and this is at least party due to the “failures” of the BoE and the OBR as “institutions”.

She continued: “There’s no doubt we’ve lost our way. But I think what is happening now in Britain is the people are now realising how bad the situation is. And I think there is going be massive pressure… for institutional change in this country, and that is what we need, in a similar way to Trump delivering the revolution in the US.

“That is what we need. And I think that will happen.”

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Ms Truss later said she believes the UK is heading for “calamity” under Prime Minister Sir Keir Starmer and claimed the economy is in a worse state now than when she was in office.

She said she sees Sir Keir and Chancellor Rachel Reeves as part of the “economic orthodoxy” and added: “That has ruined this country, and we are heading for a calamity because of that.”

Ms Truss also said she doesn’t expect the Conservatives to win the next election and this will be partly due to a failure to take on the “leftist establishment”.

“So I don’t think (Tory leader Kemi Badenoch) is going to be prime minister at this stage,” she added.

Asked by Frost whether she will ever return to frontline politics, Ms Truss said: “I never rule anything out… what I’ve always been obsessed with is I want Britain to be a great nation again, and I’m depressed about how far we’ve sunk. The dire state of our economy is in the deindustrialisation. The fact that we don’t make things the same way we used to.”

The full conversation also includes an extensive debate about the mini-budget. Liz Truss was speaking on The Master Investor Podcast with Wilfred Frost, available to watch here and listen here.

HOUSTON — Astros starter Framber Valdez said he apologized to catcher Cesar Salazar after hitting him in the chest with a pitch Tuesday night, but the left-hander insisted it wasn’t intentional.

Valdez appeared to shake off Salazar on a 1-0 pitch with the bases loaded and Trent Grisham of the New York Yankees at the plate in the fifth inning. Salazar then urged Valdez to step off the mound, but he proceeded with the pitch, which Grisham launched to deep left field to give New York a 6-0 lead in an eventual 7-1 win.

On the second pitch to the next batter, Valdez hit Salazar in the chest with a 93 mph pitch, raising questions about whether he was upset about what happened in the Grisham at-bat and if it was intended.

Valdez said it was not.

“What happened with us, we just got crossed up,” Valdez said in Spanish through an interpreter. “I called for that pitch, I threw it and we got crossed up. We went down to the dugout and I excused myself with him and I said sorry to him and I take full responsibility for that.”

Valdez was then asked directly if he did it on purpose.

“No,” he said. “It was not intentional.”

Valdez and Salazar were talking when reporters entered the clubhouse after the game, and Valdez said they had sorted things out.

“We were able to talk through it,” he said. “We spoke after the game … at his locker and everything’s good between us. It’s just stuff that happens in baseball. But yeah, we talked through it and we’re good.”

Salazar also was asked about what happened on the pitch where he was hit.

“The stadium was loud,” he said. “I thought I pressed the button, but I pressed the wrong button. I was expecting another pitch, but it wasn’t it.”

Salazar said Valdez didn’t hit him on purpose.

“No, me and Framber we actually have a really good relationship,” he said.

Information from The Associated Press was used in this report.