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By Tarun Sai Lomte May 4 2023 Reviewed by Lily Ramsey, LLM

A recent study published in the Zoonoses and Public Health Journal summarized the current knowledge on the Tahyna virus (TAHV).

Study:  Ťahyňa virus—A widespread, but neglected mosquito-borne virus in Europe. Image Credit: xpixel/Shutterstock.com Background

TAHV is a human pathogen of the California serogroup (CSG) orthobunyaviruses. It is a spherical enveloped virus around 100 nm in diameter, with three segments of negative-sense single-stranded RNA as the genome.

The genome is about 13 kb in size, and the segments are labeled as small (S), medium (M), and large (L). The S segment encodes a non-structural protein and the nucleocapsid.

The M segment encodes a polyprotein cleaved into two glycoproteins and a non-structural protein, whereas the L segment encodes an RNA-dependent RNA polymerase. The bunyaviral non-structural proteins might be pathogenic factors in vertebrates. TAHV was the first pathogenic arbovirus isolated from mosquitos in Europe.

TAHV transmission occurs via endemic mosquitos, with mammals as vertebrate hosts. Research attention shifted toward the medical significance of the virus when it was isolated from sick/hospitalized children.

Valtice fever, caused by TAHV, manifests as a febrile summer illness with laryngitis, nausea, and atypical pneumonia, particularly in children.

Acute neurologic symptoms also occur but in relatively fewer cases. There are no reports of fatalities. Given the widespread distribution of TAHV in Central Europe, it should be studied from a public health perspective.

The present study’s authors discussed the available knowledge on TAHV history, geographic distribution, transmission, diagnosis, and clinical manifestations. Ecology, hosts, and vectors of TAHV

TAHV transmission in endemic regions occurs in deciduous/mixed woodland forests with trees withstanding floods. TAHV outbreaks have been mainly recorded in southern Moravia and southern/eastern Slovakia. Related StoriesStudy indicates that targeted interventions strengthening HIV antiretroviral therapy initiation are criticalWhat is the risk for symptomatic H5N1 virus infection in humans?Study suggests the zoonotic-like avian H3N8 virus has limited efficiency for human-to-human transmission and is unlikely to cause severe disease in humans

Serologic investigations report increased TAHV exposure in flooded areas and regions adjacent to rivers, where floodplain mosquitos exist. TAHV was also detected in several biotopes in Asia.

Studies indicate that European hares are the likely amplifying hosts of TAHV. Experimental studies showed that Central Europe-endemic mammalian species develop viremia and TAHV-specific antibodies. However, only hares and rabbits have been established as competent hosts. Although infection in primates caused viremia and induced antibodies, the animals lacked clinical symptoms.

One study observed a febrile period of up to four days, reduced motility, and weakness in chimpanzees infected subcutaneously. Serosurveys detected TAHV-reactive antibodies in red deer, wild boars, fallow deer, mouflons, red deer, horses, cattle, wild rodents, European brown bears, and domestic sheep.

TAHV has been isolated from several mosquito species, including Aedes vexans, A. cinereus, and A. caspius, with many studies implicating A. vexans as the primary vector. Disease and diagnosis

Valtice fever may manifest from mild febrile illness to aseptic meningoencephalitis. TAHV infection causes symptoms similar to those caused by other CSG orthobunyaviruses, such as California encephalitis and La Crosse viruses. The main symptoms include severe headage, accompanied by nausea and dizziness.

Other symptoms include atypical pneumonia, anorexia, conjunctivitis, myalgia, laryngitis, and gastrointestinal symptoms typical of encephalitic orthobunyaviruses.

Only a small proportion of infected individuals may develop pleocytosis or severe meningitis. Serosurveys in endemic regions of Czechoslovakia revealed a high seroprevalence of up to 70%.

