World’s first jab to stop skin cancer being tested in UK patients

Published

2 weeks ago

April 26, 2024

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The world’s first personalised mRNA cancer jab for melanoma is being tested in British patients.

The “gamechanger” jab also has the potential to stop bladder, lung and kidney cancer.

It’s custom built for each person and tells the body to identify cancer cells and stops the disease returning.

A stage-two trial found it significantly reduced the risk of cancer coming back in melanoma patients and now a final trial has been launched.

University College London Hospitals NHS Foundation Trust (UCLH) is leading the phase.

Dr Heather Shaw, co-ordinating investigator of the trial, said it was “one of the most exciting things we’ve seen in a really long time”.

“This is a really finely honed tool,” she said.

“To be able to sit there and say to your patients that you’re offering them something that’s effectively like the Fat Duck at Bray versus McDonald’s – it’s that level of cordon bleu that’s coming to them.

“These things are hugely technical and finely generated for the patient. The patients are really excited about them.”

The jab is an individualised neoantigen therapy (INT) and can trigger the immune system to fight the patient’s specific type of cancer.

To create the personalised therapy, a tumour sample is removed and has its DNA sequenced – with artificial intelligence also playing a role.

Dr Shaw said: “This is very much an individualised therapy and it’s far cleverer in some senses than a vaccine.

“It is absolutely custom built for the patient – you couldn’t give this to the next patient in the line because you wouldn’t expect it to work.”

She added: “I think there is a real hope that these will be the gamechangers in immunotherapy.”

The aim is to ultimately cure the cancer and eradicate any rogue cells that might not show on scans.

The phase-two trial found people with high-risk melanomas who got the jab – alongside immunotherapy drug Keytruda – were about half (49%) as likely to die or have their cancer come back after three years than those who just had Keytruda.

The phase-three global trial will include a wider range of patients and researchers are hoping to recruit around 1,100 people.

At least 60 to 70 patients across eight UK centres are set to be recruited and the twin therapy combination will also be tested in lung, bladder and kidney cancer.

Professor Lawrence Young, from the University of Warwick, called it “one of the most exciting developments in modern cancer therapy”.

“Interest in cancer vaccines has been reignited in recent years by a deeper understanding of how the body controls immune responses and by the advent of mRNA vaccines which makes developing a vaccine based on the immune profile of a patient’s own tumour much more straightforward,” said Prof Young.

“The hope is that this approach could be extended to other cancers such as those of the lung and colon.”

UK

Kris Hallenga, founder of breast cancer charity CoppaFeel!, dies aged 38

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4 hours ago

May 6, 2024

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Kris Hallenga, founder of breast cancer charity CoppaFeel!, dies aged 38

Kris Hallenga, the founder of breast cancer charity CoppaFeel!, has died aged 38.

She was diagnosed with breast cancer when she was 23 and lived with the illness for 15 years, tirelessly campaigning for breast cancer awareness in that time.

A statement on the charity’s website said: “She hasn’t lost a battle, she wasn’t in a fight and she certainly wouldn’t want you to see her death as tragic.

“She was simply living. She was 38 and died with fulfilment and a heart full of love.”

Ms Hallenga’s breast cancer was terminal by the time it was diagnosed in 2009.

“Kris’ ambition was for no one else to find themselves in her position and so CoppaFeel! was born, to ensure breast cancers are diagnosed early and accurately,” the charity said.

Describing her as “founder, boob chief, colleague, friend and queen of glittering turds”, CoppaFeel! said she was “the biggest promoter of being ‘alive to do those things'”.

“She approached life in a wildly creative, fun and fearless way, and showed us that it is possible to live life to the full with cancer.”

Last year Ms Hallenga threw a living funeral, where guests were invited to sign a cardboard replica of her coffin and childhood footage was projected around Truro Cathedral in Cornwall.

Dawn French did the eulogy in character as the Vicar of Dibley, while Ms Hallenga gave a speech and sparkled in a glittery jumpsuit.

Afterwards, she posted on Instagram: “I’ve never felt love like it. I’ve never felt joy like it. I’ve never felt such kinship with mortality. I’ve never felt so alive.”

Ms Hallenga campaigned for cancer education to be included in the school curriculum, won the Women of the Year Outstanding Young Campaigner award, received an honorary doctorate from Nottingham Trent University and wrote a memoir titled Glittering a Turd.

A post on her Instagram page announcing the news to her 146,000 followers was signed off by her cat Lady Marmalade.

It said: “Her final message from her to you would be one that probably involved checking your chest, getting in some cold water, talking more about death and dying, that even the turdiest of turds are glitterable, that you should always see the silly side of life, that she LOVED her life and that giving Neighbours 2.0 is worth another chance.”

UK

Ipswich Town fans enjoy ‘long-awaited’ open-top bus celebrations after Premier League promotion

Published

4 hours ago

May 6, 2024

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Ipswich Town fans enjoy 'long-awaited' open-top bus celebrations after Premier League promotion

Ipswich Town fans celebrated their “long-awaited” return to the Premier League after they secured promotion over weekend.

On Saturday, Kieran McKenna’s Tractor Boys clinched their place in the top flight with a 2-0 win over now-relegated Huddersfield Town.

The result meant Ipswich will return to the Premier League for the first time since 2002.

Saturday’s victory secured the Suffolk club back-to-back promotions as they became the first team since Southampton in 2011 and 2012 to win successive promotions to the top flight from League One.

