Youth fitness linked to lower atherosclerosis risk in middle-aged men

Published

2 months ago

February 22, 2024

admin

Feb 22 2024 Linköping University

Men who were physically fit when they were young had a lower risk of atherosclerosis almost 40 years later, according to a study led by researchers at Linköping University, Sweden. The findings, published in the British Journal of Sports Medicine, suggest that atherosclerosis is one of the mechanisms behind the link between physical fitness and cardiovascular disease. Our results strengthen the notion that physical fitness is linked to health outcomes much later in life. The findings are worrying in the sense that there is a clear global trend indicating that young people are less fit now than when these study participants were young in the 1970s and 80s. Therefore, I believe that these findings may be even more important for those growing up now."

Pontus Henriksson, Senior Associate Professor, Department of Health, Medicine and Caring Sciences, Linköping University

It is well-known that being physically unfit at a young age is linked to an increased risk of cardiovascular disease much later in life. But the mechanism behind this finding is not fully understood. An important risk marker for future cardiovascular disease is the occurrence of atherosclerosis, which involves the accumulation of plaques in the arteries. The international research team behind the current study therefore wanted to investigate whether physical fitness in adolescence is linked to atherosclerosis much later, which in that case would indicate that atherosclerosis is a likely mechanism behind the observed link to cardiovascular disease.

In the study, the researchers linked information from the Swedish Military Conscription Register to SCAPIS (the Swedish Cardiopulmonary Bioimage Study), a large population study on heart and lung health in individuals aged 50 to 64 years. For almost 9,000 men who participated in SCAPIS, data on them at conscription at age 18 from 1972 to 1987 were also available. One of the strengths of the study is that it is based on the general population and that the men have been followed for a long time, an average of 38 years.

The researchers examined the coronary arteries, which supply blood to the heart muscle, using coronary CT angiography, CCTA. The study is the first to use this state-of-the-art technology to examine plaques in the coronary arteries in relation to physical fitness at a young age. In addition, the researchers studied two different types of plaques in the coronary arteries. Plaques with calcium deposits are easy to measure and have long been the focus.

"We measured not only calcified plaques in the coronary arteries, but also non-calcified plaques, which are considered more problematic. They may be more likely to rupture, which can cause heart attacks, and have a worse prognosis," says ángel Herraiz-Adillo, postdoc in the same research group.

"We see in our study that both good cardiorespiratory fitness and good muscle strength in youth are associated with a lower risk of atherosclerosis in the coronary arteries almost 40 years later," says Pontus Henriksson.

The researchers also examined atherosclerosis in the large arteries from the heart up to the brain with ultrasound.

Since only men did military service in Sweden at the time, the researchers have only been able to investigate the association between physical fitness and atherosclerosis in men. It is therefore not possible to draw conclusions for women from this particular study.

The study was funded by, among others, the Heart-Lung Foundation, which is the main funder of SCAPIS, the Knut and Alice Wallenberg Foundation, the Swedish Research Council, Vinnova and the Joanna Cocozza Foundation for Children's Medical Research. Several other researchers from Linköping University also participated in the work on the study: Karin Rådholm, Carl Johan östgren, Kristofer Hedman and Sara Higueras-Fresnillo. Source:

Linköping UniversityJournal reference:

Herraiz-Adillo, Á., et al. (2024). Physical fitness in male adolescents and atherosclerosis in middle age: a population-based cohort study. British Journal of Sports Medicine. doi.org/10.1136/bjsports-2023-107663.

UK

Sadiq Khan secures convincing win over Tory rival in London mayoral race

Published

2 hours ago

May 4, 2024

admin

Sadiq Khan secures convincing win over Tory rival in London mayoral race

Labour’s Sadiq Khan has secured a historic third term as London mayor, seeing off Tory challenger Susan Hall.

It followed “wild rumours” the incumbent could have suffered a shock defeat, although both sides subsequently said they believed Mr Khan would win.

He received 1,088,225 votes (43.8%) to be re-elected, a majority of nearly 276,000 over Ms Hall, who secured 812,397 votes (32.7%).

Follow live:
The results as they come in

It was the first time any candidate for London mayor has won a third term in office, with Mr Khan’s predecessors Boris Johnson and Ken Livingstone both having served two terms.

As he took to the stage to make his victory speech, the re-elected mayor was booed and heckled with a shout of “Khan killed London” by the far-right Britain First candidate, who received fewer votes than Count Binface.

Speaking at City Hall, Mr Khan said: “We faced a campaign of non-stop negativity, but I couldn’t be more proud that we answered the fearmongering with facts, hate with hope, and attempts to divide with efforts to unite.

“We ran a campaign that was in keeping with the spirit and values of this great city, a city that regards our diversity not as a weakness, but as an almighty strength – and one that rejects right hard-wing populism and looks forward, not back.”

He also thanked his family for their support, but apologised for them having to deal with “protests by our home” and “threats”.

While congratulating Mr Khan on his victory, Ms Hall said he should stop “patronising” people who care about London.

When she had previously challenged him in a mayoral debate about “gangs running around with machetes” in the capital, he had said she should “stop watching The Wire” – a gritty US-based crime drama.