TAHV was isolated for the first time from a human with a natural infection in 1972. Subsequently, it was isolated from hospitalized children with acute fever. TAHV seropositivity has been documented in several European countries like Hungary, Austria, Yugoslavia, Croatia, Albania, and Russia. China, Uzbekistan, and Tajikistan have also reported TAHV infections.

Serum immunoglobulin M (IgM) detection is the basis of TAHV diagnosis, with virus neutralization tests accepted as the gold standard. TAHV infection could be diagnosed using a reverse-transcription polymerase chain reaction (RT-PCR) test.

Although TAHV infections are prevalent, disease incidence is often underreported due to the lack of diagnostic tests. As such, TAHV infections remain underdiagnosed in several countries. Concluding remarks

In summary, while TAHV remains endemic to Central Europe, with a larger geographic distribution, there is limited data on fundamental ecological and virological aspects.

Mosquito surveillance should also involve screening for TAHV. Although TAHV causes a relatively mild illness, the manifestation of neurologic symptoms cannot be overlooked.

Above all, high temperatures and increased flooding events in summer could lead to TAHV transmission; therefore, control strategies and serologic surveys should be implemented in regions where TAHV or its vectors exist. Journal reference:

Mravcová, K., Camp, J.V., Hubálek, Z., Šikutová, S., Vaux, A.G.C., Medlock, J.M. & Rudolf, I. (2023) Ťahyňa virus—A widespread, but neglected mosquito‐borne virus in Europe. Zoonoses and Public Health. doi: 10.1111/zph.13042 https://onlinelibrary.wiley.com/doi/10.1111/zph.13042

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Technology

TSMC first-quarter profit tops estimates, rising 60%, but Trump trade policy threatens growth

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TSMC first-quarter profit tops estimates, rising 60%, but Trump trade policy threatens growth

A motorcycle is seen near a building of the Taiwan Semiconductor Manufacturing Company (TSMC), which is a Taiwanese multinational semiconductor contract manufacturing and design company, in Hsinchu, Taiwan, on April 16, 2025.

Daniel Ceng | Anadolu | Getty Images

Taiwan Semiconductor Manufacturing Company on Thursday beat profit expectations for the first quarter, thanks to a continued surge in demand for AI chips.

Here are TSMC’s first-quarter results versus LSEG consensus estimates:

  • Revenue: $839.25 billion New Taiwan dollars, vs. NT$835.13 billion expected
  • Net income: NT$361.56 billion, vs. NT$354.14 billion 

TSMC’s reported net income increased 60.3% from a year ago to NT$361.56 billion, while net revenue in the March quarter rose 41.6% from a year earlier to NT$839.25 billion.

The world’s largest contract chip manufacturer has benefited from the AI boom as it produces advanced processors for clients such American chip designer Nvidia.

However, the company faces headwinds from the trade policy of U.S. President Donald Trump, who has placed broad trade tariffs on Taiwan and stricter export controls on TSMC clients Nvidia and AMD.

Semiconductor export controls could also be expanded next month under the “AI diffusion rules” first proposed by the Biden administration, further restricting the sales of chipmakers that use TSMC foundries.

Taiwan currently faces a blanket 10% tariff from the Trump administration and that could rise to 32% after the President’s 90-day pause of his “reciprocal tariffs” ends unless it reaches a deal with the U.S.

As part of efforts to diversify its supply chains, TSMC has been investing billions in overseas facilities, though the lion’s share of its manufacturing remains in Taiwan.

In an apparent response to Trump’s trade policy, TSMC last month announced plans to invest an additional $100 billion in the U.S. on top of the $65 billion it has committed to three plants in the U.S.

On Monday, AMD said it would soon manufacture processor chips at one of the new Arizona-based TSMC facilities, marking the first time that its chips will be manufactured in the U.S.

The same day, Nvidia announced that it has already started production of its Blackwell chips at TSMC’s Arizona plants. It plans to produce up to half a trillion dollars of AI infrastructure in the U.S. over the next four years through partners, including TSMC.