On Monday the team rode through Ipswich on an open-top bus, with thousands of fans turning out to celebrate.

Speaking to Sky News, fans described feelings of euphoria amid the celebrations, as others were enjoying a long weekend of non-stop celebrating.

“It’s been a really really long time coming,” one fan said.

Paul Smith, who like many was on his second day of celebrating, said: “I’ve been lucky enough to live through an era of seeing the great times at Ipswich, but I dragged him [his son] along for many many years and I’m grateful his generation gets to see some great times as well.

“When you realise the teams we’re going to be playing it’s incredible.”

Paul’s son Arthur said it was “euphoric” seeing his side promoted but admitted to feeling quite “jaded” from the celebrations.

It was also quite an emotional moment for some who shared a bond with the club with family members.

Adam Conuel, another fan, described the promotion in one word: “Unbelievable”.

He added: “My grandad passed away last year, we were quite close, he was a supporter all his life too, like my dad.”

He described the celebrations as “emotional” and said “look how many people are here, it’s crazy, I never thought in my lifetime… every conversation I’ve had with my grandpa used to be ‘we were rubbish weren’t we’ and he’s missed the past two years of us being unbelievable so it’s quite emotional to watch us.”

Again and again one name surfaced from fans out celebrating – their coach McKenna.

The 37-year-old Northern Irish manager has taken the English football league by storm in recent years, charging up to the Premier League.

A former Manchester United assistant manager, McKenna was praised repeatedly by fans for his handling of the club and his brand of attacking, and successful, football.

When he took charge of Ipswich, they were languishing in League One and now within three years he has catapulted them to the Premier League.

Speaking on board the bus, McKenna told Sky Sports News: “It’s an incredible turnout, amazing seeing so much joy.

“Everyone deserves it, the whole town deserves it, the players … for how hard they’ve worked. And the supporters, who’ve followed so loyally for years and have been waiting for a day like this.

“We just set out to be as good as we could possibly be.

“The closer you get to the end you know you’re within reach of an amazing achievement and we’re so glad we were able to finish off well.”

UK

Scottish singer drafted in to replace Olly Murs at Glasgow Take That concert thought offer was a ‘joke’

Published

4 hours ago

May 6, 2024

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Scottish singer drafted in to replace Olly Murs at Glasgow Take That concert thought offer was a 'joke'

A Scottish singer plucked from obscurity at the last minute to replace Olly Murs as the opening act for Take That in Glasgow has told Sky News he thought the life-changing opportunity was a “joke”.

Daniel Rooney, 26, was playing at the Radisson Red hotel opposite the OVO Hydro when news broke that Murs was forced to cancel his support act on Friday due to transport issues.

TV presenter Ross King, who was enjoying a family dinner at the hotel, was impressed with Mr Rooney’s vocals and recommended the singer to his friend and Take That frontman Gary Barlow.

With 30 minutes to go before the show was due to start, Mr Rooney was quickly whisked to the arena and opened the festivities with a range of upbeat cover songs.

Barlow later thanked him on Instagram.

Mr Rooney, from Cambuslang in South Lanarkshire, told Sky News he thought it was a wind-up at first.

He said: “I was thinking, ‘right, who’s trying to play a wee joke on me here’. But thankfully it wasn’t a joke and Ross King was saying, ‘I’ve got an opportunity of a lifetime here, Danny boy, so are you up for it?’

“And I was.”

Mr Rooney started to feel a mixture of emotions on his way to the stage. As well as excitement, he began to feel apprehensive about what he was going to play.

He said: “I was obviously buzzing just to get that news. It was just mental.

“I had a wee discussion with the boys from Take That, who were brilliant and really good with me.

“We just agreed on making it really fun and making the songs nice big singalongs.

“It was just really great. The crowd were brilliant, and they sang to every song and the feedback was magic.”

Mr Rooney paid tribute to Mr King for the opportunity and thanked him for his warm introduction onstage to explain the situation to the crowd.

Speaking to Sky News, Mr King said: “I was listening to [Mr Rooney] while I was having dinner and was very impressed – never thinking that 30 minutes later I’d be saying ‘come with me and support Take That’.

“Gary Barlow is one of my closest pals and I’ve known the band since 1990. When Gary called me and said ‘you’re going to have to go on, Olly is stuck in London’, I thought it was a wind-up. But no.”

Mr King agreed to go on, but then pitched the idea of Mr Rooney.

Mr King added: “Daniel was the coolest guy in the Hydro and played a blinder. I was thrilled to share the stage with him and help out my old mates too.

“I know this has made news all around the world, so I hope Daniel continues to have the success he deserves.”

Mr Rooney now intends to head into the studio to record some music.

He added: “I’ve got some ideas and demos there, so this is the opportunity to get them out now and just really capitalise on the moment.”

Murs apologised for cancelling his performance at short notice after falling foul of flight issues.

The former X Factor star said he had been at Heathrow from 11am ahead of his performance on Friday night, but the flight was cancelled after “several delays” and an accident with a cabin crew member.

He later shared a video of himself being driven to Glasgow for his Saturday and Sunday performances.

Speaking on ITV’s Lorraine programme on Monday, Murs paid tribute to Mr Rooney for holding his nerve and being able to perform in front of an arena crowd of thousands with just 30 minutes’ notice.

Murs said: “Fair play to him, that’s amazing. You know what, credit to him.”