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In a new study from UC Davis and UC Berkeley, researchers have developed a method to deliver mRNA to fetal brain cells, potentially offering a way to correct genetic disorders like Angelman and Rett syndrome before birth. By injecting messenger RNA (mRNA) encapsulated in lipid nanoparticles (LNPs) directly into fetal brain cells, the study showed promising results in a mouse model for gene editing in the developing brain, reported in ACS Nano.

Understanding the Technology

The LNP technology used here acts as a “delivery vehicle” for mRNA, which serves as a blueprint for proteins in cells. By delivering mRNA that instructs the cell to build the Cas9 enzyme, which can edit genes, researchers successfully targeted cells in the fetal brain. This method could correct genetic mutations at a critical developmental stage, potentially stopping harmful cellular changes before birth. Senior researcher Dr. Aijun Wang, a UC Davis biomedical engineering professor, noted that this approach could allow for the correction of faulty genes during a crucial window in fetal brain development.

Implications and Benefits of In Utero Gene Editing

The research provides a model for how neurodevelopmental conditions could be treated early, before the blood-brain barrier forms, which usually limits treatments after birth. Correcting cells early could lead to more lasting benefits, particularly since a significant number of neurons in areas critical for memory and cognition were shown to incorporate the healthy genetic material.

Future of LNP mRNA Treatments

The LNP method also minimises the risks of inflammation, a common challenge in mRNA delivery to the brain. This research lays the groundwork for future therapies targeting the central nervous system, where treatments given in utero could translate into better health outcomes at birth. The researchers plan to continue developing this technology to see if it can be applied more widely in disease prevention before birth, with potential broader applications for other genetic conditions.

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Massive Steam Plume Spotted at Alaska’s Mount Spurr as Volcano May Erupt Soon

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Massive Steam Plume Spotted at Alaska’s Mount Spurr as Volcano May Erupt Soon

A large steam plume has been seen emerging from Mount Spurr in Alaska, signalling increased volcanic activity. Images shared by the Alaska Volcano Observatory (AVO) on March 28 confirmed steam and gas emissions visible from the volcano’s summit and a northern vent. The volcano is located around 80 miles west of Anchorage and stands at 11,070 feet high. The experts have revealed that there could be a possible eruption in the coming weeks or months. However, nothing is certain yet.

Increased Signs of Unrest Reported

According to the latest update by the Alaska Volcano Observatory steam was observed rising from the summit on March 26. A smaller plume was also recorded from a fumarole on the volcano’s northern flank. No immediate changes in seismic activity or gas levels were detected during these observations as per the AVO statement.

The AVO had earlier mentioned in a March 11 update that a noticeable rise in gas emissions indicates fresh magma has moved into the crust beneath Mount Spurr. This has led scientists to assess the chance of an eruption in the near future. The observatory clarified that the exact timing of any eruption cannot be predicted yet.

Hazards and Possible Alerts

The observatory has cautioned that the volcano’s alert level might be raised if there are further signs of escalation. According to AVO, this may include persistent seismic tremors, increased gas emissions or visible surface changes. If an eruption occurs, possible hazards include ash clouds impacting flights, ashfall across nearby areas, pyroclastic flows and mudflows known as lahars.

The volcano last erupted in 1992. That eruption resulted in heavy ashfall and affected air travel in the region. AVO has advised residents and visitors to stay informed and follow safety instructions if alerts are raised.

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Study Identifies Plasma Formation as a Pseudostreamer

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Study Identifies Plasma Formation as a Pseudostreamer

A towering spiral of plasma has been recorded extending millions of kilometres from the Sun. The video was taken by the European Space Agency’s Solar Orbiter during an eight-hour period on October 12, 2022. A coronal mass ejection caused the plasma to rise from the Sun’s surface. The footage captured something which was never observed before. It showed a swirling motion in the solar wind. As per the latest report, scientists also recorded bright streaks that were moving across the frame. Researchers also revealed that these streaks appeared as pixelated lines, which might also ressemble like UFOs. Scientists later confirmed they were distant stars visible due to the imaging process.

Study Identifies Plasma Formation as a Pseudostreamer

The study published in The Astrophysical Journal revealed that the massive structure that appeared in the photos was a large pseudostreamer. It was formed near the Sun’s north pole after a solar flare erupted. The report further highlighted that the plasma reached 1.5 times the Sun’s width and remained visible for three hours. Scientists believes the twisting movement of the plasma was due to Alfvénic fluctuations. These fluctuations happen when waves of charged particles respond to magnetic disturbances. Scientists says the pseudostreamer’s location influenced its unique shape. Magnetic fields at the Sun’s poles are stronger than those near the equator.

Unusual Streaks Explained

The video also showed bright, half-dark lines crossing the screen. These lines appeared to move in a pattern similar to arcade game graphics. ESA confirmed that these were distant stars. The video’s editing technique made them appear as streaks rather than points of light. The Solar Orbiter’s movement against the background created this effect.

Solar Activity Expected to Intensify

The Sun is currently experiencing solar maximum. Flares and solar winds have increased since early 2024. The pseudostreamer in the video formed before this peak. Scientists were surprised by its early appearance. ESA’s Solar Orbiter continues to capture detailed images of solar wind. NASA’s Parker Solar Probe and ESA’s Proba-3 mission are also studying these phenomena. More extreme solar winds are expected in the coming years.

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SpaceX Launches 27 Starlink Satellites on Falcon 9 Rocket, Booster Lands Safely

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SpaceX Launches 27 Starlink Satellites on Falcon 9 Rocket, Booster Lands Safely

SpaceX has sent another batch of satellites into orbit. On April 3, a Falcon 9 rocket launched 27 Starlink satellites from Vandenberg Space Force Base in California. The rocket lifted off at 9.02 p.m. Eastern Time and was followed by a successful landing of the first-stage booster on a drone ship stationed in the Pacific Ocean. This booster had already been used on four earlier flights. The satellites are expected to be deployed nearly an hour after takeoff if mission steps proceed as planned. The launch formed part of SpaceX’s continued effort to expand its low Earth orbit network.

Details from the Launch Mission Description

According to the mission information provided by SpaceX, the launch marked the fifth use of the same Falcon 9 booster. The drone ship used for recovery was named “Of Course I Still Love You”. This reusable system has become a routine part of SpaceX operations. The booster’s return was completed around eight minutes after liftoff. The launch contributed to the growing total of Starlink satellites which is aimed at building a global broadband network.

Launch Activity in 2025

This latest mission has brought the number of Falcon 9 launches in 2025 to 38. About two-thirds of those have supported the expansion of the Starlink constellation. Earlier this week, two separate launches were also completed. One of them included the Fram2 private astronaut mission, which carried crew members into orbit over Earth’s poles. That mission marked a new milestone in human spaceflight.

Starlink Satellite Network

Over 7100 satellites are now part of the Starlink constellation. The system is already the largest of its kind. SpaceX continues to work on expanding its coverage by launching more satellites regularly. The objective remains to provide consistent internet access worldwide, especially in regions with limited connectivity options.

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