Taiwan-listed shares of TSMC were down about 0.4%. Shares have lost about 20% so far this year.

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Environment

Oil giant BP braces for shareholder showdown over green strategy U-turn

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Oil giant BP braces for shareholder showdown over green strategy U-turn

The BP logo is displayed outside a petrol station that also offers electric vehicle recharging, on Feb. 27, 2025, in Somerset, England.

Anna Barclay | Getty Images News | Getty Images

Oil giant BP is bracing itself for a shareholder backlash at its annual general meeting (AGM) on Thursday, with a chorus of disgruntled investors planning to voice their concerns over the firm’s green strategy U-turn.

A planned resolution on the reelection of outgoing BP Chair Helge Lund has been billed as an opportunity for investors to signal discontent on climate change, corporate governance and the influence of U.S. hedge fund Elliott Management.

Britain’s beleaguered energy major, which has lagged behind more hydrocarbon-focused industry peers in recent years, has sought to resolve something of an identity crisis by launching a fundamental reset.

Seeking to rebuild investor confidence and boost near-term shareholder returns, BP in February pledged to slash renewable spending and ramp up annual expenditure on its core business of oil and gas.

The strategy reset was broadly welcomed by energy analysts, and BP CEO Murray Auchincloss has since said the pivot attracted “significant interest” in the firm’s non-core assets.

British asset manager Legal & General, a leading shareholder in BP with a roughly 1% stake, said it intends to vote against Lund’s reelection on Thursday — a position that would defy BP’s management recommendation.

Legal & General cited dissatisfaction over major revisions to the firm’s energy strategy, alongside BP’s decision not to allow a shareholder vote on the new direction.

Legal & General’s plans align with those of international asset manager Robeco, U.K. pension funds Nest and Border to Coast, as well as activist investors including Dutch group Follow This — all of which have indicated they will vote against Lund’s reelection.

Norway’s gigantic sovereign wealth fund and a number of U.S. pensions funds, however, have reportedly said they will back Lund’s reelection. Proxy advisors Institutional Shareholder Services and Glass Lewis have also recommended a vote in favor of Lund, according to Reuters.

It paves the way for a shareholder showdown at BP’s AGM, with observers closely monitoring the level of investor opposition to Lund’s reelection. Historically, votes against the chair of BP have remained under 10%.

A BP spokesperson declined to comment when contacted by CNBC.

Energy transition plans

BP’s renewed focus on oil and gas comes at a time when the London-listed energy firm is firmly in the spotlight as a potential takeover target. British rival Shell and U.S. oil giants Exxon Mobil and Chevron have all been touted as possible suitors.

“We value the significant steps BP has taken in recent years regarding its climate-related commitments and efforts, which we have supported through extensive and constructive dialogues, aimed at creating long-term value as the climate transition unfolds,” Legal & General’s investment stewardship team said on April 11.

Murray Auchincloss, chief executive officer of BP, during the “CERAWeek by S&P Global” conference in Houston, Texas, on March 11, 2025.

Bloomberg | Bloomberg | Getty Images

“However, we are deeply concerned by the recent substantive revisions made to the company’s strategy as announced at the 2025 Capital Markets Day on 26 February, coupled with the decision not to allow a shareholder vote on the newly amended climate transition strategy at the 2025 AGM,” they added.

Legal & General said BP’s announcement earlier this month that Lund will step down, likely next year, was viewed “positively,” but ongoing unease about the firm’s succession plan means it intends to vote against the AGM resolution.

Five years ago, BP became one of the first energy giants to announce plans to cut emissions to net zero “by 2050 or sooner.” As part of that push, BP pledged to slash emissions by up to 40% by 2030 and to ramp up investment in renewables projects.

The company scaled back this emissions target to 20% to 30% in February 2023, saying at the time that it needed to keep investing in oil and gas to meet global demand.