In her concession speech, she said: “The thing that matters the most, and to me, is reforming the Met and making London safe again. I hope Sadiq makes this his top priority.

“He owes it to the families of those thousands of people who have lost lives to knife crime under his mayoralty.

“And I hope too that he stops patronising people, like me, who care. This isn’t an episode of The Wire, this is real life on his watch.”

The pair had repeatedly clashed during the campaign, fought out amid concerns about knife crime and the handling of pro-Palestinian marches in the capital.

Just recently, Mr Khan had described his Conservative rival as the “most dangerous candidate I have fought against” over her past social media activity.

Hitting back, Ms Hall said she had “learnt” from her mistakes and branded his comment “outrageous”.

A clear dividing line between the candidates had been Mr Khan’s controversial expansion of the ultra low emission zone (ULEZ), which has been the subject of ongoing protests and which Ms Hall had pledged to scrap.

During the race, the Conservatives were forced to delete a clip used in an advert against Mr Khan’s record on crime after it emerged it used footage of a stampede at a New York subway station.

The result comes after Rishi Sunak’s Tory party took a hammering at the local elections, shedding hundreds of seats and losing more than 10 councils.

Meanwhile, Labour has made gains across the country, winning the Blackpool South by-election with a 26% swing from the Tories and taking control of councils in key battleground areas.

The party also picked up new mayoralties, including the critical regions of East Midlands and York and North Yorkshire, which includes Mr Sunak’s Richmond constituency.

Labour leader Sir Keir Starmer said: “This is effectively the last stop on the journey to the general election and I am really pleased to be able to show we are making progress, we have earned the trust and confidence of voters and we are making progress towards that general election.”

Mr Sunak has taken consolation in the Conservative victory in the Tees Valley mayoral race, which was retained by Lord Houchen and seems to be enough to calm rumblings among discontented Tory MPs.

However, the crunch contest for West Midlands mayor remains on a knife-edge.

Labour has also not had it all its own way, losing control of councils in Oldham and Kirklees after victories for independent candidates opposing the party’s stance on Gaza.

Labour also lost seats on other councils including Bristol, where the Greens extended its lead as the largest party and could now be set to run the city council despite narrowly failing to win outright control.

Notably, all 14 councillors in the newly created Bristol Central constituency are now Green, where the party is looking to unseat Labour’s shadow culture secretary Thangam Debbonaire at the general election.

Sky News elections analyst Professor Michael Thrasher also says although the results are bad news for the Tories, they do not put Labour on course for an overall majority in the Commons in a general election.

The Tories have so far lost 473 seats and control of 12 councils, while Labour has won eight councils and gained 185 seats.

The Liberal Democrats gained 104 seats and won control of Dorset council from the Conservatives, while the Greens are up 74 seats.

Sports

Kentucky Derby to remain on NBC through 2032

Published

2 hours ago

May 4, 2024

admin

Kentucky Derby to remain on NBC through 2032

Associated Press

May 4, 2024, 12:17 PM ET

STAMFORD, Conn. — The Kentucky Derby will remain on NBC through 2032 after the network and Churchill Downs Inc. extended their contract, announcing it hours before the running of the 150th race Saturday.

The race switched to NBC in 2001 after airing on ABC from 1975 to 2000 and CBS from 1952 to 1974. The multiyear extension will make NBC the longest-running home of the race for 3-year-old horses.

The deal includes multiplatform rights to the Kentucky Derby, Kentucky Oaks, and Derby and Oaks day programming, which will be presented on NBC, Peacock, USA Network and additional NBCU platforms.

Politics

Conservative Andy Street’s bid to be re-elected West Midlands mayor ‘too close to call’

Published

2 hours ago

May 4, 2024

admin

Conservative Andy Street's bid to be re-elected West Midlands mayor 'too close to call'

The battle for West Midlands mayor is down to the wire after a partial recount of votes was ordered.

Incumbent Tory Andy Street’s hope of securing a third term in office remains on a knife-edge in the face of a stiff challenge by Labour’s Richard Parker.

The outcome of the contest is critical to Rishi Sunak after a hammering in the local elections, which saw the Conservative Party lose more than half of its councillors who stood for re-election across England.

Local elections live

It threatens to ramp back up the pressure on the prime minister, who was hoping for a repeat of the success enjoyed by Conservative Ben Houchen who held on as the mayor of Tees Valley and to dampen rumblings of rebellion among some Tory MPs.

Former Scottish Conservative leader Ruth Davidson in the Electoral Dysfunction podcast said the rebels who want to move against Mr Sunak and change leader “would have a huge amount of fuel” if the party lost “one or other or both of Teeside and West Midlands”.

Mr Street had sought to distance himself from the Conservative brand during his campaign and instead ran on a personal platform.

Sky News recently revealed Mr Street was sending out election literature with an endorsement from former prime minister Boris Johnson which urged people to “forget about the government”.

His campaign website also made no mention of Mr Sunak on its homepage and was coloured in green rather than Conservative blue.

This breaking news story is being updated and more details will be published shortly.

Please refresh the page for the fullest version.

You can receive Breaking News alerts on a smartphone or tablet via the Sky News App. You can also follow @SkyNews on X or subscribe to our YouTube channel to keep up with the latest news.