Robeco said in its rationale that BP had refused to repeat a so-called “Say on Climate” vote for its strategy revision, despite previously requesting shareholder support for the firm’s previous and “more ambitious” transition goals.

“We have unsuccessfully requested such a consistent feedback mechanism several times, including in a public letter alongside other investors with GBP 5 trillion in assets under management,” said Michiel van Esch, head of voting at Robeco.

“As a result, we have growing concerns over the company’s resilience through the energy transition, and over the consistency of its approach to climate governance, leading us to vote against the chairman and chair of the safety and sustainability committee,” he added.

Governance concerns

Elliott Management, for its part, is widely thought to be putting pressure on BP to minimize low-carbon investments and prioritize oil and gas. It emerged recently that the activist investor has built a near 5% stake in BP, making it one of the firm’s largest shareholders.

Activist shareholder Follow This, which has a long history of pushing for Big Oil to do more to tackle climate change, said the need to vote against Lund had not disappeared following news of his looming departure. The group added that investors concerned with good governance should voice their dissatisfaction.

IEA downgrades 2025 oil demand growth outlook on escalating trade tensions

“Voting against the board is the only way for shareholders to express their dissent over BP’s refusal to allow a vote on its strategy U-turn,” Mark van Baal, founder of Follow This, said in a statement.

“Now, the board has unilaterally changed course without asking shareholder support with a vote. This raises serious governance concerns. It seems BP’s leadership is afraid of its own shareholders,” he added.

Shares of BP are down nearly 10% year-to-date.

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Science

This Is How Humans Used Fire During the Last Ice Age in Europe

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This Is How Humans Used Fire During the Last Ice Age in Europe

Fire was an essential part of the survival of the ice age individuals for daily household chores such as cooking, heating, making tools or as a source of light. However, it is baffling that there is no evidence found of the well-preserved fireplaces from the coldest places of the ice age in Europe. A study led by researchers published in the journal Geoarchaeology revealed how upper palaeolithic individuals managed fireplaces during the Last Glacial Maximum, dating back between 26,500 to 19,000 years ago. A press release from the University of Vienna dated April 14, 2025, highlighted the findings of sophisticated fire building techniques.

Ice Age Fire-Making Techniques Revealed

The study was conducted by a group of scientists led by archaeologist Philip R. Nigst at the University of Algarve and the University of Vienna to shed some light on the ice age fire mystery. The three hearths analysis at a prehistoric site at the shore of the Dnister River in Ukraine revealed that people of the last Ice Age made different types of hearths and used wood along with bones and fat, not just to light fires but also to enhance the sustaining fires in the freezing conditions. Charcoal analysis suggested that these were spruce wood.

The observations signal that they were not confined to a single method of fire building but created various hearths. These findings were published on April 1 in the journal Geoarchaeology. After conducting micro-stratigraphic analysis, colourimetric and micromorphology analysis, the scientists discovered three flat, wood-fired hearths. An interesting fact analysed that one of the fires reached over 650 degrees Celsius. As per the team, this proves that whoever created this hearth had mastery of pyrotechnics despite the harsh milieu they inhabited.

However, it was said by one of the scientists, Marjolein D. Bosch, a zooarchaeologist, said that we further need to study whether the animal bones burnt at 650 degree celsius were actually burnt as fuel or it was just an accident. The fireplaces were quite organised and sophisticated, as if these have been constructed based on the season. The large and thick appearance of one fireplace suggests the tolerance of high temperatures. Night said that these fireplaces were used by hunter-gatherers and different times of the year.

Future Scope of Discussions

The question arises why this scant evidence of fireplaces still exists, dating back to the ice age.
Murphee asks that most of the evidence be destroyed by freezing and thawing of the soil. Further added by Nigst that they may have found it difficult to manage the fuel at the last glacial maximum. This may also signal the use of other technological solutions instead of fire. The team hopes to understand more about the role fire plays in human evolution and how it aided our species to become dominant.

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